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Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
Published in:
Angewandte Chemie, 2021, v. 133, n. 29, p. 16041, doi. 10.1002/ange.202101328
By:
- Du, Guangyan;
- Jiang, Jie;
- Wu, Qibiao;
- Henning, Nathaniel J.;
- Donovan, Katherine A.;
- Yue, Hong;
- Che, Jianwei;
- Lu, Wenchao;
- Fischer, Eric S.;
- Bardeesy, Nabeel;
- Zhang, Tinghu;
- Gray, Nathanael S.
Publication type:
Article
Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations.
Published in:
Angewandte Chemie, 2020, v. 132, n. 34, p. 14589, doi. 10.1002/ange.202003500
By:
- Jang, Jaebong;
- To, Ciric;
- De Clercq, Dries J. H.;
- Park, Eunyoung;
- Ponthier, Charles M.;
- Shin, Bo Hee;
- Mushajiang, Mierzhati;
- Nowak, Radosław P.;
- Fischer, Eric S.;
- Eck, Michael J.;
- Jänne, Pasi A.;
- Gray, Nathanael S.
Publication type:
Article
Development of CDK2 and CDK5 Dual Degrader TMX‐2172.
Published in:
Angewandte Chemie, 2020, v. 132, n. 33, p. 13969, doi. 10.1002/ange.202004087
By:
- Teng, Mingxing;
- Jiang, Jie;
- He, Zhixiang;
- Kwiatkowski, Nicholas P.;
- Donovan, Katherine A.;
- Mills, Caitlin E.;
- Victor, Chiara;
- Hatcher, John M.;
- Fischer, Eric S.;
- Sorger, Peter K.;
- Zhang, Tinghu;
- Gray, Nathanael S.
Publication type:
Article
Development of Dual and Selective Degraders of Cyclin‐Dependent Kinases 4 and 6.
Published in:
Angewandte Chemie, 2019, v. 131, n. 19, p. 6387, doi. 10.1002/ange.201901336
By:
- Jiang, Baishan;
- Wang, Eric S.;
- Donovan, Katherine A.;
- Liang, Yanke;
- Fischer, Eric S.;
- Zhang, Tinghu;
- Gray, Nathanael S.
Publication type:
Article
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Published in:
Angewandte Chemie, 2018, v. 130, n. 36, p. 11803, doi. 10.1002/ange.201805187
By:
- Jang, Jaebong;
- Son, Jieun;
- Park, Eunyoung;
- Kosaka, Takayuki;
- Saxon, Jamie A.;
- De Clercq, Dries J. H.;
- Choi, Hwan Geun;
- Tanizaki, Junko;
- Eck, Michael J.;
- Jänne, Pasi A.;
- Gray, Nathanael S.
Publication type:
Article
High-throughput kinase profiling as a platform for drug discovery.
Published in:
Nature Reviews Drug Discovery, 2008, v. 7, n. 5, p. 391, doi. 10.1038/nrd2541
By:
- Goldstein, David M.;
- Gray, Nathanael S.;
- Zarrinkar, Patrick P.
Publication type:
Article
Targeting transcription in heart failure via CDK7/12/13 inhibition.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31541-8
By:
- Hsu, Austin;
- Duan, Qiming;
- Day, Daniel S.;
- Luo, Xin;
- McMahon, Sarah;
- Huang, Yu;
- Feldman, Zachary B.;
- Jiang, Zhen;
- Zhang, Tinghu;
- Liang, Yanke;
- Alexanian, Michael;
- Padmanabhan, Arun;
- Brown, Jonathan D.;
- Lin, Charles Y.;
- Gray, Nathanael S.;
- Young, Richard A.;
- Bruneau, Benoit G.;
- Haldar, Saptarsi M.
Publication type:
Article
When Kinases Meet PROTACs.
Published in:
Chinese Journal of Chemistry, 2018, v. 36, n. 10, p. 971, doi. 10.1002/cjoc.201800293
By:
- Tan, Li;
- Gray, Nathanael S.
Publication type:
Article
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Published in:
Angewandte Chemie International Edition, 2018, v. 57, n. 36, p. 11629, doi. 10.1002/anie.201805187
By:
- Jang, Jaebong;
- Son, Jieun;
- Park, Eunyoung;
- Kosaka, Takayuki;
- Saxon, Jamie A.;
- De Clercq, Dries J. H.;
- Choi, Hwan Geun;
- Tanizaki, Junko;
- Eck, Michael J.;
- Jänne, Pasi A.;
- Gray, Nathanael S.
Publication type:
Article
Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor.
Published in:
Angewandte Chemie International Edition, 2014, v. 53, n. 1, p. 199, doi. 10.1002/anie.201307387
By:
- Lim, Sang Min;
- Westover, Kenneth D.;
- Ficarro, Scott B.;
- Harrison, Rane A.;
- Choi, Hwan Geun;
- Pacold, Michael E.;
- Carrasco, Martin;
- Hunter, John;
- Kim, Nam Doo;
- Xie, Ting;
- Sim, Taebo;
- Jänne, Pasi A.;
- Meyerson, Matthew;
- Marto, Jarrod A.;
- Engen, John R.;
- Gray, Nathanael S.
Publication type:
Article
A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.
Published in:
Chemical Biology & Drug Design, 2015, v. 86, n. 2, p. 144, doi. 10.1111/cbdd.12473
By:
- Moroco, Jamie A.;
- Baumgartner, Matthew P.;
- Rust, Heather L.;
- Choi, Hwan Geun;
- Hur, Wooyoung;
- Gray, Nathanael S.;
- Camacho, Carlos J.;
- Smithgall, Thomas E.
Publication type:
Article
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 566, doi. 10.3390/ijms22020566
By:
- Wells, Carrow I.;
- Al-Ali, Hassan;
- Andrews, David M.;
- Asquith, Christopher R. M.;
- Axtman, Alison D.;
- Dikic, Ivan;
- Ebner, Daniel;
- Ettmayer, Peter;
- Fischer, Christian;
- Frederiksen, Mathias;
- Futrell, Robert E.;
- Gray, Nathanael S.;
- Hatch, Stephanie B.;
- Knapp, Stefan;
- Lücking, Ulrich;
- Michaelides, Michael;
- Mills, Caitlin E.;
- Müller, Susanne;
- Owen, Dafydd;
- Picado, Alfredo
Publication type:
Article
Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 5, p. 2037, doi. 10.1172/JCI72522
By:
- Amato, Katherine R.;
- Shan Wang;
- Hastings, Andrew K.;
- Youngblood, Victoria M.;
- Santapuram, Pranav R.;
- Haiying Chen;
- Cates, Justin M.;
- Colvin, Daniel C.;
- Fei Ye;
- Brantley-Sieders, Dana M.;
- Cook, Rebecca S.;
- Li Tan;
- Gray, Nathanael S.;
- Jin Chen
Publication type:
Article
Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID‐19 therapy.
Published in:
Journal of Medical Virology, 2023, v. 95, n. 1, p. 1, doi. 10.1002/jmv.28157
By:
- Boytz, RuthMabel;
- Słabicki, Mikołaj;
- Ramaswamy, Sita;
- Patten, J. J.;
- Zou, Charles;
- Meng, Chengcheng;
- Hurst, Brett L.;
- Wang, Jinhua;
- Nowak, Radosław P.;
- Yang, Priscilla L.;
- Sattler, Martin;
- Stone, Richard M.;
- Griffin, James D.;
- Gray, Nathanael S.;
- Gummuluru, Suryaram;
- Davey, Robert A.;
- Weisberg, Ellen
Publication type:
Article
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.
Published in:
Biochemical Journal, 2014, v. 457, n. 1, p. 215, doi. 10.1042/BJ20131152
By:
- BANERJEE, Sourav;
- BUHRLAGE, Sara J.;
- Hai-Tsang HUANG;
- Xianming DENG;
- Wenjun ZHOU;
- Jinhua WANG;
- TRAYNOR, Ryan;
- PRESCOTT, Alan R.;
- ALESSI, Dario R.;
- GRAY, Nathanael S.
Publication type:
Article
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.53003
By:
- Jong Wook Kim;
- Berrios, Christian;
- Miju Kim;
- Schade, Amy E.;
- Adelmant, Guillaume;
- Yeerna, Huwate;
- Damato, Emily;
- Iniguez, Amanda Balboni;
- Florens, Laurence;
- Washburn, Michael P.;
- Stegmaier, Kim;
- Gray, Nathanael S.;
- Tamayo, Pablo;
- Gjoerup, Ole;
- Marto, Jarrod A.;
- DeCaprio, James;
- Hahn, William C.
Publication type:
Article
MELK is not necessary for the proliferation of basal-like breast cancer cells.
Published in:
eLife, 2017, p. 1, doi. 10.7554/eLife.26693
By:
- Hai-Tsang Huang;
- Hyuk-Soo Seo;
- Tinghu Zhang;
- Yubao Wang;
- Baishan Jiang;
- Qing Li;
- Buckley, Dennis L.;
- Nabet, Behnam;
- Roberts, Justin M.;
- Paulk, Joshiawa;
- Dastjerdi, Shiva;
- Winter, Georg E.;
- McLauchlan, Hilary;
- Moran, Jennifer;
- Bradner, James E.;
- Eck, Michael J.;
- Dhe-Paganon, Sirano;
- Zhao, Jean J.;
- Gray, Nathanael S.
Publication type:
Article
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30258-y
By:
- Beyett, Tyler S.;
- To, Ciric;
- Heppner, David E.;
- Rana, Jaimin K.;
- Schmoker, Anna M.;
- Jang, Jaebong;
- De Clercq, Dries J. H.;
- Gomez, Gabriel;
- Scott, David A.;
- Gray, Nathanael S.;
- Jänne, Pasi A.;
- Eck, Michael J.
Publication type:
Article
Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
Published in:
Nature Communications, 2021, v. 12, p. 1, doi. 10.1038/s41467-021-26935-z
By:
- Kaltheuner, Ines H.;
- Anand, Kanchan;
- Moecking, Jonas;
- Düster, Robert;
- Jinhua Wang;
- Gray, Nathanael S.;
- Geyer, Matthias
Publication type:
Article
Extracellular signal--regulated kinase 5 promotes acute cellular and systemic inflammation.
Published in:
Science Signaling, 2015, v. 8, n. 391, p. 1, doi. 10.1126/scisignal.aaa3206
By:
- Wilhelmsen, Kevin;
- Fengyun Xu;
- Farrar, Katherine;
- Tran, Alphonso;
- Khakpour, Samira;
- Sundar, Shirin;
- Prakash, Arun;
- Jinhua Wang;
- Gray, Nathanael S.;
- Hellman, Judith
Publication type:
Article
The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.
Published in:
Science Signaling, 2014, v. 7, n. 349, p. 1, doi. 10.1126/scisignal.2005470
By:
- Umapathy, Ganesh;
- El Wakil, Abeer;
- Witek, Barbara;
- Chesler, Louis;
- Danielson, Laura;
- Xianming Deng;
- Gray, Nathanael S.;
- Johansson, Mikael;
- Kvarnbrink, Samuel;
- Ruuth, Kristina;
- Schönherr, Christina;
- Palmer, Ruth H.;
- Hallberg, Bengt
Publication type:
Article
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
Published in:
Nature Biotechnology, 2013, v. 31, n. 7, p. 630, doi. 10.1038/nbt.2620
By:
- Taipale, Mikko;
- Krykbaeva, Irina;
- Whitesell, Luke;
- Santagata, Sandro;
- Zhang, Jianming;
- Liu, Qingsong;
- Gray, Nathanael S;
- Lindquist, Susan
Publication type:
Article
Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.
Published in:
Nature Medicine, 2011, v. 17, n. 9, p. 1116, doi. 10.1038/nm.2402
By:
- Liu, Pixu;
- Cheng, Hailing;
- Santiago, Stephanie;
- Raeder, Maria;
- Zhang, Fan;
- Isabella, Adam;
- Yang, Janet;
- Semaan, Derek J;
- Chen, Changzhong;
- Fox, Edward A;
- Gray, Nathanael S;
- Monahan, John;
- Schlegel, Robert;
- Beroukhim, Rameen;
- Mills, Gordon B;
- Zhao, Jean J
Publication type:
Article
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
Published in:
Journal of Pathology, 2013, v. 230, n. 1, p. 17, doi. 10.1002/path.4176
By:
- Guo, Yanan;
- Chekaluk, Yvonne;
- Zhang, Jianming;
- Du, Jinyan;
- Gray, Nathanael S;
- Wu, Chin‐Lee;
- Kwiatkowski, David J
Publication type:
Article
Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Published in:
Nature Structural & Molecular Biology, 2008, v. 15, n. 10, p. 1109, doi. 10.1038/nsmb.1486
By:
- Azam, Mohammad;
- Seelinger, Markus A.;
- Gray, Nathanael S.;
- Kuriyan, John;
- Daley, George Q.
Publication type:
Article
Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor.
Published in:
Angewandte Chemie, 2014, v. 126, n. 1, p. 203, doi. 10.1002/ange.201307387
By:
- Lim, Sang Min;
- Westover, Kenneth D.;
- Ficarro, Scott B.;
- Harrison, Rane A.;
- Choi, Hwan Geun;
- Pacold, Michael E.;
- Carrasco, Martin;
- Hunter, John;
- Kim, Nam Doo;
- Xie, Ting;
- Sim, Taebo;
- Jänne, Pasi A.;
- Meyerson, Matthew;
- Marto, Jarrod A.;
- Engen, John R.;
- Gray, Nathanael S.
Publication type:
Article
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128364
By:
- Moccia, Marialuisa;
- Liu, Qingsong;
- Guida, Teresa;
- Federico, Giorgia;
- Brescia, Annalisa;
- Zhao, Zheng;
- Choi, Hwan Geun;
- Deng, Xianming;
- Tan, Li;
- Wang, Jinhua;
- Billaud, Marc;
- Gray, Nathanael S.;
- Carlomagno, Francesca;
- Santoro, Massimo
Publication type:
Article
Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092649
By:
- Codeluppi, Simone;
- Fernandez-Zafra, Teresa;
- Sandor, Katalin;
- Kjell, Jacob;
- Liu, Qingsong;
- Abrams, Mathew;
- Olson, Lars;
- Gray, Nathanael S.;
- Svensson, Camilla I.;
- Uhlén, Per
Publication type:
Article
BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner.
Published in:
PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041343
By:
- Lau, Ken S.;
- Zhang, Tinghu;
- Kendall, Krystle R.;
- Lauffenburger, Douglas;
- Gray, Nathanael S.;
- Haigis, Kevin M.
Publication type:
Article
Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation.
Published in:
PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0020226
By:
- McMillin, Douglas W.;
- Delmore, Jake;
- Negri, Joseph;
- Ooi, Melissa;
- Klippel, Steffen;
- Miduturu, Chandrasekhar V.;
- Gray, Nathanael S.;
- Richardson, Paul G.;
- Anderson, Kenneth C.;
- Kung, Andrew L.;
- Mitsiades, Constantine S.
Publication type:
Article
Inhibitor-Sensitive FGFR1 Amplification in Human Non- Small Cell Lung Cancer.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020351
By:
- Dutt, Amit;
- Ramos, Alex H.;
- Hammerman, Peter S.;
- Mermel, Craig;
- Cho, Jeonghee;
- Sharifnia, Tanaz;
- Chande, Ajit;
- Tanaka, Kumiko Elisa;
- Stransky, Nicolas;
- Greulich, Heidi;
- Gray, Nathanael S.;
- Meyerson, Matthew
Publication type:
Article
Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase.
Published in:
PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0015929
By:
- Iacob, Roxana E.;
- Jianming Zhang;
- Gray, Nathanael S.;
- Engen, John R.
Publication type:
Article
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.67772
By:
- Tang, Cheng-Chia;
- Castro Andrade, Christian D.;
- O'Meara, Maureen J.;
- Yoon, Sung-Hee;
- Sato, Tadatoshi;
- Brooks, Daniel J.;
- Bouxsein, Mary L.;
- da Silva Martins, Janaina;
- Wang, Jinhua;
- Gray, Nathanael S.;
- Misof, Barbara;
- Roschger, Paul;
- Boulin, Stephane;
- Klaushofer, Klaus;
- Velduis-Vlug, Annegreet;
- Vegting, Yosta;
- Rosen, Clifford J.;
- O'Connell, Daniel;
- Sundberg, Thomas B.;
- Xavier, Ramnik J.
Publication type:
Article
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11429-w
By:
- de Wispelaere, Mélissanne;
- Yang, Priscilla L.;
- Du, Guangyan;
- Donovan, Katherine A.;
- Zhang, Tinghu;
- Nowak, Radosław P.;
- Fischer, Eric S.;
- Gray, Nathanael S.;
- Eleuteri, Nicholas A.;
- Yuan, Jingting C.;
- Kalabathula, Joann
Publication type:
Article
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09703-y
By:
- Krajewska, Malgorzata;
- Dries, Ruben;
- Grassetti, Andrew V.;
- Dust, Sofia;
- Gao, Yang;
- Huang, Hao;
- Sharma, Bandana;
- Day, Daniel S.;
- Kwiatkowski, Nicholas;
- Pomaville, Monica;
- Dodd, Oliver;
- Chipumuro, Edmond;
- Zhang, Tinghu;
- Greenleaf, Arno L.;
- Yuan, Guo-Cheng;
- Gray, Nathanael S.;
- Young, Richard A.;
- Geyer, Matthias;
- Gerber, Scott A.;
- George, Rani E.
Publication type:
Article
Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations.
Published in:
Molecular Oncology, 2021, v. 15, n. 1, p. 27, doi. 10.1002/1878-0261.12673
By:
- Ogino, Atsuko;
- Choi, Jihyun;
- Lin, Mika;
- Wilkens, Margaret K.;
- Calles, Antonio;
- Xu, Man;
- Adeni, Anika E.;
- Chambers, Emily S.;
- Capelletti, Marzia;
- Butaney, Mohit;
- Gray, Nathanael S.;
- Gokhale, Prafulla C.;
- Palakurthi, Sangeetha;
- Kirschmeier, Paul;
- Oxnard, Geoffrey R.;
- Sholl, Lynette M.;
- Jänne, Pasi A.
Publication type:
Article
Front Cover: Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity (ChemBioChem 19/2023).
Published in:
ChemBioChem, 2023, v. 24, n. 19, p. 1, doi. 10.1002/cbic.202300535
By:
- Koide, Eriko;
- Mohardt, Mikaela L.;
- Doctor, Zainab M.;
- Yang, Annan;
- Hao, Mingfeng;
- Donovan, Katherine A.;
- Kuismi, Christina C.;
- Nelson, Alissa J.;
- Abell, Kathryn;
- Aguiar, Mike;
- Che, Jianwei;
- Stokes, Matthew P.;
- Zhang, Tinghu;
- Aguirre, Andrew J.;
- Fischer, Eric S.;
- Gray, Nathanael S.;
- Jiang, Baishan;
- Nabet, Behnam
Publication type:
Article
Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity.
Published in:
ChemBioChem, 2023, v. 24, n. 19, p. 1, doi. 10.1002/cbic.202300141
By:
- Koide, Eriko;
- Mohardt, Mikaela L.;
- Doctor, Zainab M.;
- Yang, Annan;
- Hao, Mingfeng;
- Donovan, Katherine A.;
- Kuismi, Christina C.;
- Nelson, Alissa J.;
- Abell, Kathryn;
- Aguiar, Mike;
- Che, Jianwei;
- Stokes, Matthew P.;
- Zhang, Tinghu;
- Aguirre, Andrew J.;
- Fischer, Eric S.;
- Gray, Nathanael S.;
- Jiang, Baishan;
- Nabet, Behnam
Publication type:
Article
Cover Picture: Chemical Interrogation of the Malaria Kinome (ChemBioChem 13/2014).
Published in:
ChemBioChem, 2014, v. 15, n. 13, p. 1841, doi. 10.1002/cbic.201490045
By:
- Derbyshire, Emily R.;
- Zuzarte‐Luís, Vanessa;
- Magalhães, Andreia D.;
- Kato, Nobutaka;
- Sanschagrin, Paul C.;
- Wang, Jinhua;
- Zhou, Wenjun;
- Miduturu, Chandrasekhar V.;
- Mazitschek, Ralph;
- Sliz, Piotr;
- Mota, Maria M.;
- Gray, Nathanael S.;
- Clardy, Jon
Publication type:
Article
Chemical Interrogation of the Malaria Kinome.
Published in:
ChemBioChem, 2014, v. 15, n. 13, p. 1920, doi. 10.1002/cbic.201400025
By:
- Derbyshire, Emily R.;
- Zuzarte‐Luís, Vanessa;
- Magalhães, Andreia D.;
- Kato, Nobutaka;
- Sanschagrin, Paul C.;
- Wang, Jinhua;
- Zhou, Wenjun;
- Miduturu, Chandrasekhar V.;
- Mazitschek, Ralph;
- Sliz, Piotr;
- Mota, Maria M.;
- Gray, Nathanael S.;
- Clardy, Jon
Publication type:
Article
Fluorescent Visualization of Src by Using Dasatinib-BODIPY.
Published in:
ChemBioChem, 2014, v. 15, n. 9, p. 1317, doi. 10.1002/cbic.201402010
By:
- Vetter, Michael L.;
- Zhang, Zijuan;
- Liu, Shuai;
- Wang, Jinhua;
- Cho, HaeYeon;
- Zhang, Jianming;
- Zhang, Wei;
- Gray, Nathanael S.;
- Yang, Priscilla L.
Publication type:
Article
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Published in:
Nature, 2009, v. 462, n. 7276, p. 1070, doi. 10.1038/nature08622
By:
- Wenjun Zhou;
- Ercan, Dalia;
- Liang Chen;
- Cai-Hong Yun;
- Li, Danan;
- Capelletti, Marzia;
- Cortot, Alexis B.;
- Chirieac, Lucian;
- Iacob, Roxana E.;
- Padera, Robert;
- Engen, John R.;
- Kwok-Kin Wong;
- Eck, Michael J.;
- Gray, Nathanael S.;
- Jänne, Pasi A.
Publication type:
Article
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Published in:
Nature, 2008, v. 455, n. 7215, p. 975, doi. 10.1038/nature07397
By:
- George, Rani E.;
- Sanda, Takaomi;
- Hanna, Megan;
- Fröhling, Stefan;
- II, William Luther;
- Zhang, Jianming;
- Ahn, Yebin;
- Zhou, Wenjun;
- London, Wendy B.;
- McGrady, Patrick;
- Xue, Liquan;
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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.
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Systematic analysis of BRAF<sup>V</sup><sup>600E</sup> melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.
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Molecular Systems Biology, 2015, v. 11, n. 3, p. n/a, doi. 10.15252/msb.20145877
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Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
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2020
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Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
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Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells.
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Proteomics, 2021, v. 21, n. 13, p. 1, doi. 10.1002/pmic.202000098
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