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Safety, pharmacokinetics and pharmacodynamics of branebrutinib (BMS‐986195), a covalent, irreversible inhibitor of Bruton's tyrosine kinase: Randomised phase I, placebo‐controlled trial in healthy participants.
Published in:
British Journal of Clinical Pharmacology, 2020, v. 86, n. 9, p. 1849, doi. 10.1111/bcp.14290
By:
- Catlett, Ian M.;
- Nowak, Miroslawa;
- Kundu, Sudeep;
- Zheng, Naiyu;
- Liu, Ang;
- He, Bing;
- Girgis, Ihab G.;
- Grasela, Dennis M.
Publication type:
Article
Daclatasvir + asunaprevir + beclabuvir ± ribavirin for chronic HCV genotype 1-infected treatment-naive patients.
Published in:
Liver International, 2016, v. 36, n. 2, p. 189, doi. 10.1111/liv.12964
By:
- Everson, Gregory T.;
- Sims, Karen D.;
- Thuluvath, Paul J.;
- Lawitz, Eric;
- Hassanein, Tarek;
- Rodriguez ‐ Torres, Maribel;
- Desta, Tadesse;
- Hawkins, Trevor;
- Levin, James M.;
- Hinestrosa, Federico;
- Rustgi, Vinod;
- Schwartz, Howard;
- Younossi, Zobair;
- Webster, Lynn;
- Gitlin, Norman;
- Eley, Timothy;
- Huang, Shu ‐ Pang;
- McPhee, Fiona;
- Grasela, Dennis M.;
- Gardiner, David F.
Publication type:
Article
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Published in:
Nature, 2010, v. 465, n. 7294, p. 96, doi. 10.1038/nature08960
By:
- Min Gao;
- Nettles, Richard E.;
- Belema, Makonen;
- Snyder, Lawrence B.;
- Nguyen, Van N.;
- Fridell, Robert A.;
- Serrano-Wu, Michael H.;
- Langley, David R.;
- Jin-Hua Sun;
- O'Boyle, II, Donald R.;
- Lemm, Julie A.;
- Chunfu Wang;
- Knipe, Jay O.;
- Caly Chien;
- Colonno, Richard J.;
- Grasela, Dennis M.;
- Meanwell, Nicholas A.;
- Hamann, Lawrence G.
Publication type:
Article
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.
Published in:
2019
By:
- Hotchkiss, Richard S.;
- Colston, Elizabeth;
- Yende, Sachin;
- Crouser, Elliott D.;
- Martin, Greg S.;
- Albertson, Timothy;
- Bartz, Raquel R.;
- Brakenridge, Scott C.;
- Delano, Matthew J.;
- Park, Pauline K.;
- Donnino, Michael W.;
- Tidswell, Mark;
- Mayr, Florian B.;
- Angus, Derek C.;
- Coopersmith, Craig M.;
- Moldawer, Lyle L.;
- Catlett, Ian M.;
- Girgis, Ihab G.;
- Ye, June;
- Grasela, Dennis M.
Publication type:
journal article
Lack of effect of multiple doses of cimetidine on estimated hepatic blood flow.
Published in:
Biopharmaceutics & Drug Disposition, 1987, v. 8, n. 1, p. 63, doi. 10.1002/bdd.2510080108
By:
- Grasela, Dennis M.;
- Rocci, Mario L.;
- Rotmensch, Heschi H.;
- Vlasses, Peter H.
Publication type:
Article
Model-Based Drug Development: Strengths, Weaknesses, Opportunities, and Threats for Broad Application of Pharmacometrics in Drug Development.
Published in:
Journal of Clinical Pharmacology, 2010, v. 50, n. 9, p. 31S, doi. 10.1177/0091270010377629
By:
- Wetherington, Jeffrey D.;
- Pfister, Marc;
- Banfield, Christopher;
- Stone, Julie A.;
- Krishna, Rajesh;
- Allerheiligen, Sandy;
- Grasela, Dennis M.
Publication type:
Article
Model-Based Drug Development Survey Finds Pharmacometrics Impacting Decision Making in the Pharmaceutical Industry.
Published in:
Journal of Clinical Pharmacology, 2010, v. 50, n. 9, p. 20S, doi. 10.1177/0091270010377628
By:
- Stone, Julie A.;
- Banfield, Christopher;
- Pfister, Marc;
- Tannenbaum, Stacey;
- Allerheiligen, Sandy;
- Wetherington, Jeffrey D.;
- Krishna, Rajesh;
- Grasela, Dennis M.
Publication type:
Article
Pharmacokinetic Interaction Between Efavirenz and Carbamazepine After Multiple-Dose Administration in Healthy Subjects.
Published in:
Journal of Clinical Pharmacology, 2008, v. 48, n. 8, p. 948, doi. 10.1177/0091270008319792
By:
- Ping Ji;
- Damle, Bharat;
- Jingdong Xie;
- Unger, Steve E.;
- Grasela, Dennis M.;
- Kaul, Sanjeev
Publication type:
Article
Entecavir Pharmacokinetics, Safety, and Tolerability After Multiple Ascending Doses in Healthy Subjects.
Published in:
Journal of Clinical Pharmacology, 2006, v. 46, n. 11, p. 1250, doi. 10.1177/0091270006293304
By:
- Yan, Jing-He;
- Bifano, Marc;
- Olsen, Steven;
- Smith, Robert A.;
- Zhang, Duxi;
- Grasela, Dennis M.;
- LaCreta, Frank
Publication type:
Article
The Effect of Ravuconazole on the Pharmacokinetics of Nelfinavir in Healthy Male Volunteers.
Published in:
Journal of Clinical Pharmacology, 2006, v. 46, n. 2, p. 193, doi. 10.1177/0091270005283462
By:
- Yan, Jing-He;
- Marino, Maria R.;
- Smith, Robert A.;
- Kanamaluru, Vanaja;
- O’Mara, Edward M.;
- Grasela, Dennis M.
Publication type:
Article
The Influence of Renal Function on Hydroxyurea Pharmacokinetics in Adults With Sickle Cell Disease.
Published in:
Journal of Clinical Pharmacology, 2005, v. 45, n. 4, p. 434, doi. 10.1177/0091270004273526
By:
- Yan, Jing-He;
- Ataga, Kenneth;
- Kaul, Sanjeev;
- Olson, Jeffery S.;
- Grasela, Dennis M.;
- Gothelf, Samantha;
- Kutlar, Abdulah;
- Orringer, Eugene
Publication type:
Article
Effect of an Aluminum- and Magnesium-Containing Antacid on the Bioavailability of Garenoxacin in Healthy Volunteers.
Published in:
Pharmacotherapy, 2007, v. 27, n. 7, p. 963, doi. 10.1592/phco.27.7.963
By:
- Krishna, Gopal;
- Kisicki, James C.;
- Olsen, Steven;
- Grasela, Dennis M.;
- Wang, Zaiqi
Publication type:
Article
Clinical Pharmacology of Gatifloxacin, a New Fluoroquinolone.
Published in:
Clinical Infectious Diseases, 2000, v. 31, p. S51, doi. 10.1086/314061
By:
- Grasela, Dennis M.
Publication type:
Article
Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy.
Published in:
2017
By:
- Gay, Cynthia L.;
- Bosch, Ronald J.;
- Ritz, Justin;
- Hataye, Jason M.;
- Aga, Evgenia;
- Tressler, Randall L.;
- Mason, Stephen W.;
- Hwang, Carey K.;
- Grasela, Dennis M.;
- Ray, Neelanjana;
- Cyktor, Josh C.;
- Coffin, John M.;
- Acosta, Edward P.;
- Koup, Richard A.;
- Mellors, John W.;
- Eron, Joseph J.;
- AIDS Clinical Trials 5326 Study Team
Publication type:
journal article

Found: 14