Works by Giacca, Adria

Results: 76

Nanotechnology-Enabled Closed Loop Insulin Delivery Device: In Vitro and In Vivo Evaluation of Glucose-Regulated Insulin Release for Diabetes Control.

Published in:

Advanced Functional Materials, 2011, v. 21, n. 1, p. 73, doi. 10.1002/adfm.201001762

By:

Gordijo, Claudia R.;
Koulajian, Khajag;
Shuhendler, Adam J.;
Bonifacio, Leonardo D.;
Huang, Hui Yu;
Chiang, Simon;
Ozin, Geoffrey A.;
Giacca, Adria;
Wu, Xiao Yu

Publication type:

Article

Evaluation of the specific effects of intranasal glucagon on glucose production and lipid concentration in healthy men during a pancreatic clamp.

Published in:

Diabetes, Obesity & Metabolism, 2018, v. 20, n. 2, p. 328, doi. 10.1111/dom.13069

By:

Dash, Satya;
Xiao, Changting;
Stahel, Priska;
Koulajian, Khajag;
Giacca, Adria;
Lewis, Gary F.

Publication type:

Article

Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58278-4

By:

GhavamiNejad, Amin;
Liu, Jackie Fule;
Mirzaie, Sako;
Lu, Brian;
Samarikhalaj, Melisa;
Giacca, Adria;
Wu, Xiao Yu

Publication type:

Article

Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58278-4

By:

GhavamiNejad, Amin;
Liu, Jackie Fule;
Mirzaie, Sako;
Lu, Brian;
Samarikhalaj, Melisa;
Giacca, Adria;
Wu, Xiao Yu

Publication type:

Article

β-Cell Insulin Resistance Plays a Causal Role in Fat-Induced β-Cell Dysfunction In Vitro and In Vivo.

Published in:

Endocrinology, 2024, v. 165, n. 5, p. 1, doi. 10.1210/endocr/bqae044

By:

Ivovic, Aleksandar;
Yung, Justin Hou Ming;
Oprescu, Andrei I;
Vlavcheski, Filip;
Mori, Yusaku;
Rahman, S M Niazur;
Ye, Wenyue;
Eversley, Judith A;
Wheeler, Michael B;
Woo, Minna;
Tsiani, Evangelia;
Giacca, Adria

Publication type:

Article

β-Cell Stress Pathways in Diabetes: Potential Targets for Therapy?

Published in:

Endocrinology, 2023, v. 164, n. 2, p. 1, doi. 10.1210/endocr/bqac211

By:

Rahman, S M Niazur;
Giacca, Adria

Publication type:

Article

NOD1: An Interface Between Innate Immunity and Insulin Resistance.

Published in:

Endocrinology, 2019, v. 160, n. 5, p. 1021, doi. 10.1210/en.2018-01061

By:

Rivers, Sydney L;
Klip, Amira;
Giacca, Adria

Publication type:

Article

Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ.

Published in:

Endocrinology, 2018, v. 159, n. 4, p. 1658, doi. 10.1210/en.2017-00312

By:

Lu, Huogen;
Bogdanovic, Elena;
Yu, Zhiwen;
Cho, Charles;
Liu, Lijiang;
Ho, Karen;
Guo, June;
Yeung, Lucy S N;
Lehmann, Reiner;
Hundal, Harinder S;
Giacca, Adria;
Fantus, I George

Publication type:

Article

A monolithic polymeric microdevice for pH-responsive drug delivery.

Published in:

Biomedical Microdevices, 2009, v. 11, n. 6, p. 1251, doi. 10.1007/s10544-009-9344-2

By:

Chen, Jian;
Chu, Michael;
Koulajian, Khajag;
Wu, Xiao;
Giacca, Adria;
Sun, Yu

Publication type:

Article

Cell-Specific Effects of Insulin in a Murine Model of Restenosis Under Insulin-Sensitive and Insulin-Resistant Conditions.

Published in:

Cells (2073-4409), 2024, v. 13, n. 16, p. 1387, doi. 10.3390/cells13161387

By:

Gonzalez Medina, Marel;
Liu, Zhiwei;
Wang, Johny;
Zhang, Cindy;
Cash, Sarah B.;
Cummins, Carolyn L.;
Giacca, Adria

Publication type:

Article

Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate.

Published in:

Cells (2073-4409), 2022, v. 11, n. 3, p. 545, doi. 10.3390/cells11030545

By:

Yung, Justin Hou Ming;
Yeung, Lucy Shu Nga;
Ivovic, Aleksandar;
Tan, Yao Fang;
Jentz, Emelien Mariella;
Batchuluun, Battsetseg;
Gohil, Himaben;
Wheeler, Michael B.;
Joseph, Jamie W.;
Giacca, Adria;
Mamelak, Mortimer

Publication type:

Article

Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 167, doi. 10.3390/cells11010167

By:

Den Hartogh, Danja J.;
Vlavcheski, Filip;
Giacca, Adria;
MacPherson, Rebecca E. K.;
Tsiani, Evangelia

Publication type:

Article

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes.

Published in:

Cells (2073-4409), 2020, v. 9, n. 3, p. 706, doi. 10.3390/cells9030706

By:

Yung, Justin Hou Ming;
Giacca, Adria

Publication type:

Article

Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men.

Published in:

Journal of Diabetes Investigation, 2020, v. 11, n. 4, p. 874, doi. 10.1111/jdi.13227

By:

Kaga, Hideyoshi;
Tamura, Yoshifumi;
Takeno, Kageumi;
Kakehi, Saori;
Someya, Yuki;
Funayama, Takashi;
Furukawa, Yasuhiko;
Suzuki, Ruriko;
Sugimoto, Daisuke;
Kadowaki, Satoshi;
Nishitani‐Yokoyama, Miho;
Shimada, Kazunori;
Daida, Hiroyuki;
Aoki, Shigeki;
Giacca, Adria;
Sato, Hiroaki;
Kawamori, Ryuzo;
Watada, Hirotaka

Publication type:

Article

Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.

Published in:

Nutrition & Cancer, 2016, v. 68, n. 1, p. 94, doi. 10.1080/01635581.2016.1115098

By:

Yang, Kai;
Fard, Sara;
Furrer, Rudolf;
Archer, Michael C.;
Bruce, W. Robert;
Lip, HoYin;
Mehta, Rhea;
O'Brien, Peter J.;
Giacca, Adria;
Ward, Wendy E.;
Femia, A. Pietro;
Caderni, Giovanna;
Medline, Alan;
Banks, Kate

Publication type:

Article

Mechanisms Linking Diet and Colorectal Cancer: The Possible Role of Insulin Resistance.

Published in:

Nutrition & Cancer, 2000, v. 37, n. 1, p. 19, doi. 10.1207/S15327914NC3701_2

By:

Bruce, W. Robert;
Wolever, Thomas M. S.;
Giacca, Adria

Publication type:

Article

Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men.

Published in:

Journal of the Endocrine Society, 2019, v. 3, n. 10, p. 1847, doi. 10.1210/js.2019-00167

By:

Kaga, Hideyoshi;
Tamura, Yoshifumi;
Takeno, Kageumi;
Kakehi, Saori;
Someya, Yuki;
Funayama, Takashi;
Furukawa, Yasuhiko;
Suzuki, Ruriko;
Sugimoto, Daisuke;
Kadowaki, Satoshi;
Nishitani-Yokoyama, Miho;
Shimada, Kazunori;
Daida, Hiroyuki;
Aoki, Shigeki;
Giacca, Adria;
Kanazawa, Akio;
Kawamori, Ryuzo;
Watada, Hirotaka

Publication type:

Article

ANTIPSYCHOTIC DRUGS IMPAIR BRAIN GLUCOSE SENSING RESULTING IN WHOLE BODY INSULIN RESISTANCE.

Published in:

Schizophrenia Bulletin, 2020, v. 46, p. S21, doi. 10.1093/schbul/sbaa028.049

By:

Castellani, Laura;
Kowalchuk, Chantel;
Asgariroozbehani, Roshanak;
Tran, Veronica;
BrettÂ McIntyre, William;
Hamel, Laurie;
Remington, Gary;
Giacca, Adria;
Hahn, Margaret

Publication type:

Article

Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK.

Published in:

Journal of Vascular Research, 2020, v. 57, n. 6, p. 325, doi. 10.1159/000509217

By:

Guo, June;
Pereira, Troy J.;
Mori, Yusaku;
Gonzalez Medina, Marel;
Breen, Danna M.;
Dalvi, Prasad S.;
Zhang, Hangjun;
McCole, Declan F.;
McBurney, Michael W.;
Heximer, Scott P.;
Tsiani, Evangelia L.;
Dolinsky, Vernon W.;
Giacca, Adria

Publication type:

Article

In vivo Effect of Insulin to Decrease Matrix Metalloproteinase-2 and -9 Activity after Arterial Injury.

Published in:

Journal of Vascular Research, 2013, v. 50, n. 4, p. 279, doi. 10.1159/000351611

By:

Guo, June;
Dhaliwall, Jiwanjeet K.;
Chan, Kalam K.;
Ghanim, Husam;
al Koudsi, Nael;
Lam, Loretta;
Madadi, Golnaz;
Dandona, Paresh;
Giacca, adria;
Bendeck, Michelle P.

Publication type:

Article

Insulin Inhibits and Oral Sucrose Increases Neointimal Growth after Arterial Injury in Rats.

Published in:

Journal of Vascular Research, 2010, v. 47, n. 5, p. 412, doi. 10.1159/000281581

By:

Breen, Danna M.;
Dhaliwall, Jiwanjeet K.;
Chan, Kalam K.;
Guo, June;
Lam, Loretta;
Bendeck, Michelle P.;
Giacca, Adria

Publication type:

Article

Anti-Atherogenic Effect of Insulin in vivo.

Published in:

Journal of Vascular Research, 2005, v. 42, n. 6, p. 455, doi. 10.1159/000088099

By:

Kim, Tony;
Chan, Kalam K.;
Dhaliwall, Jiwanjeet K.;
Huynh, Nghia;
Suen, Renee;
Uchino, Hiroshi;
Naigamwalla, Dinaz;
Bendeck, Michelle P.;
Giacca, Adria

Publication type:

Article

Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13224, doi. 10.3390/ijms222413224

By:

Nahle, Ashraf;
Joseph, Yemisi Deborah;
Pereira, Sandra;
Mori, Yusaku;
Poon, Frankie;
Ghadieh, Hilda E.;
Ivovic, Aleksandar;
Desai, Tejas;
Ghanem, Simona S.;
Asalla, Suman;
Muturi, Harrison T.;
Jentz, Emelien M.;
Joseph, Jamie W.;
Najjar, Sonia M.;
Giacca, Adria

Publication type:

Article

Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 14, p. 4900, doi. 10.3390/ijms21144900

By:

Den Hartogh, Danja J.;
Vlavcheski, Filip;
Giacca, Adria;
Tsiani, Evangelia

Publication type:

Article

Counterregulatory Response to Hypoglycemia Differs According to the Insulin Delivery Route, But Does Not Affect Glucose Production in Normal Humans.

Published in:

Journal of Clinical Endocrinology & Metabolism, 1999, v. 84, n. 3, p. 1037, doi. 10.1210/jcem.84.3.5539

By:

LEWIS, GARY F.;
CARPENTIER, ANDRÉ;
BILINSKI, DEBRA;
GIACCA, ADRIA;
VRANIC, MLADEN

Publication type:

Article

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m<sup>2</sup>.

Published in:

2016

By:

Takeno, Kageumi;
Tamura, Yoshifumi;
Kawaguchi, Minako;
Kakehi, Saori;
Watanabe, Takahiro;
Funayama, Takashi;
Furukawa, Yasuhiko;
Kaga, Hideyoshi;
Yamamoto, Risako;
Kim, Maengkyu;
Nishitani-Yokoyama, Miho;
Shimada, Kazunori;
Daida, Hiroyuki;
Aoki, Shigeki;
Taka, Hikari;
Fujimura, Tsutomu;
Sawada, Susumu S;
Giacca, Adria;
Kanazawa, Akio;
Fujitani, Yoshio

Publication type:

journal article

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes.

Published in:

2016

By:

Johnston, Luke W;
Harris, Stewart B;
Retnakaran, Ravi;
Zinman, Bernard;
Giacca, Adria;
Liu, Zhen;
Bazinet, Richard P;
Hanley, Anthony J

Publication type:

journal article

Plasma Nonesterified Fatty Acid Intolerance and Hyperglycemia Are Associated with Intravenous Lipid-Induced Impairment of Insulin Sensitivity and Disposition Index.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 3, p. 1256, doi. 10.1210/jc.2009-1932

By:

Carpentier, André C.;
Bourbonnais, Annie;
Frisch, Frédérique;
Giacca, Adria;
Lewis, Gary F.

Publication type:

Article

Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon.

Published in:

Advanced Materials, 2019, v. 31, n. 30, p. N.PAG, doi. 10.1002/adma.201901051

By:

GhavamiNejad, Amin;
Li, Jason;
Lu, Brian;
Zhou, Liwei;
Lam, Loretta;
Giacca, Adria;
Wu, Xiao Yu

Publication type:

Article

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Published in:

Diabetologia, 2017, v. 60, n. 10, p. 2021, doi. 10.1007/s00125-017-4345-9

By:

Ivovic, Aleksandar;
Oprescu, Andrei;
Koulajian, Khajag;
Mori, Yusaku;
Eversley, Judith;
Zhang, Liling;
Nino-Fong, Rodolfo;
Lewis, Gary;
Donath, Marc;
Karin, Michael;
Wheeler, Michael;
Ehses, Jan;
Volchuk, Allen;
Chan, Catherine;
Giacca, Adria

Publication type:

Article

Metabolic phenotypes in a Lyz2Cre recombinase mouse model.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1499858

By:

Rahman, S. M. Niazur;
Yung, Justin Hou Ming;
Volchuk, Allen;
Goldenberg, Neil M.;
Giacca, Adria

Publication type:

Article

Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation.

Published in:

Nutrients, 2020, v. 12, n. 4, p. 914, doi. 10.3390/nu12040914

By:

Vlavcheski, Filip;
Den Hartogh, Danja J.;
Giacca, Adria;
Tsiani, Evangelia

Publication type:

Article

Local insulin application on the carotid artery inhibits neointima formation.

Published in:

Canadian Journal of Physiology & Pharmacology, 2013, v. 91, n. 12, p. 1086, doi. 10.1139/cjpp-2013-0038

By:

Chiang, Simon;
Breen, Danna M.;
Guo, June;
Mori, Yusaku;
Giacca, Adria

Publication type:

Article

Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats.

Published in:

Diabetes, 2012, v. 61, n. 1, p. 197, doi. 10.2337/db11-0690

By:

Yue, Jessica T.Y.;
Burdett, Elena;
Coy, David H.;
Giacca, Adria;
Efendic, Suad;
Vranic, Mladen

Publication type:

Article

NOD1 Activators Link Innate Immunity to Insulin Resistance.

Published in:

Diabetes, 2011, v. 60, n. 9, p. 2206, doi. 10.2337/db11-0004

By:

Schertzer, Jonathan D.;
Tamrakar, Akhilesh K.;
Magalhães, Joao G.;
Pereira, Sandra;
Bilan, Philip J.;
Fullerton, Morgan D.;
Zhi Liu;
Steinberg, Gregory R.;
Giacca, Adria;
Philpott, Dana J.;
Klip, Amira

Publication type:

Article

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans.

Published in:

2011

By:

Xiao C;
Giacca A;
Lewis GF;
Xiao, Changting;
Giacca, Adria;
Lewis, Gary F

Publication type:

journal article

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans.

Published in:

Diabetes, 2011, v. 60, n. 3, p. 918, doi. 10.2337/db10-1433

By:

Changting Xiao;
Giacca, Adria;
Lewis, Gary F.

Publication type:

Article

Free Fatty Acid-Induced Reduction in Glucose-Stimulated Insulin Secretion.

Published in:

Diabetes, 2007, v. 56, n. 12, p. 2927, doi. 10.2337/db07-0075

By:

Oprescu, Andrei I.;
Bikopoulos, George;
Naassan, Anthony;
Allister, Emma M.;
Tang, Christine;
Park, Edward;
Uchino, Hiroshi;
Lewis, Gary F.;
Fantus, I. George;
Rozakis-Adcock, Maria;
Wheeler, Michael B.;
Giacca, Adria

Publication type:

Article

Evidence for a Role of Superoxide Generation in Glucose-Induced ß-Cell Dysfunction In Vivo.

Published in:

Diabetes, 2007, v. 56, n. 11, p. 2722, doi. 10.2337/db07-0279

By:

Tang, Christine;
Han, Ping;
Oprescu, Andrei I.;
Lee, Simon C.;
Gyulkhandanyan, Armen V.;
Chan, Gary N. Y.;
Wheeler, Michael B.;
Giacca, Adria

Publication type:

Article

Bisperoxovanadate Prevents FFA-Induced β-Cell Dysfunction In Vitro and In Viva.

Published in:

Diabetes, 2007, v. 56, p. A386

By:

Oprescu, Andreii;
Han, Ping;
Lewis, Garye F.;
Giacca, Adria

Publication type:

Article

Oral Antioxidant Taurine but not Oral N-Acetylcysteine Ameliorates Free Fatty Acid-Induced Impairment in Insulin Sensitivity and Beta Cell Function in Obese and Overweight, Non-Diabetic Humans.

Published in:

Diabetes, 2007, v. 56, p. A381

By:

Xiao, Changting;
Giacca, Adria;
Lewis, Garye

Publication type:

Article

β Cell Glucotoxicity In Vivo: Role of Superoxide Generation and the JNK pathway.

Published in:

Diabetes, 2007, v. 56, p. A380

By:

Tang, Christine;
Han, Ping;
Lee, Simon C.;
Ma, Tian;
Wheeler, Michael B.;
Giacca, Adria

Publication type:

Article

Acute DPP-4 Inhibition but not GLP-1R Agonist Administration Rapidly Enhances Insulin-Mediated Suppression of Endogenous Glucose Production in Mice.

Published in:

Diabetes, 2007, v. 56, p. A378

By:

Duez, Hélène M.;
Smith, Angela C.;
Szeto, Linda;
Giacca, Adria;
Drucker, Daniel J.;
Lewis, Gary F.

Publication type:

Article

Insulin Decreases Vascular Smooth Muscle Cell Migration After Arterial Injury Through a Nitric Oxide Synthase-Dependent Mechanism.

Published in:

Diabetes, 2007, v. 56, p. A188

By:

Breen, Danna M.;
Mroziewicz, Margaret;
Dhaliwall, Jiwanjeet K.;
Bendeck, Michelle P.;
Giacca, Adria

Publication type:

Article

Resveratrol, a Red Wine Polyphenol, Inhibits Neointimal Growth by Decreasing Vascular Smooth Muscle Cell Migration Independent of Nitric Oxide Synthase In Vivo.

Published in:

Diabetes, 2007, v. 56, p. A188

By:

Breen, Danna M.;
Mroziewicz, Margaret;
Dhaliwall, Jiwanjeet K.;
Tsiani, Evangelia;
Bendeck, Michelle P.;
Giacca, Adria

Publication type:

Article

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

Published in:

2004

By:

Wang, Xiaolin;
Li, Hui;
De Leo, Domenica;
Guo, Wanbei;
Koshkin, Vasilij;
Fantus, I George;
Giacca, Adria;
Chan, Catherine B;
Der, Sandy;
Wheeler, Michael B

Publication type:

journal article

Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species -- Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6.

Published in:

Diabetes, 2004, v. 53, n. 1, p. 129, doi. 10.2337/diabetes.53.1.129

By:

Xiaolin Wang;
De Leo, Domenica;
Koshkin, Vasilij;
Giacca, Adria;
Hui Li;
Wheeler, Michael B.;
Fantus, I. George;
Guo, Wanbei;
Der, Sandy;
Chan, Catherine B.

Publication type:

Article

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.

Published in:

2003

By:

Carpentier, André;
Zinman, Bernard;
Leung, Nathalie;
Giacca, Adria;
Hanley, Anthony J.G.;
Harris, Stewart B.;
Hegele, Robert A.;
Lewis, Gary F.;
Carpentier, André

Publication type:

journal article

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.

Published in:

2002

By:

Dobbins, Robert L;
Szczepaniak, Lidia S;
Myhill, Jeff;
Tamura, Yoshifumi;
Uchino, Hiroshi;
Giacca, Adria;
McGarry, J. Denis

Publication type:

journal article

The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism.

Published in:

2001

By:

Carpentier, Andre;
Patterson, Bruce W.;
Uffelman, Kristine D.;
Giacca, Adria;
Vranic, Mladen;
Cattral, Mark S.;
Lewis, Gary F.;
Carpentier, A;
Patterson, B W;
Uffelman, K D;
Giacca, A;
Vranic, M;
Cattral, M S;
Lewis, G F

Publication type:

journal article