Works by Greene, Geoffrey L.

Results: 40

Label-Free Detection of Protein–Protein Interactions on BiochipsThis work was supported by the Nanoscale Science and Engineering Center (NSEC) and the Ludwig Fund for Cancer Research. R.W.H. was supported by The University of Chicago MSTP Unendowed Student Support. We thank Professor Benita S. Katzenellenbogen for providing the human ERβ LBD plasmid and Young-Sam Lee for providing the GST–FAT plasmid.

Published in:

Angewandte Chemie, 2005, v. 117, n. 34, p. 5616, doi. 10.1002/ange.200501363

By:

Woon-Seok Yeo;
Dal-Hee Min;
Robert W. Hsieh;
Geoffrey L. Greene;
Milan Mrksich

Publication type:

Article

Subcellular distribution of oestrogen receptors.

Published in:

Nature, 1985, v. 317, n. 6032, p. 88, doi. 10.1038/317088b0

By:

GREENE, GEOFFREY L.;
KING, WILLIAM J.

Publication type:

Article

Estrogen plus Progesterone Increases Progestin Receptor Immunoreactivity in the Brain of Ovariectomized Guinea Pigs.

Published in:

Neuroendocrinology, 1989, v. 50, n. 6, p. 613, doi. 10.1159/000125290

By:

Don Carlos, Lydia L.;
Greene, Geoffrey L.;
Morrell, Joan I.

Publication type:

Article

Next-Generation ERα Inhibitors for Endocrine-Resistant ER<sup>+</sup> Breast Cancer.

Published in:

Endocrinology, 2019, v. 160, n. 4, p. 759, doi. 10.1210/en.2018-01095

By:

Fanning, Sean W;
Greene, Geoffrey L

Publication type:

Article

Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5′-methylene substituted 2′,5′-deoxyribonucleotides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2023, v. 42, n. 7, p. 538, doi. 10.1080/15257770.2023.2166064

By:

Li, Nan-Sheng;
Piccirilli, Joseph A.;
Greene, Geoffrey L.

Publication type:

Article

Structural plasticity in the oestrogen receptor ligand-binding domain.

Published in:

EMBO Reports, 2007, v. 8, n. 6, p. 563, doi. 10.1038/sj.embor.7400963

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
O'Neill, Erin E;
Nowak, Jason;
Hughs, Alun;
Kim, Younchang;
DeSombre, Eugene R;
Dilis, Robert;
Hanson, Robert N;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Article

Structural plasticity in the oestrogen receptor ligand-binding domain.

Published in:

EMBO Reports, 2007, v. 8, n. 6, p. 610, doi. 10.1038/sj.embor.7401006

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
O'Neill, Erin E;
Nowak, Jason;
Guo, Yuee;
Kim, Younchang;
DeSombre, Eugene R;
Dilis, Robert;
Hanson, Robert N;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Article

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00601-7

By:

Huggins, Rosemary J.;
Greene, Geoffrey L.

Publication type:

Article

Facilitating Drug Discovery in Breast Cancer by Virtually Screening Patients Using In Vitro Drug Response Modeling.

Published in:

Cancers, 2021, v. 13, n. 4, p. 885, doi. 10.3390/cancers13040885

By:

Gruener, Robert F.;
Ling, Alexander;
Chang, Ya-Fang;
Morrison, Gladys;
Geeleher, Paul;
Greene, Geoffrey L.;
Huang, R. Stephanie;
Wang, Zhixiang

Publication type:

Article

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor.

Published in:

Proteins, 2013, v. 81, n. 11, p. 1900, doi. 10.1002/prot.24331

By:

Huang, Wei;
Greene, Geoffrey L.;
Ravikumar, Krishnakumar M.;
Yang, Sichun

Publication type:

Article

An immunohistochemical evaluation of progesterone receptor in frozen sections, paraffin sections, and cytologic imprints of breast carcinomas.

Published in:

1991

By:

Ozzello, Luciano;
Derosa, Carolyn;
Habif, David V.;
Greene, Geoffrey L.;
Ozzello, L;
DeRosa, C;
Habif, D V;
Greene, G L

Publication type:

journal article

Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival.

Published in:

1990

By:

Pertschuk, Louis P.;
Kim, Dong S.;
Nayer, Kamran;
Feldman, Joseph G.;
Eisenberg, Karen B.;
Carter, Anne C.;
Rong, Zheng Tian;
Thelmo, William L.;
Fleisher, Jay;
Greene, Geoffrey L.;
Pertschuk, L P;
Kim, D S;
Nayer, K;
Feldman, J G;
Eisenberg, K B;
Carter, A C;
Rong, Z T;
Thelmo, W L;
Fleisher, J;
Greene, G L

Publication type:

journal article

Immunocytochemical detection of progesterone receptor in breast cancer with monoclonal antibody. Relation to biochemical assay, disease-free survival, and clinical endocrine response.

Published in:

1988

By:

Pertschuk, Louis P.;
Eisenberg, Karen Byer;
Thelmo, William L.;
Cruz, Wilhelmina P.;
Feldman, Joseph G.;
Carter, Anne C.;
Thorpe, Susan M.;
Christensen, Ib J.;
Rasmussen, Birgette B.;
Rose, Carsten;
Greene, Geoffrey L.;
Pertschuk, L P;
Feldman, J G;
Eisenberg, K B;
Carter, A C;
Thelmo, W L;
Cruz, W P;
Thorpe, S M;
Christensen, I J;
Rasmussen, B B

Publication type:

journal article

In vivo imaging reveals estrogen receptor's hidden personality.

Published in:

Nature Medicine, 2003, v. 9, n. 1, p. 22, doi. 10.1038/nm0103-22

By:

Greene, Geoffrey L.

Publication type:

Article

Progesterone Receptor Gene Restriction Fragment Length Polymorphisms in Human Breast Tumors.

Published in:

JNCI: Journal of the National Cancer Institute, 1991, v. 83, n. 16, p. 1157, doi. 10.1093/jnci/83.16.1157

By:

Fuqua, Suzanne A. W.;
Hill, Steven M.;
Chamness, Gary C.;
Benedix, Margaret G.;
Greene, Geoffrey L.;
O'Malley, Bert W.;
McGuire, William L.

Publication type:

Article

Capture of associated targets on chromatin links long-distance chromatin looping to transcriptional coordination.

Published in:

Nature Communications, 2016, v. 7, n. 9, p. 12893, doi. 10.1038/ncomms12893

By:

Bourgo, Ryan J.;
Singhal, Hari;
Greene, Geoffrey L.

Publication type:

Article

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.

Published in:

Nature Communications, 2013, v. 4, n. 1, p. 1393, doi. 10.1038/ncomms2393

By:

Bockhorn, Jessica;
Dalton, Rachel;
Nwachukwu, Chika;
Huang, Simo;
Prat, Aleix;
Yee, Kathy;
Chang, Ya-Fang;
Huo, Dezheng;
Wen, Yujia;
Swanson, Kaitlin E.;
Qiu, Tyler;
Lu, Jun;
Young Park, Seo;
Eileen Dolan, M.;
Perou, Charles M.;
Olopade, Olufunmilayo I.;
Clarke, Michael F.;
Greene, Geoffrey L.;
Liu, Huiping

Publication type:

Article

Label-Free Detection of Protein–Protein Interactions on BiochipsThis work was supported by the Nanoscale Science and Engineering Center (NSEC) and the Ludwig Fund for Cancer Research. R.W.H. was supported by The University of Chicago MSTP Unendowed Student Support. We thank Professor Benita S. Katzenellenbogen for providing the human ERβ LBD plasmid and Young-Sam Lee for providing the GST–FAT plasmid.

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 34, p. 5480, doi. 10.1002/anie.200501363

By:

Woon-Seok Yeo;
Dal-Hee Min;
Robert W. Hsieh;
Geoffrey L. Greene;
Milan Mrksich

Publication type:

Article

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.

Published in:

Nature Structural Biology, 2002, v. 9, n. 5, p. 359

By:

Shiau, Andrew K.;
Barstad, Danielle;
Radek, James T.;
Meyers, Marvin J.;
Nettles, Kendall W.;
Katzenellenbogen, Benita S.;
Katzenellenbogen, John A.;
Agard, David A.;
Greene, Geoffrey L.

Publication type:

Article

Innentitelbild: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. 13/2016).

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4174, doi. 10.1002/ange.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4324, doi. 10.1002/ange.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases.

Published in:

Cancers, 2023, v. 15, n. 19, p. 4679, doi. 10.3390/cancers15194679

By:

Porter, Baylee A.;
Frerich, Candace;
Lainé, Muriel;
Clark, Abigail B.;
Durdana, Ishrat;
Lee, Jeon;
Taya, Manisha;
Sahoo, Sunati;
Greene, Geoffrey L.;
Bennett, Lynda;
Conzen, Suzanne D.

Publication type:

Article

Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells.

Published in:

Cancers, 2022, v. 14, n. 10, p. 2380, doi. 10.3390/cancers14102380

By:

Pal, Purab;
Millner, Alec;
Semina, Svetlana E.;
Huggins, Rosemary J.;
Running, Logan;
Aga, Diana S.;
Tonetti, Debra A.;
Schiff, Rachel;
Greene, Geoffrey L.;
Atilla-Gokcumen, G. Ekin;
Frasor, Jonna

Publication type:

Article

Immunocytochemical assay for estrogen receptor with monoclonal antibody D753P gamma in routinely processed formaldehyde-fixed breast tissue. Comparison with frozen section assay and with monoclonal antibody H222.

Published in:

1993

By:

Miller, Rodney T;
Hapke, Marc R.;
Greene, Geoffrey L.;
Miller, R T;
Hapke, M R;
Greene, G L

Publication type:

journal article

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.72512

By:

Hosfield, David J.;
Weber, Sandra;
Nan Sheng Li;
Suavage, Madline;
Joiner, Carstyn F.;
Hancock, Govinda R.;
Sullivan, Emily A.;
Ndukwe, Estelle;
Han, Ross;
Cush, Sydney;
Lainé, Muriel;
Mader, Sylvie C.;
Greene, Geoffrey L.;
Fanning, Sean W.

Publication type:

Article

Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer.

Published in:

Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01843-4

By:

Lainé, Muriel;
Greene, Marianne E;
Kurleto, Justyna D;
Bozek, Grazyna;
Leng, Tiffany;
Huggins, Rosemary J;
Komm, Barry S;
Greene, Geoffrey L

Publication type:

Article

Mapping ERβ Genomic Binding Sites Reveals Unique Genomic Features and Identifies EBF1 as an ERβ Interactor.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071355

By:

Le, Thien P.;
Sun, Miao;
Luo, Xin;
Kraus, W. Lee;
Greene, Geoffrey L.

Publication type:

Article

Examining the Pathogenesis of Breast Cancer Using a Novel Agent-Based Model of Mammary Ductal Epithelium Dynamics

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064091

By:

Chapa, Joaquin;
Bourgo, Ryan J.;
Greene, Geoffrey L.;
Kulkarni, Swati;
An, Gary

Publication type:

Article

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.12792

By:

Fanning, Sean W.;
Mayne, Christopher G.;
Dharmarajan, Venkatasubramanian;
Carlson, Kathryn E.;
Martin, Teresa A.;
Novick, Scott J.;
Weiyi Toy;
Green, Bradley;
Panchamukhi, Srinivas;
Katzenellenbogen, Benita S.;
Tajkhorshid, Emad;
Griffin, Patrick R.;
Yang Shen;
Chandarlapaty, Sarat;
Katzenellenbogen, John A.;
Greene, Geoffrey L.

Publication type:

Article

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.

Published in:

Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abf1383

By:

Boudreau, Matthew W.;
Duraki, Darjan;
Wang, Lawrence;
Mao, Chengjian;
Kim, Ji Eun;
Henn, Madeline A.;
Tang, Bingtao;
Fanning, Sean W.;
Kiefer, Jeffrey;
Tarasow, Theodore M.;
Bruckheimer, Elizabeth M.;
Moreno, Ramon;
Mousses, Spyro;
Greene, Geoffrey L.;
Roy, Edward J.;
Park, Ben Ho;
Fan, Timothy M.;
Nelson, Erik R.;
Hergenrother, Paul J.;
Shapiro, David J.

Publication type:

Article

Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells.

Published in:

Breast Cancer Research, 2022, v. 24, n. 1, p. 1, doi. 10.1186/s13058-022-01515-1

By:

Semina, Svetlana E.;
Pal, Purab;
Kansara, Nidhi S.;
Huggins, Rosemary J.;
Alarid, Elaine T.;
Greene, Geoffrey L.;
Frasor, Jonna

Publication type:

Article

Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.

Published in:

2021

By:

Lainé, Muriel;
Fanning, Sean W;
Chang, Ya-Fang;
Green, Bradley;
Greene, Marianne E;
Komm, Barry;
Kurleto, Justyna D;
Phung, Linda;
Greene, Geoffrey L

Publication type:

journal article

Inside Cover: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. Int. Ed. 13/2016).

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4104, doi. 10.1002/anie.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4252, doi. 10.1002/anie.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.

Published in:

Xenobiotica, 2018, v. 48, n. 10, p. 973, doi. 10.1080/00498254.2017.1386335

By:

House, Larry;
Seminerio, Michael J.;
Mirkov, Snezana;
Ramirez, Jacqueline;
Skor, Maxwell;
Sachleben, Joseph R.;
Isikbay, Masis;
Singhal, Hari;
Greene, Geoffrey L.;
Vander Griend, Donald;
Conzen, Suzanne D.;
Ratain, Mark J.

Publication type:

Article

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Published in:

2008

By:

Nettles, Kendall W;
Bruning, John B;
Gil, German;
Nowak, Jason;
Sharma, Sanjay K;
Hahm, Johnnie B;
Kulp, Kristen;
Hochberg, Richard B;
Zhou, Haibing;
Katzenellenbogen, John A;
Katzenellenbogen, Benita S;
Kim, Younchang;
Joachimiak, Andrzej;
Greene, Geoffrey L

Publication type:

Correction Notice

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Published in:

Nature Chemical Biology, 2008, v. 4, n. 4, p. 241, doi. 10.1038/nchembio.76

By:

Nettles, Kendall W.;
Bruning, John B.;
Gil, German;
Nowak, Jason;
Sharma, Sanjay K.;
Hahm, Johnnie B.;
Kulp, Kristen;
Hochberg, Richard B.;
Haibing Zhou;
Katzenellenbogen, John A.;
Katzenellenbogen, Benita S.;
Younchang Kim;
Joachmiak, Andrzej;
Greene, Geoffrey L.

Publication type:

Article

PARP-1 as a novel target in endocrine-resistant breast cancer.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03441-4

By:

Zicarelli, Azzurra;
Talia, Marianna;
Lainé, Muriel;
Lappano, Rosamaria;
Maggiolini, Marcello;
Greene, Geoffrey L.

Publication type:

Article

Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.

Published in:

Nature Biotechnology, 2023, v. 41, n. 4, p. 541, doi. 10.1038/s41587-022-01504-x

By:

Speltz, Thomas E.;
Qiao, Zeyu;
Swenson, Colin S.;
Shangguan, Xianghang;
Coukos, John S.;
Lee, Christopher W.;
Thomas, Deborah M.;
Santana, Jesse;
Fanning, Sean W.;
Greene, Geoffrey L.;
Moellering, Raymond E.

Publication type:

Article

Ultracold neutrons: Quantum bouncing ball resonates.

Published in:

Nature Physics, 2011, v. 7, n. 6, p. 447, doi. 10.1038/nphys1990

By:

Greene, Geoffrey L.

Publication type:

Article