Works by Gough, Peter J.

Results: 18

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06155-8

By:

Taraborrelli, Lucia;
Peltzer, Nieves;
Montinaro, Antonella;
Kupka, Sebastian;
Rieser, Eva;
Hartwig, Torsten;
Sarr, Aida;
Darding, Maurice;
Draber, Peter;
Haas, Tobias L.;
Akarca, Ayse;
Marafioti, Teresa;
Pasparakis, Manolis;
Bertin, John;
Gough, Peter J.;
Bouillet, Philippe;
Strasser, Andreas;
Leverkus, Martin;
Silke, John;
Walczak, Henning

Publication type:

Article

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

Published in:

Cell Death & Disease, 2017, v. 8, n. 2, p. e2588, doi. 10.1038/cddis.2017.20

By:

Hänggi, Kay;
Vasilikos, Lazaros;
Valls, Aida Freire;
Yerbes, Rosario;
Knop, Janin;
Spilgies, Lisanne M;
Rieck, Kristy;
Misra, Tvisha;
Bertin, John;
Gough, Peter J;
Schmidt, Thomas;
de Almodòvar, Carmen Ruiz;
Wong, W Wei-Lynn

Publication type:

Article

RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Published in:

Cell Death & Disease, 2016, v. 7, n. 11, p. e2462, doi. 10.1038/cddis.2016.362

By:

Filliol, Aveline;
Piquet-Pellorce, Claire;
Le Seyec, Jacques;
Farooq, Muhammad;
Genet, Valentine;
Lucas-Clerc, Catherine;
Bertin, John;
Gough, Peter J;
Dimanche-Boitrel, Marie-Thérèse;
Vandenabeele, Peter;
Bertrand, Mathieu JM;
Samson, Michel

Publication type:

Article

Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation.

Published in:

Cell Death & Disease, 2016, v. 7, n. 9, p. e2379, doi. 10.1038/cddis.2016.307

By:

Dowling, John P;
Cai, Yubo;
Bertin, John;
Gough, Peter J;
Zhang, Jianke

Publication type:

Article

Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.

Published in:

2020

By:

Simpson, Jennifer;
Zhixuan Loh;
Ullah, Md Ashik;
Lynch, Jason P.;
Werder, Rhiannon B.;
Collinson, Natasha;
Zhang, Vivian;
Dondelinger, Yves;
Bertrand, Mathieu J. M.;
Everard, Mark L.;
Blyth, Christopher C.;
Hartel, Gunter;
Van Oosterhout, Antoon J.;
Gough, Peter J.;
Bertin, John;
Upham, John W.;
Spann, Kirsten M.;
Phipps, Simon;
Loh, Zhixuan

Publication type:

journal article

Assessment of macrophage infiltration in a Murine model of abdominal aortic aneurysm.

Published in:

Journal of Magnetic Resonance Imaging, 2009, v. 30, n. 2, p. 455, doi. 10.1002/jmri.21843

By:

Turner, Gregory H.;
Olzinski, Alan R.;
Bernard, Roberta E.;
Aravindhan, Karpagam;
Boyle, Ryan J.;
Newman, Matt J.;
Gardner, Scott D.;
Willette, Robert N.;
Gough, Peter J.;
Jucker, Beat M.

Publication type:

Article

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Published in:

Nature, 2014, v. 513, n. 7516, p. 95, doi. 10.1038/nature13706

By:

Takahashi, Nozomi;
Vereecke, Lars;
Bertrand, Mathieu J. M.;
Duprez, Linde;
Divert, Tatyana;
Sze, Mozes;
Gilbert, Barbara;
Kourula, Stephanie;
Goossens, Vera;
Lefebvre, Sylvie;
Declercq, Wim;
van Loo, Geert;
Berger, Scott B.;
Bertin, John;
Gough, Peter J.;
Gonçalves, Amanda;
Günther, Claudia;
Becker, Christoph;
Vandenabeele, Peter

Publication type:

Article

The use of human CD68 transcriptional regulatory sequences to direct high-level expression of class A scavenger receptor in macrophages in vitro and in vivo.

Published in:

Immunology, 2001, v. 103, n. 3, p. 351, doi. 10.1046/j.1365-2567.2001.01256.x

By:

Gough, Peter J.;
Gordon, Siamon;
Greaves, David R.

Publication type:

Article

Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.

Published in:

Pharmacology Research & Perspectives, 2017, v. 5, n. 6, p. 1, doi. 10.1002/prp2.377

By:

Finger, Joshua N.;
Brusq, Jean‐Marie;
Campobasso, Nino;
Cook, Michael N.;
Deutsch, Jennifer;
Haag, Heather;
Harris, Philip A.;
Jenkins, Earl L.;
Joglekar, Devika;
Lich, John D.;
Maguire, Sean;
Nagilla, Rakesh;
Rivera, Elizabeth J.;
Sun, Helen;
Votta, Bartholomew J.;
Bertin, John;
Gough, Peter J.

Publication type:

Article

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Published in:

Pharmacology Research & Perspectives, 2017, v. 5, n. 6, p. 1, doi. 10.1002/prp2.365

By:

Weisel, Kathleen;
Scott, Nicola E.;
Tompson, Debra J.;
Votta, Bartholomew J.;
Madhavan, Sujith;
Povey, Kat;
Wolstenholme, Allen;
Simeoni, Monica;
Rudo, Todd;
Richards‐Peterson, Lauren;
Sahota, Tarjinder;
Wang, J. Gene;
Lich, John;
Finger, Joshua;
Verticelli, Adeline;
Reilly, Michael;
Gough, Peter J.;
Harris, Philip A.;
Bertin, John;
Wang, Mei‐Lun

Publication type:

Article

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127083

By:

Yu, Jong W.;
Hoffman, Sandy;
Beal, Allison M.;
Dykon, Angela;
Ringenberg, Michael A.;
Hughes, Anna C.;
Dare, Lauren;
Anderson, Amber D.;
Finger, Joshua;
Kasparcova, Viera;
Rickard, David;
Berger, Scott B.;
Ramanjulu, Joshi;
Emery, John G.;
Gough, Peter J.;
Bertin, John;
Foley, Kevin P.

Publication type:

Article

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096737

By:

Rickard, David J.;
Sehon, Clark A.;
Kasparcova, Viera;
Kallal, Lorena A.;
Haile, Pamela A.;
Zeng, Xin;
Montoute, Monica N.;
Poore, Derek D.;
Li, Hu;
Wu, Zining;
Eidam, Patrick M.;
Emery, John G.;
Marquis, Robert W.;
Gough, Peter J.;
Bertin, John

Publication type:

Article

Pathogen Sensing Pathways in Human Embryonic Stem Cell Derived-Endothelial Cells: Role of NOD1 Receptors.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0091119

By:

Reed, Daniel M.;
Foldes, Gabor;
Gatheral, Timothy;
Paschalaki, Koralia E.;
Lendvai, Zsuzsanna;
Bagyura, Zsolt;
Nemeth, Tamas;
Skopal, Judit;
Merkely, Bela;
Telcian, Aurica G.;
Gogsadze, Leila;
Edwards, Michael R.;
Gough, Peter J.;
Bertin, John;
Johnston, Sebastian L.;
Harding, Sian E.;
Mitchell, Jane A.

Publication type:

Article

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0069619

By:

Rickard, David J.;
Sehon, Clark A.;
Kasparcova, Viera;
Kallal, Lorena A.;
Zeng, Xin;
Montoute, Monica N.;
Chordia, Tushar;
Poore, Derek D.;
Li, Hu;
Wu, Zining;
Eidam, Patrick M.;
Haile, Pamela A.;
Yu, Jong;
Emery, John G.;
Marquis, Robert W.;
Gough, Peter J.;
Bertin, John

Publication type:

Article

A Key Role for the Endothelium in NOD1 Mediated Vascular Inflammation: Comparison to TLR4 Responses.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042386

By:

Gatheral, Timothy;
Reed, Daniel M.;
Moreno, Laura;
Gough, Peter J.;
Votta, Bart J.;
Sehon, Clark A.;
Rickard, David J.;
Bertin, John;
Lim, Eric;
Nicholson, Andrew G.;
Mitchell, Jane A.;
Bozza, Patricia T.

Publication type:

Article

Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.

Published in:

Cells (2073-4409), 2021, v. 10, n. 5, p. 1035, doi. 10.3390/cells10051035

By:

Ouyang, Yulin;
Wen, Li;
Armstrong, Jane A.;
Chvanov, Michael;
Latawiec, Diane;
Cai, Wenhao;
Awais, Mohammad;
Mukherjee, Rajarshi;
Huang, Wei;
Gough, Peter J.;
Bertin, John;
Tepikin, Alexei V.;
Sutton, Robert;
Criddle, David N.;
Bultynck, Geert;
Tikkanen, Ritva

Publication type:

Article

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation.

Published in:

American Journal of Gastroenterology (Springer Nature), 2014, v. 109, n. 2, p. 279, doi. 10.1038/ajg.2013.403

By:

Pierdomenico, Maria;
Negroni, Anna;
Stronati, Laura;
Vitali, Roberta;
Prete, Enrica;
Bertin, John;
Gough, Peter J;
Aloi, Marina;
Cucchiara, Salvatore

Publication type:

Article

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice.

Published in:

2006

By:

Gough, Peter J.;
Gomez, Ivan G.;
Wille, Paul T.;
Raines, Elaine W.

Publication type:

journal article