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BACE1 inhibitor drugs for the treatment of Alzheimer's disease: Lessons learned, challenges to overcome, and future prospects.
- Published in:
- Global Health & Medicine, 2024, v. 6, n. 3, p. 164, doi. 10.35772/ghm.2024.01033
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- Article
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19.
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- ChemMedChem, 2022, v. 17, n. 22, p. 1, doi. 10.1002/cmdc.202200440
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- Article
Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies.
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- Marine Drugs, 2022, v. 20, n. 10, p. 587, doi. 10.3390/md20100587
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- Publication type:
- Article
Asymmetric 1,2‐Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of α‐Hydroxy Amides.
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- Chemistry - A European Journal, 2022, v. 28, n. 43, p. 1, doi. 10.1002/chem.202200941
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- Publication type:
- Article
Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands.
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- ChemMedChem, 2022, v. 17, n. 9, p. 1, doi. 10.1002/cmdc.202200058
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- Publication type:
- Article
U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors.
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- PLoS ONE, 2021, v. 16, n. 10, p. 1, doi. 10.1371/journal.pone.0258551
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- Publication type:
- Article
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
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- Molecules, 2021, v. 26, n. 19, p. 5782, doi. 10.3390/molecules26195782
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- Article
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24741-1
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- Article
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65993-z
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- Article
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics.
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- ChemMedChem, 2020, v. 15, n. 11, p. 907, doi. 10.1002/cmdc.202000223
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- Article
Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies.
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- ChemMedChem, 2019, v. 14, n. 21, p. 1863, doi. 10.1002/cmdc.201900508
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- Article
Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-41080-w
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- Article
Cover Feature: Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies (ChemMedChem 5/2019).
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- ChemMedChem, 2019, v. 14, n. 5, p. 513, doi. 10.1002/cmdc.201900100
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- Publication type:
- Article
Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies.
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- ChemMedChem, 2019, v. 14, n. 5, p. 545, doi. 10.1002/cmdc.201900100
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- Publication type:
- Article
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry.
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- ChemMedChem, 2018, v. 13, n. 22, p. 2351, doi. 10.1002/cmdc.201800518
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- Publication type:
- Article
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV‐1 Protease Inhibitors.
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- Asian Journal of Organic Chemistry, 2018, v. 7, n. 8, p. 1448, doi. 10.1002/ajoc.201800255
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- Article
Front Cover: Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants (ChemMedChem 8/2018).
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- ChemMedChem, 2018, v. 13, n. 8, p. 762, doi. 10.1002/cmdc.201800226
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- Publication type:
- Article
Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants.
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- ChemMedChem, 2018, v. 13, n. 8, p. 803, doi. 10.1002/cmdc.201700824
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- Publication type:
- Article
Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.
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- ChemMedChem, 2017, v. 12, n. 23, p. 1942, doi. 10.1002/cmdc.201700614
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- Publication type:
- Article
A fission yeast cell-based system for multidrug resistant HIV-1 proteases.
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- Cell & Bioscience, 2017, v. 7, p. 1, doi. 10.1186/s13578-016-0131-5
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- Publication type:
- Article
Enantioselective Syntheses of (-)-Alloyohimbane and (-)-Yohimbane by an Efficient Enzymatic Desymmetrization Process.
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- European Journal of Organic Chemistry, 2016, v. 2016, n. 36, p. 6001, doi. 10.1002/ejoc.201601171
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- Article
Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease.
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- 2015
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- Publication type:
- Other
Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.
- Published in:
- Marine Drugs, 2015, v. 13, n. 6, p. 3625, doi. 10.3390/md13063625
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- Publication type:
- Article
Design of gem-Difluoro- bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation.
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- ChemMedChem, 2015, v. 10, n. 1, p. 107, doi. 10.1002/cmdc.201402358
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- Publication type:
- Article
A Convergent Synthesis of Carbocyclic Sinefungin and its C-5 Epimer.
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- European Journal of Organic Chemistry, 2014, v. 2014, n. 30, p. 6761, doi. 10.1002/ejoc.201402812
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- Publication type:
- Article
S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase.
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- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076900
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- Publication type:
- Article
Synergistic Inhibitor Binding to the Papain-Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications.
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- ChemMedChem, 2013, v. 8, n. 8, p. 1361, doi. 10.1002/cmdc.201300134
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- Publication type:
- Article
Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism.
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- FASEB Journal, 2013, v. 27, n. 6, p. 2132, doi. 10.1096/fj.12-214353
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- Article
Total Synthesis of Potent Antitumor Macrolide (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy.
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- European Journal of Organic Chemistry, 2012, v. 2012, n. 22, p. 4130, doi. 10.1002/ejoc.201200286
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- Publication type:
- Article
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
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- Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 3, p. 339, doi. 10.1002/pro.2019
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- Article
Verstärkung der Bindung an das Proteinrückgrat - ein fruchtbares Konzept gegen die Arzneimittelresistenz von HIV.
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- Angewandte Chemie, 2012, v. 124, n. 8, p. 1812, doi. 10.1002/ange.201102762
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- Publication type:
- Article
Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 8, p. 1778, doi. 10.1002/anie.201102762
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- Publication type:
- Article
Developing β-secretase inhibitors for treatment of Alzheimer's disease.
- Published in:
- Journal of Neurochemistry, 2012, v. 120, p. 71, doi. 10.1111/j.1471-4159.2011.07476.x
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- Publication type:
- Article
β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.
- Published in:
- FASEB Journal, 2011, v. 25, n. 2, p. 775, doi. 10.1096/fj.10-167213
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- Article
Cover Picture: Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors (ChemMedChem 11/2010).
- Published in:
- ChemMedChem, 2010, v. 5, n. 11, p. 1797, doi. 10.1002/cmdc.201090049
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- Publication type:
- Article
Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors.
- Published in:
- ChemMedChem, 2010, v. 5, n. 11, p. 1850, doi. 10.1002/cmdc.201000318
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- Publication type:
- Article
A Symmetry-Based Concise Formal Synthesis of Platencin, a Novel Lead against 'Superbugs'.
- Published in:
- Angewandte Chemie International Edition, 2009, v. 48, n. 29, p. 5372, doi. 10.1002/anie.200902338
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- Publication type:
- Article
In vivo efficacy of BACE-1 inhibitor CTS21166 (ASP1702) in rat CNS compartments
- Published in:
- 2009
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- Publication type:
- Abstract
Total Synthesis of Potent Antitumor Agent (−)-Lasonolide A: A Cycloaddition-Based Strategy.
- Published in:
- Chemistry - An Asian Journal, 2008, v. 3, n. 10, p. 1811, doi. 10.1002/asia.200800164
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- Publication type:
- Article
Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
- Published in:
- Proteins, 2007, v. 67, n. 1, p. 232, doi. 10.1002/prot.21304
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- Publication type:
- Article
Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance.
- Published in:
- ChemMedChem, 2006, v. 1, n. 9, p. 939, doi. 10.1002/cmdc.200600103
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- Publication type:
- Article
In vivo inhibition of Aβ production by memapsin 2 (β-secretase) inhibitors.
- Published in:
- Journal of Neurochemistry, 2004, v. 89, n. 6, p. 1409, doi. 10.1111/j.1471-4159.2004.02452.x
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- Publication type:
- Article
Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A.
- Published in:
- European Journal of Organic Chemistry, 2004, v. 2004, n. 10, p. 2131, doi. 10.1002/ejoc.200300814
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- Publication type:
- Article
A Non-Antibacterial Oxazolidinone Derivative that Inhibits Epithelial Cell Sheet Migration.
- Published in:
- ChemBioChem, 2002, v. 3, n. 11, p. 1105, doi. 10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO;2-S
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- Publication type:
- Article
A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity.
- Published in:
- Angewandte Chemie International Edition, 1996, v. 35, n. 1, p. 74, doi. 10.1002/anie.199600741
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- Publication type:
- Article