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Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.
Published in:
EMBO Journal, 2000, v. 19, n. 8, p. 1827, doi. 10.1093/emboj/19.8.1827
By:
- Liu, Qing;
- Schwaller, Juerg;
- Kutok, Jeffery;
- Cain, Danielle;
- Aster, Jon C.;
- Williams, Ifor R.;
- Gilliland, D. Gary
Publication type:
Article
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.
Published in:
EMBO Journal, 1998, v. 17, n. 18, p. 5321, doi. 10.1093/emboj/17.18.5321
By:
- Schwaller, Juerg;
- Frantsve, Julie;
- Aster, Jon;
- Williams, Ifor R.;
- Tomasson, Michael H.;
- Ross, Theodora S.;
- Peeters, Pieter;
- Van Rompaey, Luc;
- Van Etten, Richard A.;
- Ilaria Jr., Robert;
- Marynen, Peter;
- Gilliland, D. Gary
Publication type:
Article
Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.
Published in:
EMBO Journal, 1997, v. 16, n. 14, p. 4374, doi. 10.1093/emboj/16.14.4374
By:
- Li Chun Wang;
- Kuo, Frank;
- Fujiwara, Yuko;
- Gilliland, D. Gary;
- Golub, Todd R.;
- Orkin, Stuart H.
Publication type:
Article
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
Published in:
2009
By:
- Mercher, Thomas;
- Raffel, Glen D.;
- Moore, Sandra A.;
- Cornejo, Melanie G.;
- Baudry-Bluteau, Dominique;
- Cagnard, Nicolas;
- Jesneck, Jonathan L.;
- Pikman, Yana;
- Cullen, Dana;
- Williams, Ifor R.;
- Akashi, Koichi;
- Shigematsu, Hirokazu;
- Bourquin, Jean-Pierre;
- Giovannini, Marco;
- Vainchenker, William;
- Levine, Ross L.;
- Lee, Benjamin H.;
- Bernard, Olivier A.;
- Gilliland, D. Gary
Publication type:
journal article
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.
Published in:
2007
By:
- Scholl, Claudia;
- Bansal, Dimple;
- Döhner, Konstanze;
- Eiwen, Karina;
- Huntly, Brian J. P.;
- Lee, Benjamin H.;
- Rücker, Frank G.;
- Schlenk, Richard F.;
- Bullinger, Lars;
- Döhner, Hartmut;
- Gilliland, D. Gary;
- Fröhling, Stefan;
- Döhner, Konstanze;
- Rücker, Frank G;
- Döhner, Hartmut;
- Fröhling, Stefan
Publication type:
journal article
Stable expression of small interfering RNA sensitizes TEL-PDGF... R to inhibition with imatinib or rapamycin.
Published in:
Journal of Clinical Investigation, 2004, v. 113, n. 12, p. 1784, doi. 10.1172/JCI200420673
By:
- Chen, Jing;
- Wall, Nathan R.;
- Kocher, Kerry;
- Duclos, Nicole;
- Fabbro, Doriano;
- Neuberg, Donna;
- Griffin, James D.;
- Shi, Yang;
- Gilliland, D. Gary
Publication type:
Article
Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.
Published in:
2004
By:
- Chen, Jing;
- Wall, Nathan R;
- Kocher, Kerry;
- Duclos, Nicole;
- Fabbro, Doriano;
- Neuberg, Donna;
- Griffin, James D;
- Shi, Yang;
- Gilliland, D Gary
Publication type:
journal article
Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1.
Published in:
Stem Cells, 2010, v. 28, n. 7, p. 1186, doi. 10.1002/stem.437
By:
- Parmar, Kalindi;
- Kim, Jungmin;
- Sykes, Stephen M.;
- Shimamura, Akiko;
- Stuckert, Patricia;
- Zhu, Kaya;
- Hamilton, Abigail;
- Deloach, Mary Kathryn;
- Kutok, Jeffery L.;
- Akashi, Koichi;
- Gilliland, D. Gary;
- D'andrea, Alan
Publication type:
Article
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Published in:
Nature Medicine, 2010, v. 16, n. 8, p. 903, doi. 10.1038/nm.2187
By:
- Kharas, Michael G.;
- Lengner, Christopher J.;
- Al-Shahrour, Fatima;
- Bullinger, Lars;
- Ball, Brian;
- Zaidi, Samir;
- Morgan, Kelly;
- Tam, Winnie;
- Paktinat, Mahnaz;
- Okabe, Rachel;
- Gozo, Maricel;
- Einhorn, William;
- Lane, Steven W.;
- Scholl, Claudia;
- Fröhling, Stefan;
- Fleming, Mark;
- Ebert, Benjamin L.;
- Gilliland, D. Gary;
- Jaenisch, Rudolf;
- Daley, George Q.
Publication type:
Article
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
Published in:
Nature Medicine, 2004, v. 10, n. 8, p. 849, doi. 10.1038/nm1084
By:
- Araki, Toshiyuki;
- Mohi, M. Golam;
- Ismat, Fraz A.;
- Bronson, Roderick T.;
- Williams, Ifor R.;
- Kutok, Jeffery L.;
- Wentian Yang;
- Pao, Lily I.;
- Gilliland, D. Gary;
- Epstein, Jonathan A.;
- Neep, Benjamin G.
Publication type:
Article
A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms.
Published in:
Nature Genetics, 2009, v. 41, n. 4, p. 455, doi. 10.1038/ng.342
By:
- Kilpivaara, Outi;
- Mukherjee, Semanti;
- Schram, Alison M.;
- Wadleigh, Martha;
- Mullally, Ann;
- Ebert, Benjamin L.;
- Bass, Adam;
- Marubayashi, Sachie;
- Heguy, Adriana;
- Garcia-Manero, Guillermo;
- Kantarjian, Hagop;
- Offit, Kenneth;
- Stone, Richard M.;
- Gilliland, D Gary;
- Klein, Robert J.;
- Levine, Ross L.
Publication type:
Article
Erratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Published in:
2008
By:
- Gang Huang;
- Pu Zhang;
- Hirai, Hideyo;
- Elf, Shannon;
- Xiaomei Yan;
- Zhao Chen;
- Koschmieder, Steffen;
- Okuno, Yutaka;
- Dayaram, Tajhal;
- Growney, Joseph D.;
- Shivdasani, Ramesh A.;
- Gilliland, D. Gary;
- Speck, Nancy A.;
- Nimer, Stephen D.;
- Tenen, Daniel G.
Publication type:
Correction Notice
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Published in:
Nature Genetics, 2008, v. 40, n. 1, p. 51, doi. 10.1038/ng.2007.7
By:
- Gang Huang;
- Pu Zhang;
- Hideyo Hirai;
- Elf, Shannon;
- Xiaomei Yan;
- Zhao Chen;
- Koschmieder, Steffen;
- Okuno, Yutaka;
- Dayaram, Tajhal;
- Growney, Joseph D.;
- Shivdasani, Ramesh A.;
- Gilliland, D. Gary;
- Speck, Nancy A.;
- Nimer, Stephen D.;
- Tenen, Daniel G.
Publication type:
Article
Molecular Genetics of Human Leukemia.
Published in:
Leukemia (08876924), 1998, v. 12, p. S7
By:
- Gilliland, D. Gary
Publication type:
Article
Intensified therapy for infants with acute lymphoblastic leukemia: results from the Dana-Farber Cancer Institute Consortium.
Published in:
1997
By:
- Silverman, Lewis B.;
- McLean, Thomas W.;
- Gelber, Richard D.;
- Donnelly, Mia J.;
- Gilliland, D. Gary;
- Tarbell, Nancy J.;
- Sallan, Stephen E.;
- Silverman, L B;
- McLean, T W;
- Gelber, R D;
- Donnelly, M J;
- Gilliland, D G;
- Tarbell, N J;
- Sallan, S E
Publication type:
journal article
Bone marrow dysplasia in patients with newly diagnosed acute myelogenous leukemia does not correlate with history of myelodysplasia or with remission rate and survival.
Published in:
1994
By:
- Ballen, Karen K.;
- Gary Gilliland, D.;
- Kalish, Leslie A.;
- Shulman, Lawrence N.;
- Ballen, K K;
- Gilliland, D G;
- Kalish, L A;
- Shulman, L N
Publication type:
journal article
Direct inhibition of the NOTCH transcription factor complex.
Published in:
2010
By:
- Moellering, Raymond E.;
- Cornejo, Melanie;
- Davis, Tina N.;
- Bianco, Cristina Del;
- Aster, Jon C.;
- Blacklow, Stephen C.;
- Kung, Andrew L.;
- Gilliland, D. Gary;
- Verdine, Gregory L.;
- Bradner, James E.
Publication type:
Correction Notice
Direct inhibition of the NOTCH transcription factor complex.
Published in:
Nature, 2009, v. 462, n. 7270, p. 182, doi. 10.1038/nature08543
By:
- Moellering, Raymond E.;
- Cornejo, Melanie;
- Davis, Tina N.;
- Bianco, Cristina Del;
- Aster, Jon C.;
- Blacklow, Stephen C.;
- Kung, Andrew L.;
- Gilliland, D. Gary;
- Verdine, Gregory L.;
- Bradner, James E.
Publication type:
Article
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Published in:
Nature, 2008, v. 455, n. 7215, p. 975, doi. 10.1038/nature07397
By:
- George, Rani E.;
- Sanda, Takaomi;
- Hanna, Megan;
- Fröhling, Stefan;
- II, William Luther;
- Zhang, Jianming;
- Ahn, Yebin;
- Zhou, Wenjun;
- London, Wendy B.;
- McGrady, Patrick;
- Xue, Liquan;
- Zozulya, Sergey;
- Gregor, Vlad E.;
- Webb, Thomas R.;
- Gray, Nathanael S.;
- Gilliland, D. Gary;
- Diller, Lisa;
- Greulich, Heidi;
- Morris, Stephan W.;
- Meyerson, Matthew
Publication type:
Article
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9.
Published in:
Nature, 2006, v. 442, n. 7104, p. 818, doi. 10.1038/nature04980
By:
- Krivtsov, Andrei V.;
- Twomey, David;
- Zhaohui Feng;
- Stubbs, Matthew C.;
- Yingzi Wang;
- Faber, Joerg;
- Levine, Jason E.;
- Jing Wang;
- Hahn, William C.;
- Gilliland, D. Gary;
- Golub, Todd R.;
- Armstrong, Scott A.
Publication type:
Article
Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice.
Published in:
Oncogene, 2000, v. 19, n. 21, p. 2505, doi. 10.1038/sj.onc.1203480
By:
- Levy, David E;
- Gilliland, D Gary
Publication type:
Article
The clinical phenotype of wild‐type, heterozygous, and homozygous JAK2V617F in polycythemia vera.
Published in:
Cancer (0008543X), 2006, v. 106, n. 3, p. 631
By:
- Ayalew Tefferi;
- Terra L. Lasho;
- Susan M. Schwager;
- Jacob S. Strand;
- Michelle Elliott;
- Ruben Mesa;
- Chin‐Yang Li;
- Martha Wadleigh;
- Stephanie J. Lee;
- D. Gary Gilliland
Publication type:
Article
Cancer biology: Summing up cancer stem cells.
Published in:
Nature, 2005, v. 435, n. 7046, p. 1169, doi. 10.1038/4351169a
By:
- Huntly, Brian J. P.;
- Gilliland, D. Gary
Publication type:
Article
KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32).
Published in:
Leukemia (08876924), 2005, v. 19, n. 1, p. 27, doi. 10.1038/sj.leu.2403548
By:
- Levine, R L;
- Wadleigh, M;
- Sternberg, D W;
- Wlodarska, I;
- Galinsky, I;
- Stone, R M;
- DeAngelo, D J;
- Gary Gilliland, D;
- Cools, J
Publication type:
Article
SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients.
Published in:
Genes, Chromosomes & Cancer, 2008, v. 47, n. 3, p. 253, doi. 10.1002/gcc.20527
By:
- Swanson, Kenneth D.;
- Winter, Jordan M.;
- Reis, Marcelo;
- Bentires-Alj, Mohamed;
- Greulich, Heidi;
- Grewal, Rupinder;
- Hruban, Ralph H.;
- Yeo, Charles J.;
- Yassin, Yosuf;
- Iartchouk, Oleg;
- Montgomery, Kate;
- Whitman, Susan P.;
- Caligiuri, Michael A.;
- Loh, Mignon L.;
- Gilliland, D. Gary;
- Look, A. Thomas;
- Kucherlapati, Raju;
- Kern, Scott E.;
- Meyerson, Matthew;
- Neel, Benjamin G.
Publication type:
Article
Prediction of therapy-related acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for lymphoma.
Published in:
American Journal of Hematology, 1997, v. 56, n. 1, p. 45, doi. 10.1002/(SICI)1096-8652(199709)56:1<45::AID-AJH10>3.0.CO;2-1
By:
- Legare, Robert D.;
- Gribben, John G.;
- Maragh, Marlon;
- Hermanowski-Vosatka, Anne;
- Roach, Sheila;
- Tantravahi, Ramana;
- Nadler, Lee M.;
- Gilliland, D. Gary
Publication type:
Article
Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time.
Published in:
British Journal of Haematology, 2006, v. 135, n. 5, p. 683, doi. 10.1111/j.1365-2141.2006.06348.x
By:
- Lasho, Terra L.;
- Pardanani, Animesh;
- McClure, Rebecca F.;
- Mesa, Ruben A.;
- Levine, Ross L.;
- Gary Gilliland, D.;
- Tefferi, Ayalew
Publication type:
Article
The JAK2V617F tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.
Published in:
British Journal of Haematology, 2005, v. 131, n. 3, p. 320, doi. 10.1111/j.1365-2141.2005.05776.x
By:
- Tefferi, Ayalew;
- Lasho, Terra L.;
- Schwager, Susan M.;
- Steensma, David P.;
- Mesa, Ruben A.;
- Chin-Yang Li;
- Wadleigh, Martha;
- Gilliland, D. Gary
Publication type:
Article
JAK2V617F mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance.
Published in:
British Journal of Haematology, 2005, v. 131, n. 2, p. 208, doi. 10.1111/j.1365-2141.2005.05764.x
By:
- Wolanskyj, Alexandra P.;
- Lasho, Terra L.;
- Schwager, Susan M.;
- McClure, Rebecca F.;
- Wadleigh, Martha;
- Lee, Stephanie J.;
- Gilliland, D. Gary;
- Tefferi, Ayalew
Publication type:
Article
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.
Published in:
2006
By:
- Pikman, Yana;
- Lee, Benjamin H.;
- Mercher, Thomas;
- McDowell, Elizabeth;
- Ebert, Benjamin L.;
- Gozo, Maricel;
- Cuker, Adam;
- Wernig, Gerlinde;
- Moore, Sandra;
- Galinsky, Ilene;
- DeAngelo, Daniel J.;
- Clark, Jennifer J.;
- Lee, Stephanie J.;
- Golub, Todd R.;
- Wadleigh, Martha;
- Gilliland, D. Gary;
- Levine, Ross L.
Publication type:
journal article
EGFR Inhibition in Non-Small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head.
Published in:
PLoS Medicine, 2005, v. 2, n. 3, p. 195, doi. 10.1371/journal.pmed.0020075
By:
- Clark, Jennifer;
- Cools, Jan;
- Gilliland, D. Gary
Publication type:
Article
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders.
Published in:
Nature Reviews Cancer, 2007, v. 7, n. 9, p. 673, doi. 10.1038/nrc2210
By:
- Levine, Ross L.;
- Pardanani, Animesh;
- Tefferi, Ayalew;
- Gilliland, D. Gary
Publication type:
Article
TIMELINE: Leukaemia stem cells and the evolution of cancer-stem-cell research.
Published in:
Nature Reviews Cancer, 2005, v. 5, n. 4, p. 311, doi. 10.1038/nrc1592
By:
- Huntly, Brian J. P.;
- Gilliland, D. Gary
Publication type:
Article
Core-binding factors in haematopoiesis and leukaemia.
Published in:
Nature Reviews Cancer, 2002, v. 2, n. 7, p. 502, doi. 10.1038/nrc840
By:
- Speck, Nancy A.;
- Gilliland, D. Gary
Publication type:
Article
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth.
Published in:
Science Signaling, 2009, v. 2, n. 97, p. 1, doi. 10.1126/scisignal.2000431
By:
- Hitosugi, Taro;
- Kang, Sumin;
- Vander Heiden, Matthew G.;
- Chung, Tae-Wook;
- Elf, Shannon;
- Lythgoe, Katherine;
- Dong, Shaozhong;
- Lonial, Sagar;
- Xu Wang;
- Chen, Georgia Z.;
- Xie, Jianxin;
- Gu, Ting-Lei;
- Polakiewicz, Roberto D.;
- Roesel, Johannes L.;
- Boggon, Titus J.;
- Khuri, Fadlo R.;
- Gilliland, D. Gary;
- Cantley, Lewis C.;
- Kaufman, Jonathan;
- Chen, Jing
Publication type:
Article

Found: 35

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.

Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.

Stable expression of small interfering RNA sensitizes TEL-PDGF... R to inhibition with imatinib or rapamycin.

Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.

A germline JAK2 SNP is associated with predisposition to the development of JAK2<sup>V617F</sup>-positive myeloproliferative neoplasms.

Erratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Molecular Genetics of Human Leukemia.

Intensified therapy for infants with acute lymphoblastic leukemia: results from the Dana-Farber Cancer Institute Consortium.

Bone marrow dysplasia in patients with newly diagnosed acute myelogenous leukemia does not correlate with history of myelodysplasia or with remission rate and survival.

Direct inhibition of the NOTCH transcription factor complex.

Direct inhibition of the NOTCH transcription factor complex.

Activating mutations in ALK provide a therapeutic target in neuroblastoma.

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9.

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice.

The clinical phenotype of wild‐type, heterozygous, and homozygous JAK2V617F in polycythemia vera.

Cancer biology: Summing up cancer stem cells.

KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32).

SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients.

Prediction of therapy-related acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for lymphoma.

Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time.

The JAK2<sup>V617F</sup> tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.

JAK2<sup>V617F</sup> mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance.

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

EGFR Inhibition in Non-Small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head.

Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders.

TIMELINE: Leukaemia stem cells and the evolution of cancer-stem-cell research.

Core-binding factors in haematopoiesis and leukaemia.

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth.