Works by Georges, Guy

Results: 39

Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells.

Published in:

Frontiers in Bioengineering & Biotechnology, 2024, p. 1, doi. 10.3389/fbioe.2024.1414408

By:

Bauer, Niels;
Boettger, Marco;
Papadaki, Styliani;
Leitner, Tanja;
Klostermann, Stefan;
Kettenberger, Hubert;
Georges, Guy;
Larraillet, Vincent;
Gluhacevic von Kruechten, Dino;
Hillringhaus, Lars;
Vogt, Annette;
Ausländer, Simon;
Popp, Oliver

Publication type:

Article

Comparative vascular responses three months after paclitaxel and everolimus-eluting stent implantation in streptozotocin-induced diabetic porcine coronary arteries.

Published in:

Cardiovascular Diabetology, 2012, v. 11, n. 1, p. 75, doi. 10.1186/1475-2840-11-75

By:

Sheehy, Alexander;
Hsu, Steven;
Bouchard, Amelie;
Lema, Pablo;
Savard, Claudine;
Guy, Louis-Georges;
Tai, Julie;
Polyakov, Igor

Publication type:

Article

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.

Published in:

Biological Chemistry, 2022, v. 403, n. 5/6, p. 495, doi. 10.1515/hsz-2021-0401

By:

Dickopf, Steffen;
Buldun, Can;
Vasic, Vedran;
Georges, Guy;
Hage, Carina;
Mayer, Klaus;
Forster, Matthias;
Wessels, Uwe;
Stubenrauch, Kay-Gunnar;
Benz, Jörg;
Ehler, Andreas;
Lauer, Matthias E.;
Ringler, Philippe;
Kobold, Sebastian;
Endres, Stefan;
Klein, Christian;
Brinkmann, Ulrich

Publication type:

Article

Inhibition of hypoxia‐induced angiogenesis by cigarette smoke exposure: impairment of the HIF‐lalpha/VEGF pathway.

Published in:

FASEB Journal, 2003, v. 17, n. 9, p. 1150, doi. 10.1096/fj.02-0172fje

By:

Michaud, Sophie-Élise;
Ménard, Catherine;
Guy, Louis-Georges;
Gennaro, Giuseppa;
Rivard, Alain

Publication type:

Article

Structural mechanism of Fab domain dissociation as a measure of interface stability.

Published in:

Journal of Computer-Aided Molecular Design, 2023, v. 37, n. 4, p. 201, doi. 10.1007/s10822-023-00501-9

By:

Pomarici, Nancy D.;
Waibl, Franz;
Quoika, Patrick K.;
Bujotzek, Alexander;
Georges, Guy;
Fernández-Quintero, Monica L.;
Liedl, Klaus R.

Publication type:

Article

Evaluation of Magnesium-based Medical Devices in Preclinical Studies: Challenges and Points to Consider.

Published in:

Toxicologic Pathology, 2019, v. 47, n. 3, p. 390, doi. 10.1177/0192623318816936

By:

Chagnon, Madeleine;
Guy, Louis-Georges;
Jackson, Nicolette

Publication type:

Article

ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04927-7

By:

Abanades, Brennan;
Wong, Wing Ki;
Boyles, Fergus;
Georges, Guy;
Bujotzek, Alexander;
Deane, Charlotte M.

Publication type:

Article

Back-to-Germline (B2G) Procedure for Antibody Devolution.

Published in:

Antibodies (2073-4468), 2019, v. 8, n. 3, p. 45, doi. 10.3390/antib8030045

By:

Schrade, Anja;
Bujotzek, Alexander;
Spick, Christian;
Wagner, Martina;
Goerl, Johannes;
Wezler, Xenia;
Georges, Guy;
Kontermann, Roland E.;
Brinkmann, Ulrich

Publication type:

Article

Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy.

Published in:

2023

By:

Vasic, Vedran;
Buldun, Can;
Ritz, Manfred;
Dickopf, Steffen;
Georges, Guy J.;
Spick, Christian;
Peuker, Alessa;
Meier, Thomas;
Mayer, Klaus;
Brinkmann, Ulrich

Publication type:

Report

Assessing developability early in the discovery process for novel biologics.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2171248

By:

Fernández-Quintero, Monica L.;
Ljungars, Anne;
Waibl, Franz;
Greiff, Victor;
Andersen, Jan Terje;
Gjølberg, Torleif T.;
Jenkins, Timothy P.;
Voldborg, Bjørn Gunnar;
Grav, Lise Marie;
Kumar, Sandeep;
Georges, Guy;
Kettenberger, Hubert;
Liedl, Klaus R.;
Tessier, Peter M.;
McCafferty, John;
Laustsen, Andreas H.

Publication type:

Article

Ensembles in solution as a new paradigm for antibody structure prediction and design.

Published in:

mAbs (1942-0862), 2021, v. 13, n. 1, p. 1, doi. 10.1080/19420862.2021.1923122

By:

Fernández-Quintero, Monica L.;
Georges, Guy;
Varga, Janos M.;
Liedl, Klaus R.

Publication type:

Article

Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope.

Published in:

2021

By:

Wong, Wing Ki;
Robinson, Sarah A.;
Bujotzek, Alexander;
Georges, Guy;
Lewis, Alan P.;
Shi, Jiye;
Snowden, James;
Taddese, Bruck;
Deane, Charlotte M.

Publication type:

Report

CDR-H3 loop ensemble in solution – conformational selection upon antibody binding.

Published in:

2019

By:

Fernández-Quintero, Monica L.;
Kraml, Johannes;
Georges, Guy;
Liedl, Klaus R.

Publication type:

Report

ABodyBuilder: Automated antibody structure prediction with data–driven accuracy estimation.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 7, p. 1259, doi. 10.1080/19420862.2016.1205773

By:

Leem, Jinwoo;
Dunbar, James;
Georges, Guy;
Shi, Jiye;
Deane, Charlotte M.

Publication type:

Article

Length-independent structural similarities enrich the antibody CDR canonical class model.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 4, p. 751, doi. 10.1080/19420862.2016.1158370

By:

Nowak, Jaroslaw;
Baker, Terry;
Georges, Guy;
Kelm, Sebastian;
Klostermann, Stefan;
Shi, Jiye;
Sridharan, Sudharsan;
Deane, Charlotte M.

Publication type:

Article

VH-VL orientation prediction for antibody humanization candidate selection: A case study.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 2, p. 288, doi. 10.1080/19420862.2015.1117720

By:

Bujotzek, Alexander;
Lipsmeier, Florian;
Harris, Seth F;
Benz, Jörg;
Kuglstatter, Andreas;
Georges, Guy

Publication type:

Article

MoFvAb: Modeling the Fv region of antibodies.

Published in:

mAbs (1942-0862), 2015, v. 7, n. 5, p. 838, doi. 10.1080/19420862.2015.1068492

By:

Bujotzek, Alexander;
Fuchs, Angelika;
Qu, Changtao;
Benz, Jörg;
Klostermann, Stefan;
Antes, Iris;
Georges, Guy

Publication type:

Article

Response to: Monoclonal antibodies targeting CD20.

Published in:

mAbs (1942-0862), 2013, v. 5, n. 3, p. 337, doi. 10.4161/mabs.24108

By:

Klein, Christian;
Lammens, Alfred;
Schäfer, Wolfgang;
Georges, Guy;
schwaiger, Manfred;
Mössner, Ekkehard;
Hopfner, Karl-Peter;
Umaña, Pablo;
Niederfellner, Gerhard

Publication type:

Article

Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties.

Published in:

mAbs (1942-0862), 2013, v. 5, n. 1, p. 1, doi. 10.4161/mabs.22771

By:

Klein, Christian;
Lammens, Alfred;
Schäfer, Wolfgang;
Georges, Guy;
Schwaiger, Manfred;
Mössner, Ekkehard;
Hopfner, Karl-Peter;
Umaña, Pablo;
Niederfellner, Gerhard

Publication type:

Article

Major salivary gland aplasia and hypoplasia in Down syndrome: review of the literature and report of a case.

Published in:

Clinical Case Reports, 2017, v. 5, n. 6, p. 939, doi. 10.1002/ccr3.975

By:

Chadi, Mary Jane;
Saint Georges, Guy;
Albert, Francine;
Mainville, Gisele;
Nguyen, Julie Mi;
Kauzman, Adel

Publication type:

Article

Position effects in mice carrying a lacZ transgene in cis with the β-globin LCR can be explained by a graded model.

Published in:

Nucleic Acids Research, 1997, v. 25, n. Supplement, p. 4400, doi. 10.1093/nar/25.21.4400

By:

Guy, Louis-Georges;
Kothary, Rashmi;
Wall, Lee

Publication type:

Article

In vitro and in vivo degradation of microfiber bioresorbable coronary scaffold.

Published in:

Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2018, v. 106, n. 5, p. 1842, doi. 10.1002/jbm.b.33987

By:

Huang, Chi‐Hung;
Lee, Sheng‐Yang;
Horng, Sonida;
Guy, Louis‐Georges;
Yu, Ting‐Bin

Publication type:

Article

ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation.

Published in:

Bioinformatics, 2022, v. 38, n. 7, p. 1877, doi. 10.1093/bioinformatics/btac016

By:

Abanades, Brennan;
Georges, Guy;
Bujotzek, Alexander;
Deane, Charlotte M

Publication type:

Article

Co-evolutionary distance predictions contain flexibility information.

Published in:

Bioinformatics, 2022, v. 38, n. 1, p. 65, doi. 10.1093/bioinformatics/btab562

By:

Schwarz, Dominik;
Georges, Guy;
Kelm, Sebastian;
Shi, Jiye;
Vangone, Anna;
Deane, Charlotte M

Publication type:

Article

SCALOP: sequence-based antibody canonical loop structure annotation.

Published in:

Bioinformatics, 2019, v. 35, n. 10, p. 1774, doi. 10.1093/bioinformatics/bty877

By:

Wong, Wing Ki;
Georges, Guy;
Ros, Francesca;
Kelm, Sebastian;
Lewis, Alan P;
Taddese, Bruck;
Leem, Jinwoo;
Deane, Charlotte M

Publication type:

Article

Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.

Published in:

Bioinformatics, 2017, v. 33, n. 9, p. 1346, doi. 10.1093/bioinformatics/btw823

By:

Marks, Claire;
Nowak, Jaroslaw;
Klostermann, Stefan;
Georges, Guy;
Dunbar, James;
Jiye Shi;
Kelm, Sebastian;
Deane, Charlotte M.

Publication type:

Article

SAbPred: a structure-based antibody prediction server.

Published in:

Nucleic Acids Research, 2016, v. 44, n. W1, p. W474, doi. 10.1093/nar/gkw361

By:

Dunbar, James;
Krawczyk, Konrad;
Leem, Jinwoo;
Marks, Claire;
Nowak, Jaroslaw;
Regep, Cristian;
Georges, Guy;
Kelm, Sebastian;
Popovic, Bojana;
Deane, Charlotte M.

Publication type:

Article

SAbDab: the structural antibody database.

Published in:

Nucleic Acids Research, 2014, v. 42, n. D1, p. D1140, doi. 10.1093/nar/gkt1043

By:

Dunbar, James;
Krawczyk, Konrad;
Leem, Jinwoo;
Baker, Terry;
Fuchs, Angelika;
Georges, Guy;
Shi, Jiye;
Deane, Charlotte M.

Publication type:

Article

Antibodies exhibit multiple paratope states influencing VH–VL domain orientations.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42003-020-01319-z

By:

Fernández-Quintero, Monica L.;
Pomarici, Nancy D.;
Math, Barbara A.;
Kroell, Katharina B.;
Waibl, Franz;
Bujotzek, Alexander;
Georges, Guy;
Liedl, Klaus R.

Publication type:

Article

Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18477-7

By:

Dengl, Stefan;
Mayer, Klaus;
Bormann, Felix;
Duerr, Harald;
Hoffmann, Eike;
Nussbaum, Bianca;
Tischler, Michael;
Wagner, Martina;
Kuglstatter, Andreas;
Leibrock, Lea;
Buldun, Can;
Georges, Guy;
Brinkmann, Ulrich

Publication type:

Article

VH‐VL interdomain dynamics observed by computer simulations and NMR.

Published in:

Proteins, 2020, v. 88, n. 7, p. 830, doi. 10.1002/prot.25872

By:

Fernández‐Quintero, Monica L.;
Hoerschinger, Valentin J.;
Lamp, Leonida M.;
Bujotzek, Alexander;
Georges, Guy;
Liedl, Klaus R.

Publication type:

Article

Antibody side chain conformations are position‐dependent.

Published in:

Proteins, 2018, v. 86, n. 4, p. 383, doi. 10.1002/prot.25453

By:

Leem, Jinwoo;
Georges, Guy;
Shi, Jiye;
Deane, Charlotte M.

Publication type:

Article

The H3 loop of antibodies shows unique structural characteristics.

Published in:

Proteins, 2017, v. 85, n. 7, p. 1311, doi. 10.1002/prot.25291

By:

Regep, Cristian;
Georges, Guy;
Shi, Jiye;
Popovic, Bojana;
Deane, Charlotte M.

Publication type:

Article

Prediction of VH-VL domain orientation for antibody variable domain modeling.

Published in:

Proteins, 2015, v. 83, n. 4, p. 681, doi. 10.1002/prot.24756

By:

Bujotzek, Alexander;
Dunbar, James;
Lipsmeier, Florian;
Schäfer, Wolfgang;
Antes, Iris;
Deane, Charlotte M.;
Georges, Guy

Publication type:

Article

The Patent and Literature Antibody Database (PLAbDab): an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures.

Published in:

Nucleic Acids Research, 2024, v. 52, n. D1, p. D545, doi. 10.1093/nar/gkad1056

By:

Abanades, Brennan;
Olsen, Tobias H;
Raybould, Matthew I J;
Aguilar-Sanjuan, Broncio;
Wong, Wing Ki;
Georges, Guy;
Bujotzek, Alexander;
Deane, Charlotte M

Publication type:

Article

Bispecific antibodies—effects of point mutations on CH3-CH3 interface stability.

Published in:

PEDS: Protein Engineering, Design & Selection, 2022, v. 35, p. 1, doi. 10.1093/protein/gzac012

By:

Pomarici, Nancy D;
Fernández-Quintero, Monica L;
Quoika, Patrick K;
Waibl, Franz;
Bujotzek, Alexander;
Georges, Guy;
Liedl, Klaus R

Publication type:

Article

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Published in:

2018

By:

Moll, Solange;
Yasui, Yukari;
Abed, Ahmed;
Murata, Takeshi;
Shimada, Hideaki;
Maeda, Akira;
Fukushima, Naoshi;
Kanamori, Masakazu;
Uhles, Sabine;
Badi, Laura;
Cagarelli, Thomas;
Formentini, Ivan;
Drawnel, Faye;
Georges, Guy;
Bergauer, Tobias;
Gasser, Rodolfo;
Bonfil, R. Daniel;
Fridman, Rafael;
Richter, Hans;
Funk, Juergen

Publication type:

journal article

Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.675655

By:

Fernández-Quintero, Monica L.;
Kroell, Katharina B.;
Bacher, Lisa M.;
Loeffler, Johannes R.;
Quoika, Patrick K.;
Georges, Guy;
Bujotzek, Alexander;
Kettenberger, Hubert;
Liedl, Klaus R.

Publication type:

Article

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.

Published in:

FASEB Journal, 2015, v. 29, n. 5, p. 1763, doi. 10.1096/fj.14-263665

By:

Dengl, Stefan;
Hoffmann, Eike;
Grote, Michael;
Wagner, Cornelia;
Mundigl, Olaf;
Georges, Guy;
Thorey, Irmgard;
Stubenrauch, Kay-Gunnar;
Bujotzek, Alexander;
Josel, Hans-Peter;
Dziadek, Sebastian;
Benz, Joerg;
Brinkmann, Ulrich

Publication type:

Article

Works by Georges, Guy

Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells.

Comparative vascular responses three months after paclitaxel and everolimus-eluting stent implantation in streptozotocin-induced diabetic porcine coronary arteries.

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.

Inhibition of hypoxia‐induced angiogenesis by cigarette smoke exposure: impairment of the HIF‐lalpha/VEGF pathway.

Structural mechanism of Fab domain dissociation as a measure of interface stability.

Evaluation of Magnesium-based Medical Devices in Preclinical Studies: Challenges and Points to Consider.

ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.

Back-to-Germline (B2G) Procedure for Antibody Devolution.

Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy.

Assessing developability early in the discovery process for novel biologics.

Ensembles in solution as a new paradigm for antibody structure prediction and design.

Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope.

CDR-H3 loop ensemble in solution – conformational selection upon antibody binding.

ABodyBuilder: Automated antibody structure prediction with data–driven accuracy estimation.

Length-independent structural similarities enrich the antibody CDR canonical class model.

VH-VL orientation prediction for antibody humanization candidate selection: A case study.

MoFvAb: Modeling the Fv region of antibodies.

Response to: Monoclonal antibodies targeting CD20.

Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties.

Major salivary gland aplasia and hypoplasia in Down syndrome: review of the literature and report of a case.

Position effects in mice carrying a lacZ transgene in cis with the β-globin LCR can be explained by a graded model.

In vitro and in vivo degradation of microfiber bioresorbable coronary scaffold.

ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation.

Co-evolutionary distance predictions contain flexibility information.

SCALOP: sequence-based antibody canonical loop structure annotation.

Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.

SAbPred: a structure-based antibody prediction server.

SAbDab: the structural antibody database.

Antibodies exhibit multiple paratope states influencing V<sub>H</sub>–V<sub>L</sub> domain orientations.

Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.

V<sub>H</sub>‐V<sub>L</sub> interdomain dynamics observed by computer simulations and NMR.

Antibody side chain conformations are position‐dependent.

The H3 loop of antibodies shows unique structural characteristics.

Prediction of VH-VL domain orientation for antibody variable domain modeling.

The Patent and Literature Antibody Database (PLAbDab): an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures.

Bispecific antibodies—effects of point mutations on CH3-CH3 interface stability.

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Germline-Dependent Antibody Paratope States and Pairing Specific V<sub>H</sub>-V<sub>L</sub> Interface Dynamics.

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.