Works by Georg, Gunda I.

Results: 30

Strategies to Develop Na,K-ATPase-α4 Inhibitors as Male Contraceptives.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5646, doi. 10.3390/ijms26125646

By:

Syeda, Shameem S.;
Sánchez, Gladis;
McDermott, Jeffrey P.;
Cheryala, Narsihmulu;
Wong, Henry L.;
Georg, Gunda I.;
Blanco, Gustavo

Publication type:

Article

Synthesis of Oximidine II by a Copper-Mediated Reductive Ene-Yne Macrocyclization.

Published in:

Angewandte Chemie, 2011, v. 123, n. 34, p. 8001, doi. 10.1002/ange.201103081

By:

Schneider, Christopher M.;
Khownium, Kriangsak;
Li, Wei;
Spletstoser, Jared T.;
Haack, Torsten;
Georg, Gunda I.

Publication type:

Article

A convenient preparation of 2-[15N]-amino-4,6-dimethoxypyrimidine.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1990, v. 28, n. 4, p. 433, doi. 10.1002/jlcr.2580280410

By:

Spencer, Thomas K.;
Georg, Gunda I.;
Aubé, Jeffrey

Publication type:

Article

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer.

Published in:

Science Translational Medicine, 2012, v. 4, n. 156, p. 1, doi. 10.1126/scitranslmed.3004334

By:

Chugh, Rohit;
Sangwan, Veena;
Patil, Satish P.;
Dudeja, Vikas;
Dawra, Rajinder K.;
Banerjee, Sulagna;
Schumacher, Robert J.;
Blazar, Bruce R.;
Georg, Gunda I.;
Vickers, Selwyn M.;
Saluja, Ashok K.

Publication type:

Article

Identification and Screening of Selective WEE2 Inhibitors to Develop Non‐Hormonal Contraceptives that Specifically Target Meiosis.

Published in:

ChemistrySelect, 2019, v. 4, n. 45, p. 13363, doi. 10.1002/slct.201903696

By:

Hanna, Carol B.;
Yao, Shan;
Martin, Mat;
Schönbrunn, Ernst;
Georg, Gunda I.;
Jensen, Jeffrey T.;
Cuellar, Rebecca A. D.

Publication type:

Article

Synthesis of Oximidine II by a Copper-Mediated Reductive Ene-Yne Macrocyclization.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 34, p. 7855, doi. 10.1002/anie.201103081

By:

Schneider, Christopher M.;
Khownium, Kriangsak;
Li, Wei;
Spletstoser, Jared T.;
Haack, Torsten;
Georg, Gunda I.

Publication type:

Article

N-Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 1, p. 301, doi. 10.3390/ijms21010301

By:

Gupta, Vijayalaxmi;
Hild, Sheri A.;
Jakkaraj, Sudhakar R.;
Carlson, Erick J.;
Wong, Henry L.;
Allen, C. Leigh;
Georg, Gunda I.;
Tash, Joseph S.

Publication type:

Article

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38732-x

By:

Faber, Erik B.;
Sun, Luxin;
Tang, Jian;
Roberts, Emily;
Ganeshkumar, Sornakala;
Wang, Nan;
Rasmussen, Damien;
Majumdar, Abir;
Hirsch, Laura E.;
John, Kristen;
Yang, An;
Khalid, Hira;
Hawkinson, Jon E.;
Levinson, Nicholas M.;
Chennathukuzhi, Vargheese;
Harki, Daniel A.;
Schönbrunn, Ernst;
Georg, Gunda I.

Publication type:

Article

Rapid Delivery of Diazepam from Supersaturated Solutions Prepared Using Prodrug/Enzyme Mixtures: Toward Intranasal Treatment of Seizure Emergencies.

Published in:

AAPS Journal, 2014, v. 16, n. 3, p. 577, doi. 10.1208/s12248-014-9596-5

By:

Kapoor, Mamta;
Winter, Tate;
Lis, Lev;
Georg, Gunda I.;
Siegel, Ronald A.

Publication type:

Article

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component (Eur. J. Org. Chem. 18/2014).

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 18, p. n/a, doi. 10.1002/ejoc.201490048

By:

Seki, Hajime;
Georg, Gunda I.

Publication type:

Article

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component.

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 18, p. 3777, doi. 10.1002/ejoc.201402232

By:

Seki, Hajime;
Georg, Gunda I.

Publication type:

Article

Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 4, p. 601, doi. 10.3390/biom15040601

By:

Nayyab, Saman;
Gervasi, Marıá Gracia;
Tourzani, Darya A.;
Shamailova, Yeva;
Akizawa, Hiroki;
Taghavi, Mahboubeh;
Cui, Wei;
Fissore, Rafael;
Salicioni, Ana Maria;
Georg, Gunda I.;
Snyder, Elizabeth;
Visconti, Pablo E.

Publication type:

Article

Structure-Activity Studies of N-Butyl-1-deoxynojirimycin ( NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.

Published in:

ChemMedChem, 2017, v. 12, n. 23, p. 1977, doi. 10.1002/cmdc.201700558

By:

Gu, Xingxian;
Gupta, Vijayalaxmi;
Yang, Yan;
Zhu, Jin‐Yi;
Carlson, Erick J.;
Kingsley, Carolyn;
Tash, Joseph S.;
Schönbrunn, Ernst;
Hawkinson, Jon;
Georg, Gunda I.

Publication type:

Article

Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).

Published in:

ChemMedChem, 2017, v. 12, n. 22, p. 1857, doi. 10.1002/cmdc.201700503

By:

Hawkinson, Jon E.;
Sinville, Rondedrick;
Mudaliar, Deepti;
Shetty, Jagathpala;
Ward, Timothy;
Herr, John C.;
Georg, Gunda I.

Publication type:

Article

Synthesis and Cytotoxicity Evaluation of C4- and C5-Modified Analogues of the α,β-Unsaturated Lactone of Pironetin.

Published in:

ChemMedChem, 2017, v. 12, n. 7, p. 520, doi. 10.1002/cmdc.201700084

By:

Huang, David S.;
Wong, Henry L.;
Georg, Gunda I.

Publication type:

Article

Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues.

Published in:

ChemMedChem, 2016, v. 11, n. 15, p. 1600, doi. 10.1002/cmdc.201600024

By:

Schneider, Christopher M.;
Li, Wei;
Khownium, Kriangsak;
Lushington, Gerald H.;
Georg, Gunda I.

Publication type:

Article

Cover Picture: Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues (ChemMedChem 15/2016).

Published in:

ChemMedChem, 2016, v. 11, n. 15, p. 1578, doi. 10.1002/cmdc.201600376

By:

Schneider, Christopher M.;
Li, Wei;
Khownium, Kriangsak;
Lushington, Gerald H.;
Georg, Gunda I.

Publication type:

Article

From Dioxin to Drug Lead-The Development of 2,3,7,8-Tetrachlorophenothiazine.

Published in:

ChemMedChem, 2007, v. 2, n. 6, p. 890, doi. 10.1002/cmdc.200700005

By:

Fried, Kristian W.;
Schneider, Christopher M.;
Schramm, Karl-Werner;
Datta, Apurba;
Chahbane, Naima;
Corsten, Claudia;
Powell, Douglas R.;
Lenoir, Dieter;
Kettrup, Antonius;
Terranova, Paul;
Georg, Gunda I.;
Rozman, Karl K.

Publication type:

Article

Investigation of selective retinoic acid receptor alpha antagonist ER‐50891 and related analogs for male contraception.

Published in:

Archiv der Pharmazie, 2023, v. 356, n. 7, p. 1, doi. 10.1002/ardp.202300031

By:

Kyzer, Jillian L.;
Noman, Md Abdullah Al;
Cuellar, Rebecca A. D.;
Chung, Sanny S. W.;
Maitra, Soma;
Naqvi, Tahmina;
Hawkinson, Jon E.;
Wolgemuth, Debra J.;
Georg, Gunda I.

Publication type:

Article

1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains.

Published in:

Archiv der Pharmazie, 2022, v. 355, n. 11, p. 1, doi. 10.1002/ardp.202200288

By:

Jiang, Jiewei;
Zhao, Pei‐Liang;
Sigua, Logan H.;
Chan, Alice;
Schönbrunn, Ernst;
Qi, Jun;
Georg, Gunda I.

Publication type:

Article

Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes.

Published in:

Archiv der Pharmazie, 2016, v. 349, n. 4, p. 233, doi. 10.1002/ardp.201500440

By:

Syeda, Shameem S.;
Rice, Daren;
Hook, Derek J.;
Heckert, Leslie L.;
Georg, Gunda I.

Publication type:

Article

Transition Metal-Free Direct Trifluoromethylation of 2,3-Dihydropyridin-4(1 H)-ones at Room Temperature.

Published in:

Advanced Synthesis & Catalysis, 2014, v. 356, n. 17, p. 3510, doi. 10.1002/adsc.201400417

By:

Yu, Yi ‐ Yun;
Ranade, Adwait R.;
Georg, Gunda I.

Publication type:

Article

Cover Picture: Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes (Adv. Synth. Catal. 6/2014).

Published in:

Advanced Synthesis & Catalysis, 2014, v. 356, n. 6, p. 1125, doi. 10.1002/adsc.201400050

By:

Yu, Yi ‐ Yun;
Georg, Gunda I.

Publication type:

Article

Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes.

Published in:

2014

By:

Yu, Yi ‐ Yun;
Georg, Gunda I.

Publication type:

Other

TSSK3, a novel target for male contraception, is required for spermiogenesis.

Published in:

Molecular Reproduction & Development, 2021, v. 88, n. 11, p. 718, doi. 10.1002/mrd.23539

By:

Nayyab, Saman;
Gervasi, María G.;
Tourzani, Darya A.;
Caraballo, Diego A.;
Jha, Kula N.;
Teves, Maria E.;
Cui, Wei;
Georg, Gunda I.;
Visconti, Pablo E.;
Salicioni, Ana M.

Publication type:

Article

The cryptophycins: Their synthesis and anticancer activity.

Published in:

Medicinal Research Reviews, 2002, v. 22, n. 2, p. 85, doi. 10.1002/med.10002

By:

Eggen, MariJean;
Georg, Gunda I.

Publication type:

Article

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2.

Published in:

Molecules, 2015, v. 20, n. 1, p. 1643, doi. 10.3390/molecules20011643

By:

Olesen, Sanne H.;
Ingles, Donna J.;
Jin-Yi Zhu;
Martin, Mathew P.;
Betzi, Stephane;
Georg, Gunda I.;
Tash, Joseph S.;
Schönbrunn, Ernst

Publication type:

Article

Corrigendum: Discovery and Characterization of Multiple Classes of Human CatSper Blockers.

Published in:

ChemMedChem, 2022, v. 17, n. 19, p. 1, doi. 10.1002/cmdc.202200441

By:

Carlson, Erick J.;
Francis, Rawle;
Liu, Yutong;
Li, Ping;
Lyon, Maximilian;
Santi, Celia M.;
Hook, Derek J.;
Hawkinson, Jon E.;
Georg, Gunda I.

Publication type:

Article

Discovery and Characterization of Multiple Classes of Human CatSper Blockers.

Published in:

ChemMedChem, 2022, v. 17, n. 15, p. 1, doi. 10.1002/cmdc.202000499

By:

Carlson, Erick J.;
Francis, Rawle;
Liu, Yutong;
Li, Ping;
Lyon, Maximilian;
Santi, Celia M.;
Hook, Derek J.;
Hawkinson, Jon E.;
Georg, Gunda I.

Publication type:

Article

Dihydropyridine Lactam Analogs Targeting BET Bromodomains.

Published in:

ChemMedChem, 2022, v. 17, n. 1, p. 1, doi. 10.1002/cmdc.202100407

By:

Jiang, Jiewei;
Sigua, Logan H.;
Chan, Alice;
Kalra, Prakriti;
Pomerantz, William C.K.;
Schönbrunn, Ernst;
Qi, Jun;
Georg, Gunda I.

Publication type:

Article

Works by Georg, Gunda I.

Strategies to Develop Na,K-ATPase-α4 Inhibitors as Male Contraceptives.

Synthesis of Oximidine II by a Copper-Mediated Reductive Ene-Yne Macrocyclization.

A convenient preparation of 2-[<sup>15</sup>N]-amino-4,6-dimethoxypyrimidine.

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer.

Identification and Screening of Selective WEE2 Inhibitors to Develop Non‐Hormonal Contraceptives that Specifically Target Meiosis.

Synthesis of Oximidine II by a Copper-Mediated Reductive Ene-Yne Macrocyclization.

N-Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats.

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.

Rapid Delivery of Diazepam from Supersaturated Solutions Prepared Using Prodrug/Enzyme Mixtures: Toward Intranasal Treatment of Seizure Emergencies.

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component (Eur. J. Org. Chem. 18/2014).

Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component.

Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.

Structure-Activity Studies of N-Butyl-1-deoxynojirimycin ( NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.

Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).

Synthesis and Cytotoxicity Evaluation of C4- and C5-Modified Analogues of the α,β-Unsaturated Lactone of Pironetin.

Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues.

Cover Picture: Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues (ChemMedChem 15/2016).

From Dioxin to Drug Lead-The Development of 2,3,7,8-Tetrachlorophenothiazine.

Investigation of selective retinoic acid receptor alpha antagonist ER‐50891 and related analogs for male contraception.

1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains.

Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT<sub>2</sub> Photoaffinity Probes.

Transition Metal-Free Direct Trifluoromethylation of 2,3-Dihydropyridin-4(1 H)-ones at Room Temperature.

Cover Picture: Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes (Adv. Synth. Catal. 6/2014).

Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes.

TSSK3, a novel target for male contraception, is required for spermiogenesis.

The cryptophycins: Their synthesis and anticancer activity.

Stability of the Human Hsp90-p50<sup>Cdc37</sup> Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2.

Corrigendum: Discovery and Characterization of Multiple Classes of Human CatSper Blockers.

Discovery and Characterization of Multiple Classes of Human CatSper Blockers.

Dihydropyridine Lactam Analogs Targeting BET Bromodomains.