Works by Grimwood, Sarah

Results: 26

Application of cross-species PET imaging to assess neurotransmitter release in brain.

Published in:

Psychopharmacology, 2015, v. 232, n. 21/22, p. 4129, doi. 10.1007/s00213-015-3938-6

By:

Finnema, Sjoerd;
Scheinin, Mika;
Shahid, Mohammed;
Lehto, Jussi;
Borroni, Edilio;
Bang-Andersen, Benny;
Sallinen, Jukka;
Wong, Erik;
Farde, Lars;
Halldin, Christer;
Grimwood, Sarah

Publication type:

Article

Donepezil causes acute increases in regional cerebral blood flow in normal rat

Published in:

2011

By:

Goodman, James;
Xie, Zhiyong;
Soares, Holly;
Grimwood, Sarah

Publication type:

Abstract

Donepezil causes acute increases in regional cerebral blood flow in normal rat

Published in:

2011

By:

Goodman, James;
Xie, Zhiyong;
Soares, Holly;
Grimwood, Sarah

Publication type:

Abstract

Pharmacokinetics, safety and tolerability of PF-04995274: A 5HT4 partial agonist being developed for the treatment of Alzheimer's disease

Published in:

2011

By:

Nicholas, Timothy;
Raunig, David;
Duvvuri, Sridhar;
Plotka, Anna;
Schwam, Elias;
Grimwood, Sarah;
Park, Yo-sub;
Rowinski, Carolyn;
Rapp, Tracey L;
Bergeron, Michelle;
Leurent, Claire

Publication type:

Abstract

Translational receptor occupancy for the 5-HT4 partial agonist PF-04995274 in rats, non-human primates and healthy volunteers

Published in:

2011

By:

Grimwood, Sarah;
Drummond, Elena;
Zasadny, Ken;
Skaddan, Marc;
Brodney, Michael;
Coffman, Karen;
Nicholas, Timothy;
Duvvuri, Sridhar;
Raunig, David;
Leurent, Claire;
Rowinski, Carolyn;
Park, Yo-Sub;
Ogden, Adam;
Sawant, Aarti;
Miller, Emily;
Rapp, Tracey L;
Wang, Yi;
Planeta-Wilson, Beata;
Ropchan, Jim;
Carson, Richard

Publication type:

Abstract

Significant reduction of brain and CSF amyloid-β in mice following acute administration of a brain-penetrant BACE1 inhibitor

Published in:

2010

By:

Hajos-Korcsok, Eva;
Nolan, Charles;
Oborski, Christine;
Lanyon, Lorraine;
Liston, Dane;
Ambroise, Claude;
Fisher, Katherine;
Noell, Stephen;
Christoffersen, Curt;
Grimwood, Sarah;
Hannah, Divine;
Bian, Feng;
Liu, Jianhua;
Nelson, Frederick;
Lu, Yasong;
Coffey, Heather;
Ogilvie, Kevin;
Coffman, Karen;
Efremov, Ivan;
Helal, Christopher

Publication type:

Abstract

PF-04447943, a novel PDE9A inhibitor, increases cGMP levels in cerebrospinal fluid: Translation from non-clinical species to healthy human volunteers

Published in:

2009

By:

Nicholas, Timothy;
Evans, Rebecca;
Styren, Scot;
Qiu, Ruolun;
Wang, Ellen Q.;
Nelson, Frederick;
Le, Vu;
Grimwood, Sarah;
Christoffersen, Curt;
Banerjee, Subhashis;
Corrigan, Brian;
Kocan, Geralyn;
Geoghegan, Kieran;
Carrieri, Charles;
Raha, Nancy;
Verhoest, Patrick;
Soares, Holly

Publication type:

Abstract

[3H]DAA1106 binding to hippocampal peripheral benzodiazepine receptors in kainic acid-treated Tg2576 and C57BL6 mice

Published in:

2009

By:

Lu, Yifeng;
Liu, Xiaohong;
Hanks, Ashley;
Samaroo, Harry;
Wallace, Karin;
Bales, Kelly;
Stephenson, Diane;
Grimwood, Sarah

Publication type:

Abstract

Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain.

Published in:

International Journal of Neuropsychopharmacology, 2015, v. 18, n. 3, p. 1, doi. 10.1093/ijnp/pyu081

By:

Finnema, Sjoerd J;
Hughes, Zoë A;
Haaparanta-Solin, Merja;
Stepanov, Vladimir;
Nakao, Ryuji;
Varnäs, Katarina;
Varrone, Andrea;
Arponen, Eveliina;
Marjamäki, Päivi;
Pohjanoksa, Katariina;
Vuorilehto, Lauri;
Babalola, Phebian A;
Solin, Olof;
Grimwood, Sarah;
Sallinen, Jukka;
Farde, Lars;
Scheinin, Mika;
Halldin, Christer

Publication type:

Article

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D Receptor Occupancy.

Published in:

Pharmaceutical Research, 2016, v. 33, n. 5, p. 1305, doi. 10.1007/s11095-016-1888-2

By:

Johnson, Martin;
Kozielska, Magdalena;
Pilla Reddy, Venkatesh;
Vermeulen, An;
Barton, Hugh;
Grimwood, Sarah;
Greef, Rik;
Groothuis, Geny;
Danhof, Meindert;
Proost, Johannes

Publication type:

Article

Translational Modeling in Schizophrenia: Predicting Human Dopamine D Receptor Occupancy.

Published in:

Pharmaceutical Research, 2016, v. 33, n. 4, p. 1003, doi. 10.1007/s11095-015-1846-4

By:

Johnson, Martin;
Kozielska, Magdalena;
Pilla Reddy, Venkatesh;
Vermeulen, An;
Barton, Hugh;
Grimwood, Sarah;
Greef, Rik;
Groothuis, Geny;
Danhof, Meindert;
Proost, Johannes

Publication type:

Article

Dopamine D2 Receptor Occupancy as a Predictor of Catalepsy in Rats: A Pharmacokinetic-Pharmacodynamic Modeling Approach.

Published in:

Pharmaceutical Research, 2014, v. 31, n. 10, p. 2605, doi. 10.1007/s11095-014-1358-7

By:

Johnson, Martin;
Kozielska, Magdalena;
Pilla Reddy, Venkatesh;
Vermeulen, An;
Barton, Hugh;
Grimwood, Sarah;
Greef, Rik;
Groothuis, Geny;
Danhof, Meindert;
Proost, Johannes

Publication type:

Article

Pharmacokinetic-Pharmacodynamic Modeling of the D and 5-HT Receptor Occupancy of Risperidone and Paliperidone in Rats.

Published in:

Pharmaceutical Research, 2012, v. 29, n. 7, p. 1932, doi. 10.1007/s11095-012-0722-8

By:

Kozielska, Magdalena;
Johnson, Martin;
Pilla Reddy, Venkatesh;
Vermeulen, An;
Li, Cheryl;
Grimwood, Sarah;
Greef, Rik;
Groothuis, Geny;
Danhof, Meindert;
Proost, Johannes

Publication type:

Article

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Dopamine D Receptor Occupancy of Olanzapine in Rats.

Published in:

Pharmaceutical Research, 2011, v. 28, n. 10, p. 2490, doi. 10.1007/s11095-011-0477-7

By:

Johnson, Martin;
Kozielska, Magdalena;
Pilla Reddy, Venkatesh;
Vermeulen, An;
Li, Cheryl;
Grimwood, Sarah;
Greef, Rik;
Groothuis, Geny;
Danhof, Meindert;
Proost, Johannes

Publication type:

Article

Characterization of [C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2017, v. 44, n. 2, p. 308, doi. 10.1007/s00259-016-3544-9

By:

Yang, Kai-Chun;
Stepanov, Vladimir;
Amini, Nahid;
Martinsson, Stefan;
Takano, Akihiro;
Nielsen, Jacob;
Bundgaard, Christoffer;
Bang-Andersen, Benny;
Grimwood, Sarah;
Halldin, Christer;
Farde, Lars;
Finnema, Sjoerd

Publication type:

Article

The role of the neonatal intensive care nurse in decision-making: Advocacy, involvement in ethical decisions and communication.

Published in:

International Journal of Nursing Practice (Wiley-Blackwell), 2005, v. 11, n. 3, p. 108, doi. 10.1111/j.1440-172X.2005.00512.x

By:

Monterosso, Leanne;
Kristjanson, Linda;
Sly, Peter D;
Mulcahy, Mary;
Holland, Beng Gee;
Grimwood, Sarah;
White, Kate

Publication type:

Article

Quantitative PK-PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans.

Published in:

AAPS Journal, 2011, v. 13, n. 4, p. 565, doi. 10.1208/s12248-011-9296-3

By:

Chang, Cheng;
Byon, Wonkyung;
Lu, Yifeng;
Jacobsen, Leslie;
Badura, Lori;
Sawant-Basak, Aarti;
Miller, Emily;
Liu, Jing;
Grimwood, Sarah;
Wang, Ellen;
Maurer, Tristan

Publication type:

Article

Modulation of soluble APPα in brain by PF-04995274, a 5HT4 partial agonist, following single oral doses in healthy human volunteers: Study design and PK-PD analysis

Published in:

2012

By:

Duvvuri, Sridhar;
Nicholas, Timothy;
Leurent, Claire;
Raunig, David;
Plotka, Anna;
Schwam, Elias;
Grimwood, Sarah;
Rowinski, Carolyn;
Rapp, Tracey L.

Publication type:

Abstract

Delineation of the Structural Determinants of the N-Methyl-D-Aspartate Receptor Glycine Binding Site.

Published in:

Journal of Neurochemistry, 1999, v. 72, n. 4, p. 1694, doi. 10.1046/j.1471-4159.1999.721694.x

By:

Sandhu, Satpal;
Grimwood, Sarah;
Mortishire-Smith, Russell J.;
Whiting, Paul J.;
le Bourdellès, Béatrice

Publication type:

Article

Modulation of 45Ca2+ Influx into Cells Stably Expressing Recombinant Human NMDA Receptors by Ligands Acting at Distinct Recognition Sites.

Published in:

Journal of Neurochemistry, 1996, v. 66, n. 6, p. 2589, doi. 10.1046/j.1471-4159.1996.66062589.x

By:

Grimwood, Sarah;
Gilbert, Elizabeth;
Ragan, C. Ian;
Hutson, Peter H.

Publication type:

Article

Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N-Methyl- d-Aspartate Receptor Subtypes.

Published in:

Journal of Neurochemistry, 1996, v. 66, n. 6, p. 2239, doi. 10.1046/j.1471-4159.1996.66062239.x

By:

Grimwood, Sarah;
Le Bourdellès, Béatrice;
Atack, John R.;
Barton, Cheryl;
Cockett, Wendy;
Cook, Susan M.;
Gilbert, Elizabeth;
Hutson, Peter H.;
McKernan, Ruth M.;
Myers, Jan;
Ragan, C. Ian;
Wingrove, Peter B.;
Whiting, Paul J.

Publication type:

Article

Recombinant Human NMDA Homomeric NR1 Receptors Expressed in Mammalian Cells Form a High-Affinity Glycine Antagonist Binding Site.

Published in:

Journal of Neurochemistry, 1995, v. 64, n. 2, p. 525, doi. 10.1046/j.1471-4159.1995.64020525.x

By:

Grimwood, Sarah;
Le Bourdellès, Béatrice;
Whiting, Paul J.

Publication type:

Article

Electrophysiological recordings in rats performing the sustained attention task.

Published in:

FASEB Journal, 2013, v. 27, p. 894.6, doi. 10.1096/fasebj.27.1_supplement.894.6

By:

Edgerton, Jeremy;
Neal, Sarah;
Harvey, Brian;
Kiss, Tamás;
Grimwood, Sarah

Publication type:

Article

An investigation of metabotropic glutamate receptor 5 negative allosteric modulators in physiological and behavioral indicators of anxiety and cognition in rodents.

Published in:

FASEB Journal, 2013, v. 27, p. 1099.4, doi. 10.1096/fasebj.27.1_supplement.1099.4

By:

Moon, Joshua;
McGinnis, Dina;
Smith, Deborah L;
Graf, Radka;
Hughes, Zoe;
Grimwood, Sarah;
Miller, Emily;
Trapa, Patrick;
Shaffer, Christopher L;
Siok, Chester J

Publication type:

Article

N -Methyl-d-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors.

Published in:

Journal of Neurochemistry, 2002, v. 82, n. 4, p. 794, doi. 10.1046/j.1471-4159.2002.01014.x

By:

Grimwood, Sarah;
Wafford, Keith A.;
Macaulay, Alison;
Hutson, Pete H.

Publication type:

Article

Characterisation of N-Methyl-D-Aspartate Receptor-Specific [³H]Ifenprodil Binding to Recombinant Human NR1a/NR2B Receptors Compared with Native Receptors in Rodent Brain Membranes.

Published in:

Journal of Neurochemistry, 2000, v. 75, n. 6, p. 2455, doi. 10.1046/j.1471-4159.2000.0752455.x

By:

Grimwood, Sarah;
Richards, Pawel;
Murray, Fraser;
Harrison, Neil;
Wingrove, Peter B.

Publication type:

Article

Works by Grimwood, Sarah

Application of cross-species PET imaging to assess neurotransmitter release in brain.

Donepezil causes acute increases in regional cerebral blood flow in normal rat

Donepezil causes acute increases in regional cerebral blood flow in normal rat

Pharmacokinetics, safety and tolerability of PF-04995274: A 5HT4 partial agonist being developed for the treatment of Alzheimer's disease

Translational receptor occupancy for the 5-HT4 partial agonist PF-04995274 in rats, non-human primates and healthy volunteers

Significant reduction of brain and CSF amyloid-β in mice following acute administration of a brain-penetrant BACE1 inhibitor

PF-04447943, a novel PDE9A inhibitor, increases cGMP levels in cerebrospinal fluid: Translation from non-clinical species to healthy human volunteers

[<sup>3</sup>H]DAA1106 binding to hippocampal peripheral benzodiazepine receptors in kainic acid-treated Tg2576 and C57BL6 mice

Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain.

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D Receptor Occupancy.

Translational Modeling in Schizophrenia: Predicting Human Dopamine D Receptor Occupancy.

Dopamine D2 Receptor Occupancy as a Predictor of Catalepsy in Rats: A Pharmacokinetic-Pharmacodynamic Modeling Approach.

Pharmacokinetic-Pharmacodynamic Modeling of the D and 5-HT Receptor Occupancy of Risperidone and Paliperidone in Rats.

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Dopamine D Receptor Occupancy of Olanzapine in Rats.

Characterization of [C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

The role of the neonatal intensive care nurse in decision-making: Advocacy, involvement in ethical decisions and communication.

Quantitative PK-PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans.

Modulation of soluble APPα in brain by PF-04995274, a 5HT<sub>4</sub> partial agonist, following single oral doses in healthy human volunteers: Study design and PK-PD analysis

Delineation of the Structural Determinants of the N-Methyl-D-Aspartate Receptor Glycine Binding Site.

Modulation of <sup>45</sup>Ca<sup>2+</sup> Influx into Cells Stably Expressing Recombinant Human NMDA Receptors by Ligands Acting at Distinct Recognition Sites.

Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N-Methyl- d-Aspartate Receptor Subtypes.

Recombinant Human NMDA Homomeric NR1 Receptors Expressed in Mammalian Cells Form a High-Affinity Glycine Antagonist Binding Site.

Electrophysiological recordings in rats performing the sustained attention task.

An investigation of metabotropic glutamate receptor 5 negative allosteric modulators in physiological and behavioral indicators of anxiety and cognition in rodents.

N -Methyl-d-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors.

Characterisation of N-Methyl-D-Aspartate Receptor-Specific [³H]Ifenprodil Binding to Recombinant Human NR1a/NR2B Receptors Compared with Native Receptors in Rodent Brain Membranes.