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Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo.
- Published in:
- Life Science Alliance, 2021, v. 4, n. 7, p. 1, doi. 10.26508/lsa.202101108
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- Publication type:
- Article
Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42626-3
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- Publication type:
- Article
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
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- Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01044-1
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- Publication type:
- Article
Designing antibodies against LRRK2-targeted tau epitopes.
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- PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0204367
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- Publication type:
- Article
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.
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- PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0195211
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- Publication type:
- Article
Free-water imaging reveals unique brain microstructural deficits in hispanic individuals with Dementia.
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- Brain Imaging & Behavior, 2024, v. 18, n. 1, p. 106, doi. 10.1007/s11682-023-00819-w
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- Publication type:
- Article
Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis.
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- Journal of Neuroscience, 2013, v. 33, n. 9, p. 3765, doi. 10.1523/JNEUROSCI.4251-12.2013
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- Publication type:
- Article
Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/ CREB Pathway Independently of β-Amyloid.
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- Journal of Neuroscience, 2012, v. 32, n. 33, p. 11390, doi. 10.1523/JNEUROSCI.0757-12.2012
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- Publication type:
- Article
Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy.
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- Journal of Neuroscience, 2011, v. 31, n. 11, p. 4124, doi. 10.1523/JNEUROSCI.5077-10.2011
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- Publication type:
- Article
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.
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- Journal of Neuroscience, 2010, v. 30, n. 48, p. 16160, doi. 10.1523/JNEUROSCI.4436-10.2010
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- Publication type:
- Article
Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice.
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- Journal of Neuroscience, 2010, v. 30, n. 46, p. 15374, doi. 10.1523/JNEUROSCI.3155-10.2010
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- Publication type:
- Article
BRI2 (ITM2b) Inhibits Aβ Deposition In Vivo.
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- Journal of Neuroscience, 2008, v. 28, n. 23, p. 6030, doi. 10.1523/JNEUROSCI.0891-08.2008
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- Publication type:
- Article
IFN-γ promotes τ phosphorylation without affecting mature tangles.
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- FASEB Journal, 2015, v. 29, n. 10, p. 4384, doi. 10.1096/fj.15-275834
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- Publication type:
- Article
Steroids as γ-secretase modulators.
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- FASEB Journal, 2013, v. 27, n. 9, p. 3775, doi. 10.1096/fj.12-225649
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- Publication type:
- Article
Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.
- Published in:
- FASEB Journal, 2010, v. 24, n. 2, p. 548, doi. 10.1096/fj.09-141754
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- Publication type:
- Article
Using leucine zipper to facilitate α-synuclein assembly.
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- FASEB Journal, 2008, v. 22, n. 9, p. 3165, doi. 10.1096/fj.08-108365
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- Publication type:
- Article
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.
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- Journal of Neurochemistry, 2014, v. 131, n. 6, p. 859, doi. 10.1111/jnc.12806
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- Publication type:
- Article
Disease modifying therapy for AD?
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- Journal of Neurochemistry, 2006, v. 99, n. 3, p. 689, doi. 10.1111/j.1471-4159.2006.04211.x
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- Publication type:
- Article
Inhibitors of Rho-kinase modulate amyloid-β (Aβ) secretion but lack selectivity for Aβ42.
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- Journal of Neurochemistry, 2006, v. 96, n. 2, p. 355, doi. 10.1111/j.1471-4159.2005.03553.x
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- Publication type:
- Article
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
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- Journal of Neurochemistry, 2006, v. 96, n. 1, p. 218, doi. 10.1111/j.1471-4159.2005.03548.x
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- Publication type:
- Article
Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy.
- Published in:
- Journal of Neuroinflammation, 2006, v. 3, p. 17, doi. 10.1186/1742-2094-3-17
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- Publication type:
- Article
Role of CRF and the hypothalamic‐pituitary‐adrenal axis in stroke: revisiting temporal considerations and targeting a new generation of therapeutics.
- Published in:
- FEBS Journal, 2023, v. 290, n. 8, p. 1986, doi. 10.1111/febs.16380
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- Publication type:
- Article
Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice.
- Published in:
- Molecular Therapy, 2015, v. 23, n. 1, p. 53, doi. 10.1038/mt.2014.180
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- Publication type:
- Article
Modulation of Aβ42 in vivo by ?-secretase modulator in primates and humans.
- Published in:
- Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0137-y
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- Publication type:
- Article
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
- Published in:
- Alzheimer's Research & Therapy, 2012, v. 4, n. 3, p. 1, doi. 10.1186/alzrt121
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- Publication type:
- Article
Recent Alzheimer's disease research highlights.
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- Alzheimer's Research & Therapy, 2012, v. 4, n. 3, p. 1, doi. 10.1186/alzrt117
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- Publication type:
- Article
Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.
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- Alzheimer's Research & Therapy, 2012, v. 4, n. 3, p. 1, doi. 10.1186/alzrt124
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- Publication type:
- Article
Right sizing funding for Alzheimer's disease.
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- 2011
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- Publication type:
- Editorial
Intracerebral but Not Peripheral Infection of Live Porphyromonas gingivalis Exacerbates Alzheimer's Disease Like Amyloid Pathology in APP-TgCRND8 Mice.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 6, p. 3328, doi. 10.3390/ijms23063328
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- Publication type:
- Article
Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.
- Published in:
- Molecular Neurobiology, 2020, v. 57, n. 4, p. 1986, doi. 10.1007/s12035-019-01859-4
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- Publication type:
- Article
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
- Published in:
- Acta Neuropathologica, 2021, v. 141, n. 3, p. 359, doi. 10.1007/s00401-021-02264-9
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- Publication type:
- Article
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.
- Published in:
- Acta Neuropathologica, 2018, v. 136, n. 5, p. 709, doi. 10.1007/s00401-018-1900-5
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- Publication type:
- Article
Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.
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- Acta Neuropathologica, 2016, v. 132, n. 2, p. 197, doi. 10.1007/s00401-016-1576-7
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- Publication type:
- Article
Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.
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- 2016
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- Publication type:
- Letter
Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission.
- Published in:
- 2015
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- Publication type:
- Letter
Erratum to: Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.
- Published in:
- 2014
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- Publication type:
- Erratum
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.
- Published in:
- Acta Neuropathologica, 2014, v. 127, n. 5, p. 645, doi. 10.1007/s00401-014-1268-0
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- Publication type:
- Article
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
- Published in:
- Acta Neuropathologica, 2013, v. 126, n. 1, p. 39, doi. 10.1007/s00401-013-1123-8
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- Publication type:
- Article
Fyn depletion ameliorates tauP301L-induced neuropathology.
- Published in:
- Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-00979-6
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- Publication type:
- Article
Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis.
- Published in:
- Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-00911-y
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- Publication type:
- Article
Murine Aß over-production produces diffuse and compact Alzheimer-type amyloid deposits.
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- Acta Neuropathologica Communications, 2015, v. 3, p. 1, doi. 10.1186/s40478-015-0252-9
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- Publication type:
- Article
Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.
- Published in:
- Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.01288
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- Publication type:
- Article
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.
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- Oncogene, 2005, v. 24, n. 42, p. 6333, doi. 10.1038/sj.onc.1208783
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- Publication type:
- Article
Brain Targeted AAV1-GALC Gene Therapy Reduces Psychosine and Extends Lifespan in a Mouse Model of Krabbe Disease.
- Published in:
- Genes, 2023, v. 14, n. 8, p. 1517, doi. 10.3390/genes14081517
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- Publication type:
- Article
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model.
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- EMBO Molecular Medicine, 2022, v. 14, n. 4, p. 1, doi. 10.15252/emmm.201809824
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- Publication type:
- Article
High‐affinity interactions and signal transduction between Aβ oligomers and TREM2.
- Published in:
- EMBO Molecular Medicine, 2018, v. 10, n. 11, p. N.PAG, doi. 10.15252/emmm.201809027
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- Publication type:
- Article
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
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- EMBO Molecular Medicine, 2017, v. 9, n. 7, p. 950, doi. 10.15252/emmm.201607265
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- Publication type:
- Article
Targeting psychologic stress signaling pathways in Alzheimer's disease.
- Published in:
- Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0190-z
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- Publication type:
- Article
Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.
- Published in:
- Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0182-z
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- Publication type:
- Article
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.
- Published in:
- Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-016-0142-z
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- Publication type:
- Article