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Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise.
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- Annals of the New York Academy of Sciences, 2000, v. 903, n. 1, p. 204, doi. 10.1111/j.1749-6632.2000.tb06370.x
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- Article
Vascular Endothelium Is a Site of Free Radical Production and Inflammation in Areas of Neuronal Loss in Thiamine-deficient Brain.
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- Annals of the New York Academy of Sciences, 2000, v. 903, n. 1, p. 353, doi. 10.1111/j.1749-6632.2000.tb06386.x
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- Article
Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains, Cultured Cells, and an Animal Model of Chronic Oxidative Deficits.
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- Annals of the New York Academy of Sciences, 1999, v. 893, n. 1, p. 79, doi. 10.1111/j.1749-6632.1999.tb07819.x
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- Article
Molecular Mechanisms of Memory and the Pathophysiology of Alzheimer's Disease.
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- Annals of the New York Academy of Sciences, 1994, v. 747, n. 1, p. 245, doi. 10.1111/j.1749-6632.1994.tb44413.x
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- Article
A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments.
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- Journal of Alzheimer's Disease, 2010, v. 20, p. 591, doi. 10.3233/JAD-2010-100336
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- Article
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments.
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- 2010
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- Publication type:
- journal article
Disturbances of the Blood-Brain Barrier without Expression of Amyloid Precursor Protein- Containing Neuritic Clusters or Neuronal Loss during Late Stages of Thiamine Deficiency in Guinea Pigs.
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- Developmental Neuroscience, 1998, v. 20, n. 4/5, p. 454, doi. 10.1159/000017343
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- Article
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
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- FASEB Journal, 2013, v. 27, n. 6, p. 2392, doi. 10.1096/fj.12-220202
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- Publication type:
- Article
Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.
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- Journal of Neurochemistry, 2015, v. 134, n. 1, p. 86, doi. 10.1111/jnc.13096
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- Publication type:
- Article
Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a.
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- Journal of Neurochemistry, 2011, v. 118, n. 3, p. 440, doi. 10.1111/j.1471-4159.2011.07333.x
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- Article
Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis.
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- Journal of Neurochemistry, 2009, v. 109, p. 214, doi. 10.1111/j.1471-4159.2009.05955.x
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- Publication type:
- Article
Inhibition of theα-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine.
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- Journal of Neurochemistry, 2005, v. 92, n. 2, p. 302, doi. 10.1111/j.1471-4159.2004.02868.x
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- Publication type:
- Article
Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease.
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- Annals of the New York Academy of Sciences, 2008, v. 1147, p. 221, doi. 10.1196/annals.1427.038
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- Publication type:
- Article
Preface.
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- Annals of the New York Academy of Sciences, 2008, v. 1147, p. xi, doi. 10.1196/annals.1427.039
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- Publication type:
- Article
Mild metabolic perturbations alter succinylation of mitochondrial proteins.
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- Journal of Neuroscience Research, 2017, v. 95, n. 11, p. 2244, doi. 10.1002/jnr.24103
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- Publication type:
- Article
Brain [U-<sup>13</sup>C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.
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- Journal of Neuroscience Research, 2011, v. 89, n. 12, p. 1997, doi. 10.1002/jnr.22606
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- Publication type:
- Article
Inhibitors of the α‐ketoglutarate dehydrogenase complex alter [1‐13C]glucose and [U‐13C]glutamate metabolism in cerebellar granule neurons.
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- Journal of Neuroscience Research, 2006, v. 83, n. 3, p. 450, doi. 10.1002/jnr.20749
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- Publication type:
- Article
Inhibition of α-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.
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- Journal of Neuroscience Research, 2003, v. 74, n. 2, p. 309, doi. 10.1002/jnr.10756
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- Publication type:
- Article
The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12403, doi. 10.3390/ijms232012403
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- Publication type:
- Article
Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer's Disease.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13188, doi. 10.3390/ijms222413188
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- Publication type:
- Article
Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam).
- Published in:
- PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0302998
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- Publication type:
- Article
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
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- Journal of Neurochemistry, 2004, v. 88, n. 6, p. 1352, doi. 10.1046/j.1471-4159.2003.02263.x
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- Article
Frontal Lobe Dysfunction in Progressive Supranuclear Palsy.
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- Journal of Neurochemistry, 2000, v. 74, n. 2, p. 878, doi. 10.1046/j.1471-4159.2000.740878.x
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- Publication type:
- Article
Metabolic Impairment Elicits Brain Cell Type-Selective Changes in Oxidative Stress and Cell Death in Culture.
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- Journal of Neurochemistry, 2000, v. 74, n. 1, p. 114, doi. 10.1046/j.1471-4159.2000.0740114.x
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- Publication type:
- Article
Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia.
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- Journal of Neurochemistry, 1999, v. 72, n. 5, p. 1948, doi. 10.1046/j.1471-4159.1999.0721948.x
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- Article
Protein-Bound Acrolein.
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- Journal of Neurochemistry, 1999, v. 72, n. 2, p. 751, doi. 10.1046/j.1471-4159.1999.0720751.x
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- Publication type:
- Article
Immunochemical Characterization of the Deficiency of the α-Ketoglutarate Dehydrogenase Complex in Thiamine-Deficient Rat Brain.
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- Journal of Neurochemistry, 1998, v. 70, n. 3, p. 1143, doi. 10.1046/j.1471-4159.1998.70031143.x
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- Article
Regional Reductions of Transketolase in Thiamine-Deficient Rat Brain.
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- Journal of Neurochemistry, 1996, v. 67, n. 2, p. 684, doi. 10.1046/j.1471-4159.1996.67020684.x
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- Publication type:
- Article
Heterogeneous Expression of Transketolase in Rat Brain.
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- Journal of Neurochemistry, 1995, v. 64, n. 3, p. 1034, doi. 10.1046/j.1471-4159.1995.64031034.x
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- Publication type:
- Article
Phosphatidylinositol Metabolism During In Vitro Hypoxia.
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- Journal of Neurochemistry, 1989, v. 52, n. 3, p. 830, doi. 10.1111/j.1471-4159.1989.tb02528.x
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- Publication type:
- Article
Effect of Decreased Oxygen on In Vitro Release of Endogenous 3,4-Dihydroxyphenylethylamine from Mouse Striatum.
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- Journal of Neurochemistry, 1986, v. 47, n. 6, p. 1924, doi. 10.1111/j.1471-4159.1986.tb13109.x
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- Article
Monoamine Neurotransmitter Metabolism and Locomotor Activity During Chemical Hypoxia.
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- Journal of Neurochemistry, 1986, v. 46, n. 3, p. 733, doi. 10.1111/j.1471-4159.1986.tb13033.x
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- Publication type:
- Article
Subsynaptosomal Calcium Distribution During Hypoxia and 3,4-Diaminopyridine Treatment.
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- Journal of Neurochemistry, 1985, v. 45, n. 6, p. 1779, doi. 10.1111/j.1471-4159.1985.tb10534.x
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- Publication type:
- Article
Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects.
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- Neuropsychiatric Disease & Treatment, 2015, v. 11, p. 565, doi. 10.2147/NDT.S74898
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- Publication type:
- Article
Succinylation Links Metabolism to Protein Functions.
- Published in:
- Neurochemical Research, 2019, v. 44, n. 10, p. 2346, doi. 10.1007/s11064-019-02780-x
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- Publication type:
- Article
GLUCOSE METABOLISM AS A THERAPEUTIC TARGET IN ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P611, doi. 10.1016/j.jalz.2017.06.667
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- Publication type:
- Article
Mitochondrial deficits lead to Alzheimer-like changes in calcium homeostasis
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- 2010
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- Abstract
P1-069: Plaque formation is exacerbated in an animal model of the reduction in energy metabolism that accompanies Alzheimer's disease
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- 2008
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- Publication type:
- Abstract
P4-391: Correlations of neurobiologic abnormalities with clinical disabilities in Alzheimer disease (AD)
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- 2006
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- Publication type:
- Abstract
P3-358: Novel functions of the alpha-Ketoglutarate dehydrogenase complex may mediate oxidant-induced diverse changes in mitochondrial enzymes in Alzheimer’s disease
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-391: Correlations of neurobiologic abnormalities with clinical disabilities in Alzheimer disease (AD)
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-358: Novel functions of the alpha-Ketoglutarate dehydrogenase complex may mediate oxidant-induced diverse changes in mitochondrial enzymes in Alzheimer’s disease
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Synaptosomal Calcium Metabolism During Hypoxia and 3,4-Diaminopyridine Treatment.
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- Journal of Neurochemistry, 1984, v. 42, n. 1, p. 248, doi. 10.1111/j.1471-4159.1984.tb09725.x
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- Publication type:
- Article
Studies on the Pyruvate Dehydrogenase Complex in Brain with the Arylamine Acetyltransferase-Coupled Assay.
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- Journal of Neurochemistry, 1982, v. 38, n. 6, p. 1627, doi. 10.1111/j.1471-4159.1982.tb06643.x
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- Publication type:
- Article
Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine.
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- Journal of Neurochemistry, 1981, v. 37, n. 4, p. 978, doi. 10.1111/j.1471-4159.1981.tb04484.x
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- Publication type:
- Article
Oxygen Dependence of Glucose and Acetylcholine Metabolism in Slices and Synaptosomes from Rat Brain.
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- Journal of Neurochemistry, 1981, v. 37, n. 2, p. 305, doi. 10.1111/j.1471-4159.1981.tb00456.x
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- Publication type:
- Article
Acetylcholine Synthesis and CO<sub>2</sub> Production from Variously Labeled Glucose in Rat Brain Slices and Synaptosomes.
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- Journal of Neurochemistry, 1981, v. 37, n. 1, p. 88, doi. 10.1111/j.1471-4159.1981.tb05294.x
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- Publication type:
- Article
Decreases in Amino Acid and Acetylcholine Metabolism During Hypoxia.
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- Journal of Neurochemistry, 1981, v. 37, n. 1, p. 192, doi. 10.1111/j.1471-4159.1981.tb05308.x
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- Publication type:
- Article
Impaired Synthesis of Acetylcholine by Mild Hypoxic Hypoxia or Nitrous Oxide.
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- Journal of Neurochemistry, 1981, v. 36, n. 1, p. 28, doi. 10.1111/j.1471-4159.1981.tb02373.x
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- Publication type:
- Article
ALTERATIONS IN ACETYLCHOLINE SYNTHESIS AND CYCLIC NUCLEOTIDES IN MILD CEREBRAL HYPOXIA.
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- Journal of Neurochemistry, 1978, v. 31, n. 4, p. 757, doi. 10.1111/j.1471-4159.1978.tb00107.x
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- Publication type:
- Article