Works by Gonçalves, Manuel A F V

Results: 31

Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells.

Published in:

Journal of Gene Medicine, 2013, v. 15, n. 1, p. 1, doi. 10.1002/jgm.2687

By:

Janssen, Josephine M.;
Liu, Jin;
Skokan, Jaroslav;
Gonçalves, Manuel A. F. V.;
Vries, Antoine A. F.

Publication type:

Article

Conventional and Tropism-Modified High-Capacity Adenoviral Vectors Exhibit Similar Transduction Profiles in Human iPSC-Derived Retinal Organoids.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 1, p. 55, doi. 10.3390/ijms26010055

By:

McDonald, Andrew;
Gallego, Carmen;
Andriessen, Charlotte;
Orlová, Michaela;
Gonçalves, Manuel A. F. V.;
Wijnholds, Jan

Publication type:

Article

High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells.

Published in:

Cells (2073-4409), 2020, v. 9, n. 4, p. 869, doi. 10.3390/cells9040869

By:

Brescia, Marcella;
Janssen, Josephine M.;
Liu, Jin;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Rapid and Sensitive Lentivirus Vector-Based Conditional Gene Expression Assay to Monitor and Quantify Cell Fusion Activity.

Published in:

PLoS ONE, 2010, v. 5, n. 6, p. 1, doi. 10.1371/journal.pone.0010954

By:

Gonçalves, Manuel A. F. V.;
Janssen, Josephine M.;
Holkers, Maarten;
de Vries, Antoine A. F.

Publication type:

Article

Targeted Chromosomal Insertion of Large DNA into the Human Genome by a Fiber-Modified High-Capacity Adenovirus-Based Vector System.

Published in:

PLoS ONE, 2008, v. 3, n. 8, p. 1, doi. 10.1371/journal.pone.0003084

By:

Gonçalves, Manuel A. F. V.;
Holkers, Maarten;
van Nierop, Gijsbert P.;
Wieringa, Roeland;
Pau, Maria G.;
de Vries, Antoine A. F.

Publication type:

Article

Adenovirus: from foe to friend.

Published in:

Reviews in Medical Virology, 2006, v. 16, n. 3, p. 167, doi. 10.1002/rmv.494

By:

Gonçalves, Manuel A. F. V.;
de Vries, Antoine A. F.

Publication type:

Article

Adeno-associated virus: from defective virus to effective vector.

Published in:

Virology Journal, 2005, v. 2, p. 43, doi. 10.1186/1743-422X-2-43

By:

Gonçalves, Manuel A. F. V.

Publication type:

Article

Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells.

Published in:

Scientific Reports, 2016, p. 37051, doi. 10.1038/srep37051

By:

Maggio, Ignazio;
Liu, Jin;
Janssen, Josephine M.;
Chen, Xiaoyu;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 2, p. 213, doi. 10.1093/hmg/ddi438

By:

Gonçalves, Manuel A. F. V.;
de Vries, Antoine A. F.;
Holkers, Maarten;
van de Watering, Marloes J. M.;
van der Velde, Ietje;
van Nierop, Gijsbert P.;
Valerio, Dinko;
Knaän-Shanzer, Shoshan

Publication type:

Article

Comparative Analysis of Methods for Assessing On-Target Gene Editing Efficiencies.

Published in:

Methods & Protocols, 2025, v. 8, n. 2, p. 23, doi. 10.3390/mps8020023

By:

Yao, Bing;
Yang, Qiangbing;
Gonçalves, Manuel A. F. V.;
Schiffelers, Raymond;
Sluijter, Joost P. G.;
Lei, Zhiyong

Publication type:

Article

Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal Myocytes.

Published in:

Molecular Therapy, 2011, v. 19, n. 7, p. 1331, doi. 10.1038/mt.2010.308

By:

Gonçalves, Manuel A. F. V.;
Janssen, Josephine M.;
Nguyen, Quynh G.;
Athanasopoulos, Takis;
Hauschka, Stephen D.;
Dickson, George;
de Vries, Antoine A. F.

Publication type:

Article

Genetic Complementation of Human Muscle Cells via Directed Stem Cell Fusion.

Published in:

Molecular Therapy, 2008, v. 16, n. 4, p. 741, doi. 10.1038/mt.2008.16

By:

Gonçalves, Manuel A. F. V.;
Swildens, Jim;
Holkers, Maarten;
Narain, Anjali;
van Nierop, Gijsbert P.;
van de Watering, Marloes J. M.;
Knaän-Shanzer, Shoshan;
de Vries, Antoine A. F.

Publication type:

Article

Transduction of Myogenic Cells by Retargeted Dual High-Capacity Hybrid Viral Vectors: Robust Dystrophin Synthesis in Duchenne Muscular Dystrophy Muscle Cells.

Published in:

Molecular Therapy, 2006, v. 13, n. 5, p. 976, doi. 10.1016/j.ymthe.2005.11.018

By:

Gonçalves, Manuel A. F. V.;
Holkers, Maarten;
Cudré-Mauroux, Christophe;
van Nierop, Gijsbert P.;
Knaän-Shanzer, Shoshan;
van der Velde, Ietje;
Valerio, Dinko;
de Vries, Antoine A.F.

Publication type:

Article

Adenoviral vector DNA for accurate genome editing with engineered nucleases.

Published in:

Nature Methods, 2014, v. 11, n. 10, p. 1051, doi. 10.1038/nmeth.3075

By:

Holkers, Maarten;
Maggio, Ignazio;
Henriques, Sara F D;
Janssen, Josephine M;
Cathomen, Toni;
Gonçalves, Manuel A F V

Publication type:

Article

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05105

By:

Maggio, Ignazio;
Holkers, Maarten;
Jin Liu;
Janssen, Josephine M.;
Xiaoyu Chen;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Donor insertion into CX3CR1 allows epigenetic modulation of a constitutive promoter on hematopoietic stem cells and its activation upon myeloid differentiation Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 8, p. 1, doi. 10.1093/nar/gkaf344

By:

Ramos-Hernández, Iris;
Fuster-García, Carla;
Aguilar-González, Araceli;
Lozano-Vinagre, María L;
Guenechea-Amurrio, Guillermo;
Sanchez-Luque, Francisco J;
Gonçalves, Manuel A F V;
Cathomen, Toni;
Muñoz, Pilar;
Molina-Estévez, Francisco J;
Martín, Francisco

Publication type:

Article

Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 2, p. 1, doi. 10.1093/nar/gkae1213

By:

Li, Zhen;
Wang, Xiaoling;
Janssen, Josephine M;
Liu, Jin;
Tasca, Francesca;
Hoeben, Rob C;
Gonçalves, Manuel A F V

Publication type:

Article

Selection-free precise gene repair using high-capacity adenovector delivery of advanced prime editing systems rescues dystrophin synthesis in DMD muscle cells.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 5, p. 2740, doi. 10.1093/nar/gkae057

By:

Wang, Qian;
Capelletti, Sabrina;
Liu, Jin;
Janssen, Josephine M;
Gonçalves, Manuel A F V

Publication type:

Article

Precise homology-directed installation of large genomic edits in human cells with cleaving and nicking high-specificity Cas9 variants.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 7, p. 3465, doi. 10.1093/nar/gkad165

By:

Wang, Qian;
Liu, Jin;
Janssen, Josephine M;
Gonçalves, Manuel A F V

Publication type:

Article

Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 13, p. 7761, doi. 10.1093/nar/gkac567

By:

Tasca, Francesca;
Brescia, Marcella;
Wang, Qian;
Liu, Jin;
Janssen, Josephine M;
Szuhai, Karoly;
Gonçalves, Manuel A F V

Publication type:

Article

Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 20, p. 11986, doi. 10.1093/nar/gkab938

By:

Wang, Qian;
Liu, Jin;
Janssen, Josephine M;
Tasca, Francesca;
Mei, Hailiang;
Gonçalves, Manuel A F V

Publication type:

Article

Precise and broad scope genome editing based on high-specificity Cas9 nickases.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 2, p. 1, doi. 10.1093/nar/gkaa1236

By:

Qian Wang;
Jin Liu;
Janssen, Josephine M.;
Le Bouteiller, Marie;
Frock, Richard L.;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 2, p. 974, doi. 10.1093/nar/gkz1121

By:

Chen, Xiaoyu;
Tasca, Francesca;
Wang, Qian;
Liu, Jin;
Janssen, Josephine M;
Brescia, Marcella D;
Bellin, Milena;
Szuhai, Karoly;
Kenrick, Josefin;
Frock, Richard L;
Gonçalves, Manuel A F V

Publication type:

Article

Novel Therapeutic Approaches for the Treatment of Retinal Degenerative Diseases: Focus on CRISPR/Cas-Based Gene Editing.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.00838

By:

Gallego, Carmen;
Gonçalves, Manuel A. F. V.;
Wijnholds, Jan

Publication type:

Article

Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment.

Published in:

Current Cardiology Reports, 2024, v. 26, n. 11, p. 1197, doi. 10.1007/s11886-024-02118-2

By:

Yao, Bing;
Lei, Zhiyong;
Gonçalves, Manuel A. F. V.;
Sluijter, Joost P. G.

Publication type:

Article

The emerging role of viral vectors as vehicles for DMD gene editing.

Published in:

Genome Medicine, 2016, v. 8, p. 1, doi. 10.1186/s13073-016-0316-x

By:

Maggio, Ignazio;
Xiaoyu Chen;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 3, p. 1449, doi. 10.1093/nar/gkv1540

By:

Maggio, Ignazio;
Stefanucci, Luca;
Janssen, Josephine M.;
Jin Liu;
Xiaoyu Chen;
Mouly, Vincent;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 5, p. e63, doi. 10.1093/nar/gks1446

By:

Holkers, Maarten;
Maggio, Ignazio;
Liu, Jin;
Janssen, Josephine M.;
Miselli, Francesca;
Mussolino, Claudio;
Recchia, Alessandra;
Cathomen, Toni;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 8, p. 3443

By:

Gonçalves, Manuel A. F. V.;
van Nierop, Gijsbert P.;
Holkers, Maarten;
de Vries, Antoine A. F.

Publication type:

Article

Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 5, p. 1984, doi. 10.1093/nar/gkr976

By:

Holkers, Maarten;
de Vries, Antoine A. F.;
Gonçalves, Manuel A. F. V.

Publication type:

Article

Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 17, p. 5725, doi. 10.1093/nar/gkp643

By:

van Nierop, Gijsbert P.;
de Vries, Antoine A. F.;
Holkers, Maarten;
Vrijsen, Krijn R.;
Gonçalves, Manuel A. F. V.

Publication type:

Article