Works by Gomez-Suaga, Patricia

Results: 30

Mitochondrial Dysfunction in Repeat Expansion Diseases.

Published in:

Antioxidants, 2023, v. 12, n. 8, p. 1593, doi. 10.3390/antiox12081593

By:

Giménez-Bejarano, Alberto;
Alegre-Cortés, Eva;
Yakhine-Diop, Sokhna M. S.;
Gómez-Suaga, Patricia;
Fuentes, José M.

Publication type:

Article

Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1).

Published in:

Cells (2073-4409), 2022, v. 11, n. 19, p. 3018, doi. 10.3390/cells11193018

By:

Alegre-Cortés, Eva;
Giménez-Bejarano, Alberto;
Uribe-Carretero, Elisabet;
Paredes-Barquero, Marta;
Marques, André R. A.;
Lopes-da-Silva, Mafalda;
Vieira, Otília V.;
Canales-Cortés, Saray;
Camello, Pedro J.;
Martínez-Chacón, Guadalupe;
Aiastui, Ana;
Fernández-Torrón, Roberto;
López de Munain, Adolfo;
Gomez-Suaga, Patricia;
Niso-Santano, Mireia;
González-Polo, Rosa A.;
Fuentes, José M.;
Yakhine-Diop, Sokhna M. S.

Publication type:

Article

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Published in:

Molecular Neurodegeneration, 2018, v. 13, p. 1, doi. 10.1186/s13024-018-0235-y

By:

Madero-Pérez, Jesús;
Fdez, Elena;
Fernández, Belén;
Lara Ordóñez, Antonio J.;
Blanca Ramírez, Marian;
Gómez-Suaga, Patricia;
Waschbüsch, Dieter;
Lobbestael, Evy;
Baekelandt, Veerle;
Nairn, Angus C.;
Ruiz-Martínez, Javier;
Aiastui, Ana;
López de Munain, Adolfo;
Lis, Pawel;
Comptdaer, Thomas;
Taymans, Jean-Marc;
Chartier-Harlin, Marie-Christine;
Beilina, Alexandria;
Gonnelli, Adriano;
Cookson, Mark R.

Publication type:

Article

Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca<sup>2+</sup> and synaptic defects.

Published in:

Acta Neuropathologica Communications, 2024, v. 9, n. 1, p. 1, doi. 10.1186/s40478-024-01742-x

By:

Markovinovic, Andrea;
Martín-Guerrero, Sandra M.;
Mórotz, Gábor M.;
Salam, Shaakir;
Gomez-Suaga, Patricia;
Paillusson, Sebastien;
Greig, Jenny;
Lee, Younbok;
Mitchell, Jacqueline C.;
Noble, Wendy;
Miller, Christopher C.J.

Publication type:

Article

Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis.

Published in:

Neural Regeneration Research, 2024, v. 19, n. 7, p. 1407, doi. 10.4103/1673-5374.387988

By:

Hartopp, Naomi;
Markovinovic, Andrea;
Miller, Christopher C. J.;
Gomez-Suaga, Patricia

Publication type:

Article

Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia.

Published in:

Aging Cell, 2022, v. 21, n. 2, p. 1, doi. 10.1111/acel.13549

By:

Gomez-Suaga, Patricia;
Mórotz, Gábor M.;
Markovinovic, Andrea;
Martín-Guerrero, Sandra M.;
Preza, Elisavet;
Arias, Natalia;
Mayl, Keith;
Aabdien, Afra;
Gesheva, Vesela;
Nishimura, Agnes;
Annibali, Ambra;
Younbok Lee;
Mitchell, Jacqueline C.;
Wray, Selina;
Shaw, Christopher;
Noble, Wendy;
Miller, Christopher C. J.

Publication type:

Article

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

Published in:

2012

By:

Gómez-Suaga, Patricia;
Fdez, Elena;
Blanca Ramírez, Marian;
Hilfiker, Sabine

Publication type:

Journal Article

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

Published in:

Parkinson's Disease (20420080), 2012, p. 1, doi. 10.1155/2012/324521

By:

Gómez-Suaga, Patricia;
Fdez, Elena;
Blanca Ramírez, Marian;
Hilfiker, Sabine

Publication type:

Article

ER-mitochondria signaling regulates autophagy.

Published in:

Autophagy, 2017, v. 13, n. 7, p. 1250, doi. 10.1080/15548627.2017.1317913

By:

Gomez-Suaga, Patricia;
Paillusson, Sebastien;
Miller, Christopher C. J.

Publication type:

Article

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Published in:

Autophagy, 2016, v. 12, n. 9, p. 1487, doi. 10.1080/15548627.2016.1190072

By:

Fernández, Belén;
Fdez, Elena;
Gómez-Suaga, Patricia;
Gil, Fernando;
Molina-Villalba, Isabel;
Ferrer, Isidro;
Patel, Sandip;
Churchill, Grant C.;
Hilfiker, Sabine

Publication type:

Article

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

Published in:

Autophagy, 2012, v. 8, n. 4, p. 692, doi. 10.4161/auto.19305

By:

Gómez-Suaga, Patricia;
Hilfiker, Sabine

Publication type:

Article

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca homeostasis and mitochondrial ATP production.

Published in:

Acta Neuropathologica, 2017, v. 134, n. 1, p. 129, doi. 10.1007/s00401-017-1704-z

By:

Paillusson, Sébastien;
Gomez-Suaga, Patricia;
Stoica, Radu;
Little, Daniel;
Gissen, Paul;
Devine, Michael;
Noble, Wendy;
Hanger, Diane;
Miller, Christopher

Publication type:

Article

Biological effects of olive oil phenolic compounds on mitochondria.

Published in:

Molecular & Cellular Oncology, 2022, v. 9, n. 1, p. 1, doi. 10.1080/23723556.2022.2044263

By:

Blanco-Benítez, Mercedes;
Calderón-Fernández, Ana;
Canales-Cortés, Saray;
Alegre-Cortés, Eva;
Uribe-Carretero, Elisabet;
Paredes-Barquero, Marta;
Gimenez-Bejarano, Alberto;
Duque González, Gema;
Gómez-Suaga, Patricia;
Ortega-Vidal, Juan;
Salido, Sofía;
Altarejos, Joaquín;
Martínez-Chacón, Guadalupe;
Niso-Santano, Mireia;
Fuentes, José M.;
González-Polo, Rosa A.;
Yakhine-Diop, Sokhna M. S.

Publication type:

Article

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.

Published in:

Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0715-5

By:

Mórotz, Gábor M.;
Glennon, Elizabeth B.;
Gomez-Suaga, Patricia;
Lau, Dawn H. W.;
Robinson, Eleanor D.;
Sedlák, Éva;
Vagnoni, Alessio;
Noble, Wendy;
Miller, Christopher C. J.

Publication type:

Article

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity.

Published in:

Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0688-4

By:

Gómez-Suaga, Patricia;
Pérez-Nievas, Beatriz G.;
Glennon, Elizabeth B.;
Lau, Dawn H. W.;
Paillusson, Sebastien;
Mórotz, Gábor M.;
Calì, Tito;
Pizzo, Paola;
Noble, Wendy;
Miller, Christopher C. J.

Publication type:

Article

Upstream deregulation of calcium signaling in Parkinson's disease.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00053

By:

Rivero-Ríos, Pilar;
Gómez-Suaga, Patricia;
Fdez, Elena;
Hilfiker, Sabine

Publication type:

Article

Upstream deregulation of calcium signalling in Parkinson's disease.

Published in:

Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00053

By:

Rivero-Ríos, Pilar;
Gómez-Suaga, Patricia;
Fdez, Elena;
Hilfiker, Sabine

Publication type:

Article

The presence of disease‐associated tau leads to adverse effects on the autophagy and endolysosomal pathway in a cell model of tauopathy.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.063630

By:

Pollack, Saskia J;
Dakkak, Dina;
Guo, Tong;
Gómez‐Suaga, Patricia;
Noble, Wendy;
Hanger, Diane P

Publication type:

Article

Defects in the autophagy lysosomal pathway in a cell model of disease‐associated tau.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051303

By:

Pollack, Saskia J;
Dakkak, Dina;
Guo, Tong;
Gómez‐Suaga, Patricia;
Noble, Wendy;
Hanger, Diane P

Publication type:

Article

Autophagy and lysosomal defects in cells expressing disease‐associated tau.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058299

By:

Pollack, Saskia J;
Dakkak, Dina;
Guo, Tong;
Gómez‐Suaga, Patricia;
Noble, Wendy;
Hanger, Diane P

Publication type:

Article

PARKINSON’S DISEASE-ASSOCIATED MUTATIONS IN LRRK2 CAUSE CENTROSOMAL DEFECTS VIA RAB8A PHOSPHORYLATION.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1501, doi. 10.1016/j.jalz.2017.07.604

By:

Madero-Pérez, Jesús;
Fdez, Elena;
Fernández, Belén;
Lara Ordóñez, Antonio J.;
Ramírez, Marian Blanca;
Gómez-Suaga, Patricia;
Waschbüsch, Dieter;
Lobbestael, Evy;
Baekelandt, Veerle;
Nairn, Angus C.;
Ruiz-Martínez, Javier;
Aiastui, Ana;
de Munaín, Adolfo López;
Lis, Pawel;
Comptdaer, Thomas;
Taymans, Jean-Marc;
Chartier-Harlin, Marie-Christine;
Beilina, Alexandra;
Gonnelli, Adriano;
Cookson, Mark R.

Publication type:

Article

ALS/ FTD-associated FUS activates GSK-3β to disrupt the VAPB- PTPIP51 interaction and ER-mitochondria associations.

Published in:

EMBO Reports, 2016, v. 17, n. 9, p. 1326, doi. 10.15252/embr.201541726

By:

Stoica, Radu;
Paillusson, Sébastien;
Gomez‐Suaga, Patricia;
Mitchell, Jacqueline C;
Lau, Dawn HW;
Gray, Emma H;
Sancho, Rosa M;
Vizcay‐Barrena, Gema;
De Vos, Kurt J;
Shaw, Christopher E;
Hanger, Diane P;
Noble, Wendy;
Miller, Christopher CJ

Publication type:

Article

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 25, p. 6779, doi. 10.1093/hmg/ddu395

By:

Gómez-Suaga, Patricia;
Rivero-Ríos, Pilar;
Fdez, Elena;
Blanca Ramírez, Marian;
Ferrer, Isidro;
Aiastui, Ana;
López De Munain, Adolfo;
Hilfiker, Sabine

Publication type:

Article

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 25, p. 1, doi. 10.1093/hmg/ddu395

By:

Gómez-Suaga, Patricia;
Rivero-Ríos, Pilar;
Fdez, Elena;
Ramírez, Marian Blanca;
Ferrer, Isidro;
Aiastui, Ana;
López De Munain, Adolfo;
Hilfiker, Sabine

Publication type:

Article

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 3, p. 511, doi. 10.1093/hmg/ddr481

By:

Gómez-Suaga, Patricia;
Luzón-Toro, Berta;
Churamani, Dev;
Zhang, Ling;
Bloor-Young, Duncan;
Patel, Sandip;
Woodman, Philip G.;
Churchill, Grant C.;
Hilfiker, Sabine

Publication type:

Article

ER-mitochondria signaling in Parkinson’s disease.

Published in:

Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-017-0079-3

By:

Gómez-Suaga, Patricia;
Bravo-San Pedro, José M;
González-Polo, Rosa A.;
Fuentes, José M.;
Niso-Santano, Mireia

Publication type:

Article

Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis.

Published in:

Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-017-0022-7

By:

Lau, Dawn H. W.;
Hartopp, Naomi;
Welsh, Natalie J.;
Mueller, Sarah;
Glennon, Elizabeth B.;
Mórotz, Gábor M.;
Annibali, Ambra;
Gomez-Suaga, Patricia;
Stoica, Radu;
Paillusson, Sebastien;
Miller, Christopher C. J.

Publication type:

Article

Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.

Published in:

Biochemical Society Transactions, 2015, v. 43, n. 3, p. 390, doi. 10.1042/BST20140301

By:

Rivero-Rıós, Pilar;
Gómez-Suaga, Patricia;
Fernández, Belén;
Madero-Pérez, Jesús;
Schwab, Andrew J.;
Ebert, Allison D.;
Hilfiker, Sabine

Publication type:

Article

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signallinga.

Published in:

Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1140, doi. 10.1042/BST20120138

By:

Gómez-Suaga, Patricia;
Churchill, Grant C.;
Patel, Sandip;
Hilfiker, Sabine

Publication type:

Article

Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05337-6

By:

Pollack, Saskia J.;
Dakkak, Dina;
Guo, Tong;
Chennell, George;
Gomez-Suaga, Patricia;
Noble, Wendy;
Jimenez-Sanchez, Maria;
Hanger, Diane P.

Publication type:

Article