Works by Greenhaff, Paul L

Results: 80

Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscleprotein loss and lactate accumulation in rats.

Published in:

Clinical Science, 2017, v. 131, n. 13, p. 1437, doi. 10.1042/CS20170958

By:

Crossland, Hannah;
Constantin-Teodosiu, Dumitru;
Gardiner, Sheila M.;
Greenhaff, Paul L.

Publication type:

Article

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Published in:

Experimental Physiology, 2024, v. 109, n. 8, p. 1274, doi. 10.1113/EP091590

By:

Gupta, Ayushman;
Nicholas, Rosemary;
McGing, Jordan J.;
Nixon, Aline V.;
Mallinson, Joanne E.;
McKeever, Tricia M.;
Bradley, Christopher R.;
Piasecki, Mathew;
Cox, Eleanor F.;
Bonnington, James;
Lord, Janet M.;
Brightling, Christopher E.;
Evans, Rachael A.;
Hall, Ian P.;
Francis, Susan T.;
Greenhaff, Paul L.;
Bolton, Charlotte E.

Publication type:

Article

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies.

Published in:

Alimentary Pharmacology & Therapeutics, 2021, v. 54, n. 4, p. 368, doi. 10.1111/apt.16465

By:

McGing, Jordan J.;
Radford, Shellie Jean;
Francis, Susan T.;
Serres, Sébastien;
Greenhaff, Paul L.;
Moran, Gordon W.

Publication type:

Article

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients.

Published in:

PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0235702

By:

Casanova-Vallve, Nuria;
Constantin-Teodosiu, Dumitru;
Filer, Andrew;
Hardy, Rowan S.;
Greenhaff, Paul L.;
Chapman, Victoria

Publication type:

Article

Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia.

Published in:

Bioscience Reports, 2021, v. 41, n. 6, p. 1, doi. 10.1042/BSR20203170

By:

Handzlik, Michal K.;
Tooth, David J.;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L.;
Cole, Mark A.

Publication type:

Article

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2024, v. 15, n. 2, p. 603, doi. 10.1002/jcsm.13431

By:

Shur, Natalie F.;
Simpson, Elizabeth J.;
Crossland, Hannah;
Constantin, Despina;
Cordon, Sally M.;
Constantin‐Teodosiu, Dumitru;
Stephens, Francis B.;
Brook, Matthew S.;
Atherton, Philip J.;
Smith, Kenneth;
Wilkinson, Daniel J.;
Mougin, Olivier E.;
Bradley, Christopher;
Macdonald, Ian A.;
Greenhaff, Paul L.

Publication type:

Article

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 6, p. 2999, doi. 10.1002/jcsm.13075

By:

Shur, Natalie F.;
Simpson, Elizabeth J.;
Crossland, Hannah;
Chivaka, Prince K.;
Constantin, Despina;
Cordon, Sally M.;
Constantin‐Teodosiu, Dumitru;
Stephens, Francis B.;
Lobo, Dileep N.;
Szewczyk, Nate;
Narici, Marco;
Prats, Clara;
Macdonald, Ian A.;
Greenhaff, Paul L.

Publication type:

Article

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2019, v. 10, n. 6, p. 1276, doi. 10.1002/jcsm.12472

By:

Gharahdaghi, Nima;
Rudrappa, Supreeth;
Brook, Matthew S.;
Idris, Iskandar;
Crossland, Hannah;
Hamrock, Claire;
Abdul Aziz, Muhammad Hariz;
Kadi, Fawzi;
Tarum, Janelle;
Greenhaff, Paul L.;
Constantin‐Teodosiu, Dumitru;
Cegielski, Jessica;
Phillips, Bethan E.;
Wilkinson, Daniel J.;
Szewczyk, Nathaniel J.;
Smith, Kenneth;
Atherton, Philip J.

Publication type:

Article

Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2016, v. 7, n. 2, p. 181, doi. 10.1002/jcsm.12040

By:

Gaffney, Christopher J.;
Shephard, Freya;
Chu, Jeff;
Baillie, David L.;
Rose, Ann;
Constantin ‐ Teodosiu, Dumitru;
Greenhaff, Paul L.;
Szewczyk, Nathaniel J.

Publication type:

Article

Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance--A Qualitative Review.

Published in:

Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00361

By:

Rudrappa, Supreeth S.;
Wilkinson, Daniel J.;
Greenhaff, Paul L.;
Smith, Kenneth;
Idris, Iskandar;
Atherton, Philip J.;
Han-Zhong Feng;
Fan Ye;
Feng He

Publication type:

Article

Carnosine and taurine contents in individual fibers of human vastus lateralis muscle.

Published in:

Journal of Sports Sciences, 1998, v. 16, n. 7, p. 639, doi. 10.1080/026404198366443

By:

Harris, Roger C.;
Dunnett, Mark;
Greenhaff, Paul L.

Publication type:

Article

Pre-Operative nutrition In Neck of femur Trial (POINT) - carbohydrate loading in patients with fragility hip fracture: study protocol for a randomised controlled trial.

Published in:

Trials, 2014, v. 15, n. 1, p. 2, doi. 10.1186/1745-6215-15-475

By:

Moppett, Iain K.;
Greenhaff, Paul L.;
Ollivere, Ben J.;
Joachim, Theophillus;
Lobo, Dileep N.;
Rowlands, Martin

Publication type:

Article

Pre-Operative nutrition In Neck of femur Trial (POINT)--carbohydrate loading in patients with fragility hip fracture: study protocol for a randomised controlled trial.

Published in:

2014

By:

Moppett, Iain K;
Greenhaff, Paul L;
Ollivere, Ben J;
Joachim, Theophillus;
Lobo, Dileep N;
Rowlands, Martin

Publication type:

journal article

Metabolomics as an Important Tool for Determining the Mechanisms of Human Skeletal Muscle Deconditioning.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13575, doi. 10.3390/ijms222413575

By:

Alldritt, Isabelle;
Greenhaff, Paul L.;
Wilkinson, Daniel J.

Publication type:

Article

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 9775, doi. 10.3390/ijms22189775

By:

Crossland, Hannah;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L.

Publication type:

Article

PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5942, doi. 10.3390/ijms21165942

By:

Chien, Hung-Che;
Greenhaff, Paul L.;
Constantin-Teodosiu, Dumitru

Publication type:

Article

Gender and age differences in plasma carnitine, muscle strength, and exercise tolerance in haemodialysis patients.

Published in:

Nephrology Dialysis Transplantation, 2002, v. 17, n. 10, p. 1808

By:

Constantin‐Teodosiu, Dumitru;
Young, Stephanie;
Wellock, Fiona;
Short, Anthony H.;
Burden, Richard P.;
Morgan, Anthony G.;
Greenhaff, Paul L.

Publication type:

Article

PPARδ agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.

Published in:

Journal of Physiology, 2009, v. 587, n. 1, p. 231, doi. 10.1113/jphysiol.2008.164210

By:

Constantin-Teodosiu, Dumitru;
Baker, David J.;
Constantin, Despina;
Greenhaff, Paul L.

Publication type:

Article

Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy.

Published in:

Journal of Physiology, 2009, v. 587, n. 1, p. 219, doi. 10.1113/jphysiol.2008.164699

By:

Mallinson, Joanne E.;
Constantin-Teodosiu, Dumitru;
Sidaway, James;
Westwood, F. Russell;
Greenhaff, Paul L.

Publication type:

Article

A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.

Published in:

Journal of Physiology, 2008, v. 586, n. 22, p. 5589, doi. 10.1113/jphysiol.2008.160150

By:

Crossland, Hannah;
Constantin-Teodosiu, Dumitru;
Gardiner, Sheila M.;
Constantin, Despina;
Greenhaff, Paul L.

Publication type:

Article

PPARδ agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.

Published in:

Journal of Physiology, 2007, v. 583, n. 1, p. 381, doi. 10.1113/jphysiol.2007.135459

By:

Constantin, Despina;
Constantin-Teodosiu, Dumitru;
Layfield, Robert;
Tsintzas, Kostas;
Bennett, Andrew J.;
Greenhaff, Paul L.

Publication type:

Article

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.

Published in:

Journal of Physiology, 2007, v. 581, n. 2, p. 431, doi. 10.1113/jphysiol.2006.125799

By:

Stephens, Francis B.;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L.

Publication type:

Article

An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle.

Published in:

Journal of Physiology, 2005, v. 565, n. 2, p. 637, doi. 10.1113/jphysiol.2004.079939

By:

Dawson, Kristen D.;
Baker, David J.;
Greenhaff, Paul L.;
Gibala, Martin J.

Publication type:

Article

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

Published in:

Journal of Physiology, 2004, v. 561, n. 3, p. 851, doi. 10.1113/jphysiol.2004.069419

By:

Timmons, James A.;
Constantin-Teodosiu, Dimitru;
Poucher, Simon M.;
Greenhaff, Paul L.

Publication type:

Article

Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans.

Published in:

Journal of Physiology, 2004, v. 561, n. 2, p. 647, doi. 10.1113/jphysiol.2004.073411

By:

Constantin-Teodosiu, Dumitru;
Peirce, Nicholas S.;
Fox, John;
Greenhaff, Paul L.

Publication type:

Article

Milestones in Human Physiology: Muscle Energy Metabolism and Blood Flow during Contraction.

Published in:

Journal of Physiology, 2003, v. 551, n. 2, p. 397, doi. 10.1113/jphysiol.2003.044412

By:

Greenhaff, Paul L.

Publication type:

Article

The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle.

Published in:

Journal of Physiology, 2002, v. 545, n. 1, p. 297, doi. 10.1113/jphysiol.2002.021055

By:

Roberts, Paul A.;
Loxham, Susan J. G.;
Poucher, Simon M.;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L.

Publication type:

Article

The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.

Published in:

Journal of Physiology, 2002, v. 544, n. 2, p. 591, doi. 10.1113/jphysiol.2002.021097

By:

Roberts, Paul A.;
Loxham, Susan J. G.;
Poucher, Simon M.;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L.

Publication type:

Article

Exercise with low muscle glycogen augments TCA cycle anaplerosis but impairs oxidative energy provision in humans.

Published in:

Journal of Physiology, 2002, v. 540, n. 3, p. 1079, doi. 10.1113/jphysiol.2001.012983

By:

Gibala, Martin J.;
Peirce, Nick;
Constantin-Teodosiu, Dimitru;
Greenhaff, Paul L.

Publication type:

Article

Low intensity exercise in humans accelerates mitochondrial ATP production and pulmonary oxygen kinetics during subsequent more intense exercise.

Published in:

Journal of Physiology, 2002, v. 538, n. 3, p. 931, doi. 10.1113/jphysiol.2001.013238

By:

Campbell-O'Sullivan, Síun P.;
Constantin-Teodosiu, Dumitru;
Peirce, Nicholas;
Greenhaff, Paul L.

Publication type:

Article

Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.

Published in:

Journal of Physiology, 2002, v. 538, n. 1, p. 195, doi. 10.1113/jphysiol.2001.012984

By:

Grassi, Bruno;
Hogan, Michael C.;
Greenhaff, Paul L.;
Hamann, Jason J.;
Kelley, Kevin M.;
Aschenbach, William G.;
Constantin-Teodosiu, Dumitru;
Gladden, L. Bruce

Publication type:

Article

The creatine-phosphocreatine system: there's more than one song in its repertoire.

Published in:

Journal of Physiology, 2001, v. 537, n. 3, p. 657, doi. 10.1111/j.1469-7793.2001.00657.x

By:

Greenhaff, Paul L.

Publication type:

Article

Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans.

Published in:

Journal of Physiology, 2001, v. 536, n. 2, p. 625, doi. 10.1111/j.1469-7793.2001.0625c.xd

By:

Hespel, Peter;
Op't Eijnde, Bert;
Leemputte, Marc Van;
Ursø, Birgitte;
Greenhaff, Paul L.;
Labarque, Valery;
Dymarkowski, Steven;
Hecke, Paul Van;
Richter, Erik A.

Publication type:

Article

The effects of increasing exercise intensity on muscle fuel utilisation in humans.

Published in:

Journal of Physiology, 2001, v. 536, n. 1, p. 295, doi. 10.1111/j.1469-7793.2001.00295.x

By:

Loon, Luc J. C. van;
Greenhaff, Paul L.;
Constantin-Teodosiu, D.;
Saris, Wim H. M.;
Wagenmakers, Anton J. M.

Publication type:

Article

Dual effects of dichloroacetate on cardiac ischaemic preconditioning in the rat isolated perfused heart.

Published in:

1998

By:

Randall, Michael D;
Keon, Claudia A;
Greenhaff, Paul L;
Constantin-Teodosiu, Dumitru;
Randall, M D;
Keon, C A;
Greenhaff, P L;
Constantin-Teodosiu, D

Publication type:

journal article

Tricarboxylic Acid Cycle Intermediate Pool Size: Functional Importance for Oxidative Metabolism in Exercising Human Skeletal Muscle.

Published in:

Sports Medicine, 2007, v. 37, n. 12, p. 1071, doi. 10.2165/00007256-200737120-00005

By:

Bowtell, Joanna L;
Marwood, Simon;
Bruce, Mark;
Constantin-Teodosiu, Dumitru;
Greenhaff, Paul L

Publication type:

Article

The influence of immobility on muscle loss in older people with frailty and fragility fractures.

Published in:

GeroScience, 2024, v. 46, n. 6, p. 5473, doi. 10.1007/s11357-024-01177-1

By:

Lunt, Eleanor K.;
Gordon, Adam L.;
Greenhaff, Paul L.;
Gladman, John F. R.

Publication type:

Article

Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle.

Published in:

GeroScience, 2023, v. 45, n. 1, p. 451, doi. 10.1007/s11357-022-00651-y

By:

Brook, Matthew S.;
Wilkinson, Daniel J.;
Tarum, Janelle;
Mitchell, Kyle W.;
Lund, Jonathan L.;
Phillips, Bethan E.;
Szewczyk, Nathaniel J.;
Kadi, Fawzi;
Greenhaff, Paul L.;
Smith, Ken;
Atherton, Philip J.

Publication type:

Article

Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age.

Published in:

GeroScience, 2023, v. 45, n. 1, p. 331, doi. 10.1007/s11357-022-00636-x

By:

Crossland, Hannah;
Brook, Matthew S.;
Quinlan, Jonathan I.;
Franchi, Martino V.;
Phillips, Bethan E.;
Wilkinson, Daniel J.;
Maganaris, Constantinos N.;
Greenhaff, Paul L.;
Szewczyk, Nathaniel J.;
Smith, Kenneth;
Narici, Marco V.;
Atherton, Philip J.

Publication type:

Article

Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise.

Published in:

Aging Cell, 2021, v. 20, n. 2, p. 1, doi. 10.1111/acel.13303

By:

Chee, Carolyn;
Shannon, Chris E.;
Burns, Aisling;
Selby, Anna L.;
Wilkinson, Daniel;
Smith, Kenneth;
Greenhaff, Paul L.;
Stephens, Francis B.

Publication type:

Article

Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24 h but does not change lipid uptake in healthy men.

Published in:

Journal of Physiology, 2021, v. 599, n. 8, p. 2197, doi. 10.1113/JP281021

By:

Burns, Aisling M.;
Nixon, Aline;
Mallinson, Joanne;
Cordon, Sally M.;
Stephens, Francis B.;
Greenhaff, Paul L.

Publication type:

Article

Regulation of musculoskeletal tissues in ageing and health: the human perspective – Celebrating the research of Professor Mike Rennie.

Published in:

Journal of Physiology, 2019, v. 597, n. 5, p. 1233, doi. 10.1113/JP276972

By:

Greenhaff, Paul L.

Publication type:

Article

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end‐points.

Published in:

Journal of Physiology, 2019, v. 597, n. 5, p. 1259, doi. 10.1113/JP275444

By:

Crossland, Hannah;
Skirrow, Sarah;
Constantin‐Teodosiu, Dumitru;
Greenhaff, Paul L.;
Puthucheary, Zudin A.

Publication type:

Article

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Published in:

Journal of Physiology, 2018, v. 596, n. 15, p. 3357, doi. 10.1113/JP275357

By:

Handzlik, Michal K.;
Cole, Mark A.;
Constantin‐Teodosiu, Dumitru;
Greenhaff, Paul L.

Publication type:

Article

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent.

Published in:

Journal of Physiology, 2017, v. 595, n. 17, p. 5765, doi. 10.1113/JP274415

By:

Porter, Craig;
Constantin‐Teodosiu, Dumitru;
Constantin, Despina;
Leighton, Brendan;
Poucher, Simon M.;
Greenhaff, Paul L.

Publication type:

Article

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Published in:

Journal of Physiology, 2016, v. 594, n. 24, p. 7399, doi. 10.1113/JP272857

By:

Brook, Matthew S.;
Wilkinson, Daniel J.;
Mitchell, William K.;
Lund, Jonathan N.;
Phillips, Bethan E.;
Szewczyk, Nathaniel J.;
Greenhaff, Paul L.;
Smith, Kenneth;
Atherton, Philip J.

Publication type:

Article

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Published in:

Journal of Physiology, 2015, v. 593, n. 5, p. 1239, doi. 10.1113/jphysiol.2014.285577

By:

Mallinson, Joanne E.;
Marimuthu, Kanagaraj;
Murton, Andrew;
Selby, Anna;
Smith, Kenneth;
Constantin‐Teodosiu, Dumitru;
Rennie, Michael J.;
Greenhaff, Paul L.

Publication type:

Article

Age is just a number! Or is it?

Published in:

Journal of Physiology, 2015, v. 593, n. 3, p. 491, doi. 10.1113/jphysiol.2014.288373

By:

Atherton, Philip J.;
Greenhaff, Paul L.

Publication type:

Article

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans.

Published in:

Journal of Physiology, 2013, v. 591, n. 18, p. 4655, doi. 10.1113/jphysiol.2013.255364

By:

Stephens, Francis B.;
Wall, Benjamin T.;
Marimuthu, Kanagaraj;
Shannon, Chris E.;
Constantin‐Teodosiu, Dumitru;
Macdonald, Ian A.;
Greenhaff, Paul L.

Publication type:

Article

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Published in:

Journal of Physiology, 2012, v. 590, n. 24, p. 6389, doi. 10.1113/jphysiol.2012.238022

By:

Mallinson, Joanne E.;
Constantin-Teodosiu, Dumitru;
Glaves, Philip D.;
Martin, Elizabeth A.;
Davies, Wendy J.;
Westwood, F. Russell;
Sidaway, James E.;
Greenhaff, Paul L.

Publication type:

Article