Works by Gordenin, Dmitry A

Results: 42

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Published in:

Nature Genetics, 2015, v. 47, n. 9, p. 1067, doi. 10.1038/ng.3378

By:

Sterling, Joan F;
Malc, Ewa P;
Fargo, David C;
Mieczkowski, Piotr A;
Kwiatkowski, David J;
Saini, Natalie;
Kim, Jaegil;
Roberts, Steven A;
Getz, Gad;
Chan, Kin;
Gordenin, Dmitry A;
Klimczak, Leszek J

Publication type:

Article

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 970, doi. 10.1038/ng.2702

By:

Roberts, Steven A;
Lawrence, Michael S;
Klimczak, Leszek J;
Grimm, Sara A;
Fargo, David;
Stojanov, Petar;
Kiezun, Adam;
Kryukov, Gregory V;
Carter, Scott L;
Saksena, Gordon;
Harris, Shawn;
Shah, Ruchir R;
Resnick, Michael A;
Getz, Gad;
Gordenin, Dmitry A

Publication type:

Article

Cadmium is a mutagen that acts by inhibiting mismatch repair.

Published in:

Nature Genetics, 2003, v. 34, n. 3, p. 326, doi. 10.1038/ng1172

By:

Jin, Yong Hwan;
Clark, Alan B;
Slebos, Robbert J C;
Al-Refai, Hanan;
Taylor, Jack A;
Kunkel, Thomas A;
Resnick, Michael A;
Gordenin, Dmitry A

Publication type:

Article

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

Published in:

2020

By:

Sakofsky, Cynthia J.;
Saini, Natalie;
Klimczak, Leszek J.;
Chan, Kin;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Burkholder, Adam B.;
Fargo, David;
Gordenin, Dmitry A.

Publication type:

Correction Notice

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

Published in:

PLoS Biology, 2019, v. 17, n. 9, p. 1, doi. 10.1371/journal.pbio.3000464

By:

Sakofsky, Cynthia J.;
Saini, Natalie;
Klimczak, Leszek J.;
Chan, Kin;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Burkholder, Adam B.;
Fargo, David;
Gordenin, Dmitry A.

Publication type:

Article

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

Published in:

PLoS Biology, 2019, v. 17, n. 5, p. 1, doi. 10.1371/journal.pbio.3000263

By:

Degtyareva, Natalya P.;
Saini, Natalie;
Sterling, Joan F.;
Placentra, Victoria C.;
Klimczak, Leszek J.;
Gordenin, Dmitry A.;
Doetsch, Paul W.

Publication type:

Article

Suppression of Allelic Recombination and Aneuploidy by Cohesin Is Independent of Chk1 in Saccharomyces cerevisiae.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0113435

By:

Covo, Shay;
Chiou, Eric;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.

Published in:

PLoS Genetics, 2021, v. 17, n. 1, p. 1, doi. 10.1371/journal.pgen.1009302

By:

Saini, Natalie;
Giacobone, Camille K.;
Klimczak, Leszek J.;
Papas, Brian N.;
Burkholder, Adam B.;
Li, Jian-Liang;
Fargo, David C.;
Bai, Re;
Gerrish, Kevin;
Innes, Cynthia L.;
Schurman, Shepherd H.;
Gordenin, Dmitry A.

Publication type:

Article

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.

Published in:

PLoS Pathogens, 2019, v. 15, n. 10, p. 1, doi. 10.1371/journal.ppat.1008080

By:

Perelygina, Ludmila;
Chen, Min-hsin;
Suppiah, Suganthi;
Adebayo, Adebola;
Abernathy, Emily;
Dorsey, Morna;
Bercovitch, Lionel;
Paris, Kenneth;
White, Kevin P.;
Krol, Alfons;
Dhossche, Julie;
Torshin, Ivan Y.;
Saini, Natalie;
Klimczak, Leszek J.;
Gordenin, Dmitry A.;
Zharkikh, Andrey;
Plotkin, Stanley;
Sullivan, Kathleen E.;
Icenogle, Joseph

Publication type:

Article

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

Published in:

PLoS Genetics, 2016, v. 12, n. 10, p. 1, doi. 10.1371/journal.pgen.1006385

By:

Saini, Natalie;
Roberts, Steven A.;
Klimczak, Leszek J.;
Chan, Kin;
Grimm, Sara A.;
Dai, Shuangshuang;
Fargo, David C.;
Boyer, Jayne C.;
Kaufmann, William K.;
Taylor, Jack A.;
Lee, Eunjung;
Cortes-Ciriano, Isidro;
Park, Peter J.;
Schurman, Shepherd H.;
Malc, Ewa P.;
Mieczkowski, Piotr A.;
Gordenin, Dmitry A.

Publication type:

Article

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Published in:

Environmental & Molecular Mutagenesis, 2018, v. 59, n. 8, p. 672, doi. 10.1002/em.22215

By:

Saini, Natalie;
Gordenin, Dmitry A.;
Wilson, D.

Publication type:

Article

Hypermutation in human cancer genomes: footprints and mechanisms.

Published in:

Nature Reviews Cancer, 2015, v. 15, n. 11, p. 694, doi. 10.1038/nrc4028

By:

Roberts, Steven A.;
Gordenin, Dmitry A.

Publication type:

Article

Hypermutation in human cancer genomes: footprints and mechanisms.

Published in:

Nature Reviews Cancer, 2014, v. 14, n. 12, p. 786, doi. 10.1038/nrc3816

By:

Roberts, Steven A.;
Gordenin, Dmitry A.

Publication type:

Article

The Sister Chromatid Cohesion Pathway Suppresses Multiple Chromosome Gain and Chromosome Amplification.

Published in:

Genetics, 2014, v. 196, n. 2, p. 373, doi. 10.1534/genetics.113.159202

By:

Covo, Shay;
Puccia, Christopher M.;
Argueso, Juan Lucas;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.

Published in:

Human Molecular Genetics, 1999, v. 8, n. 12, p. 2263, doi. 10.1093/hmg/8.12.2263

By:

Greene, Amy L.;
Snipe, Joyce R.;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

The Transition of Closely Opposed Lesions to Double-Strand Breaks during Long-Patch Base Excision Repair Is Prevented by the Coordinated Action of DNA Polymerase δ and Rad27/Fen1.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 5, p. 1212, doi. 10.1128/MCB.01499-08

By:

Wenjian Ma;
Panduri, Vijayalakshmi;
Sterling, Joan F.;
Van Houten, Bennett;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness.

Published in:

BioEssays, 2014, v. 36, n. 4, p. 382, doi. 10.1002/bies.201300140

By:

Roberts, Steven A.;
Gordenin, Dmitry A.

Publication type:

Article

Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion.

Published in:

Cell Cycle, 2012, v. 11, n. 21, p. 3937, doi. 10.4161/cc.21945

By:

Covo, Shay;
Wenjian Ma;
Westmoreland, James W.;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Damage-induced localized hypermutability.

Published in:

Cell Cycle, 2011, v. 10, n. 7, p. 1073, doi. 10.4161/cc.10.7.15319

By:

Burch, Lauranell H.;
Yong Yang;
Sterling, Joan F.;
Roberts, Steven A.;
Chao, Frank G.;
Hong Xu;
Leilei Zhang;
Walsh, Jesse;
Resnick, Michael A.;
Mieczkowski, Piotr A.;
Gordenin, Dmitry A.

Publication type:

Article

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

Published in:

EMBO Journal, 2002, v. 21, n. 21, p. 5930, doi. 10.1093/emboj/cdf587

By:

Storici, Francesca;
Henneke, Ghislaine;
Ferrari, Elena;
Gordenin, Dmitry A.;
Hübscher, Ulrich;
Resnick, Michael A.

Publication type:

Article

Inverted Alu repeats unstable in yeast are excluded from the human genome.

Published in:

EMBO Journal, 2000, v. 19, n. 14, p. 3822, doi. 10.1093/emboj/19.14.3822

By:

Lobachev, Kirill S.;
Stenger, Judith E.;
Kozyreva, Olga G.;
Jurka, Jerzy;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Conservative Repair of a Chromosomal Double-Strand Break by Single-Strand DNA through Two Steps of Annealing.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 20, p. 25, doi. 10.1128/MCB.00672-06

By:

Storici, Francesca;
Snipe, Joyce R.;
Chan, Godwin K.;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 17, p. 9075, doi. 10.1093/nar/gkad611

By:

Hudson, Kathleen M;
Klimczak, Leszek J;
Sterling, Joan F;
Burkholder, Adam B;
Kazanov, Marat D;
Saini, Natalie;
Mieczkowski, Piotr A;
Gordenin, Dmitry A

Publication type:

Article

Changes in metabolic landscapes shape divergent but distinct mutational signatures and cytotoxic consequences of redox stress.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 10, p. 5056, doi. 10.1093/nar/gkad305

By:

Degtyareva, Natalya P;
Placentra, Victoria C;
Gabel, Scott A;
Klimczak, Leszek J;
Gordenin, Dmitry A;
Wagner, Brett A;
Buettner, Garry R;
Mueller, Geoffrey A;
Smirnova, Tatyana I;
Doetsch, Paul W

Publication type:

Article

Mutation signatures specific to DNA alkylating agents in yeast and cancers.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 7, p. 3692, doi. 10.1093/nar/gkaa150

By:

Saini, Natalie;
Sterling, Joan F;
Sakofsky, Cynthia J;
Giacobone, Camille K;
Klimczak, Leszek J;
Burkholder, Adam B;
Malc, Ewa P;
Mieczkowski, Piotr A;
Gordenin, Dmitry A

Publication type:

Article

Michael Ter-Avanesyan (1949-2018) – Advent of the scientist.

Published in:

Prion, 2019, v. 13, n. 1, p. 33, doi. 10.1080/19336896.2018.1563427

By:

Gordenin, Dmitry A.;
Mironova, Ludmila N.

Publication type:

Article

RNA-templated DNA repair.

Published in:

2007

By:

Storici, Francesca;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Correction Notice

RNA-templated DNA repair.

Published in:

Nature, 2007, v. 447, n. 7142, p. 338, doi. 10.1038/nature05720

By:

Storici, Francesca;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Gordenin, Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces...

Published in:

Genetics, 1998, v. 148, n. 4, p. 1507, doi. 10.1093/genetics/148.4.1507

By:

Lobachev, Kirill S.;
Shor, Boris M.;
Tran, Hiep T.;
Taylor, Wendy;
Keen, J. Dianne;
Resnick, Michael A.;
Gordenin, Dmitry A.

Publication type:

Article

The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair...

Published in:

Genetics, 1996, v. 143, n. 4, p. 1579, doi. 10.1093/genetics/143.4.1579

By:

Tran, Hiep T.;
Gordenin, Dmitry A.

Publication type:

Article

From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution.

Published in:

Cells (2073-4409), 2021, v. 10, n. 6, p. 1557, doi. 10.3390/cells10061557

By:

Kockler, Zachary W.;
Gordenin, Dmitry A.

Publication type:

Article

Functional analysis of human MutSα and MutSβ complexes in yeast.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 3, p. 736, doi. 10.1093/nar/27.3.736

By:

Clark, Alan B.;
Cook, Molly E.;
Tran, Hiep T.;
Gordenin, Dmitry A.;
Resnick, Michael A.;
Kunkel, Thomas A.

Publication type:

Article

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 19, p. 8995, doi. 10.1093/nar/gkt671

By:

Degtyareva, Natalya P.;
Heyburn, Lanier;
Sterling, Joan;
Resnick, Michael A.;
Gordenin, Dmitry A.;
Doetsch, Paul W.

Publication type:

Article

Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 6, p. 1836, doi. 10.1093/nar/gkm1148

By:

Ma, Wenjian;
Resnick, Michael A.;
Gordenin, Dmitry A.

Publication type:

Article

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast.

Published in:

G3: Genes | Genomes | Genetics, 2024, v. 14, n. 10, p. 1, doi. 10.1093/g3journal/jkae196

By:

Dennen, Matthew S;
Kockler, Zachary W;
Roberts, Steven A;
Burkholder, Adam B;
Klimczak, Leszek J;
Gordenin, Dmitry A

Publication type:

Article

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.

Published in:

PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0237689

By:

Klimczak, Leszek J.;
Randall, Thomas A.;
Saini, Natalie;
Li, Jian-Liang;
Gordenin, Dmitry A.

Publication type:

Article

Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study.

Published in:

American Journal of Epidemiology, 2021, v. 190, n. 6, p. 962, doi. 10.1093/aje/kwaa234

By:

Landi, Maria Teresa;
Synnott, Naoise C;
Rosenbaum, Jennifer;
Zhang, Tongwu;
Zhu, Bin;
Shi, Jianxin;
Zhao, Wei;
Kebede, Michael;
Sang, Jian;
Choi, Jiyeon;
Mendoza, Laura;
Pacheco, Marwil;
Hicks, Belynda;
Caporaso, Neil E;
Abubakar, Mustapha;
Gordenin, Dmitry A;
Wedge, David C;
Alexandrov, Ludmil B;
Rothman, Nathaniel;
Lan, Qing

Publication type:

Article

Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study.

Published in:

American Journal of Epidemiology, 2021, v. 190, n. 5, p. 962, doi. 10.1093/aje/kwaa234

By:

Landi, Maria Teresa;
Synnott, Naoise C;
Rosenbaum, Jennifer;
Zhang, Tongwu;
Zhu, Bin;
Shi, Jianxin;
Zhao, Wei;
Kebede, Michael;
Sang, Jian;
Choi, Jiyeon;
Mendoza, Laura;
Pacheco, Marwil;
Hicks, Belynda;
Caporaso, Neil E;
Abubakar, Mustapha;
Gordenin, Dmitry A;
Wedge, David C;
Alexandrov, Ludmil B;
Rothman, Nathaniel;
Lan, Qing

Publication type:

Article

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent.

Published in:

PLoS Genetics, 2012, v. 8, n. 12, p. 1, doi. 10.1371/journal.pgen.1003149

By:

Chan, Kin;
Sterling, Joan F.;
Roberts, Steven A.;
Bhagwat, Ashok S.;
Resnick, Michael A.;
Gordenin, Dmitry A.

Publication type:

Article

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease.

Published in:

PLoS Genetics, 2011, v. 7, n. 4, p. 1, doi. 10.1371/journal.pgen.1002059

By:

Ma, Wenjian;
Westmoreland, Jim W.;
Gordenin, Dmitry A.;
Resnick, Mike A.

Publication type:

Article

Cohesin Is Limiting for the Suppression of DNA Damage-Induced Recombination between Homologous Chromosomes.

Published in:

PLoS Genetics, 2010, v. 6, n. 7, p. 1, doi. 10.1371/journal.pgen.1001006

By:

Covo, Shay;
Westmoreland, James W.;
Gordenin., Dmitry A.;
Resnick, Michael A.

Publication type:

Article

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae.

Published in:

PLoS Genetics, 2008, v. 4, n. 11, p. 1, doi. 10.1371/journal.pgen.1000264

By:

Yong Yang;
Sterling, Joan;
Storici, Francesca;
Resnick, Michael A.;
Gordenin, Dmitry A.

Publication type:

Article