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Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038405
By:
- Fra, Anna M.;
- Gooptu, Bibek;
- Ferrarotti, Ilaria;
- Miranda, Elena;
- Scabini, Roberta;
- Ronzoni, Riccardo;
- Benini, Federica;
- Corda, Luciano;
- Medicina, Daniela;
- Luisetti, Maurizio;
- Schiaffonati, Luisa
Publication type:
Article
In Silico Assessment of Potential Druggable Pockets on the Surface of α1-Antitrypsin Conformers.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036612
By:
- Patschull, Anathe O. M.;
- Gooptu, Bibek;
- Ashford, Paul;
- Daviter, Tina;
- Nobeli, Irene
Publication type:
Article
Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
Published in:
2013
By:
- HAQ, Imran;
- IRVING, James A.;
- FAULL, Sarah V.;
- DICKENS, Jennifer A.;
- ORDÓÑEZ, Adriana;
- BELORGEY, Didier;
- GOOPTU, Bibek;
- LOMAS, David A.
Publication type:
Correction Notice
Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
Published in:
Bioscience Reports, 2013, v. 33, n. 3, p. 499, doi. 10.1042/BSR20130038
By:
- HAQ, Imran;
- IRVING, James A.;
- FAULL, Sarah V.;
- DICKENS, Jennifer A.;
- ORDÓÑEZ, Adriana;
- BELORGEY, Didier;
- GOOPTU, Bibek;
- LOMAS, David A.
Publication type:
Article
Deficiency Mutations of Alpha-1 Antitrypsin.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2016, v. 54, n. 1, p. 71, doi. 10.1165/rcmb.2015-0154OC
By:
- Haq, Imran;
- Irving, James A.;
- Saleh, Aarash D.;
- Dron, Louis;
- Regan-Mochrie, Gemma L.;
- Motamedi-Shad, Neda;
- Hurst, John R.;
- Gooptu, Bibek;
- Lomas, David A.
Publication type:
Article
Deficiency mutations of α1-antitrypsin differentially affect folding, function and polymerization.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2016, v. 54, n. 1, p. E1, doi. 10.1165/rcmb.2015-0154oc
By:
- Haq, Imran;
- Irving, James A.;
- Saleh, Aarash D.;
- Dron, Louis;
- Regan-Mochrie, Gemma L.;
- Motamedi-Shad, Neda;
- Hurst, John R.;
- Gooptu, Bibek;
- Lomas, David A.
Publication type:
Article
Tensin1 expression and function in chronic obstructive pulmonary disease.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55405-2
By:
- Stylianou, Panayiota;
- Clark, Katherine;
- Gooptu, Bibek;
- Smallwood, Dawn;
- Brightling, Christopher E.;
- Amrani, Yassine;
- Roach, Katy M.;
- Bradding, Peter
Publication type:
Article
Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
Published in:
FEBS Journal, 2015, v. 282, n. 23, p. 4565, doi. 10.1111/febs.13517
By:
- Moriconi, Claudia;
- Ordoñez, Adriana;
- Lupo, Giuseppe;
- Gooptu, Bibek;
- Irving, James A.;
- Noto, Rosina;
- Martorana, Vincenzo;
- Manno, Mauro;
- Timpano, Valentina;
- Guadagno, Noemi A.;
- Dalton, Lucy;
- Marciniak, Stefan J.;
- Lomas, David A.;
- Miranda, Elena
Publication type:
Article
Fuel Siphoner's lung: a case of inhalational pneumonia.
Published in:
2023
By:
- Azam, Rabia;
- Zafar, Hafsa;
- Gooptu, Bibek
Publication type:
Case Study
Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, UK perspective.
Published in:
2022
By:
- Mehta, Puja;
- Hoyles, Rachel K;
- Gunawardena, Harsha;
- Gooptu, Bibek;
- Chaudhuri, Nazia;
- Heightmann, Melissa J;
- Garthwaite, Helen;
- Penn, Henry;
- Datta, Arnab;
- Hamdulay, Shahir;
- Lams, Boris;
- Agarwal, Sangita;
- Wickremesinghe, Melissa;
- Jenkins, Gisli;
- Porter, Joanna C;
- Denton, Christopher P
Publication type:
Editorial
Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders.
Published in:
2015
By:
- Gordon, Patrick;
- Gooptu, Bibek
Publication type:
Journal Article
Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders.
Published in:
2015
By:
- Gordon, Patrick;
- Gooptu, Bibek
Publication type:
Editorial
Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 4, p. 642, doi. 10.1093/hmg/ddv501
By:
- Ronzoni, Riccardo;
- Berardelli, Romina;
- Medicina, Daniela;
- Sitia, Roberto;
- Gooptu, Bibek;
- Fra, Anna Maria
Publication type:
Article
Familial hypereosinophilia associated with eosinophilic gastrointestinal symptoms in individuals with a missense mutation in CKLF‐like MARVEL transmembrane domain containing 3.
Published in:
Clinical & Experimental Allergy, 2021, v. 51, n. 11, p. 1501, doi. 10.1111/cea.13957
By:
- Wardlaw, Andrew J;
- Barwell, Julian;
- Hitchman, Charles;
- Shrine, Nick;
- Bennett, Neil;
- Adewoye, Ade;
- Ozturk, Hasret;
- Ntereke, Tumisang;
- Wurm, Peter;
- Tobin, Martin;
- Gooptu, Bibek;
- Hollox, Ed;
- Wain, Louise V.
Publication type:
Article
H, N and C backbone resonance assignments of the archetypal serpin α-antitrypsin.
Published in:
Biomolecular NMR Assignments, 2012, v. 6, n. 2, p. 153, doi. 10.1007/s12104-011-9345-y
By:
- Nyon, Mun;
- Kirkpatrick, John;
- Cabrita, Lisa;
- Christodoulou, John;
- Gooptu, Bibek
Publication type:
Article
Real‐world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha‐1‐antitrypsin deficiency.
Published in:
Human Mutation, 2018, v. 39, n. 9, p. 1203, doi. 10.1002/humu.23562
By:
- Giacopuzzi, Edoardo;
- Laffranchi, Mattia;
- Berardelli, Romina;
- Ravasio, Viola;
- Ferrarotti, Ilaria;
- Gooptu, Bibek;
- Borsani, Giuseppe;
- Fra, Annamaria
Publication type:
Article
Familial dementia caused by polymerization of mutant neuroserpin.
Published in:
Nature, 1999, v. 401, n. 6751, p. 376, doi. 10.1038/43897
By:
- Davis, Richard L.;
- Shrimpton, Antony E.;
- Holohan, Peter D.;
- Bradshaw, Charles;
- Feiglin, David;
- Collins, George H.;
- Sonderegger, Peter;
- Kinter, Jochen;
- Becker, Lyn Marie;
- Lacbawan, Felicitas;
- Krasnewich, Donna;
- Muenke, Maximilian;
- Lawrence, Daniel A.;
- Yerby, Mark S.;
- Shaw, Cheng-Mei;
- Gooptu, Bibek;
- Elliott, Peter R.;
- Finch, John T.;
- Carrell, Robin W.;
- Lomas, David A.
Publication type:
Article
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1-antitrypsin upon ligand binding.
Published in:
Protein Science: A Publication of the Protein Society, 2015, v. 24, n. 8, p. 1301, doi. 10.1002/pro.2706
By:
- Nyon, Mun Peak;
- Prentice, Tanya;
- Day, Jemma;
- Kirkpatrick, John;
- Sivalingam, Ganesh N.;
- Levy, Geraldine;
- Haq, Imran;
- Irving, James A.;
- Lomas, David A.;
- Christodoulou, John;
- Gooptu, Bibek;
- Thalassinos, Konstantinos
Publication type:
Article

Found: 18

Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization.

In Silico Assessment of Potential Druggable Pockets on the Surface of α<sub>1</sub>-Antitrypsin Conformers.

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Deficiency Mutations of Alpha-1 Antitrypsin.

Deficiency mutations of α<sub>1</sub>-antitrypsin differentially affect folding, function and polymerization.

Tensin1 expression and function in chronic obstructive pulmonary disease.

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.

Fuel Siphoner's lung: a case of inhalational pneumonia.

Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, UK perspective.

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders.

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

Familial hypereosinophilia associated with eosinophilic gastrointestinal symptoms in individuals with a missense mutation in CKLF‐like MARVEL transmembrane domain containing 3.

H, N and C backbone resonance assignments of the archetypal serpin α-antitrypsin.

Real‐world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha‐1‐antitrypsin deficiency.

Familial dementia caused by polymerization of mutant neuroserpin.

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α<sub>1</sub>-antitrypsin upon ligand binding.