Works by Gertsch, Jürg

Results: 64

Phytocannabinoids beyond the Cannabis plant - do they exist?

Published in:

2010

By:

Gertsch, Jürg;
Pertwee, Roger G;
Di Marzo, Vincenzo;
Gertsch, Jürg

Publication type:

journal article

Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation?

Published in:

2017

By:

Gertsch, Jürg;
Gertsch, Jürg

Publication type:

journal article

CNS Drug Discovery in Academia: Where Basic Research Meets Innovation.

Published in:

ChemBioChem, 2024, v. 25, n. 19, p. 1, doi. 10.1002/cbic.202400397

By:

Gertsch, Jürg;
Chicca, Andrea

Publication type:

Article

Berichtigung: Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine.

Published in:

Angewandte Chemie, 2011, v. 123, n. 18, p. 4124, doi. 10.1002/ange.201190035

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine.

Published in:

Angewandte Chemie, 2010, v. 122, n. 33, p. 5903, doi. 10.1002/ange.201001853

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Innentitelbild: Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine (Angew. Chem. 33/2010).

Published in:

Angewandte Chemie, 2010, v. 122, n. 33, p. 5716, doi. 10.1002/ange.201003240

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Entwurf und Synthese von 12-Aza-Epothilonen (Azathilonen) – “nicht-natürliche Naturstoffe” mit potenter AntitumorwirkungBettina Sager, Jaqueline Loretan und Robert Reuter sei herzlich für die exzellente technische...

Published in:

Angewandte Chemie, 2006, v. 118, n. 35, p. 6013, doi. 10.1002/ange.200601359

By:

Fabian Feyen;
Jürg Gertsch;
Markus Wartmann;
Karl-Heinz Altmann

Publication type:

Article

Synthesis, Profiling, and Bioactive Conformation of trans‐Cyclopropyl Epothilones.

Published in:

Helvetica Chimica Acta, 2019, v. 102, n. 5, p. N.PAG, doi. 10.1002/hlca.201900078

By:

Kuzniewski, Christian N.;
Glauser, Simon;
Gaugaz, Fabienne Z.;
Schiess, Raphael;
Rodríguez‐Salarichs, Javier;
Vetterli, Stefan;
Horlacher, Oliver P.;
Gertsch, Jürg;
Redondo‐Horcajo, Mariano;
Canales, Angeles;
Jiménez‐Barbero, Jesús;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50960-3

By:

Hirschi, Stephan;
Lemmin, Thomas;
Ayoub, Nooraldeen;
Kalbermatter, David;
Pellegata, Daniele;
Ucurum, Zöhre;
Gertsch, Jürg;
Fotiadis, Dimitrios

Publication type:

Article

Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50960-3

By:

Hirschi, Stephan;
Lemmin, Thomas;
Ayoub, Nooraldeen;
Kalbermatter, David;
Pellegata, Daniele;
Ucurum, Zöhre;
Gertsch, Jürg;
Fotiadis, Dimitrios

Publication type:

Article

Synthesis of Morpholine‐Based Analogues of (−)‐Zampanolide and Their Biological Activity.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 19, p. 5936, doi. 10.1002/chem.202003996

By:

Bold, Christian Paul;
Gut, Melanie;
Schürmann, Jasmine;
Lucena‐Agell, Daniel;
Gertsch, Jürg;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.

Published in:

Cell Discovery, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41421-021-00247-4

By:

Yan, Renhong;
Li, Yaning;
Müller, Jennifer;
Zhang, Yuanyuan;
Singer, Simon;
Xia, Lu;
Zhong, Xinyue;
Gertsch, Jürg;
Altmann, Karl-Heinz;
Zhou, Qiang

Publication type:

Article

Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation.

Published in:

Cells (2073-4409), 2023, v. 12, n. 11, p. 1540, doi. 10.3390/cells12111540

By:

Skiba, Adrianna;
Pellegata, Daniele;
Morozova, Veronika;
Kozioł, Ewelina;
Budzyńska, Barbara;
Lee, Simon Ming-Yuen;
Gertsch, Jürg;
Skalicka-Woźniak, Krystyna

Publication type:

Article

Juniperonic Acid Biosynthesis is Essential in Caenorhabditis elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 2127, doi. 10.3390/cells9092127

By:

Guha, Sujay;
Calarco, Serafina;
Gachet, M. Salomé;
Gertsch, Jürg

Publication type:

Article

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29124-8

By:

Hinden, Liad;
Ahmad, Majdoleen;
Hamad, Sharleen;
Nemirovski, Alina;
Szanda, Gergő;
Glasmacher, Sandra;
Kogot-Levin, Aviram;
Abramovitch, Rinat;
Thorens, Bernard;
Gertsch, Jürg;
Leibowitz, Gil;
Tam, Joseph

Publication type:

Article

New Natural Noncannabinoid Ligands for Cannabinoid Type-2 (CB2) Receptors.

Published in:

Journal of Receptors & Signal Transduction, 2006, v. 26, n. 5/6, p. 709, doi. 10.1080/10799890600942674

By:

GERTSCH, JÜRG;
RADUNER, STEFAN;
ALTMANN, KARL-HEINZ

Publication type:

Article

Corrigendum: Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 18, p. 4038, doi. 10.1002/anie.201190034

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Inside Cover: Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine (Angew. Chem. Int. Ed. 33/2010).

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 33, p. 5584, doi. 10.1002/anie.201003240

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 33, p. 5767, doi. 10.1002/anie.201001853

By:

De Simone, Filippo;
Gertsch, Jürg;
Waser, Jérôme

Publication type:

Article

Total Synthesis of the Marine Diterpenoid Blumiolide C.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 52, p. 10081, doi. 10.1002/anie.200804004

By:

Hamel, Cotinica;
Prusov, Evgeny V.;
Gertsch, Jürg;
Schweizer, W. Bernd;
Altmann, Karl-Heinz

Publication type:

Article

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport.

Published in:

Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 21, p. 12681, doi. 10.1111/jcmm.15840

By:

Zaugg, Jonas;
Huang, Xiao;
Ziegler, Fabian;
Rubin, Matthias;
Graff, Julien;
Müller, Jennifer;
Moser‐Hässig, Ruedi;
Powell, Theresa;
Gertsch, Jürg;
Altmann, Karl‐Heinz;
Albrecht, Christiane

Publication type:

Article

Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 4, p. 7057, doi. 10.3390/ijms16047057

By:

Patsenker, Eleonora;
Sachse, Philip;
Chicca, Andrea;
Gachet, María Salomé;
Schneider, Vreni;
Mattsson, Johan;
Lanz, Christian;
Worni, Mathias;
de Gottardi, Andrea;
Semmo, Mariam;
Hampe, Jochen;
Schafmayer, Clemens;
Brenneisen, Rudolf;
Gertsch, Jürg;
Stickel, Felix;
Semmo, Nasser

Publication type:

Article

Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects.

Published in:

British Journal of Clinical Pharmacology, 2016, v. 81, n. 5, p. 980, doi. 10.1111/bcp.12863

By:

Liechti, Matthias E.;
Quednow, Boris B.;
Liakoni, Evangelia;
Dornbierer, Dario;
Rotz, Robin;
Gachet, Maria Salomé;
Gertsch, Jürg;
Seifritz, Erich;
Bosch, Oliver G.

Publication type:

Article

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

Published in:

2021

By:

Alexander, Stephen PH;
Fabbro, Doriano;
Kelly, Eamonn;
Mathie, Alistair;
Peters, John A;
Veale, Emma L;
Armstrong, Jane F;
Faccenda, Elena;
Harding, Simon D;
Pawson, Adam J;
Southan, Christopher;
Davies, Jamie A;
Boison, Detlev;
Burns, Kathryn Elisa;
Dessauer, Carmen;
Gertsch, Jürg;
Helsby, Nuala Ann;
Izzo, Angelo A.;
Koesling, Doris;
Ostrom, Rennolds

Publication type:

journal article

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Published in:

2018

By:

Ozhathil, Lijo Cherian;
Delalande, Clémence;
Bianchi, Beatrice;
Nemeth, Gabor;
Kappel, Sven;
Thomet, Urs;
Ross‐Kaschitza, Daniela;
Simonin, Céline;
Rubin, Matthias;
Gertsch, Jürg;
Lochner, Martin;
Peinelt, Christine;
Reymond, Jean‐Louis;
Abriel, Hugues;
Ross-Kaschitza, Daniela;
Reymond, Jean-Louis

Publication type:

journal article

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Published in:

2018

By:

Varga, Zoltan V.;
Matyas, Csaba;
Erdelyi, Katalin;
Cinar, Resat;
Nieri, Daniela;
Chicca, Andrea;
Nemeth, Balazs Tamas;
Paloczi, Janos;
Lajtos, Tamas;
Corey, Lukas;
Hasko, Gyorgy;
Gao, Bin;
Kunos, George;
Gertsch, Jürg;
Pacher, Pal

Publication type:

journal article

Anti-inflammatory cannabinoids in diet.

Published in:

Communicative & Integrative Biology, 2008, v. 1, n. 1, p. 26, doi. 10.4161/cib.1.1.6568

By:

Gertsch, Jürg

Publication type:

Article

4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.

Published in:

Journal of Neuroinflammation, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12974-015-0307-7

By:

Chicca, Andrea;
Gachet, Maria Salomé;
Petrucci, Vanessa;
Schuehly, Wolfgang;
Charles, Roch-Philippe;
Gertsch, Jürg

Publication type:

Article

Comparative targeted lipidomics between serum and cerebrospinal fluid of multiple sclerosis patients shows sex and age-specific differences of endocannabinoids and glucocorticoids.

Published in:

Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01864-2

By:

Meier, Philip;
Glasmacher, Sandra;
Salmen, Anke;
Chan, Andrew;
Gertsch, Jürg

Publication type:

Article

Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers.

Published in:

Psychopharmacology, 2017, v. 234, n. 13, p. 1957, doi. 10.1007/s00213-017-4603-z

By:

Rotz, Robin;
Kometer, Michael;
Dornbierer, Dario;
Gertsch, Jürg;
Salomé Gachet, M.;
Vollenweider, Franz;
Seifritz, Erich;
Bosch, Oliver;
Quednow, Boris

Publication type:

Article

Mitochondrial CB1 receptors regulate neuronal energy metabolism.

Published in:

Nature Neuroscience, 2012, v. 15, n. 4, p. 558, doi. 10.1038/nn.3053

By:

Bénard, Giovanni;
Massa, Federico;
Puente, Nagore;
Lourenço, Joana;
Bellocchio, Luigi;
Soria-Gómez, Edgar;
Matias, Isabel;
Delamarre, Anna;
Metna-Laurent, Mathilde;
Cannich, Astrid;
Hebert-Chatelain, Etienne;
Mulle, Christophe;
Ortega-Gutiérrez, Silvia;
Martín-Fontecha, Mar;
Klugmann, Matthias;
Guggenhuber, Stephan;
Lutz, Beat;
Gertsch, Jürg;
Chaouloff, Francis;
López-Rodríguez, María Luz

Publication type:

Article

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Published in:

Chimia, 2024, v. 78, n. 7/8, p. 499, doi. 10.2533/chimia.2024.499

By:

Aebia, Johannes;
Atza, Kenneth;
Ametamey, Simon M.;
Benza, Jörg;
Blaising, Julie;
Butini, Stefania;
Campiani, Giuseppe;
Carreira, Erick M.;
Collin, Ludovic;
de Lago, Eva;
Gazzi, Thais;
Gertsch, Jürg;
Gobbi, Luca;
Guba, Wolfgang;
Fernández-Ruize, Javier;
Fingerle, Jürgen;
Haider, Ahmed;
Yingfang He;
Heitman, Laura H.;
Honer, Michael

Publication type:

Article

Structure, Function and Pharmacology of SLC7 Family Members and Homologues.

Published in:

Chimia, 2022, v. 76, n. 12, p. 1011, doi. 10.2533/chimia.2022.1011

By:

Jeckelmann, Jean-Marc;
Zaugg, Jonas;
Morozova, Veronika;
Müller, Jennifer;
Kantipudi, Satish;
Schroeder, Mariana;
Graff, Julien;
Albrecht, Christiane;
Altmann, Karl-Heinz;
Gertsch, Jürg;
Fotiadis, Dimitrios

Publication type:

Article

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00180

By:

Reynoso-Moreno, Inés;
Chicca, Andrea;
Flores-Soto, Mario E.;
Viveros-Paredes, Juan M.;
Gertsch, Jürg

Publication type:

Article

Cover Picture: Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12-Aza-Epothilone (Azathilone) (ChemBioChem 15/2009).

Published in:

ChemBioChem, 2009, v. 10, n. 15, p. 2405, doi. 10.1002/cbic.200990065

By:

Gertsch, Jürg;
Feyen, Fabian;
Bützberger, Alexander;
Gerber, Barbara;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz

Publication type:

Article

Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12-Aza-Epothilone (Azathilone).

Published in:

ChemBioChem, 2009, v. 10, n. 15, p. 2513, doi. 10.1002/cbic.200900376

By:

Gertsch, Jürg;
Feyen, Fabian;
Bützberger, Alexander;
Gerber, Barbara;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz

Publication type:

Article

Differential Effects of Natural Product Microtubule Stabilizers on Microtubule Assembly: Single Agent and Combination Studies with Taxol, Epothilone B, and Discodermolide.

Published in:

ChemBioChem, 2009, v. 10, n. 1, p. 166, doi. 10.1002/cbic.200800556

By:

Gertsch, Jürg;
Meier, Sarah;
Müller, Martin;
Altmann, Karl-Heinz

Publication type:

Article

Front Cover: Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies (ChemMedChem 17/2019).

Published in:

ChemMedChem, 2019, v. 14, n. 17, p. 1573, doi. 10.1002/cmdc.201900490

By:

Bartholomäus, Ruben;
Nicolussi, Simon;
Baumann, Alice;
Rau, Mark;
Simão, Ana Catarina;
Gertsch, Jürg;
Altmann, Karl‐Heinz

Publication type:

Article

Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies.

Published in:

ChemMedChem, 2019, v. 14, n. 17, p. 1590, doi. 10.1002/cmdc.201900390

By:

Bartholomäus, Ruben;
Nicolussi, Simon;
Baumann, Alice;
Rau, Mark;
Simão, Ana Catarina;
Gertsch, Jürg;
Altmann, Karl‐Heinz

Publication type:

Article

Structure-Activity Relationships in Side-Chain-Modified Epothilone Analogues-How Important is the Position of the Nitrogen Atom?

Published in:

ChemMedChem, 2006, v. 1, n. 1, p. 37, doi. 10.1002/cmdc.200500051

By:

Bold, Guido;
Wojeik, Séverine;
Caravatti, Giorgio;
Lindauer, Renate;
Stierlin, Claire;
Gertsch, Jürg;
Wartmann, Markus;
Altmann, Karl-Heinz

Publication type:

Article

Design and Synthesis of 12-Aza-Epothilones (Azathilones)—“Non-Natural” Natural Products with Potent Anticancer ActivityWe thank Bettina Sager, Jacqueline Loretan, and Robert Reuter for their excellent technical assistance. The Electron Microscopy Centre (EMEZ) of ETH Zürich is acknowledged for excellent technical support.

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 35, p. 5880, doi. 10.1002/anie.200601359

By:

Fabian Feyen;
Jürg Gertsch;
Markus Wartmann;
Karl-Heinz Altmann

Publication type:

Article

Synthesis and Biological Activity of 7,8,9-Trideoxy- and 7 R DesTHP-Peloruside A.

Published in:

Chemistry - A European Journal, 2013, v. 19, n. 39, p. 13105, doi. 10.1002/chem.201301796

By:

Wullschleger, Christoph W.;
Gertsch, Jürg;
Altmann, Karl‐Heinz

Publication type:

Article

Total Synthesis of (−)-Zampanolide and Structure-Activity Relationship Studies on (−)-Dactylolide Derivatives.

Published in:

Chemistry - A European Journal, 2012, v. 18, n. 52, p. 16868, doi. 10.1002/chem.201202553

By:

Zurwerra, Didier;
Glaus, Florian;
Betschart, Leo;
Schuster, Julia;
Gertsch, Jürg;
Ganci, Walter;
Altmann, Karl-Heinz

Publication type:

Article

Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors.

Published in:

Glia (0894-1491), 2021, v. 69, n. 2, p. 377, doi. 10.1002/glia.23903

By:

Schuele, Lena‐Louise;
Glasmacher, Sandra;
Gertsch, Jürg;
Roggan, Marie Denise;
Transfeld, Janis‐Lisa;
Bindila, Laura;
Lutz, Beat;
Kolbe, Carl‐Christian;
Bilkei‐Gorzo, Andras;
Zimmer, Andreas;
Leidmaa, Este

Publication type:

Article

4-O′-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.

Published in:

Journal of Molecular Medicine, 2017, v. 95, n. 10, p. 1077, doi. 10.1007/s00109-017-1556-y

By:

Patsenker, Eleonora;
Chicca, Andrea;
Petrucci, Vanessa;
Moghadamrad, Sheida;
Gottardi, Andrea;
Hampe, Jochen;
Gertsch, Jürg;
Semmo, Nasser;
Stickel, Felix

Publication type:

Article

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper.

Published in:

Antioxidants, 2021, v. 10, n. 10, p. 1642, doi. 10.3390/antiox10101642

By:

Luca, Simon Vlad;
Gaweł-Bęben, Katarzyna;
Strzępek-Gomółka, Marcelina;
Czech, Karolina;
Trifan, Adriana;
Zengin, Gokhan;
Korona-Glowniak, Izabela;
Minceva, Mirjana;
Gertsch, Jürg;
Skalicka-Woźniak, Krystyna

Publication type:

Article

Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRafV600E/Pten−/− mice.

Published in:

Cancer & Metabolism, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40170-025-00378-2

By:

Morozova, Veronika;
Pellegata, Daniele;
Charles, Roch-Philippe;
Gertsch, Jürg

Publication type:

Article

Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma.

Published in:

Cancers, 2021, v. 13, n. 8, p. 1934, doi. 10.3390/cancers13081934

By:

Gruber, Thomas;
Robatel, Steve;
Kremenovic, Mirela;
Bäriswyl, Lukas;
Gertsch, Jürg;
Schenk, Mirjam;
Sarin, Kavita Y.

Publication type:

Article

β‐Caryophyllene ameliorates cisplatin‐induced nephrotoxicity in a cannabinoid 2 receptor‐dependent manner.

Published in:

FASEB Journal, 2013, v. 27, p. 704.3, doi. 10.1096/fasebj.27.1_supplement.704.3

By:

PACHER, PAL;
Horvath, Bela;
Mukhopadhyay, Partha;
Wink, David;
Gertsch, Jürg

Publication type:

Article

Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies?

Published in:

Journal of Pharmacy & Pharmacology, 2009, v. 61, n. 7, p. 839, doi. 10.1211/jpp/61.07.0002

By:

Susanne Oesch;
Jürg Gertsch

Publication type:

Article