Works by Gobec, Stanislav

Results: 90

Synthesis and Antibacterial Properties of 3‐Amino‐β‐Lactams Bearing a Heteroatom‐Containing C4 Substituent.

Published in:

ChemMedChem, 2025, v. 20, n. 9, p. 1, doi. 10.1002/cmdc.202400994

By:

Bredael, Kato;
Vanhecke, Fien;
Vandenheede, Emma;
Stevens, Christian V.;
Gobec, Stanislav;
D'hooghe, Matthias

Publication type:

Article

α‐Unsaturated 3‐Amino‐1‐carboxymethyl‐β‐lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 70, p. 16128, doi. 10.1002/chem.201904139

By:

Decuyper, Lena;
Magdalenić, Katarina;
Verstraete, Marie;
Jukič, Marko;
Sosič, Izidor;
Sauvage, Eric;
Amoroso, Ana Maria;
Verlaine, Olivier;
Joris, Bernard;
Gobec, Stanislav;
D'hooghe, Matthias

Publication type:

Article

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.

Published in:

Angewandte Chemie, 2016, v. 128, n. 19, p. 5839, doi. 10.1002/ange.201600190

By:

Sosič, Izidor;
Gobec, Martina;
Brus, Boris;
Knez, Damijan;
Živec, Matej;
Konc, Janez;
Lešnik, Samo;
Ogrizek, Mitja;
Obreza, Aleš;
Žigon, Dušan;
Janežič, Dušanka;
Mlinarič ‐ Raščan, Irena;
Gobec, Stanislav

Publication type:

Article

Antibacterial and β‐Lactamase Inhibitory Activity of Monocyclic β‐Lactams.

Published in:

Medicinal Research Reviews, 2018, v. 38, n. 2, p. 426, doi. 10.1002/med.21443

By:

Decuyper, Lena;
Jukič, Marko;
Sosič, Izidor;
Žula, Aleš;
D'hooghe, Matthias;
Gobec, Stanislav

Publication type:

Article

BoBER: web interface to the base of bioisosterically exchangeable replacements.

Published in:

Journal of Cheminformatics, 2017, v. 9, n. 1, p. 1, doi. 10.1186/s13321-017-0251-x

By:

Lešnik, Samo;
Škrlj, Blaž;
Eržen, Nika;
Bren, Urban;
Gobec, Stanislav;
Konc, Janez;
Janežič, Dušanka

Publication type:

Article

In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3‐Amino‐1‐carboxymethyl‐β‐lactams as Inhibitors of Penicillin‐Binding Proteins of Resistant Bacteria.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 57, p. 15254, doi. 10.1002/chem.201801868

By:

Decuyper, Lena;
Deketelaere, Sari;
Vanparys, Lore;
Jukič, Marko;
Sosič, Izidor;
Sauvage, Eric;
Amoroso, Ana Maria;
Verlaine, Olivier;
Joris, Bernard;
Gobec, Stanislav;
D'hooghe, Matthias

Publication type:

Article

Catalytic Approach to Diverse α‐Aminoboronic Acid Derivatives by Iridium‐Catalyzed Hydrogenation of Trifluoroborate‐Iminiums.

Published in:

Advanced Synthesis & Catalysis, 2021, v. 363, n. 9, p. 2396, doi. 10.1002/adsc.202001350

By:

Šterman, Andrej;
Košmrlj, Janez;
Žigart, Nina;
Gobec, Stanislav;
Sosič, Izidor;
Časar, Zdenko

Publication type:

Article

Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97404-2

By:

Zakošek Pipan, Maja;
Prpar Mihevc, Sonja;
Štrbenc, Malan;
Košak, Urban;
German Ilić, Ilija;
Trontelj, Jurij;
Žakelj, Simon;
Gobec, Stanislav;
Pavlin, Darja;
Majdič, Gregor

Publication type:

Article

Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2011, v. 6, n. 1, p. 201, doi. 10.1515/HMBCI.2011.012

By:

Starčević, Štefan;
Božnar, Polona;
Turk, Samo;
Gobec, Stanislav;
Rižner, Tea Lanišnik

Publication type:

Article

Combined Liquid Chromatography–Tandem Mass Spectrometry Analysis of Progesterone Metabolites.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0117984

By:

Sinreih, Maša;
Zukunft, Sven;
Sosič, Izidor;
Cesar, Jožko;
Gobec, Stanislav;
Adamski, Jerzy;
Lanišnik Rižner, Tea

Publication type:

Article

The Binding Mode of Second-Generation Sulfonamide Inhibitors of MurD: Clues for Rational Design of Potent MurD Inhibitors.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052817

By:

Simčič, Mihael;
Sosič, Izidor;
Hodošček, Milan;
Barreteau, Hé lène;
Blanot, Didier;
Gobec, Stanislav;
Grdadolnik, Simona Golič

Publication type:

Article

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0039922

By:

Škedelj, Veronika;
Arsovska, Emilija;
Tomašić, Tihomir;
Kroflič, Ana;
Hodnik, Vesna;
Hrast, Martina;
Bešter-Rogač, Marija;
Anderluh, Gregor;
Gobec, Stanislav;
Bostock, Julieanne;
Chopra, Ian;
O'Neill, Alex J.;
Randall, Christopher;
Zega, Anamarija;
Cascales, Eric

Publication type:

Article

Selective Cytotoxicity of Amidinopiperidine Based Compounds Towards Burkitt's Lymphoma Cells Involves Proteasome Inhibition.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041961

By:

Gobec, Martina;
Obreza, Ales;
Prijatelj, Matevz;
Brus, Boris;
Gobec, Stanislav;
Mlinaric-Rascan, Irena

Publication type:

Article

Redox-Based Inactivation of Cysteine Cathepsins by Compounds Containing the 4-Aminophenol Moiety.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027197

By:

Mirković, Bojana;
Sosič, Izidor;
Gobec, Stanislav;
Kos, Janko

Publication type:

Article

New Noncovalent Inhibitors of Penicillin-Binding Proteins from Penicillin-Resistant Bacteria.

Published in:

PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019418

By:

Turk, Samo;
Verlaine, Olivier;
Gerards, Thomas;
Živec, Matej;
Humljan, Jan;
Sosič, Izidor;
Amoroso, Ana;
Zervosen, Astrid;
Luxen, André;
Joris, Bernard;
Gobec, Stanislav

Publication type:

Article

In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 6, p. 1101, doi. 10.1111/cbdd.13172

By:

Hrast, Martina;
Jukič, Marko;
Patin, Delphine;
Tod, Julie;
Dowson, Christopher G.;
Roper, David I.;
Barreteau, Hélène;
Gobec, Stanislav

Publication type:

Article

Nep1-like proteins as a target for plant pathogen control.

Published in:

PLoS Pathogens, 2021, v. 17, n. 4, p. 1, doi. 10.1371/journal.ppat.1009477

By:

Pirc, Katja;
Hodnik, Vesna;
Snoj, Tina;
Lenarčič, Tea;
Caserman, Simon;
Podobnik, Marjetka;
Böhm, Hannah;
Albert, Isabell;
Kotar, Anita;
Plavec, Janez;
Borišek, Jure;
Damuzzo, Martina;
Magistrato, Alessandra;
Brus, Boris;
Sosič, Izidor;
Gobec, Stanislav;
Nürnberger, Thorsten;
Anderluh, Gregor

Publication type:

Article

Virtual Screening and Biochemical Testing of Borocycles as Immunoproteasome Inhibitors.

Published in:

Periodica Polytechnica: Chemical Engineering, 2021, v. 65, n. 3, p. 292, doi. 10.3311/PPch.17202

By:

Kollár, Levente;
Ferenczy, György Gábor;
Proj, Matic;
Gobec, Martina;
Gobec, Stanislav;
Sosič, Izidor;
Keserű, György Miklós

Publication type:

Article

Synthesis and Penicillin‐binding Protein Inhibitory Assessment of Dipeptidic 4‐Phenyl‐β‐lactams from α‐Amino Acid‐derived Imines.

Published in:

Chemistry - An Asian Journal, 2020, v. 15, n. 1, p. 51, doi. 10.1002/asia.201901470

By:

Decuyper, Lena;
Jukič, Marko;
Sosič, Izidor;
Amoroso, Ana Maria;
Verlaine, Olivier;
Joris, Bernard;
Gobec, Stanislav;
D'hooghe, Matthias

Publication type:

Article

Monocyclic beta–lactams for therapeutic uses: a patent overview (2010–2020).

Published in:

Expert Opinion on Therapeutic Patents, 2021, v. 31, n. 3, p. 247, doi. 10.1080/13543776.2021.1865919

By:

Grabrijan, Katarina;
Strašek, Nika;
Gobec, Stanislav

Publication type:

Article

A patent review of immunoproteasome inhibitors.

Published in:

Expert Opinion on Therapeutic Patents, 2018, v. 28, n. 7, p. 517, doi. 10.1080/13543776.2018.1484904

By:

Ogorevc, Eva;
Schiffrer, Eva Shannon;
Sosič, Izidor;
Gobec, Stanislav

Publication type:

Article

Evaluation of US 2016/0115161 A1: isoindoline compounds and methods of their use.

Published in:

Expert Opinion on Therapeutic Patents, 2017, v. 27, n. 6, p. 637, doi. 10.1080/13543776.2017.1322954

By:

Frlan, Rok;
Gobec, Stanislav

Publication type:

Article

Virtual screening for potential inhibitors of bacterial MurC and MurD ligases.

Published in:

Journal of Molecular Modeling, 2012, v. 18, n. 3, p. 1063, doi. 10.1007/s00894-011-1139-8

By:

Tomašić, Tihomir;
Kovač, Andreja;
Klebe, Gerhard;
Blanot, Didier;
Gobec, Stanislav;
Kikelj, Danijel;
Mašič, Lucija

Publication type:

Article

D-Glucosamine in iron-catalysed.

Published in:

Applied Organometallic Chemistry, 2015, v. 29, n. 8, p. 528, doi. 10.1002/aoc.3327

By:

Sova, Matej;
Frlan, Rok;
Gobec, Stanislav;
Stavber, Gaj;
Časar, Zdenko

Publication type:

Article

Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2024, v. 39, n. 1, p. 1, doi. 10.1080/14756366.2024.2305833

By:

Kollár, Levente;
Grabrijan, Katarina;
Hrast Rambaher, Martina;
Bozovičar, Krištof;
Imre, Tímea;
Ferenczy, György G.;
Gobec, Stanislav;
Keserű, György M.

Publication type:

Article

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 387, doi. 10.1080/14756366.2022.2149745

By:

Proj, Matic;
Hrast, Martina;
Bajc, Gregor;
Frlan, Rok;
Meden, Anže;
Butala, Matej;
Gobec, Stanislav

Publication type:

Article

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 498, doi. 10.1080/14756366.2019.1710502

By:

Pajk, Stane;
Knez, Damijan;
Košak, Urban;
Zorović, Maja;
Brazzolotto, Xavier;
Coquelle, Nicolas;
Nachon, Florian;
Colletier, Jacques-Philippe;
Živin, Marko;
Stojan, Jure;
Gobec, Stanislav

Publication type:

Article

Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 1010, doi. 10.1080/14756366.2019.1608981

By:

Hrast, Martina;
Rožman, Kaja;
Ogris, Iza;
Škedelj, Veronika;
Patin, Delphine;
Sova, Matej;
Barreteau, Hélène;
Gobec, Stanislav;
Grdadolnik, Simona Golič;
Zega, Anamarija

Publication type:

Article

New inhibitors of fungal 17β-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2007, v. 22, n. 1, p. 29, doi. 10.1080/14756360600953819

By:

Živec, Matej;
Sova, Matej;
Brunskole, Mojca;
Lenaršič, Roman;
Rižner, Tea Lanišnik;
Gobec, Stanislav

Publication type:

Article

New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: Inhibition of antigen 85C mycolyltransferase activity and cytotoxicity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2006, v. 21, n. 4, p. 391, doi. 10.1080/14756360600703214

By:

Kovač, Andreja;
Wilson, Rosalind A.;
Besra, Gurdyal S.;
Filipič, Metka;
Kikelj, Danijel;
Gobec, Stanislav

Publication type:

Article

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02118-7

By:

Batson, Sarah;
Lloyd, Adrian J.;
Rea, Dean;
Fülöp, Vilmos;
Thoroughgood, Christopher W.;
Dowson, Christopher G.;
Roper, David I.;
Majce, Vita;
de Chia, Cesira;
de Carvalho, Luiz Pedro S.;
Gobec, Stanislav;
Simmons, Katie J.;
Fishwick, Colin W. G.

Publication type:

Article

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL BENZYLAMINE DERIVATIVES WITH HYDROXYETHYLAMINE PHARMACOPHORIC MOIETY AS MULTIFUNCTIONAL COMPOUNDS TARGETING CHOLINESTERASE, BETA-SECRETASE AND BETA-AMYLOID AGGREGATION.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P280, doi. 10.1016/j.jalz.2017.06.171

By:

Malawska, Barbara;
Panek, Dawid;
Wieckowska, Anna;
Jonczyk, Jakub;
Godyn, Justyna;
Bajda, Marek;
Knez, Damijan;
Gobec, Stanislav

Publication type:

Article

Reaching toward underexplored targets in antibacterial drug design.

Published in:

Drug Development Research, 2019, v. 80, n. 1, p. 6, doi. 10.1002/ddr.21465

By:

Jukič, Marko;
Gobec, Stanislav;
Sova, Matej

Publication type:

Article

MurD enzymes: some recent developments.

Published in:

Biomolecular Concepts, 2013, v. 4, n. 6, p. 539, doi. 10.1515/bmc-2013-0024

By:

Šink, Roman;
Barreteau, Hélène;
Patin, Delphine;
Mengin-Lecreulx, Dominique;
Gobec, Stanislav;
Blanot, Didier

Publication type:

Article

Heterocyclic electrophiles as new MurA inhibitors.

Published in:

Archiv der Pharmazie, 2018, v. 351, n. 12, p. 1, doi. 10.1002/ardp.201800184

By:

Keeley, Aaron;
Ábrányi‐Balogh, Péter;
Hrast, Martina;
Imre, Tímea;
Ilaš, Janez;
Gobec, Stanislav;
Keserű, György M.

Publication type:

Article

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.

Published in:

Archiv der Pharmazie, 2015, v. 348, n. 8, p. 556, doi. 10.1002/ardp.201500117

By:

Szałaj, Natalia;
Bajda, Marek;
Dudek, Katarzyna;
Brus, Boris;
Gobec, Stanislav;
Malawska, Barbara

Publication type:

Article

N -Hydroxy- N -Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.

Published in:

Molecules, 2022, v. 27, n. 21, p. 7437, doi. 10.3390/molecules27217437

By:

Bautista-Aguilera, Óscar M.;
Alonso, José M.;
Catto, Marco;
Iriepa, Isabel;
Knez, Damijan;
Gobec, Stanislav;
Marco-Contelles, José

Publication type:

Article

Screening of Big Pharma's Library against Various in-house Biological Targets.

Published in:

Molecules, 2022, v. 27, n. 14, p. N.PAG, doi. 10.3390/molecules27144484

By:

Knez, Damijan;
Gobec, Stanislav;
Hrast, Martina

Publication type:

Article

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B.

Published in:

Molecules, 2021, v. 26, n. 14, p. 4118, doi. 10.3390/molecules26144118

By:

Mazej, Tjaša;
Knez, Damijan;
Meden, Anže;
Gobec, Stanislav;
Sova, Matej

Publication type:

Article

Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 2, p. 356, doi. 10.3390/molecules26020356

By:

Schiffrer, Eva Shannon;
Proj, Matic;
Gobec, Martina;
Rejc, Luka;
Šterman, Andrej;
Mravljak, Janez;
Gobec, Stanislav;
Sosič, Izidor;
Matos, Maria João

Publication type:

Article

Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome.

Published in:

Molecules, 2020, v. 25, n. 6, p. 1305, doi. 10.3390/molecules25061305

By:

Rožman, Kaja;
Alexander, Evan M.;
Ogorevc, Eva;
Bozovičar, Krištof;
Sosič, Izidor;
Aldrich, Courtney C.;
Gobec, Stanislav;
Piantanida, Ivo

Publication type:

Article

Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual Screening.

Published in:

Molecules, 2019, v. 24, n. 14, p. 2590, doi. 10.3390/molecules24142590

By:

Scarpino, Andrea;
Bajusz, Dávid;
Proj, Matic;
Gobec, Martina;
Sosič, Izidor;
Gobec, Stanislav;
Ferenczy, György G.;
Keserű, György M.;
Gemma, Sandra

Publication type:

Article

Application of the N-Dibenzyl Protective Group in the Preparation of β-Lactam Pseudopeptides.

Published in:

Molecules, 2019, v. 24, n. 7, p. 1261, doi. 10.3390/molecules24071261

By:

Frlan, Rok;
Hrast, Martina;
Gobec, Stanislav;
Rutledge, Peter J.

Publication type:

Article

Synthesis and Initial Characterization of a Reversible, Selective 18F-Labeled Radiotracer for Human Butyrylcholinesterase.

Published in:

Molecular Imaging & Biology, 2021, v. 23, n. 4, p. 505, doi. 10.1007/s11307-021-01584-2

By:

Gentzsch, Christian;
Chen, Xinyu;
Spatz, Philipp;
Košak, Urban;
Knez, Damijan;
Nose, Naoko;
Gobec, Stanislav;
Higuchi, Takahiro;
Decker, Michael

Publication type:

Article

A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.855653

By:

Proj, Matic;
De Jonghe, Steven;
Van Loy, Tom;
Jukič, Marko;
Meden, Anže;
Ciber, Luka;
Podlipnik, Črtomir;
Grošelj, Uroš;
Konc, Janez;
Schols, Dominique;
Gobec, Stanislav

Publication type:

Article

Mur ligase F as a new target for the flavonoids quercitrin, myricetin, and (–)-epicatechin.

Published in:

Journal of Computer-Aided Molecular Design, 2023, v. 37, n. 12, p. 721, doi. 10.1007/s10822-023-00535-z

By:

Rambaher, Martina Hrast;
Zdovc, Irena;
Glavač, Nina Kočevar;
Gobec, Stanislav;
Frlan, Rok

Publication type:

Article

WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2021, v. 35, n. 2, p. 223, doi. 10.1007/s10822-020-00371-5

By:

Scarpino, Andrea;
Petri, László;
Knez, Damijan;
Imre, Tímea;
Ábrányi-Balogh, Péter;
Ferenczy, György G.;
Gobec, Stanislav;
Keserű, György M.

Publication type:

Article

Molecular dynamics to enhance structure-based virtual screening on cathepsin B.

Published in:

Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 8, p. 707, doi. 10.1007/s10822-015-9847-2

By:

Ogrizek, Mitja;
Turk, Samo;
Lešnik, Samo;
Sosič, Izidor;
Hodošček, Milan;
Mirković, Bojana;
Kos, Janko;
Janežič, Dušanka;
Gobec, Stanislav;
Konc, Janez

Publication type:

Article

Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF): experimental and computational characterization.

Published in:

Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 6, p. 541, doi. 10.1007/s10822-015-9843-6

By:

Perdih, Andrej;
Hrast, Martina;
Pureber, Kaja;
Barreteau, Hélène;
Grdadolnik, Simona;
Kocjan, Darko;
Gobec, Stanislav;
Solmajer, Tom;
Wolber, Gerhard

Publication type:

Article

Modulation of tumour necrosis factor production with desmuramyldipeptide analogues.

Published in:

Pflügers Archiv: European Journal of Physiology, 2000, v. 440, n. 7, p. r064

By:

Simčič, Saša;
Wraber, Branka;
Sollner, Marija;
Urleb, Uroš;
Gobec, Stanislav

Publication type:

Article