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Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 8383, doi. 10.3390/ijms21218383
By:
- Vyse, Timothy J.;
- Cunninghame Graham, Deborah S.
Publication type:
Article
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
Published in:
Nature Genetics, 2012, v. 44, n. 11, p. 1227, doi. 10.1038/ng.2439
By:
- Manjarrez-Orduño, Nataly;
- Marasco, Emiliano;
- Chung, Sharon A;
- Katz, Matthew S;
- Kiridly, Jenna F;
- Simpfendorfer, Kim R;
- Freudenberg, Jan;
- Ballard, David H;
- Nashi, Emil;
- Hopkins, Thomas J;
- Cunninghame Graham, Deborah S;
- Lee, Annette T;
- Coenen, Marieke J H;
- Franke, Barbara;
- Swinkels, Dorine W;
- Graham, Robert R;
- Kimberly, Robert P;
- Gaffney, Patrick M;
- Vyse, Timothy J;
- Behrens, Timothy W
Publication type:
Article
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
Published in:
Nature Genetics, 2008, v. 40, n. 9, p. 1059, doi. 10.1038/ng.200
By:
- Graham, Robert R.;
- Cotsapas, Chris;
- Davies, Leela;
- Hackett, Rachel;
- Lessard, Christopher J.;
- Leon, Joanlise M.;
- Burtt, Noel P.;
- Guiducci, Candace;
- Parkin, Melissa;
- Gates, Casey;
- Plenge, Robert M.;
- Behrens, Timothy W.;
- Wither, Joan E.;
- Rioux, John D.;
- Fortin, Paul R.;
- Graham, Deborah Cunninghame;
- Wong, Andrew K.;
- Vyse, Timothy J.;
- Daly, Mark J.;
- Altshuler, David
Publication type:
Article
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.
Published in:
Nature Genetics, 2008, v. 40, n. 1, p. 83, doi. 10.1038/ng.2007.47
By:
- Cunninghame Graham, Deborah S.;
- Graham, Robert R.;
- Manku, Harinder;
- Wong, Andrew K.;
- Whittaker, John C.;
- Gaffney, Patrick M.;
- Moser, Kathy L.;
- Rioux, John D.;
- Altshuler, David;
- Behrens, Timothy W.;
- Vyse, Timothy J.
Publication type:
Article
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
Published in:
Nature Genetics, 2007, v. 39, n. 6, p. 721, doi. 10.1038/ng2046
By:
- Fanciulli, Manuela;
- Norsworthy, Penny J.;
- Petretto, Enrico;
- Dong, Rong;
- Harper, Lorraine;
- Kamesh, Lavanya;
- Heward, Joanne M.;
- Gough, Stephen C. L.;
- de Smith, Adam;
- Blakemore, Alexandra I. F.;
- Froguel, Philippe;
- Owen, Catherine J.;
- Pearce, Simon H. S.;
- Teixeira, Luis;
- Guillevin, Loic;
- Cunninghame Graham, Deborah S.;
- Pusey, Charles D.;
- Cook, H. Terence;
- Vyse, Timothy J.;
- Aitman, Timothy J.
Publication type:
Article
Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.
Published in:
PLoS Genetics, 2017, v. 13, n. 10, p. 1, doi. 10.1371/journal.pgen.1007071
By:
- Odhams, Christopher A.;
- Cunninghame Graham, Deborah S.;
- Vyse, Timothy J.
Publication type:
Article
Association of the co-stimulator OX40L with systemic lupus erythematosus.
Published in:
Journal of Molecular Medicine, 2009, v. 87, n. 3, p. 229, doi. 10.1007/s00109-008-0431-2
By:
- Manku, Harinder;
- Cunninghame Graham, Deborah S.;
- Vyse, Timothy J.
Publication type:
Article
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10106-2
By:
- Odhams, Christopher A.;
- Roberts, Amy L.;
- Vester, Susan K.;
- Duarte, Carolina S. T.;
- Beales, Charlie T.;
- Clarke, Alexander J.;
- Lindinger, Sonja;
- Daffern, Samuel J.;
- Zito, Antonino;
- Chen, Lingyan;
- Jones, Leonardo L.;
- Boteva, Lora;
- Morris, David L.;
- Small, Kerrin S.;
- Fernando, Michelle M. A.;
- Graham, Deborah S. Cunninghame;
- Vyse, Timothy J.
Publication type:
Article
The genetics of lupus: a functional perspective.
Published in:
Arthritis Research & Therapy, 2012, v. 14, n. 3, p. 211, doi. 10.1186/ar3844
By:
- Guerra, Sandra G.;
- Vyse, Timothy J.;
- Cunninghame Graham, Deborah S.
Publication type:
Article
Transancestral mapping and genetic load in systemic lupus erythematosus.
Published in:
Nature Communications, 2017, v. 8, n. 7, p. 16021, doi. 10.1038/ncomms16021
By:
- Langefeld, Carl D.;
- Ainsworth, Hannah C.;
- Graham, Deborah S. Cunninghame;
- Kelly, Jennifer A.;
- Comeau, Mary E.;
- Marion, Miranda C.;
- Howard, Timothy D.;
- Ramos, Paula S.;
- Croker, Jennifer A.;
- Morris, David L.;
- Sandling, Johanna K.;
- Almlöf, Jonas Carlsson;
- Acevedo-Vásquez, Eduardo M.;
- Alarcón, Graciela S.;
- Babini, Alejandra M.;
- Baca, Vicente;
- Bengtsson, Anders A.;
- Berbotto, Guillermo A.;
- Bijl, Marc;
- Brown, Elizabeth E.
Publication type:
Article
Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 10, p. 1745, doi. 10.1093/hmg/ddaa030
By:
- Chen, Lingyan;
- Wang, Yong-Fei;
- Liu, Lu;
- Bielowka, Adrianna;
- Ahmed, Rahell;
- Zhang, Huoru;
- Tombleson, Phil;
- Roberts, Amy L;
- Odhams, Christopher A;
- Graham, Deborah S Cunninghame;
- Zhang, Xuejun;
- Yang, Wanling;
- Vyse, Timothy J;
- Morris, David L
Publication type:
Article
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 5, p. 1003, doi. 10.1093/hmg/ddw417
By:
- Odhams, Christopher A.;
- Cortini, Andrea;
- Lingyan Chen;
- Roberts, Amy L.;
- Viñuela, Ana;
- Buil, Alfonso;
- Small, Kerrin S.;
- Dermitzakis, Emmanouil T.;
- Morris, David L.;
- Vyse, Timothy J.;
- Graham, Deborah S. Cunninghame
Publication type:
Article
Abnormal B Cell Development in Systemic Lupus Erythematosus.
Published in:
Arthritis & Rheumatology, 2018, v. 70, n. 4, p. 496, doi. 10.1002/art.40396
By:
- Karrar, Sarah;
- Cunninghame Graham, Deborah S.
Publication type:
Article
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus.
Published in:
PLoS Genetics, 2011, v. 7, n. 10, p. 1, doi. 10.1371/journal.pgen.1002341
By:
- Graham, Deborah S. Cunninghame;
- Morris, David L.;
- Bhangale, Tushar R.;
- Criswell, Lindsey A.;
- Syvänen, Ann-Christine;
- Rönnblom, Lars;
- Behrens, Timothy W.;
- Graham, Robert R.;
- Vyse, Timothy J.
Publication type:
Article
Dense mapping of IL18 shows no association in SLE.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 5, p. 1026, doi. 10.1093/hmg/ddq536
By:
- Guerra, Sandra G.;
- Morris, David L.;
- Gateva, Vesela;
- Graham, Robert R.;
- Vyse, Timothy J.;
- Cunninghame Graham, Deborah S.
Publication type:
Article
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
Published in:
Human Molecular Genetics, 2007, v. 16, n. 6, p. 579, doi. 10.1093/hmg/ddl469
By:
- Graham, Deborah S. Cunninghame;
- Manku, Harinder;
- Wagner, Susanne;
- Reid, Julia;
- Timms, Kirsten;
- Gutin, Alexander;
- Lanchbury, Jerry S.;
- Vyse, Tim J.
Publication type:
Article
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 1, p. 137
By:
- Russell, Andrew I.;
- Cunninghame Graham, Deborah S.;
- Shepherd, Christopher;
- Roberton, Cheri A.;
- Whittaker, John;
- Meeks, John;
- Powell, Richard J.;
- Isenberg, David A.;
- Walport, Mark J.;
- Vyse, Timothy J.
Publication type:
Article
COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection.
Published in:
PLoS Genetics, 2022, v. 18, n. 11, p. 1, doi. 10.1371/journal.pgen.1010253
By:
- Wang, Yuxuan;
- Guga, Suri;
- Wu, Kejia;
- Khaw, Zoe;
- Tzoumkas, Konstantinos;
- Tombleson, Phil;
- Comeau, Mary E.;
- Langefeld, Carl D.;
- Cunninghame Graham, Deborah S.;
- Morris, David L.;
- Vyse, Timothy J.
Publication type:
Article

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