Works by Grazioso, Giovanni

Results: 37

Unlocking the Antibiofilm Potential of Natural Compounds by Targeting the NADH:quinone Oxidoreductase WrbA.

Published in:

Antioxidants, 2023, v. 12, n. 8, p. 1612, doi. 10.3390/antiox12081612

By:

Ratti, Alessandro;
Fassi, Enrico M. A.;
Forlani, Fabio;
Zangrossi, Maurizio;
Mori, Matteo;
Cappitelli, Francesca;
Roda, Gabriella;
Villa, Stefania;
Villa, Federica;
Grazioso, Giovanni

Publication type:

Article

Alkene Epoxidations Mediated by Mn-Salen Macrocyclic Catalysts.

Published in:

Catalysts (2073-4344), 2021, v. 11, n. 4, p. 465, doi. 10.3390/catal11040465

By:

Pappalardo, Andrea;
Ballistreri, Francesco P.;
Toscano, Rosa Maria;
Chiacchio, Maria Assunta;
Legnani, Laura;
Grazioso, Giovanni;
Veltri, Lucia;
Trusso Sfrazzetto, Giuseppe

Publication type:

Article

Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid.

Published in:

Pharmaceutics, 2023, v. 15, n. 6, p. 1757, doi. 10.3390/pharmaceutics15061757

By:

Ratti, Alessandro;
Fassi, Enrico M. A.;
Forlani, Fabio;
Mori, Matteo;
Villa, Federica;
Cappitelli, Francesca;
Sgrignani, Jacopo;
Roda, Gabriella;
Cavalli, Andrea;
Villa, Stefania;
Grazioso, Giovanni

Publication type:

Article

Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity.

Published in:

Pharmaceutics, 2022, v. 14, n. 3, p. 665, doi. 10.3390/pharmaceutics14030665

By:

Lammi, Carmen;
Fassi, Enrico M. A.;
Li, Jianqiang;
Bartolomei, Martina;
Benigno, Giulia;
Roda, Gabriella;
Arnoldi, Anna;
Grazioso, Giovanni

Publication type:

Article

PCSK9 inhibitors: a patent review 2018-2023.

Published in:

Expert Opinion on Therapeutic Patents, 2024, v. 34, n. 4, p. 245, doi. 10.1080/13543776.2024.2340569

By:

Fassi, Enrico Mario Alessandro;
Citarella, Andrea;
Albani, Marco;
Milano, Erica Ginevra;
Legnani, Laura;
Lammi, Carmen;
Silvani, Alessandra;
Grazioso, Giovanni

Publication type:

Article

Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 5, p. 249, doi. 10.3390/antibiotics9050249

By:

Bassini, Emanuele;
Gazzotti, Stefano;
Sannio, Filomena;
Lo Presti, Leonardo;
Sgrignani, Jacopo;
Docquier, Jean-Denis;
Grazioso, Giovanni;
Silvani, Alessandra

Publication type:

Article

Computational Design of Novel Cyclic Peptides Endowed with Autophagy-Inhibiting Activity on Cancer Cell Lines.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4622, doi. 10.3390/ijms25094622

By:

Albani, Marco;
Fassi, Enrico Mario Alessandro;
Moretti, Roberta Manuela;
Garofalo, Mariangela;
Montagnani Marelli, Marina;
Roda, Gabriella;
Sgrignani, Jacopo;
Cavalli, Andrea;
Grazioso, Giovanni

Publication type:

Article

Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 5070, doi. 10.3390/ijms23095070

By:

Fassi, Enrico Mario Alessandro;
Garofalo, Mariangela;
Sgrignani, Jacopo;
Dei Cas, Michele;
Mori, Matteo;
Roda, Gabriella;
Cavalli, Andrea;
Grazioso, Giovanni

Publication type:

Article

Structure-based drug design, synthesis and biological assays of <italic>P. falciparum</italic> Atg3–Atg8 protein–protein interaction inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2018, v. 32, n. 3, p. 473, doi. 10.1007/s10822-018-0102-5

By:

Villa, Stefania;
Legnani, Laura;
Colombo, Diego;
Gelain, Arianna;
Lammi, Carmen;
Bongiorno, Daniele;
Ilboudo, Denise P.;
McGee, Kellen E.;
Bosch, Jürgen;
Grazioso, Giovanni

Publication type:

Article

Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2016, v. 30, n. 10, p. 851, doi. 10.1007/s10822-016-9962-8

By:

Sgrignani, Jacopo;
De Luca, Filomena;
Torosyan, Hayarpi;
Docquier, Jean-Denis;
Duan, Da;
Novati, Beatrice;
Prati, Fabio;
Colombo, Giorgio;
Grazioso, Giovanni

Publication type:

Article

Covalent docking of selected boron-based serine beta-lactamase inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 5, p. 441, doi. 10.1007/s10822-015-9834-7

By:

Sgrignani, Jacopo;
Novati, Beatrice;
Grazioso, Giovanni;
Colombo, Giorgio

Publication type:

Article

Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes.

Published in:

Journal of Computer-Aided Molecular Design, 2013, v. 27, n. 11, p. 975, doi. 10.1007/s10822-013-9694-y

By:

Dallanoce, Clelia;
Grazioso, Giovanni;
Pomè, Diego Yuri;
Sciaccaluga, Miriam;
Matera, Carlo;
Gotti, Cecilia;
Fucile, Sergio;
De Amici, Marco

Publication type:

Article

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester.

Published in:

Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 9, p. 1035, doi. 10.1007/s10822-012-9596-4

By:

Grazioso, Giovanni;
Legnani, Laura;
Toma, Lucio;
Ettari, Roberta;
Micale, Nicola;
Micheli, Carlo

Publication type:

Article

Nicotine-Modulated Subunit Stoichiometry Affects Stability and Trafficking of α3β4 Nicotinic Receptor.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 30, p. 12316, doi. 10.1523/JNEUROSCI.2393-13.2013

By:

Mazzo, Francesca;
Pistillo, Francesco;
Grazioso, Giovanni;
Clementi, Francesco;
Borgese, Nica;
Gotti, Cecilia;
Colombo, Sara Francesca

Publication type:

Article

Insights into docking and scoring neuronal α4β2 nicotinic receptor agonists using molecular dynamics simulations and QM/MM calculations.

Published in:

Journal of Computational Chemistry, 2009, v. 30, n. 15, p. 2443, doi. 10.1002/jcc.21251

By:

SGRIGNANI, JACOPO;
BONACCINI, CLAUDIA;
GRAZIOSO, GIOVANNI;
CHIOCCIOLI, MATTEO;
CAVALLI, ANDREA;
GRATTERI, PAOLA

Publication type:

Article

Alpha7 nicotinic acetylcholine receptor agonists: Prediction of their binding affinity through a molecular mechanics Poisson–Boltzmann surface area approach.

Published in:

Journal of Computational Chemistry, 2008, v. 29, n. 15, p. 2593, doi. 10.1002/jcc.21019

By:

Grazioso, Giovanni;
Cavalli, Andrea;
De Amici, Marco;
Recanatini, Maurizio;
De Micheli, Carlo

Publication type:

Article

Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-35819-0

By:

Lammi, Carmen;
Sgrignani, Jacopo;
Arnoldi, Anna;
Grazioso, Giovanni

Publication type:

Article

Investigation of Chlorella pyrenoidosa Protein as a Source of Novel Angiotensin I-Converting Enzyme (ACE) and Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides.

Published in:

Nutrients, 2021, v. 13, n. 5, p. 1624, doi. 10.3390/nu13051624

By:

Li, Yuchen;
Aiello, Gilda;
Fassi, Enrico Mario Alessandro;
Boschin, Giovanna;
Bartolomei, Martina;
Bollati, Carlotta;
Roda, Gabriella;
Arnoldi, Anna;
Grazioso, Giovanni;
Lammi, Carmen;
Nagaoka, Satoshi

Publication type:

Article

Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met).

Published in:

Nutrients, 2021, v. 13, n. 3, p. 863, doi. 10.3390/nu13030863

By:

Lammi, Carmen;
Aiello, Gilda;
Bollati, Carlotta;
Li, Jianqiang;
Bartolomei, Martina;
Ranaldi, Giulia;
Ferruzza, Simonetta;
Fassi, Enrico Mario Alessandro;
Grazioso, Giovanni;
Sambuy, Yula;
Arnoldi, Anna;
Nagaoka, Satoshi

Publication type:

Article

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors.

Published in:

ChemMedChem, 2012, v. 7, n. 9, p. 1594, doi. 10.1002/cmdc.201200274

By:

Ettari, Roberta;
Micale, Nicola;
Grazioso, Giovanni;
Bova, Floriana;
Schirmeister, Tanja;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ.

Published in:

ChemMedChem, 2011, v. 6, n. 5, p. 889, doi. 10.1002/cmdc.201000514

By:

Dallanoce, Clelia;
Magrone, Pietro;
Matera, Carlo;
Frigerio, Fabio;
Grazioso, Giovanni;
De Amici, Marco;
Fucile, Sergio;
Piccari, Vanessa;
Frydenvang, Karla;
Pucci, Luca;
Gotti, Cecilia;
Clementi, Francesco;
De Micheli, Carlo

Publication type:

Article

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist.

Published in:

ChemMedChem, 2009, v. 4, n. 3, p. 415, doi. 10.1002/cmdc.200800341

By:

Calabrò, Maria Luisa;
Raneri, Daniela;
Ficarra, Paola;
Mennini, Tiziana;
Colleoni, Simona;
Grazioso, Giovanni;
Micale, Nicola;
Zappalà, Maria;
Grasso, Silvana

Publication type:

Article

Synthesis of Conformationally Constrained Glutamic Acid Homologues and Investigation of Their Pharmacological Profiles.

Published in:

ChemMedChem, 2007, v. 2, n. 11, p. 1639, doi. 10.1002/cmdc.200700118

By:

Conti, Paola;
Pinto, Andrea;
Tamborini, Lucia;
Grazioso, Giovanni;
De Sarro, Giovambattista;
Bräuner-Osborne, Hans;
Szabo, Geza;
Gábor Hársing, László;
De Micheli, Carlo

Publication type:

Article

The response of Escherichia coli biofilm to salicylic acid.

Published in:

Biofouling, 2017, v. 33, n. 3, p. 235, doi. 10.1080/08927014.2017.1286649

By:

Cattò, Cristina;
Grazioso, Giovanni;
Dell’Orto, Silvia;
Gelain, Arianna;
Villa, Stefania;
Marzano, Valeria;
Vitali, Alberto;
Villa, Federica;
Cappitelli, Francesca;
Forlani, Fabio

Publication type:

Article

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors.

Published in:

FASEB Journal, 2011, v. 25, n. 11, p. 3775, doi. 10.1096/fj.10-179853

By:

Pucci, Luca;
Grazioso, Giovanni;
Dallanoce, Clelia;
Rizzi, Luca;
De Micheli, Carlo;
Clementi, Francesco;
Bertrand, Sonia;
Bertrand, Daniel;
Longhi, Renato;
De Amici, Marco;
Gotti, Cecilia

Publication type:

Article

New Analogues of Epiboxidine Incorporating the 4,5-Dihydroisoxazole Nucleus: Synthesis, Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors, and Molecular Modeling Investigations.

Published in:

Chemistry & Biodiversity, 2009, v. 6, n. 2, p. 244, doi. 10.1002/cbdv.200800077

By:

Dallanoce, Clelia;
Magrone, Pietro;
Bazza, Paola;
Grazioso, Giovanni;
Rizzi, Luca;
Riganti, Loredana;
Gotti, Cecilia;
Clementi, Francesco;
Frydenvang, Karla;
De Amici, Marco

Publication type:

Article

Synthesis of Novel N<sup>1</sup>-Substituted Bicyclic Pyrazole Amino Acids and Evaluation of Their Interaction with Glutamate Receptors.

Published in:

Chemistry & Biodiversity, 2005, v. 2, n. 6, p. 748, doi. 10.1002/cbdv.200590052

By:

Conti, Paola;
Grazioso, Giovanni;
Joppolo di Ventimiglia, Samuele;
Pinto, Andrea;
Roda, Gabriella;
Madsen, Ulf;
Bräuner-Osborne, Hans;
Nielsen, Birgitte;
Costagli, Chiara;
Galli, Alessandro

Publication type:

Article

Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors.

Published in:

European Journal of Organic Chemistry, 2003, v. 2003, n. 22, p. 4455, doi. 10.1002/ejoc.200300424

By:

Paola Conti;
Marco De Amici;
Giovanni Grazioso;
Gabriella Roda;
Tine B. Stensbøl;
Hans Bräuner-Osborne;
Ulf Madsen;
Lucio Toma;
Carlo De Micheli

Publication type:

Article

FYCO1 Peptide Analogs: Design and Characterization of Autophagy Inhibitors as Co-Adjuvants in Taxane Chemotherapy of Prostate Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5365, doi. 10.3390/ijms26115365

By:

Fassi, Enrico Mario Alessandro;
Moretti, Roberta Manuela;
Montagnani Marelli, Marina;
Garofalo, Mariangela;
Gori, Alessandro;
Pesce, Cristiano;
Albani, Marco;
Milano, Erica Ginevra;
Sgrignani, Jacopo;
Cavalli, Andrea;
Grazioso, Giovanni

Publication type:

Article

Exploring Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Autoproteolysis Process by Molecular Simulations: Hints for Drug Design.

Published in:

ChemMedChem, 2020, v. 15, n. 16, p. 1601, doi. 10.1002/cmdc.202000431

By:

Sgrignani, Jacopo;
Fassi, Enrico M. A.;
Lammi, Carmen;
Roda, Gabriella;
Grazioso, Giovanni

Publication type:

Article

Elagolix Sodium Salt and Its Synthetic Intermediates: A Spectroscopic, Crystallographic, and Conformational Study.

Published in:

Molecules, 2023, v. 28, n. 9, p. 3861, doi. 10.3390/molecules28093861

By:

Ciceri, Samuele;
Colombo, Diego;
Fassi, Enrico M. A.;
Ferraboschi, Patrizia;
Grazioso, Giovanni;
Grisenti, Paride;
Iannone, Marco;
Castellano, Carlo;
Meneghetti, Fiorella

Publication type:

Article

Development of AMBER Parameters for Molecular Simulations of Selected Boron-Based Covalent Ligands.

Published in:

Molecules, 2023, v. 28, n. 6, p. 2866, doi. 10.3390/molecules28062866

By:

Chiacchio, Maria Assunta;
Legnani, Laura;
Fassi, Enrico Mario Alessandro;
Roda, Gabriella;
Grazioso, Giovanni

Publication type:

Article

Computational Design, Synthesis, and Biophysical Evaluation of β-Amido Boronic Acids as SARS-CoV-2 M pro Inhibitors.

Published in:

Molecules, 2023, v. 28, n. 5, p. 2356, doi. 10.3390/molecules28052356

By:

Fassi, Enrico M. A.;
Manenti, Marco;
Citarella, Andrea;
Dei Cas, Michele;
Casati, Sara;
Micale, Nicola;
Schirmeister, Tanja;
Roda, Gabriella;
Silvani, Alessandra;
Grazioso, Giovanni

Publication type:

Article

Combining Experimental Data and Computational Methods for the Non-Computer Specialist.

Published in:

Molecules, 2020, v. 25, n. 20, p. 4783, doi. 10.3390/molecules25204783

By:

Cárdenas, Reinier;
Martínez-Seoane, Javier;
Amero, Carlos;
Sgrignani, Jacopo;
Grazioso, Giovanni

Publication type:

Article

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies—Present State, Challenges, and Perspectives.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4040, doi. 10.3390/molecules25184040

By:

Bauerová-Hlinková, Vladena;
Hajdúchová, Dominika;
Bauer, Jacob A.;
Sgrignani, Jacopo;
Grazioso, Giovanni

Publication type:

Article

How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs.

Published in:

Molecules, 2020, v. 25, n. 7, p. 1756, doi. 10.3390/molecules25071756

By:

Garofalo, Mariangela;
Grazioso, Giovanni;
Cavalli, Andrea;
Sgrignani, Jacopo

Publication type:

Article

Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells.

Published in:

Scientific Reports, 2016, p. 29931, doi. 10.1038/srep29931

By:

Lammi, Carmen;
Zanoni, Chiara;
Aiello, Gilda;
Arnoldi, Anna;
Grazioso, Giovanni

Publication type:

Article