Works matching AU Gershengorn, Marvin

Results: 64

Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum.

Published in:

Nature, 1987, v. 325, n. 6106, p. 726, doi. 10.1038/325726a0

By:

Imai, Atsushi;
Gershengorn, Marvin C.

Publication type:

Article

Evidence That Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors.

Published in:

Thyroid, 2018, v. 28, n. 5, p. 650, doi. 10.1089/thy.2018.0089

By:

Marcus-Samuels, Bernice;
Krieger, Christine C.;
Boutin, Alisa;
Kahaly, George J.;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Rebuttal to Smith and Janssen ( Thyroid 2017;27:746-747. DOI: 10.1089/thy.2017.0281).

Published in:

Thyroid, 2017, v. 27, n. 11, p. 1459, doi. 10.1089/thy.2017.0472

By:

Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis.

Published in:

Thyroid, 2017, v. 27, n. 5, p. 746, doi. 10.1089/thy.2017.0105

By:

Krieger, Christine C.;
Neumann, Susanne;
Marcus-Samuels, Bernice;
Gershengorn, Marvin C.

Publication type:

Article

Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes.

Published in:

Thyroid, 2016, v. 26, n. 12, p. 1794, doi. 10.1089/thy.2016.0323

By:

Morgan, Sarah J.;
Neumann, Susanne;
Marcus-Samuels, Bernice;
Gershengorn, Marvin C.

Publication type:

Article

Persistent cAMP Signaling by TSH Receptors Revealed by Phosphodiesterase Inhibition.

Published in:

Thyroid, 2013, v. 23, n. 11, p. 1484, doi. 10.1089/thy.2013.0089

By:

Geras-Raaka, Elizabeth;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

A Drug-Like Antagonist Inhibits Thyrotropin Receptor-Mediated Stimulation of cAMP Production in Graves' Orbital Fibroblasts.

Published in:

Thyroid, 2012, v. 22, n. 8, p. 839, doi. 10.1089/thy.2011.0520

By:

Neumann, Susanne;
Pope, Arthur;
Geras-Raaka, Elizabeth;
Raaka, Bruce M.;
Bahn, Rebecca S.;
Gershengorn, Marvin C.

Publication type:

Article

History of the Clinical Endocrinology Branch of the National Institute of Diabetes and Digestive and Kidney Diseases: Impact on Understanding and Treatment of Diseases of the Thyroid Gland.

Published in:

Thyroid, 2012, v. 22, n. 2, p. 109, doi. 10.1089/thy.2012.2202.com

By:

Gershengorn, Marvin C.

Publication type:

Article

Small-Molecule Thyrotropin Receptor Agonist Activates Naturally Occurring Thyrotropin-Insensitive Mutants and Reveals Their Distinct Cyclic Adenosine Monophosphate Signal Persistence.

Published in:

Thyroid, 2011, v. 21, n. 8, p. 907, doi. 10.1089/thy.2011.0025

By:

Allen, Michael D.;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Case History: A Novel Activating Mutation in Transmembrane Helix 6 of the Thyrotropin Receptor as Cause of Hereditary Nonautoimmune Hyperthyroidism.

Published in:

Thyroid, 2006, v. 16, n. 5, p. 505

By:

Benjamin U. Nwosu;
Loukas Gourgiotis;
Marvin C. Gershengorn;
Susanne Neumann

Publication type:

Article

PAR-3 Knockdown Enhances Adhesion Rate of PANC-1 Cells via Increased Expression of Integrinαv and E-Cadherin.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0093879

By:

Segal, Liora;
Katz, Liora S.;
Shapira, Hagit;
Sandbank, Judith;
Geras-Raaka, Elizabeth;
Gershengorn, Marvin C.;
Oron, Yoram

Publication type:

Article

A Novel HMM-Based Method for Detecting Enriched Transcription Factor Binding Sites Reveals RUNX3 as a Potential Target in Pancreatic Cancer Biology.

Published in:

PLoS ONE, 2010, v. 5, n. 12, p. 1, doi. 10.1371/journal.pone.0014423

By:

Levkovitz, Liron;
Yosef, Nir;
Gershengorn, Marvin C.;
Ruppin, Eytan;
Sharan, Roded;
Oron, Yoram

Publication type:

Article

Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.

Published in:

FASEB Journal, 2012, v. 26, n. 8, p. 3473, doi. 10.1096/fj.12-207860

By:

Boutin, Alisa;
Allen, Michael D.;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.

Published in:

FASEB Journal, 2011, v. 25, n. 10, p. 3687, doi. 10.1096/fj.11-188961

By:

Allen, Michael D.;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization.

Published in:

FASEB Journal, 2010, v. 24, n. 10, p. 3992, doi. 10.1096/fj.10-161745

By:

Neumann, Susanne;
Geras-Raaka, Elizabeth;
Marcus-Samuels, Bernice;
Gershengorn, Marvin C.

Publication type:

Article

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Published in:

FASEB Journal, 2010, v. 24, n. 7, p. 2347, doi. 10.1096/fj.09-149146

By:

Kleinau, Gunnar;
Haas, Ann-Karin;
Neumann, Susanne;
Worth, Catherine L.;
Hoyer, Inna;
Furkert, Jens;
Rutz, Claudia;
Gershengorn, Marvin C.;
Schülein, Ralf;
Krause, Gerd

Publication type:

Article

Inhibiting thyrotropin/insulin-like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro.

Published in:

2017

By:

Place, Robert F;
Krieger, Christine C;
Neumann, Susanne;
Gershengorn, Marvin C

Publication type:

journal article

Inhibition of TSH Receptor Expression by a Cyclotriazadisulfonamide as a Potential Treatment of Graves Hyperthyroidism.

Published in:

Endocrinology, 2025, v. 166, n. 4, p. 1, doi. 10.1210/endocr/bqaf037

By:

Krieger, Christine C;
Neumann, Susanne;
Sui, Xiangliang;
Templin, Jay Scott;
Kapri, Topprasad;
Demillo, Violeta G;
Olsen, Ryan K;
Intasiri, Amarawan;
Gershengorn, Marvin C;
Bell, Thomas W

Publication type:

Article

Opposing Effects of EGF Receptor Signaling on Proliferation and Differentiation Initiated by EGF or TSH/EGF Receptor Transactivation.

Published in:

Endocrinology, 2022, v. 163, n. 12, p. 1, doi. 10.1210/endocr/bqac136

By:

Boutin, Alisa;
Marcus-Samuels, Bernice;
Eliseeva, Elena;
Neumann, Susanne;
Gershengorn, Marvin C

Publication type:

Article

TSH Elicits Cell-Autonomous, Biphasic Responses: A Mechanism Inhibiting Hyperstimulation.

Published in:

Endocrinology, 2020, v. 161, n. 8, p. 1, doi. 10.1210/endocr/bqaa103

By:

Boutin, Alisa;
Neumann, Susanne;
Gershengorn, Marvin C

Publication type:

Article

Arrestin- β -1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.

Published in:

Endocrinology, 2019, v. 160, n. 6, p. 1468, doi. 10.1210/en.2019-00055

By:

Krieger, Christine C;
Boutin, Alisa;
Jang, Daesong;
Morgan, Sarah J;
Banga, J Paul;
Kahaly, George J;
Klubo-Gwiezdzinska, Joanna;
Neumann, Susanne;
Gershengorn, Marvin C

Publication type:

Article

T<sub>3</sub> and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice.

Published in:

Endocrinology, 2018, v. 159, n. 1, p. 557, doi. 10.1210/en.2017-00579

By:

Katz, Liora S;
Xu, Shiliyang;
Ge, Kai;
Scott, Donald K;
Gershengorn, Marvin C

Publication type:

Article

Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin-releasing hormone receptor: role of cellular calcium and protein kinase C.

Published in:

British Journal of Pharmacology, 1999, v. 126, n. 5, p. 1097, doi. 10.1038/sj.bjp.0702415

By:

Grimberg, Hagit;
Zaltsman, Ilona;
Lupu-Meiri, Monica;
Gershengorn, Marvin C;
Oron, Yoram

Publication type:

Article

Linsitinib Decreases Thyrotropin-Induced Thyroid Hormone Synthesis by Inhibiting Crosstalk Between Thyroid-Stimulating Hormone and Insulin-Like Growth Factor 1 Receptors in Human Thyrocytes In Vitro and In Vivo in Mice.

Published in:

Thyroid, 2025, v. 35, n. 2, p. 216, doi. 10.1089/thy.2024.0393

By:

Boutin, Alisa;
Eliseeva, Elena;
Templin, Scott;
Marcus-Samuels, Bernice;
Anderson, D. Eric;
Gershengorn, Marvin C.;
Neumann, Susanne

Publication type:

Article

Graves' Autoantibodies Exhibit Different Stimulating Activities in Cultures of Thyrocytes and Orbital Fibroblasts Not Reflected by Clinical Assays.

Published in:

Thyroid, 2022, v. 32, n. 1, p. 90, doi. 10.1089/thy.2021.0326

By:

Krieger, Christine C.;
Kahaly, George J.;
Azam, Asma;
Klubo-Gwiezdzinska, Joanna;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Thyrotropin, but Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes.

Published in:

Thyroid, 2020, v. 30, n. 2, p. 270, doi. 10.1089/thy.2019.0418

By:

Jang, Daesong;
Morgan, Sarah J.;
Klubo-Gwiezdzinska, Joanna;
Banga, J. Paul;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.989626

By:

Krieger, Christine C.;
Boutin, Alisa;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Combined Immunosuppressive Therapy for Severe Graves Dermopathy.

Published in:

2021

By:

Gubbi, Sriram;
Araque, Katherine Andrea;
Avadhanula, Shirisha;
Azam, Asma;
Merkel, Roxanne;
Cochran, Craig;
Burbelo, Peter Denis;
Waldman, Meryl;
Neumann, Susanne;
Gershengorn, Marvin Carl;
Skarulis, Monica;
Klubo-Gwiezdzinska, Joanna

Publication type:

Case Study

Human islet-derived precursor cells can cycle between epithelial clusters and mesenchymal phenotypes.

Published in:

Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 8b, p. 2570, doi. 10.1111/j.1582-4934.2008.00570.x

By:

Davani, Behrous;
Ariely, Sahar;
Ikonomou, Laertis;
Oron, Yoram;
Gershengorn, Marvin C.

Publication type:

Article

Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2.

Published in:

Proteins, 2008, v. 71, n. 2, p. 783, doi. 10.1002/prot.21763

By:

Deflorian, Francesca;
Engel, Stanislav;
Colson, Anny-Odile;
Raaka, Bruce M.;
Gershengorn, Marvin C.;
Costanzi, Stefano

Publication type:

Article

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.

Published in:

Nature, 1998, v. 391, n. 6662, p. 86, doi. 10.1038/34193

By:

Bais, Carlos;
Santomasso, Bianca;
Coso, Omar;
Arvanitakis, Leandros;
Geras Raaka, Elizabeth;
Gutkind, J. Silvio;
Asch, Adam S.;
Cesarman, Ethel;
Gershengorn, Marvin C.;
Mesri, Enrique A.

Publication type:

Article

Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice.

Published in:

Neuropsychopharmacology, 2013, v. 38, n. 6, p. 950, doi. 10.1038/npp.2012.256

By:

Thirunarayanan, Nanthakumar;
Nir, Eshel A;
Raaka, Bruce M;
Gershengorn, Marvin C

Publication type:

Article

TRH-Receptor-Type-2-Deficient Mice are Euthyroid and Exhibit Increased Depression and Reduced Anxiety Phenotypes.

Published in:

Neuropsychopharmacology, 2009, v. 34, n. 6, p. 1601, doi. 10.1038/npp.2008.217

By:

Sun, Yuhua;
Zupan, Bojana;
Raaka, Bruce M.;
Toth, Miklos;
Gershengorn, Marvin C.

Publication type:

Article

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.

Published in:

Cellular & Molecular Life Sciences, 2011, v. 68, n. 1, p. 159, doi. 10.1007/s00018-010-0451-2

By:

Haas, Ann-Karin;
Kleinau, Gunnar;
Hoyer, Inna;
Neumann, Susanne;
Furkert, Jens;
Rutz, Claudia;
Schülein, Ralf;
Gershengorn, Marvin;
Krause, Gerd

Publication type:

Article

An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 9, p. 2306, doi. 10.1210/clinem/dgae114

By:

Sarkar, Rhitajit;
Bolel, Priyanka;
Kapoor, Abhijeet;
Eliseeva, Elena;
Dulcey, Andrés E;
Templin, Jay S;
Wang, Amy Q;
Xu, Xin;
Southall, Noel;
Klubo-Gwiezdzinska, Joanna;
Neumann, Susanne;
Marugan, Juan J;
Gershengorn, Marvin C

Publication type:

Article

Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 4, p. e1653, doi. 10.1210/clinem/dgab824

By:

Krieger, Christine C.;
Sui, Xiangliang;
Kahaly, George J.;
Neumann, Susanne;
Gershengorn, Marvin C.

Publication type:

Article

Platelet-Derived Growth Factor BB Mimics Serum-Induced Dispersal of Pancreatic Epithelial Cell Clusters.

Published in:

Journal of Cellular Physiology, 2014, v. 229, n. 6, p. 743, doi. 10.1002/jcp.24493

By:

Hiram‐Bab, Sahar;
Katz, Liora S.;
Shapira, Hagit;
Sandbank, Judith;
Gershengorn, Marvin C.;
Oron, Yoram

Publication type:

Article

Knock-down of plasminogen-activator inhibitor-1 enhances expression of E-cadherin and promotes epithelial differentiation of human pancreatic adenocarcinoma cells.

Published in:

Journal of Cellular Physiology, 2012, v. 227, n. 11, p. 3621, doi. 10.1002/jcp.24068

By:

Lupu-Meiri, Monica;
Geras-Raaka, Elizabeth;
Lupu, Ruth;
Shapira, Hagit;
Sandbank, Judith;
Segal, Liora;
Gershengorn, Marvin C.;
Oron, Yoram

Publication type:

Article

Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1.

Published in:

Journal of Cellular Physiology, 2008, v. 216, n. 3, p. 632, doi. 10.1002/jcp.21441

By:

Deshet, Naamit;
Lupu-Meiri, Monica;
Espinoza, Ingrid;
Fili, Oded;
Shapira, Yuval;
Lupu, Ruth;
Gershengorn, Marvin C.;
Oron, Yoram

Publication type:

Article

Trypsin and thrombin accelerate aggregation of human endocrine pancreas precursor cells<FNR></FNR><FN>This article is a US Government work and, as such, is in the public domain in the United States of America. </FN>.

Published in:

Journal of Cellular Physiology, 2006, v. 206, n. 2, p. 322, doi. 10.1002/jcp.20459

By:

Chiju Wei;
Geras-Raaka, Elizabeth;
Marcus-Samuels, Bernice;
Oron, Yoram;
Gershengorn, Marvin C.

Publication type:

Article

Contribution of response kinetics to the response pattern: Studies of responses to thyrotropin-releasing hormone in Xenopus oocytes.

Published in:

Journal of Cellular Physiology, 1995, v. 162, n. 2, p. 284, doi. 10.1002/jcp.1041620214

By:

Lipinsky, Dafna;
Gershengorn, Marvin C.;
Oron, Yoram

Publication type:

Article

Dynorphin Stimulates Corticotropin Release from Mouse Anterior Pituitary AtT-20 Cells through Nonopioid Mechanisms.

Published in:

Neuroendocrinology, 2000, v. 71, n. 3, p. 170, doi. 10.1159/000054534

By:

Cheng, Peter Y.;
Birk, Alex V.;
Gershengorn, Marvin C.;
Szeto, Hazel H.

Publication type:

Article

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.

Published in:

2016

By:

Krieger, Christine C;
Place, Robert F;
Bevilacqua, Carmine;
Marcus-Samuels, Bernice;
Abel, Brent S;
Skarulis, Monica C;
Kahaly, George J;
Neumann, Susanne;
Gershengorn, Marvin C

Publication type:

journal article

Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins.

Published in:

2015

By:

Krieger, Christine C;
Neumann, Susanne;
Place, Robert F;
Marcus-Samuels, Bernice;
Gershengorn, Marvin C

Publication type:

journal article

A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy.

Published in:

2013

By:

Turcu, Adina F;
Kumar, Seema;
Neumann, Susanne;
Coenen, Michael;
Iyer, Seethalakshmi;
Chiriboga, Pamela;
Gershengorn, Marvin C;
Bahn, Rebecca S

Publication type:

journal article

Update in TSH receptor agonists and antagonists.

Published in:

2012

By:

Gershengorn MC;
Neumann S;
Gershengorn, Marvin C;
Neumann, Susanne

Publication type:

journal article

A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.

Published in:

2011

By:

Neumann, Susanne;
Eliseeva, Elena;
McCoy, Joshua G;
Napolitano, Giorgio;
Giuliani, Cesidio;
Monaco, Fabrizio;
Huang, Wenwei;
Gershengorn, Marvin C

Publication type:

journal article

Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.

Published in:

Frontiers in Endocrinology, 2016, v. 7, p. 1, doi. 10.3389/fendo.2016.00168

By:

Morgan, Sarah J.;
Neumann, Susanne;
Marcus-Samuels, Bernice;
Gershengorn, Marvin C.

Publication type:

Article

An Enantiomer of an Oral small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties.

Published in:

Frontiers in Endocrinology, 2016, p. 1, doi. 10.3389/fendo.2016.00105

By:

Neumann, Susanne;
Padia, Umesh;
Cullen, Mary Jane;
Eliseeva, Elena;
Nir, Eshel A.;
Place, Robert F.;
Gershengorn, Sarah J. Morgan and Marvin C.

Publication type:

Article

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor.

Published in:

Frontiers in Endocrinology, 2012, v. 3, p. 1, doi. 10.3389/fendo.2012.00120

By:

Thirunarayanan, Nanthakumar;
Raaka, Bruce M.;
Gershengorn, Marvin C.

Publication type:

Article