Works by Gerhardt, Ellen

Results: 28

Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1.

Published in:

Aging Cell, 2024, v. 23, n. 5, p. 1, doi. 10.1111/acel.14128

By:

Galka, Dajana;
Ali, Tariq T.;
Bast, Alexander;
Niederleithinger, Marie;
Gerhardt, Ellen;
Motosugi, Ryo;
Sakata, Eri;
Knop, Michael;
Outeiro, Tiago F.;
Popova, Blagovesta;
Braus, Gerhard H.

Publication type:

Article

Membrane binding, internalization, and sorting of alpha-synuclein in the cell.

Published in:

Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0578-1

By:

Masaracchia, Caterina;
Hnida, Marilena;
Gerhardt, Ellen;
Lopes da Fonseca, Tomás;
Villar-Pique, Anna;
Branco, Tiago;
Stahlberg, Markus A.;
Dean, Camin;
Fernández, Claudio O.;
Milosevic, Ira;
Outeiro, Tiago F.

Publication type:

Article

α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP<sup>C</sup>-CCR5 dependent pathway.

Published in:

Cell Death & Disease, 2024, v. 15, n. 4, p. 1, doi. 10.1038/s41419-024-06630-9

By:

Oliveira da Silva, Marina I.;
Santejo, Miguel;
Babcock, Isaac W.;
Magalhães, Ana;
Minamide, Laurie S.;
Won, Seok-Joon;
Castillo, Erika;
Gerhardt, Ellen;
Fahlbusch, Christiane;
Swanson, Raymond A.;
Outeiro, Tiago F.;
Taipa, Ricardo;
Ruff, Michael;
Bamburg, James R.;
Liz, Márcia A.

Publication type:

Article

FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 29, p. 6765, doi. 10.1523/JNEUROSCI.1700-05.2005

By:

Beier, Christoph P.;
Wischhusen, Jörg;
Gleichmann, Marc;
Gerhardt, Ellen;
Pekanovic, Ana;
Krueger, Andreas;
Taylor, Verdon;
Suter, Ueli;
Krammer, Peter H.;
Endres, Matthias;
Weller, Michael;
Schulz, Jörg B.

Publication type:

Article

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 1, p. 31, doi. 10.1093/hmg/ddy326

By:

Pinho, Raquel;
Paiva, Isabel;
Jerčić, Kristina Gotovac;
Fonseca-Ornelas, Luis;
Gerhardt, Ellen;
Fahlbusch, Christiane;
Garcia-Esparcia, Paula;
Kerimoglu, Cemil;
Pavlou, Maria A S;
Villar-Piqué, Anna;
Szegő, Éva;
Fonseca, Tomás Lopes da;
Odoardi, Francesca;
Soeroes, Szabolcs;
Rego, Ana Cristina;
Fischle, Wolfgang;
Schwamborn, Jens C;
Meyer, Thomas;
Kügler, Sebastian;
Ferrer, Isidre

Publication type:

Article

Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.

Published in:

PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157852

By:

Pinho, Raquel;
Guedes, Leonor C.;
Soreq, Lilach;
Lobo, Patrícia P.;
Mestre, Tiago;
Coelho, Miguel;
Rosa, Mário M.;
Gonçalves, Nilza;
Wales, Pauline;
Mendes, Tiago;
Gerhardt, Ellen;
Fahlbusch, Christiane;
Bonifati, Vincenzo;
Bonin, Michael;
Miltenberger-Miltényi, Gabriel;
Borovecki, Fran;
Soreq, Hermona;
Ferreira, Joaquim J.;
F. Outeiro, Tiago

Publication type:

Article

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

Published in:

Biochemical Society Transactions, 2019, v. 47, n. 3, p. 827, doi. 10.1042/BST20180466

By:

Outeiro, Tiago Fleming;
Harvey, Kirsten;
Dominguez-Meijide, Antonio;
Gerhardt, Ellen

Publication type:

Article

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.

Published in:

Brain: A Journal of Neurology, 2010, v. 133, n. 8, p. 2248, doi. 10.1093/brain/awq179

By:

Linker, Ralf A.;
Lee, De-Hyung;
Demir, Seray;
Wiese, Stefan;
Kruse, Niels;
Siglienti, Ines;
Gerhardt, Ellen;
Neumann, Harald;
Sendtner, Michael;
Lühder, Fred;
Gold, Ralf

Publication type:

Article

Correction: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

Published in:

2017

By:

Pinho, Raquel;
Guedes, Leonor C.;
Soreq, Lilach;
Lobo, Patrícia P.;
Mestre, Tiago;
Coelho, Miguel;
Rosa, Mário M.;
Gonçalves, Nilza;
Wales, Pauline;
Mendes, Tiago;
Gerhardt, Ellen;
Fahlbusch, Christiane;
Bonifati, Vincenzo;
Bonin, Michael;
Miltenberger-Miltényi, Gabriel;
Borovecki, Fran;
Soreq, Hermona;
Ferreira, Joaquim J.;
Outeiro, Tiago F.

Publication type:

Correction Notice

Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kölliker–Fuse nucleus of rat.

Published in:

Journal of Physiology, 2008, v. 586, n. 9, p. 2331, doi. 10.1113/jphysiol.2007.148916

By:

Kron, Miriam;
Reuter, Julia;
Gerhardt, Ellen;
Manzke, Till;
Zhang, Weiqi;
Dutschmann, Mathias

Publication type:

Article

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06846-9

By:

Torres-Garcia, Laura;
P. Domingues, Joana M.;
Brandi, Edoardo;
Haikal, Caroline;
Mudannayake, Janitha M.;
Brás, Inês C.;
Gerhardt, Ellen;
Li, Wen;
Svanbergsson, Alexander;
Outeiro, Tiago F.;
Gouras, Gunnar K.;
Li, Jia-Yi

Publication type:

Article

Functions of the Large Hepatitis B Virus Surface Protein in Viral Particle Morphogenesis.

Published in:

Intervirology, 1996, v. 39, n. 1/2, p. 23, doi. 10.1159/000150471

By:

Bruss, Volker;
Gerhardt, Ellen;
Vieluf, Kerstin;
Wunderlich, Gerhard

Publication type:

Article

Synucleinopathies: Where we are and where we need to go.

Published in:

Journal of Neurochemistry, 2020, v. 153, n. 4, p. 433, doi. 10.1111/jnc.14965

By:

Brás, Inês Caldeira;
Dominguez‐Meijide, Antonio;
Gerhardt, Ellen;
Koss, David;
Lázaro, Diana F.;
Santos, Patrícia I.;
Vasili, Eftychia;
Xylaki, Mary;
Outeiro, Tiago Fleming

Publication type:

Article

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 6, p. 5269, doi. 10.1007/s12035-017-0755-4

By:

Brasil, Aline A.;
Magalhães, Rayne S. S.;
De Carvalho, Mariana D. C.;
Paiva, Isabel;
Gerhardt, Ellen;
Pereira, Marcos D.;
Outeiro, Tiago F.;
Eleutherio, Elis C. A.

Publication type:

Article

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

Published in:

Molecular Neurobiology, 2016, v. 53, n. 5, p. 3124, doi. 10.1007/s12035-015-9209-z

By:

Guerreiro, Patrícia;
Gerhardt, Ellen;
Lopes da Fonseca, Tomás;
Bähr, Mathias;
Outeiro, Tiago;
Eckermann, Katrin

Publication type:

Article

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 12, p. 2231, doi. 10.1093/hmg/ddx114

By:

Paiva, Isabel;
Pinho, Raquel;
Pavlou, Maria Angeliki;
Hennion, Magali;
Wales, Pauline;
Schütz, Anna-Lena;
Rajput, Ashish;
Szegő, Éva M.;
Kerimoglu, Cemil;
Gerhardt, Ellen;
Rego, Ana Cristina;
Fischer, André;
Bonn, Stefan;
Outeiro, Tiago F.

Publication type:

Article

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 2, p. 275, doi. 10.1093/hmg/ddv470

By:

Tenreiro, Sandra;
Rosado-Ramos, Rita;
Gerhardt, Ellen;
Favretto, Filippo;
Magalhães, Filipa;
Popova, Blagovesta;
Becker, Stefan;
Zweckstetter, Markus;
Braus, Gerhard H.;
Tiago Fleming Outeiro

Publication type:

Article

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 1, p. 76, doi. 10.1093/hmg/ddu421

By:

Blum, David;
Herrera, Federico;
Francelle, Laetitia;
Mendes, Tiago;
Basquin, Marie;
Obriot, Hélène;
Demeyer, Dominique;
Sergeant, Nicolas;
Gerhardt, Ellen;
Brouillet, Emmanuel;
Buée, Luc;
Outeiro, Tiago F.

Publication type:

Article

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028855

By:

Gerhardt, Ellen;
Gräber, Simone;
Éva M. Szegoő;
Moisoi, Nicoleta;
Martins, L. Miguel;
Outeiro, Tiago F.;
Kermer, Pawel

Publication type:

Article

Fas/CD95 Regulatory Protein Faim2 Is Neuroprotective after Transient Brain Ischemia.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 1, p. 225, doi. 10.1523/JNEUROSCI.2188-10.2011

By:

Reich, Arno;
Spering, Christopher;
Gertz, Karen;
Harms, Christoph;
Gerhardt, Ellen;
Kronenberg, Golo;
Nave, Klaus A.;
Schwab, Markus;
Tauber, Simone C.;
Drinkut, Anja;
Harms, Kristian;
Beier, Chrstioph P.;
Voigt, Aaron;
Göbbels, Sandra;
Endres, Matthias;
Schulz, Jörg B.

Publication type:

Article

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation.

Published in:

PLoS Genetics, 2014, v. 10, n. 11, p. 1, doi. 10.1371/journal.pgen.1004741

By:

Lázaro, Diana F.;
Rodrigues, Eva F.;
Langohr, Ramona;
Shahpasandzadeh, Hedieh;
Ribeiro, Thales;
Guerreiro, Patrícia;
Gerhardt, Ellen;
Kröhnert, Katharina;
Klucken, Jochen;
Pereira, Marcos D.;
Popova, Blagovesta;
Kruse, Niels;
Mollenhauer, Brit;
Rizzoli, Silvio O.;
Braus, Gerhard H.;
Danzer, Karin M.;
Outeiro, Tiago F.

Publication type:

Article

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity.

Published in:

PLoS Genetics, 2012, v. 8, n. 2, p. 1, doi. 10.1371/journal.pgen.1002488

By:

Butler, Erin K.;
Voigt, Aaron;
Lutz, A. Kathrin;
Toegel, Jane P.;
Gerhardt, Ellen;
Karsten, Peter;
Falkenburger, Björn;
Reinartz, Andrea;
Winklhofer, Konstanze F.;
Schulz, Jörg B.

Publication type:

Article

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

Published in:

2017

By:

de Oliveira, Rita Machado;
Vicente Miranda, Hugo;
Francelle, Laetitia;
Pinho, Raquel;
Szegö, Éva M.;
Martinho, Renato;
Munari, Francesca;
Lázaro, Diana F.;
Moniot, Sébastien;
Guerreiro, Patrícia;
Fonseca-Ornelas, Luis;
Marijanovic, Zrinka;
Antas, Pedro;
Gerhardt, Ellen;
Enguita, Francisco Javier;
Fauvet, Bruno;
Penque, Deborah;
Pais, Teresa Faria;
Tong, Qiang;
Becker, Stefan

Publication type:

Correction Notice

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

Published in:

PLoS Biology, 2017, v. 15, n. 3, p. 1, doi. 10.1371/journal.pbio.2000374

By:

de Oliveira, Rita Machado;
Vicente Miranda, Hugo;
Francelle, Laetitia;
Pinho, Raquel;
Szegö, Éva M.;
Martinho, Renato;
Munari, Francesca;
Lázaro, Diana F.;
Moniot, Sébastien;
Guerreiro, Patrícia;
Fonseca, Luis;
Marijanovic, Zrinka;
Antas, Pedro;
Gerhardt, Ellen;
Enguita, Francisco Javier;
Fauvet, Bruno;
Penque, Deborah;
Pais, Teresa Faria;
Tong, Qiang;
Becker, Stefan

Publication type:

Article

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.

Published in:

Human Molecular Genetics, 2003, v. 12, n. 11, p. 1223, doi. 10.1093/hmg/ddg134

By:

Marx, Frank P.;
Holzmann, Carsten;
Strauss, Karsten M.;
Li, Lei;
Eberhardt, Olaf;
Gerhardt, Ellen;
Cookson, Mark R.;
Hernandez, Dena;
Farrer, Matt J.;
Kachergus, Jennifer;
Engelender, Simone;
Ross, Christopher A.;
Berger, Klaus;
Schöls, Ludger;
Schulz, Jörg B.;
Riess, Olaf;
Krüger, Rejko

Publication type:

Article

Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance.

Published in:

Chemistry - Methods, 2022, v. 2, n. 7, p. 1, doi. 10.1002/cmtd.202200023

By:

Ding, Yonghong;
Korchak, Sergey;
Mamone, Salvatore;
Jagtap, Anil P.;
Stevanato, Gabriele;
Sternkopf, Sonja;
Moll, Denis;
Schroeder, Henning;
Becker, Stefan;
Fischer, André;
Gerhardt, Ellen;
Outeiro, Tiago F.;
Opazo, Felipe;
Griesinger, Christian;
Glöggler, Stefan

Publication type:

Article

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

Published in:

Journal of Neurochemistry, 2009, v. 108, n. 1, p. 139, doi. 10.1111/j.1471-4159.2008.05755.x

By:

Krenz, Antje;
Falkenburger, Björn H.;
Gerhardt, Ellen;
Drinkut, Anja;
Schulz, Jörg B.

Publication type:

Article

Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes:in vitroparadigm of differential neurotoxicity.

Published in:

Journal of Neurochemistry, 2004, v. 91, n. 5, p. 1067, doi. 10.1111/j.1471-4159.2004.02774.x

By:

Wick, Antje;
Wick, Wolfgang;
Hirrlinger, Johannes;
Gerhardt, Ellen;
Dringen, Ralf;
Dichgans, Johannes;
Weller, Michael;
Schulz, Jörg B.

Publication type:

Article