Works by Giembycz, Mark A.

Results: 42

An estimation of beta 2-adrenoceptor reserve on human bronchial smooth muscle for some sympathomimetic bronchodilators.

Published in:

2009

By:

Giembycz, Mark A

Publication type:

journal article

Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

Published in:

2004

By:

Clarke, Deborah L.;
Belvisi, Maria G.;
Catley, Matthew C.;
Yacoub, Magdi H.;
Newton, Robert;
Giembycz, Mark A.

Publication type:

journal article

E-Ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype.

Published in:

British Journal of Pharmacology, 2004, v. 141, n. 4, p. 600, doi. 10.1038/sj.bjp.0705648

By:

Clarke, Deborah L.;
Giembycz, Mark A.;
Patel, Hema J.;
Belvisi, Maria G.

Publication type:

Article

Verotoxin activates mitogen-activated protein kinase in human peripheral blood monocytes: role in apoptosis and proinflammatory cytokine release.

Published in:

2003

By:

Cameron, Pamela;
Smith, Susan J.;
Giembycz, Mark A.;
Rotondo, Dino;
Plevin, Robin

Publication type:

journal article

Pharmacological comparison of LTB4-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.

Published in:

British Journal of Pharmacology, 2001, v. 134, n. 4, p. 797, doi. 10.1038/sj.bjp.0704314

By:

Lynch, Oonagh T;
Giembycz, Mark A;
Barnes, Peter J;
Lindsay, Mark A

Publication type:

Article

Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10.

Published in:

British Journal of Pharmacology, 2001, v. 134, n. 1, p. 58, doi. 10.1038/sj.bjp.0704238

By:

Seldon, Paul M;
Giembycz, Mark A

Publication type:

Article

Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase.

Published in:

British Journal of Pharmacology, 2001, v. 133, n. 8, p. 1201, doi. 10.1038/sj.bjp.0704213

By:

Spicuzza, Lucia;
Belvisi, Maria G;
Birrell, Mark A;
Barnes, Peter J;
Hele, David J;
Giembycz, Mark A

Publication type:

Article

Chronic systemic administration of salmeterol to rats promotes pulmonary β2-adrenoceptor desensitization and down-regulation of Gsα.

Published in:

British Journal of Pharmacology, 2001, v. 132, n. 6, p. 1261, doi. 10.1038/sj.bjp.0703946

By:

Finney, Paul A;
Donnelly, Louise E;
Belvisi, Maria G;
Chuang, Tsu-Tshen;
Birrell, Mark;
Harris, Andrew;
Mak, Judith C W;
Scorer, Carol;
Barnes, Peter J;
Adcock, Ian M;
Giembycz, Mark A

Publication type:

Article

p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism.

Published in:

2000

By:

Meja, Koremu K;
Seldon, Paul M;
Nasuhara, Yasuyuki;
Ito, Kazuhiro;
Barnes, Peter J;
Lindsay, Mark A;
Giembycz, Mark A;
Meja, K K;
Seldon, P M;
Nasuhara, Y;
Ito, K;
Barnes, P J;
Lindsay, M A;
Giembycz, M A

Publication type:

journal article

Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.

Published in:

2000

By:

Koch, Andrea;
Nasuhara, Yasuyuki;
Barnes, Peter J;
Lindsay, Mark A;
Giembycz, Mark A;
Koch, A;
Nasuhara, Y;
Barnes, P J;
Lindsay, M A;
Giembycz, M A

Publication type:

journal article

Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis.

Published in:

British Journal of Pharmacology, 2000, v. 130, n. 7, p. 1433, doi. 10.1038/sj.bjp.0703452

By:

Webb, Benjamin L J;
Hirst, Stuart J;
Giembycz, Mark A

Publication type:

Article

'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.

Published in:

1999

By:

Lynch, Oonagh T;
Giembycz, Mark A;
Barnes, Peter J;
Hellewell, Paul G;
Lindsay, Mark A;
Lynch, O T;
Giembycz, M A;
Barnes, P J;
Hellewell, P G;
Lindsay, M A

Publication type:

journal article

Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis.

Published in:

British Journal of Pharmacology, 1999, v. 128, n. 2, p. 327, doi. 10.1038/sj.bjp.0702779

By:

Bernareggi, Micaela M;
Belvisi, Maria G;
Patel, Hema;
Barnes, Peter J;
Giembycz, Mark A

Publication type:

Article

Differential Roles of the α and β Catalytic Subunits of PKA in the Regulation of Formoterol‐modulated Gene Expression Changes in Human Airway Epithelial Cells.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4247

By:

Hamed, Omar;
Giembycz, Mark A.

Publication type:

Article

Mitogen-Activated Protein Kinase Modulation of Nuclear Factor-κB--Induced Granulocyte Macrophage--Colony-Stimulating Factor Release from Human Alveolar Macrophages.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2004, v. 30, n. 3, p. 342, doi. 10.1165/rcmb.2003-0122OC

By:

Koch, Andrea;
Giembycz, Mark;
Kazuhiro Ito;
Sam Lim;
Jazrawi, Elen;
Barnes, Peter J.;
Adcock, Ian;
Erdmann, Erland;
K. Fan Chung

Publication type:

Article

Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170269

By:

George, Tresa;
Bell, Matthew;
Chakraborty, Mainak;
Siderovski, David P.;
Giembycz, Mark A.;
Newton, Robert

Publication type:

Article

Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases.

Published in:

2021

By:

Mokry, Juraj;
Giembycz, Mark;
Mokra, Daniela

Publication type:

Editorial

α and β catalytic subunits of cAMP-dependent protein kinase regulate formoterol-induced inflammatory gene expression changes in human bronchial epithelial cells.

Published in:

2022

By:

Hamed, Omar;
Joshi, Radhika;
Mostafa, Mahmoud M.;
Giembycz, Mark A.

Publication type:

journal article

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Published in:

2018

By:

Curtis, Michael J.;
Alexander, Steve;
Cirino, Giuseppe;
Docherty, James R.;
George, Christopher H.;
Giembycz, Mark A.;
Hoyer, Daniel;
Insel, Paul A.;
Izzo, Angelo A.;
Yong Ji;
MacEwan, David J.;
Sobey, Christopher G.;
Stanford, S. Clare;
Teixeira, Mauro M.;
Wonnacott, Sue;
Ahluwalia, Amrita;
Ji, Yong

Publication type:

Editorial

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.

Published in:

2018

By:

Alexander, Steve P H;
Roberts, Richard E;
Broughton, Brad R S;
Sobey, Christopher G;
George, Christopher H;
Stanford, S Clare;
Cirino, Giuseppe;
Docherty, James R;
Giembycz, Mark A;
Hoyer, Daniel;
Insel, Paul A;
Izzo, Angelo A;
Ji, Yong;
MacEwan, David J;
Mangum, Jonathan;
Wonnacott, Sue;
Ahluwalia, Amrita

Publication type:

Editorial

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts.

Published in:

2017

By:

George, Christopher H;
Stanford, S Clare;
Alexander, Steve;
Cirino, Giuseppe;
Docherty, James R;
Giembycz, Mark A;
Hoyer, Daniel;
Insel, Paul A;
Izzo, Angelo A;
Ji, Yong;
MacEwan, David J;
Sobey, Christopher G;
Wonnacott, Sue;
Ahluwalia, Amrita

Publication type:

Editorial

Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update.

Published in:

2016

By:

Newton, Robert;
Giembycz, Mark A

Publication type:

journal article

Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells.

Published in:

2016

By:

Fernando, Maria R;
Giembycz, Mark A;
McKay, Derek M

Publication type:

journal article

Experimental design and analysis and their reporting: new guidance for publication in BJP.

Published in:

2015

By:

Curtis, Michael J;
Bond, Richard A;
Spina, Domenico;
Ahluwalia, Amrita;
Alexander, Stephen P A;
Giembycz, Mark A;
Gilchrist, Annette;
Hoyer, Daniel;
Insel, Paul A;
Izzo, Angelo A;
Lawrence, Andrew J;
MacEwan, David J;
Moon, Lawrence D F;
Wonnacott, Sue;
Weston, Arthur H;
McGrath, John C

Publication type:

Editorial

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Published in:

2013

By:

Birrell MA;
Maher SA;
Buckley J;
Dale N;
Bonvini S;
Raemdonck K;
Pullen N;
Giembycz MA;
Belvisi MG;
Birrell, Mark A;
Maher, Sarah A;
Buckley, James;
Dale, Nicole;
Bonvini, Sara;
Raemdonck, Kristof;
Pullen, Nick;
Giembycz, Mark A;
Belvisi, Maria G

Publication type:

journal article

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Published in:

British Journal of Pharmacology, 2013, v. 168, n. 1, p. 129, doi. 10.1111/j.1476-5381.2012.02088.x

By:

Birrell, Mark A;
Maher, Sarah A;
Buckley, James;
Dale, Nicole;
Bonvini, Sara;
Raemdonck, Kristof;
PullEN, Nick;
Giembycz, Mark A;
Belvisi, Maria G

Publication type:

Article

Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors.

Published in:

British Journal of Pharmacology, 1998, v. 124, n. 1, p. 129, doi. 10.1038/sj.bjp.0701819

By:

Kelly, John J;
Barnes, Peter J;
Giembycz, Mark A

Publication type:

Article

Prostaglandin E2 suppression of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by interacting with prostanoid receptors of the EP3-subtype.

Published in:

British Journal of Pharmacology, 1998, v. 123, n. 6, p. 1246, doi. 10.1038/sj.bjp.0701720

By:

Spicuzza, Lucia;
Giembycz, Mark A.;
Barnes, Peter J.;
Belvisi, Maria G.

Publication type:

Article

Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor- α generation.

Published in:

British Journal of Pharmacology, 1997, v. 122, n. 1, p. 149, doi. 10.1038/sj.bjp.0701360

By:

Meja, Koremu K.;
Barnes, Peter J.;
Giembycz, Mark A.

Publication type:

Article

Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin.

Published in:

British Journal of Pharmacology, 1997, v. 120, n. 5, p. 735, doi. 10.1038/sj.bjp.0701013

By:

Patel, Hema J;
Giembycz, Mark A;
Spicuzza, Lucia;
Barnes, Peter J;
Belvisi, Maria G

Publication type:

Article

Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone.

Published in:

British Journal of Pharmacology, 1997, v. 120, n. 4, p. 545, doi. 10.1038/sj.bjp.0700998

By:

Saunders, Michael A.;
Mitchell, Jane A.;
Seldon, Paul M.;
Yacoub, Magdi H.;
Barnes, Peter J.;
Giembycz, Mark A.;
Belvisi, Maria G.

Publication type:

Article

Hydrogen Peroxide Reverses IL-5 Afforded Eosinophil Survival and Promotes Constitutive Human Eosinophil Apoptosis.

Published in:

International Archives of Allergy & Immunology, 2002, v. 127, n. 1, p. 73, doi. 10.1159/000048171

By:

Kankaanranta, Hannu;
Giembycz, Mark A.;
Barnes, Peter J.;
Haddad, El-Bdaoui;
Saarelainen, Seppo;
Zhang, Xianzhi;
Moilanen, Eeva;
Lindsay, Mark A.

Publication type:

Article

Dual Transmembrane Signalling Mechanisms in Eosinophils: Evidence for Two Functionally Distinct Receptors for Platelet-Activating Factor.

Published in:

International Archives of Allergy & Immunology, 1992, v. 99, n. 2-4, p. 226, doi. 10.1159/000236253

By:

Kroegel, Claus;
Warner, Jane A.;
Giembycz, Mark A.;
Matthys, Heinrich;
Lichtenstein, Larry M.;
Barnes, Peter J.

Publication type:

Article

A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation.

Published in:

Allergy, Asthma & Clinical Immunology, 2018, v. 14, p. N.PAG, doi. 10.1186/s13223-018-0266-5

By:

George, Tresa;
Chakraborty, Mainak;
Giembycz, Mark A.;
Newton, Robert

Publication type:

Article

First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis.

Published in:

Allergy & Asthma Proceedings, 2007, v. 28, n. 1, p. 79, doi. 10.2500/aap.2007.28.2961

By:

Hasala, Hannele;
Moilanen, Eeva;
Janka-Junttila, Mirkka;
Giembycz, Mark A.;
Kankaanranta, Hannu

Publication type:

Article

An update and appraisal of the cilomilast Phase III clinical development programme for chronic obstructive pulmonary disease.

Published in:

British Journal of Clinical Pharmacology, 2006, v. 62, n. 2, p. 138, doi. 10.1111/j.1365-2125.2006.02640.x

By:

Giembycz, Mark A.

Publication type:

Article

Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands.

Published in:

PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0116773

By:

Rider, Christopher F.;
Shah, Suharsh;
Miller-Larsson, Anna;
Giembycz, Mark A.;
Newton, Robert

Publication type:

Article

Tumour Necrosis Factor-α Regulates Human Eosinophil Apoptosis via Ligation of TNF-Receptor 1 and Balance between NF-κB and AP-1.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090298

By:

Kankaanranta, Hannu;
Ilmarinen, Pinja;
Zhang, Xianzhi;
Adcock, Ian M.;
Lahti, Aleksi;
Barnes, Peter J.;
Giembycz, Mark A.;
Lindsay, Mark A.;
Moilanen, Eeva

Publication type:

Article

Glucocorticoid Repression of Inflammatory Gene Expression Shows Differential Responsiveness by Transactivation- and Transrepression-Dependent Mechanisms.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0053936

By:

King, Elizabeth M.;
Chivers, Joanna E.;
Rider, Christopher F.;
Minnich, Anne;
Giembycz, Mark A.;
Newton, Robert

Publication type:

Article

Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 Inhibitor.

Published in:

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2010, v. 7, n. 2, p. 141, doi. 10.3109/15412551003758304

By:

Gross, Nicholas J.;
Giembycz, Mark A.;
Rennard, Stephen I.

Publication type:

Article

Ketotifen Induces Primary Necrosis of Human Eosinophils.

Published in:

Journal of Ocular Pharmacology & Therapeutics, 2005, v. 21, n. 4, p. 318, doi. 10.1089/jop.2005.21.318

By:

Hasela, Hannele;
Malm-Erjefält, Monika;
Erjefält, Jonas;
Giembycz, Mark A.;
Xianzhi Zhang;
Moilanen, Eeva;
Kankaanranta, Hannu

Publication type:

Article

PHOSPHODIESTERASE INHIBITORS: WILL THEY REPLACE THEOPHYLLINE?

Published in:

Clinical & Experimental Allergy, 1993, v. 23, p. 66, doi. 10.1111/j.1365-2222.1993.tb02967.x

By:

Barnes, Peter J.;
Giembycz, Mark

Publication type:

Article