Works by Gilham, Dean

Results: 11

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease.

Published in:

Cardiovascular Therapeutics, 2020, p. 1, doi. 10.1155/2020/9397109

By:

Wasiak, Sylwia;
Gilham, Dean;
Daze, Emily;
Tsujikawa, Laura M.;
Halliday, Christopher;
Stotz, Stephanie C.;
Rakai, Brooke D.;
Fu, Li;
Jahagirdar, Ravi;
Sweeney, Michael;
Johansson, Jan O.;
Wong, Norman C. W.;
Kulikowski, Ewelina

Publication type:

Article

FO080 APABETALONE, AN INHIBITOR OF BET PROTEINS, IMPROVES CARDIOVASCULAR RISK AND REDUCES ALKALINE PHOSPHATASE IN BOTH CVD PATIENTS AND PRIMARY HUMAN CELL CULTURE SYSTEMS.

Published in:

Nephrology Dialysis Transplantation, 2019, v. 34, p. N.PAG, doi. 10.1093/ndt/gfz096.FO080

By:

Gilham, Dean;
Tsujikawa, Laura;
Wasiak, Sylwia;
Halliday, Christopher;
Lebioda, Ken;
Kalantar-Zadeh, Kamyar;
Beddhu, Srinivasan;
Brandenburg, Vincent;
Tonelli, Marcello;
Jahagirdar, Ravi;
Wong, Norman C W;
Zoccali, Carmine;
Johansson, Jan O;
Sweeney, Michael;
Haarhaus, Mathias;
Kulikowski, Ewelina

Publication type:

Article

Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells.

Published in:

Biomedicines, 2023, v. 11, n. 10, p. 2683, doi. 10.3390/biomedicines11102683

By:

Sarsons, Christopher D.;
Gilham, Dean;
Tsujikawa, Laura M.;
Wasiak, Sylwia;
Fu, Li;
Rakai, Brooke D.;
Stotz, Stephanie C.;
Carestia, Agostina;
Sweeney, Michael;
Kulikowski, Ewelina

Publication type:

Article

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.

Published in:

Biomedicines, 2023, v. 11, n. 6, p. 1663, doi. 10.3390/biomedicines11061663

By:

Gilham, Dean;
Wasiak, Sylwia;
Rakai, Brooke D.;
Fu, Li;
Tsujikawa, Laura M.;
Sarsons, Christopher D.;
Carestia, Agostina;
Lebioda, Kenneth;
Johansson, Jan O.;
Sweeney, Michael;
Kalantar-Zadeh, Kamyar;
Kulikowski, Ewelina

Publication type:

Article

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.

Published in:

Biomedicines, 2021, v. 9, n. 4, p. 437, doi. 10.3390/biomedicines9040437

By:

Gilham, Dean;
Smith, Audrey L.;
Fu, Li;
Moore, Dalia Y.;
Muralidharan, Abenaya;
Reid, St. Patrick M.;
Stotz, Stephanie C.;
Johansson, Jan O.;
Sweeney, Michael;
Wong, Norman C. W.;
Kulikowski, Ewelina;
El-Gamal, Dalia

Publication type:

Article

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.

Published in:

2007

By:

Hofmann, Susanna M.;
Li Zhou;
Perez-Tilve, Diego;
Greer, Todd;
Grant, Erin;
Wancata, Lauren;
Thomas, Andrew;
Pfluger, Paul T.;
Basford, Joshua E.;
Gilham, Dean;
Herz, Joachim;
Tschöp, Matthias H.;
Hui, David Y.;
Zhou, Li;
Tschöp, Matthias H

Publication type:

journal article

Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion.

Published in:

FASEB Journal, 2003, v. 17, n. 12, p. 1685, doi. 10.1096/fj.02-0728fje

By:

Gilham, Dean;
Ho, Samuel;
Rasouli, Mehdi;
Martres, Paul;
Vance, Dennis E.;
Lehner, Richard

Publication type:

Article

Metabolic Control by S6 Kinases Depends on Dietary Lipids.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032631

By:

Castañeda, Tamara R.;
Abplanalp, William;
Sung Hee Um;
Pfluger, Paul T.;
Schrott, Brigitte;
Brown, Kimberly;
Grant, Erin;
Carnevalli, Larissa;
Benoit, Stephen C.;
Morgan, Donald A.;
Gilham, Dean;
Hui, David Y.;
Rahmouni, Kamal;
Thomas, George;
Kozma, Sara C.;
Clegg, Deborah J.;
Tschöp, Matthias H.

Publication type:

Article

The Physiological Role of Triacylglycerol Hydrolase in Lipid Metabolism.

Published in:

Reviews in Endocrine & Metabolic Disorders, 2004, v. 5, n. 4, p. 303

By:

Dean Gilham;
Richard Lehner

Publication type:

Article

474-P: Apabetalone (RVX-208) Attenuates an Inflammatory Milieu that Enhances Adhesion of Monocytes to Endothelial Cells in Type 2 Diabetes Mellitus with Cardiovascular Disease Patients.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-474-P

By:

TSUJIKAWA, LAURA;
KULIKOWSKI, EWELINA;
CALOSING, CYRUS;
WASIAK, SYLWIA;
GILHAM, DEAN;
HALLIDAY, CHRISTOPHER;
JOHANSSON, JAN O.;
SWEENEY, MICHAEL;
WONG, NORMAN C.

Publication type:

Article

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.

Published in:

Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0696-z

By:

Tsujikawa, Laura M.;
Fu, Li;
Das, Shovon;
Halliday, Christopher;
Rakai, Brooke D.;
Stotz, Stephanie C.;
Sarsons, Christopher D.;
Gilham, Dean;
Daze, Emily;
Wasiak, Sylwia;
Studer, Deborah;
Rinker, Kristina D.;
Sweeney, Michael;
Johansson, Jan O.;
Wong, Norman C. W.;
Kulikowski, Ewelina

Publication type:

Article