Works matching AU Germain, Doris

Results: 31

Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responses.

Published in:

Aging Cell, 2022, v. 21, n. 10, p. 1, doi. 10.1111/acel.13665

By:

Jenkins, Edmund Charles;
Chattopadhyay, Mrittika;
Gomez, Maria;
Torre, Denis;
Ma'ayan, Avi;
Torres‐Martin, Miguel;
Sia, Daniela;
Germain, Doris

Publication type:

Article

Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 4, p. 388, doi. 10.15252/emmm.201606273

By:

Takabatake, Yukie;
Oxvig, Claus;
Nagi, Chandandeep;
Adelson, Kerin;
Jaffer, Shabnam;
Schmidt, Hank;
Keely, Patricia J;
Eliceiri, Kevin W;
Mandeli, John;
Germain, Doris

Publication type:

Article

Proteasome mapping reveals sexual dimorphism in tissue‐specific sensitivity to protein aggregations.

Published in:

EMBO Reports, 2020, v. 21, n. 4, p. 1, doi. 10.15252/embr.201948978

By:

Jenkins, Edmund Charles;
Shah, Nagma;
Gomez, Maria;
Casalena, Gabriella;
Zhao, Dazhi;
Kenny, Timothy C;
Guariglia, Sara Rose;
Manfredi, Giovanni;
Germain, Doris

Publication type:

Article

Skp2B attenuates p53 function by inhibiting prohibitin.

Published in:

EMBO Reports, 2010, v. 11, n. 3, p. 220, doi. 10.1038/embor.2010.2

By:

Chander, Harish;
Halpern, Max;
Resnick-Silverman, Lois;
Manfredi, James J;
Germain, Doris

Publication type:

Article

Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma.

Published in:

Oncogene, 2003, v. 22, n. 28, p. 4425, doi. 10.1038/sj.onc.1206488

By:

Pirkmaier, Andreja;
Dow, Renee;
Ganiatsas, Soula;
Waring, Paul;
Warren, Kerry;
Thompson, Anne;
Hendley, Joy;
Germain, Doris

Publication type:

Article

A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT.

Published in:

Oncogene, 2001, v. 20, n. 28, p. 3641, doi. 10.1038/sj.onc.1204501

By:

Ganiatsas, Soula;
Dow, Renee;
Thompson, Anne;
Schulman, Brenda;
Germain, Doris

Publication type:

Article

Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclins.

Published in:

Oncogene, 1999, v. 18, n. 47, p. 6454, doi. 10.1038/sj.onc.1203030

By:

Russell, Adrian;
Hendley, Joy;
Germain, Doris

Publication type:

Article

Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.

Published in:

Oncogene, 1999, v. 18, n. 11, p. 1983, doi. 10.1038/sj.onc.1202511

By:

Russell, Adrian;
Thompson, M Anne;
Hendley, Joy;
Trute, Lyn;
Armes, Jane;
Germain, Doris

Publication type:

Article

Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.

Published in:

Oncogene, 1999, v. 18, n. 11, p. 1983, doi. 10.1038/sj.onc.1202511

By:

Russell, Adrian;
Thompson, M Anne;
Hendley, Joy;
Trute, Lyn;
Armes, Jane;
Germain, Doris

Publication type:

Article

Toward the identification and the targeting of key players of the mitochondrial unfolded protein response (UPR) in cancer.

Published in:

Journal of Bioenergetics & Biomembranes, 2017, v. 49, n. 4, p. 291, doi. 10.1007/s10863-017-9716-x

By:

Germain, Doris

Publication type:

Article

From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3.

Published in:

Journal of Bioenergetics & Biomembranes, 2017, v. 49, n. 4, p. 297, doi. 10.1007/s10863-017-9722-z

By:

Kenny, Timothy;
Germain, Doris

Publication type:

Article

Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer subtype determination according to age?

Published in:

Aging & Cancer, 2021, v. 2, n. 3, p. 75, doi. 10.1002/aac2.12035

By:

Jenkins, Edmund Charles;
Chattopadhyay, Mrittika;
Germain, Doris

Publication type:

Article

Cydlin D1 Overexpression and Response to Bortezomib Treatment in a Breast Cancer Model.

Published in:

JNCI: Journal of the National Cancer Institute, 2006, v. 98, n. 17, p. 1238, doi. 10.1093/jnci/djj334

By:

Ishii, Yuki;
Pirkmaier, Andreja;
Alvarez, James V.;
Frank, David A.;
Keselman, Inna;
Logothetis, Diomedes;
Mandeli, John;
Connell, Matthew J. O.;
Waxman, Samuel;
Germain, Doris

Publication type:

Article

Ubiquitin-dependent and -independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseases.

Published in:

Molecular Microbiology, 2008, v. 70, n. 6, p. 1334, doi. 10.1111/j.1365-2958.2008.06502.x

By:

Germain, Doris

Publication type:

Article

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07338-z

By:

Lee, Youngmin A.;
Noon, Luke A.;
Akat, Kemal M.;
Ybanez, Maria D.;
Lee, Ting-Fang;
Berres, Marie-Luise;
Fujiwara, Naoto;
Goossens, Nicolas;
Chou, Hsin-I;
Parvin-Nejad, Fatemeh P.;
Khambu, Bilon;
Kramer, Elisabeth G. M.;
Gordon, Ronald;
Pfleger, Cathie;
Germain, Doris;
John, Gareth R.;
Campbell, Kirk N.;
Yue, Zhenyu;
Yin, Xiao-Ming;
Cuervo, Ana Maria

Publication type:

Article

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2.

Published in:

2019

By:

Slocum, Elizabeth;
Craig, Amanda;
Villanueva, Augusto;
Germain, Doris

Publication type:

journal article

Doxycycline promotes proteasome fitness in the central nervous system.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96540-z

By:

Jenkins, Edmund Charles;
O'Connell, Matthew J.;
Manfredi, Giovanni;
Germain, Doris

Publication type:

Article

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival.

Published in:

Science Translational Medicine, 2013, v. 5, n. 169, p. 1, doi. 10.1126/scitranslmed.3004688

By:

Hatami, Raheleh;
Sieuwerts, Anieta M.;
Izadmehr, Sudeh;
Zhong Yao;
Rui Fang Qiao;
Papa, Luena;
Look, Maxime P.;
Smid, Marcel;
Ohlssen, Jessica;
Levine, Alice C.;
Germain, Doris;
Burstein, David;
Kirschenbaum, Alexander;
DiFeo, Analisa;
Foekens, John A.;
Narla, Goutham

Publication type:

Article

Raloxifene is a Female-specific Proteostasis Therapeutic in the Spinal Cord.

Published in:

Endocrinology, 2021, v. 162, n. 2, p. 1, doi. 10.1210/endocr/bqaa221

By:

Jenkins, Edmund Charles;
Casalena, Gabriella;
Gomez, Maria;
Zhao, Dazhi;
Kenny, Timothy C;
Shah, Nagma;
Manfredi, Giovanni;
Germain, Doris

Publication type:

Article

Germline CAG repeat length of the androgen receptor and time to progression in patients with prostate cancer treated with androgen deprivation therapy.

Published in:

BJU International, 2011, v. 108, n. 7, p. 1086, doi. 10.1111/j.1464-410X.2010.10037.x

By:

Misra, Dipika;
Xie, Wanling;
Regan, Meredith M.;
Ross, Robert W.;
Lee, Gwo-shu;
Germain, Doris;
Kantoff, Philip W.;
Oh, William K.

Publication type:

Article

Sex specific activation of the ERα axis of the mitochondrial UPR (UPR<sup>mt</sup>) in the G93A-SOD1 mouse model of familial ALS.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 7, p. 1318, doi. 10.1093/hmg/ddx049

By:

Riar, Amanjot K.;
Burstein, Suzanne R.;
Palomo, Gloria M.;
Arreguin, Andrea;
Manfredi, Giovanni;
Germain, Doris

Publication type:

Article

Can THEM6 targeting stop resistance to prostate cancer treatment?

Published in:

EMBO Molecular Medicine, 2022, v. 14, n. 3, p. 1, doi. 10.15252/emmm.202115504

By:

Chattopadhyay, Mrittika;
Germain, Doris

Publication type:

Article

Skp2B Overexpression Alters a Prohibitin-p53 Axis and the Transcription of PAPP-A, the Protease of Insulin-Like Growth Factor Binding Protein 4.

Published in:

PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0022456

By:

Chander, Harish;
Halpern, Max;
Resnick-Silverman, Lois;
Manfredi, James J.;
Germain, Doris

Publication type:

Article

Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer.

Published in:

Oncogene, 2005, v. 24, n. 21, p. 3448, doi. 10.1038/sj.onc.1208328

By:

Radke, Susanne;
Pirkmaier, Andreja;
Germain, Doris

Publication type:

Article

Skp2 and Skp2B team up against Rb and p53.

Published in:

Cell Division, 2011, v. 6, n. 1, p. 1, doi. 10.1186/1747-1028-6-1

By:

Germain, Doris

Publication type:

Article

SirT3 Regulates the Mitochondrial Unfolded Protein Response.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 4, p. 699, doi. 10.1128/MCB.01337-13

By:

Papa, Luena;
Germain, Doris

Publication type:

Article

Skp2B Stimulates Mammary Gland Development by Inhibiting REA, the Repressor of the Estrogen Receptor.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 21, p. 23, doi. 10.1128/MCB.01239-07

By:

Umanskaya, Karina;
Radke, Susanne;
Chander, Harish;
Monardo, Rosie;
Xinsong Xu;
Zhen-Qiang Pan;
O'Connell, Matthew J.;
Germain, Doris

Publication type:

Article

The Multi-Faced Role of PAPP-A in Post-Partum Breast Cancer: IGF-Signaling is Only the Beginning.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2020, v. 25, n. 3, p. 181, doi. 10.1007/s10911-020-09456-1

By:

Jenkins, Edmund Charles;
Brown, Samantha O.;
Germain, Doris

Publication type:

Article

The Mitochondrial Unfolded Protein Response as a non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.

Published in:

Frontiers in Oncology, 2017, p. 1, doi. 10.3389/fonc.2017.00159

By:

Kenny, Timothy C.;
Manfredi, Giovanni;
Germain, Doris

Publication type:

Article

Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.

Published in:

Breast Cancer Research, 2014, v. 16, n. 6, p. 59, doi. 10.1186/s13058-014-0503-x

By:

Chander, Harish;
Brien, Colin D.;
Truesdell, Peter;
Watt, Kathleen;
Meens, Jalna;
Schick, Colleen;
Germain, Doris;
Craig, Andrew W. B.

Publication type:

Article

Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.

Published in:

2014

By:

Chander, Harish;
Brien, Colin D;
Truesdell, Peter;
Watt, Kathleen;
Meens, Jalna;
Schick, Colleen;
Germain, Doris;
Craig, Andrew W;
Craig, Andrew W B

Publication type:

journal article