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40 Years of CSF Toxicity Studies in ALS: What Have We Learnt About ALS Pathophysiology?
- Published in:
- Frontiers in Molecular Neuroscience, 2021, v. 13, p. N.PAG, doi. 10.3389/fnmol.2021.647895
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- Publication type:
- Article
TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis.
- Published in:
- 2018
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- Publication type:
- journal article
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca<sup>2+</sup>-permeable AMPA receptor-mediated excitotoxicity.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-017-02729-0
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- Publication type:
- Article
Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?
- Published in:
- Frontiers in Molecular Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnmol.2019.00124
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- Publication type:
- Article
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts.
- Published in:
- Brain: A Journal of Neurology, 2023, v. 146, n. 12, p. 5124, doi. 10.1093/brain/awad243
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- Publication type:
- Article
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.
- Published in:
- Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02705-1
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- Publication type:
- Article
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
- Published in:
- Acta Neuropathologica, 2021, v. 141, n. 2, p. 257, doi. 10.1007/s00401-020-02252-5
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- Publication type:
- Article
pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.
- Published in:
- Journal of Pathology: Clinical Research, 2023, v. 9, n. 1, p. 44, doi. 10.1002/cjp2.297
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- Publication type:
- Article
The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila.
- Published in:
- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031899
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- Publication type:
- Article
Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis.
- Published in:
- Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.705306
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- Publication type:
- Article
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS.
- Published in:
- Journal of Pathology, 2022, v. 258, n. 4, p. 366, doi. 10.1002/path.6008
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- Publication type:
- Article
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis.
- Published in:
- Journal of Pathology, 2022, v. 256, n. 3, p. 262, doi. 10.1002/path.5846
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- Publication type:
- Article
Dysregulation of AMPA receptor subunit expression in sporadic ALS post‐mortem brain.
- Published in:
- Journal of Pathology, 2020, v. 250, n. 1, p. 67, doi. 10.1002/path.5351
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- Publication type:
- Article
Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research.
- Published in:
- Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00511
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- Publication type:
- Article
Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model.
- Published in:
- Brain Communications, 2021, v. 3, n. 4, p. 1, doi. 10.1093/braincomms/fcab255
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- Publication type:
- Article
Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.
- Published in:
- Brain Communications, 2021, v. 3, n. 4, p. 1, doi. 10.1093/braincomms/fcab242
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- Publication type:
- Article
Clusterin protects neurons against intracellular proteotoxicity.
- Published in:
- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0481-1
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- Publication type:
- Article
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
- Published in:
- Human Molecular Genetics, 2016, v. 25, n. 18, p. 3908, doi. 10.1093/hmg/ddw232
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- Publication type:
- Article