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First‐in‐Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll‐like Receptors 7 and 8, in Healthy Volunteers.
Published in:
Clinical Pharmacology in Drug Development, 2023, v. 12, n. 4, p. 363, doi. 10.1002/cpdd.1176
By:
- Yamakawa, Naoto;
- Tago, Fumitoshi;
- Nakai, Kenya;
- Kitahara, Yasumi;
- Ikari, Shingo;
- Hojo, Seiichiro;
- Hall, Nancy;
- Aluri, Jagadeesh;
- Hussein, Ziad;
- Gevorkyan, Hakop;
- Maruyama, Tatsuya;
- Ishizaka, Sally;
- Yagi, Takuya
Publication type:
Article
PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OF LY3202626, A NOVEL BACE1 INHIBITOR, IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P418, doi. 10.1016/j.jalz.2016.06.791
By:
- Willis, Brian A.;
- Lowe, Stephen L.;
- Daugherty, Leslie L.;
- Dean, Robert A.;
- English, Brett;
- Ereshefsky, Larry;
- Gevorkyan, Hakop;
- James, Douglas E.;
- Jhee, Stanford;
- Lin, Qun;
- Lo, Albert;
- Mergott, Dustin J.;
- Monk, Scott A.;
- Nakano, Masako;
- Zimmer, Jennifer A.;
- Irizarry, Michael C.
Publication type:
Article
BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)
Published in:
2012
By:
- Martenyi, Ferenc;
- Dean, Robert A.;
- Lowe, Stephen;
- Nakano, Masako;
- Monk, Scott;
- Willis, Brian A.;
- Gonzales, Celedon;
- Mergott, Dustin;
- Leslie, Daugherty;
- May, Patrick;
- James, Audia;
- Gevorkyan, Hakop;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Citron, Martin
Publication type:
Abstract
Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
Published in:
British Journal of Clinical Pharmacology, 2022, v. 88, n. 2, p. 600, doi. 10.1111/bcp.14975
By:
- Yin, Wei;
- Mamashli, Fahimeh;
- Buhl, Derek L.;
- Khudyakov, Polyna;
- Volfson, Dmitri;
- Martenyi, Ferenc;
- Gevorkyan, Hakop;
- Rosen, Laura;
- Simen, Arthur A.
Publication type:
Article
Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects.
Published in:
British Journal of Clinical Pharmacology, 2020, v. 86, n. 11, p. 2286, doi. 10.1111/bcp.14331
By:
- Watanabe, Mai;
- Marcy, Brian;
- Kinoshita, Kohnosuke;
- Fukasawa, Misako;
- Hikichi, Hirohiko;
- Chaki, Shigeyuki;
- Okuyama, Shigeru;
- Gevorkyan, Hakop;
- Yoshida, Shigeru
Publication type:
Article
The effect of LCZ696 (sacubitril/valsartan) on amyloid-β concentrations in cerebrospinal fluid in healthy subjects.
Published in:
British Journal of Clinical Pharmacology, 2016, v. 81, n. 5, p. 878, doi. 10.1111/bcp.12861
By:
- Langenickel, Thomas H.;
- Tsubouchi, Chiaki;
- Ayalasomayajula, Surya;
- Pal, Parasar;
- Valentin, Marie‐Anne;
- Hinder, Markus;
- Jhee, Stanford;
- Gevorkyan, Hakop;
- Rajman, Iris
Publication type:
Article
A phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-063, a selective PDE10A inhibitor.
Published in:
Psychopharmacology, 2016, v. 233, n. 21/22, p. 3787, doi. 10.1007/s00213-016-4412-9
By:
- Tsai, Max;
- Chrones, Lambros;
- Xie, Jinhui;
- Gevorkyan, Hakop;
- Macek, Thomas
Publication type:
Article
Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers.
Published in:
2019
By:
- Ackert, Jessica;
- Mohamed, Khadeeja;
- Slakter, Jason S.;
- El-Harazi, Sherif;
- Berni, Alessandro;
- Gevorkyan, Hakop;
- Hardaker, Elizabeth;
- Hussaini, Azra;
- Jones, Siôn W.;
- Koh, Gavin C. K. W.;
- Patel, Jyoti;
- Rasmussen, Scott;
- Kelly, Deborah S.;
- Barañano, David E.;
- Thompson, John T.;
- Warren, Keith A.;
- Sergott, Robert C.;
- Tonkyn, John;
- Wolstenholme, Allen;
- Coleman, Hanna
Publication type:
journal article

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