Works by Gibson, Gary E.

Results: 72

Vitamin B1 (thiamine) and dementia.

Published in:

Annals of the New York Academy of Sciences, 2016, v. 1367, n. 1, p. 21, doi. 10.1111/nyas.13031

By:

Gibson, Gary E.;
Hirsch, Joseph A.;
Fonzetti, Pasquale;
Jordan, Barry D.;
Cirio, Rosanna T.;
Elder, Jessica

Publication type:

Article

Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam).

Published in:

PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0302998

By:

Feldman, Howard H.;
Luchsinger, José A.;
Léger, Gabriel C.;
Taylor, Curtis;
Jacobs, Diane M.;
Salmon, David P.;
Edland, Steven D.;
Messer, Karen;
Revta, Carolyn;
Flowers, Sarah A.;
Jones, Kerry S.;
Koulman, Albert;
Yarasheski, Kevin E.;
Verghese, Philip B.;
Venkatesh, Venky;
Zetterberg, Henrik;
Durant, January;
Lupo, Jody-Lynn;
Gibson, Gary E.

Publication type:

Article

Succinylation Links Metabolism to Protein Functions.

Published in:

Neurochemical Research, 2019, v. 44, n. 10, p. 2346, doi. 10.1007/s11064-019-02780-x

By:

Yang, Yun;
Gibson, Gary E.

Publication type:

Article

Mitochondrial deficits lead to Alzheimer-like changes in calcium homeostasis

Published in:

2010

By:

Gibson, Gary E.;
Chen, Huan-Lian;
Xu, Hui;
Denton, Travis;
Shi, Qingli

Publication type:

Abstract

P1-069: Plaque formation is exacerbated in an animal model of the reduction in energy metabolism that accompanies Alzheimer's disease

Published in:

2008

By:

Gibson, Gary E.;
Karuppagounder, Saravanan S.;
Xu, Hui;
Shi, Qingli;
Chen, Lian-H;
Beal, Flint M.;
Gandy, Sam E.

Publication type:

Abstract

P4-391: Correlations of neurobiologic abnormalities with clinical disabilities in Alzheimer disease (AD)

Published in:

2006

By:

Blass, John P.;
Gibson, Gary E.

Publication type:

Abstract

P3-358: Novel functions of the alpha-Ketoglutarate dehydrogenase complex may mediate oxidant-induced diverse changes in mitochondrial enzymes in Alzheimer’s disease

Published in:

2006

By:

Gibson, Gary E.;
Xu, Hui;
Kleinman, Wayne;
Shi, Qingli

Publication type:

Abstract

P4-391: Correlations of neurobiologic abnormalities with clinical disabilities in Alzheimer disease (AD)

Published in:

2006

By:

Blass, John P.;
Gibson, Gary E.

Publication type:

Abstract

P3-358: Novel functions of the alpha-Ketoglutarate dehydrogenase complex may mediate oxidant-induced diverse changes in mitochondrial enzymes in Alzheimer’s disease

Published in:

2006

By:

Gibson, Gary E.;
Xu, Hui;
Kleinman, Wayne;
Shi, Qingli

Publication type:

Abstract

Inhibition of α-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

Published in:

Journal of Neuroscience Research, 2003, v. 74, n. 2, p. 309, doi. 10.1002/jnr.10756

By:

Hsueh-Meei Huang;
Hsiu-Chong Ou;
Hui Xu;
Huan-Lian Chen;
Corinne Fowler;
Gary E. Gibson

Publication type:

Article

Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications.

Published in:

Annals of Neurology, 2005, v. 57, n. 5, p. 695

By:

Parvesh Bubber;
Vahram Haroutunian;
Gene Fisch;
John P. Blass;
Gary E. Gibson

Publication type:

Article

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Published in:

2001

By:

Andreassen, Ole A.;
Ferrante, Robert J.;
Huang, Hsueh-Meei;
Dedeoglu, Alpaslan;
Park, Larry;
Ferrante, Kimberly L.;
Kwon, Jennifer;
Borchelt, David R.;
Ross, Christopher A.;
Gibson, Gary E.;
Beal, M. Flint;
Andreassen, O A;
Ferrante, R J;
Huang, H M;
Dedeoglu, A;
Park, L;
Ferrante, K L;
Kwon, J;
Borchelt, D R;
Ross, C A

Publication type:

journal article

Obituary: In Memory of Myron Flint Beal, MD, November 6, 1950-June 12, 2021.

Published in:

2021

By:

Tapias, Victor;
Gibson, Gary E.;
Iadecola, Costantino

Publication type:

journal article

Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington’s Disease Patients.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0160384

By:

Naseri, Nima N.;
Bonica, Joseph;
Xu, Hui;
Park, Larry C.;
Arjomand, Jamshid;
Chen, Zhengming;
Gibson, Gary E.

Publication type:

Article

Improvement of 8-arm maze performance in aged fischer 344 rats with 3,4-diaminopyridine.

Published in:

Experimental Aging Research, 1983, v. 9, n. 3, p. 211, doi. 10.1080/03610738308258454

By:

Davis, Hasker P.;
Idowu, Augusta;
Gibson, Gary E.

Publication type:

Article

Disturbances of the Blood-Brain Barrier without Expression of Amyloid Precursor Protein- Containing Neuritic Clusters or Neuronal Loss during Late Stages of Thiamine Deficiency in Guinea Pigs.

Published in:

Developmental Neuroscience, 1998, v. 20, n. 4/5, p. 454, doi. 10.1159/000017343

By:

Calingasan, Noel Y.;
Park, Larry C.H.;
Gandy, Samuel E.;
Gibson, Gary E.

Publication type:

Article

Mild metabolic perturbations alter succinylation of mitochondrial proteins.

Published in:

Journal of Neuroscience Research, 2017, v. 95, n. 11, p. 2244, doi. 10.1002/jnr.24103

By:

Chen, Huanlian;
Xu, Hui;
Potash, Samuel;
Starkov, Anatoly;
Belousov, Vsevolod V.;
Bilan, Dmitry S.;
Denton, Travis T.;
Gibson, Gary E.

Publication type:

Article

Brain [U-<sup>13</sup>C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.

Published in:

Journal of Neuroscience Research, 2011, v. 89, n. 12, p. 1997, doi. 10.1002/jnr.22606

By:

Nilsen, Linn Hege;
Shi, Qingli;
Gibson, Gary E.;
Sonnewald, Ursula

Publication type:

Article

Inhibitors of the α‐ketoglutarate dehydrogenase complex alter [1‐13C]glucose and [U‐13C]glutamate metabolism in cerebellar granule neurons.

Published in:

Journal of Neuroscience Research, 2006, v. 83, n. 3, p. 450, doi. 10.1002/jnr.20749

By:

Sónia Sá Santos;
Gary E. Gibson;
Arthur J.L. Cooper;
Travis T. Denton;
Charles M. Thompson;
Victoria I. Bunik;
Paula M. Alves;
Ursula Sonnewald

Publication type:

Article

Cerebrometabolic Aspects of Delirium in Relationship to Dementia.

Published in:

Dementia & Geriatric Cognitive Disorders, 1999, v. 10, n. 5, p. 335, doi. 10.1159/000017165

By:

Blass, John P.;
Gibson, Gary E.

Publication type:

Article

Distribution of the α-ketoglutarate dehydrogenase complex in rat brain.

Published in:

Journal of Comparative Neurology, 1994, v. 346, n. 3, p. 461, doi. 10.1002/cne.903460309

By:

Calingasan, Noel Y.;
Baker, Harriet;
Sheu, Kwan-Fu Rex;
Gibson, Gary E.

Publication type:

Article

Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 903, n. 1, p. 204, doi. 10.1111/j.1749-6632.2000.tb06370.x

By:

BLASS, JOHN P.;
SHEU, REX KWAN-FU;
GIBSON, GARY E.

Publication type:

Article

Vascular Endothelium Is a Site of Free Radical Production and Inflammation in Areas of Neuronal Loss in Thiamine-deficient Brain.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 903, n. 1, p. 353, doi. 10.1111/j.1749-6632.2000.tb06386.x

By:

CALINGASAN, NOEL Y.;
GIBSON, GARY E.

Publication type:

Article

Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains, Cultured Cells, and an Animal Model of Chronic Oxidative Deficits.

Published in:

Annals of the New York Academy of Sciences, 1999, v. 893, n. 1, p. 79, doi. 10.1111/j.1749-6632.1999.tb07819.x

By:

GIBSON, GARY E.;
PARK, LARRY C. H.;
ZHANG, HUI;
SORBI, SANDRO;
CALINGASAN, NOEL Y.

Publication type:

Article

Molecular Mechanisms of Memory and the Pathophysiology of Alzheimer's Disease.

Published in:

Annals of the New York Academy of Sciences, 1994, v. 747, n. 1, p. 245, doi. 10.1111/j.1749-6632.1994.tb44413.x

By:

ETCHEBERRIGARAY, RENÉ;
GIBSON, GARY E.;
ALKON, DANIEL L.

Publication type:

Article

The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12403, doi. 10.3390/ijms232012403

By:

Hansen, Grace E.;
Gibson, Gary E.

Publication type:

Article

Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer's Disease.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13188, doi. 10.3390/ijms222413188

By:

Bhawal, Ruchika;
Fu, Qin;
Anderson, Elizabeth T.;
Gibson, Gary E.;
Zhang, Sheng

Publication type:

Article

Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease.

Published in:

Annals of the New York Academy of Sciences, 2008, v. 1147, p. 221, doi. 10.1196/annals.1427.038

By:

Gibson, Gary E.;
Karuppagounder, Saravanan S.;
Shi, Qingli

Publication type:

Article

Preface.

Published in:

Annals of the New York Academy of Sciences, 2008, v. 1147, p. xi, doi. 10.1196/annals.1427.039

By:

Gibson, Gary E.;
Ratan, Rajiv R.;
Beal, M. Flint

Publication type:

Article

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments.

Published in:

Journal of Alzheimer's Disease, 2010, v. 20, p. 591, doi. 10.3233/JAD-2010-100336

By:

Gibson, Gary E.;
Qingli Shi

Publication type:

Article

A mitocentric view of Alzheimer's disease suggests multi-faceted treatments.

Published in:

2010

By:

Gibson GE;
Shi Q;
Gibson, Gary E;
Shi, Qingli

Publication type:

journal article

Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans.

Published in:

Journal of Alzheimer's Disease, 2006, v. 9, n. 2, p. 207, doi. 10.3233/JAD-2006-9212

By:

Blass, John P.;
Gibson, Gary E.

Publication type:

Article

The role of the metabolic lesion in Alzheimer's disease.

Published in:

2002

By:

Blass, John P.;
Gibson, Gary E.;
Hoyer, Siegfried

Publication type:

journal article

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.

Published in:

Journal of Neurochemistry, 2021, v. 158, n. 2, p. 282, doi. 10.1111/jnc.15377

By:

Lidan Sun;
Bhawal, Ruchika;
Hui Xu;
Huanlian Chen;
Anderson, Elizabeth T.;
Haroutunian, Vahrum;
Cross, Abigail C.;
Sheng Zhang;
Gibson, Gary E.

Publication type:

Article

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.

Published in:

Journal of Neurochemistry, 2021, v. 158, n. 1, p. 282, doi. 10.1111/jnc.15377

By:

Sun, Lidan;
Bhawal, Ruchika;
Xu, Hui;
Chen, Huanlian;
Anderson, Elizabeth T.;
Haroutunian, Vahrum;
Cross, Abigail C.;
Zhang, Sheng;
Gibson, Gary E.

Publication type:

Article

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human‐induced pluripotent stem cells, neural stem cells, and neurons.

Published in:

Journal of Neurochemistry, 2021, v. 156, n. 6, p. 867, doi. 10.1111/jnc.15160

By:

Chen, Huanlian;
Cross, Abigail C.;
Thakkar, Ankita;
Xu, Hui;
Li, Aiqun;
Paull, Dan;
Noggle, Scott A.;
Kruger, Laken;
Denton, Travis T.;
Gibson, Gary E.

Publication type:

Article

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease -- beneficial or detrimental?

Published in:

Journal of Neurochemistry, 2016, v. 139, n. 5, p. 823, doi. 10.1111/jnc.13836

By:

Chen, Huanlian;
Denton, Travis T.;
Xu, Hui;
Calingasan, Noel;
Beal, M. Flint;
Gibson, Gary E.

Publication type:

Article

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

Published in:

Journal of Neurochemistry, 2015, v. 134, n. 1, p. 86, doi. 10.1111/jnc.13096

By:

Gibson, Gary E.;
Xu, Hui;
Chen, Huan‐Lian;
Chen, Wei;
Denton, Travis T.;
Zhang, Sheng

Publication type:

Article

Dopamine, Acetylcholine, and Glutamate Interactions in Aging Behavioral and Neurochemical Correlates.

Published in:

Annals of the New York Academy of Sciences, 1987, v. 515, n. 1, p. 191, doi. 10.1111/j.1749-6632.1988.tb32984.x

By:

FREEMAN, GARY B.;
GIBSON, GARY E.

Publication type:

Article

A Seamless Phase 2A‐Phase 2B Multi‐Center Trial to Test the Benefits of Benfotiamine on the Progression of Alzheimer's Disease‐Benfoteam: Design and Methods.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S6, p. 1, doi. 10.1002/alz.091963

By:

Luchsinger, Jose A.;
Feldman, Howard H.;
Messer, Karen;
Edland, Steven D.;
Leger, Gabriel C;
Jacobs, Diane M.;
Salmon, David P.;
Revta, Carolyn;
Lupo, Jody‐Lynn;
Durant, January;
Gibson, Gary E.

Publication type:

Article

Pharmacological thiamine (Vitamin B1) as a treatment for alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S6, p. 1, doi. 10.1002/alz.086468

By:

Gibson, Gary E.;
Flowers, Sarah A;
Feldman, Howard H.;
Luchsinger, Jose A;
Zhang, Sheng

Publication type:

Article

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 3, p. 1041, doi. 10.1002/alz.12845

By:

Yassine, Hussein N.;
Self, Wade;
Kerman, Bilal E.;
Santoni, Giulia;
Navalpur Shanmugam, NandaKumar;
Abdullah, Laila;
Golden, Lesley R.;
Fonteh, Alfred N.;
Harrington, Michael G.;
Gräff, Johannes;
Gibson, Gary E.;
Kalaria, Raj;
Luchsinger, Jose A.;
Feldman, Howard H.;
Swerdlow, Russell H.;
Johnson, Lance A.;
Albensi, Benedict C.;
Zlokovic, Berislav V.;
Tanzi, Rudolph;
Cunnane, Stephen

Publication type:

Article

GLUCOSE METABOLISM AS A THERAPEUTIC TARGET IN ALZHEIMER’S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P611, doi. 10.1016/j.jalz.2017.06.667

By:

Gibson, Gary E.;
Elder, Jessica;
Cirio, Rosanna;
Fonzetti, Pasquale;
Hirsch, Joseph;
Jordan, Barry

Publication type:

Article

Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia.

Published in:

Journal of Neurochemistry, 1999, v. 72, n. 5, p. 1948, doi. 10.1046/j.1471-4159.1999.0721948.x

By:

Park, Larry C. H.;
Zhang, Hui;
Sheu, Kwan-Fu Rex;
Calingasan, Noel Y.;
Kristal, Bruce S.;
Lindsay, J. Gordon;
Gibson, Gary E.

Publication type:

Article

Protein-Bound Acrolein.

Published in:

Journal of Neurochemistry, 1999, v. 72, n. 2, p. 751, doi. 10.1046/j.1471-4159.1999.0720751.x

By:

Calingasan, Noel Y;
Uchida, Koji;
Gibson, Gary E

Publication type:

Article

Immunochemical Characterization of the Deficiency of the α-Ketoglutarate Dehydrogenase Complex in Thiamine-Deficient Rat Brain.

Published in:

Journal of Neurochemistry, 1998, v. 70, n. 3, p. 1143, doi. 10.1046/j.1471-4159.1998.70031143.x

By:

Sheu, Kwan-Fu Rex;
Calingasan, Noel Y.;
Lindsay, J. Gordon;
Gibson, Gary E.

Publication type:

Article

Regional Reductions of Transketolase in Thiamine-Deficient Rat Brain.

Published in:

Journal of Neurochemistry, 1996, v. 67, n. 2, p. 684, doi. 10.1046/j.1471-4159.1996.67020684.x

By:

Sheu, Kwan-Fu Rex;
Calingasan, Noel Y.;
Dienel, Gerald A.;
Baker, Harriet;
Jung, Eun-Hee;
Kim, Kwang-Soo;
Paoletti, Francesco;
Gibson, Gary E.

Publication type:

Article

Heterogeneous Expression of Transketolase in Rat Brain.

Published in:

Journal of Neurochemistry, 1995, v. 64, n. 3, p. 1034, doi. 10.1046/j.1471-4159.1995.64031034.x

By:

Calingasan, Noel Y.;
Sheu, Kwan-Fu Rex;
Baker, Harriet;
Jung, Eun-Hee;
Paoletti, Francesco;
Gibson, Gary E.

Publication type:

Article

Phosphatidylinositol Metabolism During In Vitro Hypoxia.

Published in:

Journal of Neurochemistry, 1989, v. 52, n. 3, p. 830, doi. 10.1111/j.1471-4159.1989.tb02528.x

By:

Huang, Hsueh-Meei;
Gibson, Gary E.

Publication type:

Article

Effect of Decreased Oxygen on In Vitro Release of Endogenous 3,4-Dihydroxyphenylethylamine from Mouse Striatum.

Published in:

Journal of Neurochemistry, 1986, v. 47, n. 6, p. 1924, doi. 10.1111/j.1471-4159.1986.tb13109.x

By:

Freeman, Gary B.;
Gibson, Gary E.

Publication type:

Article