Works by Gentilucci, Luca

Results: 35

Engineering and Exploiting Immobilized Peptide Organocatalysts for Modern Synthesis.

Published in:

Molecules, 2025, v. 30, n. 12, p. 2517, doi. 10.3390/molecules30122517

By:

Francescato, Marco;
Liao, Hang;
Gentilucci, Luca

Publication type:

Article

Selective detection of α4β1 integrin (VLA‐4)‐expressing cells using peptide‐functionalized nanostructured materials mimicking endothelial surfaces adjacent to inflammatory sites.

Published in:

Peptide Science, 2018, v. 110, n. 5, p. N.PAG, doi. 10.1002/bip.23081

By:

De Marco, Rossella;
Greco, Arianna;
Calonghi, Natalia;
Dattoli, Samantha D.;
Baiula, Monica;
Spampinato, Santi;
Picchetti, Pierre;
De Cola, Luisa;
Anselmi, Michele;
Cipriani, Francesca;
Gentilucci, Luca

Publication type:

Article

Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 3, p. 1015, doi. 10.1002/chem.202003471

By:

Anselmi, Michele;
Borbély, Adina;
Figueras, Eduard;
Michalek, Carmela;
Kemker, Isabell;
Gentilucci, Luca;
Sewald, Norbert

Publication type:

Article

Preparation of Non-Toxic Fluorescent Peptide-Coated Silica/PEG Nanoparticles from Peptide-Block Copolymer Conjugates.

Published in:

Micro (2673-8023), 2022, v. 2, n. 2, p. 240, doi. 10.3390/micro2020016

By:

Santino, Federica;
Stavole, Pasquale;
He, Tingting;
Pieraccini, Silvia;
Paolillo, Mayra;
Prodi, Luca;
Rampazzo, Enrico;
Gentilucci, Luca

Publication type:

Article

Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications.

Published in:

Biomedicines, 2024, v. 12, n. 2, p. 316, doi. 10.3390/biomedicines12020316

By:

He, Tingting;
Giacomini, Daria;
Tolomelli, Alessandra;
Baiula, Monica;
Gentilucci, Luca

Publication type:

Article

Design of α/β-Hybrid Peptide Ligands of α4β1 Integrin Equipped with a Linkable Side Chain for Chemoselective Biofunctionalization of Microstructured Materials.

Published in:

Biomedicines, 2021, v. 9, n. 11, p. 1737, doi. 10.3390/biomedicines9111737

By:

Anselmi, Michele;
Baiula, Monica;
Santino, Federica;
Zhao, Junwei;
Spampinato, Santi;
Calonghi, Natalia;
Gentilucci, Luca

Publication type:

Article

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N -Methylated Mini-Hepcidins.

Published in:

Biomedicines, 2021, v. 9, n. 2, p. 164, doi. 10.3390/biomedicines9020164

By:

Goncalves Monteiro, Daniela;
van Dijk, Johannes W. A.;
Aliyanto, Randy;
Fung, Eileen;
Nemeth, Elizabeta;
Ganz, Tomas;
Rosengren, Johan;
Clark, Richard J.;
Gentilucci, Luca

Publication type:

Article

Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials.

Published in:

Biomedicines, 2020, v. 8, n. 9, p. 307, doi. 10.3390/biomedicines8090307

By:

Zhao, Junwei;
Santino, Federica;
Giacomini, Daria;
Gentilucci, Luca

Publication type:

Article

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

Published in:

FEBS Journal, 2008, v. 275, n. 9, p. 2315, doi. 10.1111/j.1742-4658.2008.06386.x

By:

Gentilucci, Luca;
Squassabia, Federico;
Demarco, Rossella;
Artali, Roberto;
Cardillo, Giuliana;
Tolomelli, Alessandra;
Spampinato, Santi;
Bedini, Andrea

Publication type:

Article

Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α 4 β 1 Integrin.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9588, doi. 10.3390/ijms24119588

By:

Baiula, Monica;
Anselmi, Michele;
Musiani, Francesco;
Ghidini, Alessia;
Carbone, Jacopo;
Caligiana, Alberto;
Maurizio, Andrea;
Spampinato, Santi;
Gentilucci, Luca

Publication type:

Article

Synthesis, Biological Activity and Molecular Docking of Chimeric Peptides Targeting Opioid and NOP Receptors.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12700, doi. 10.3390/ijms232012700

By:

Wtorek, Karol;
Ghidini, Alessia;
Gentilucci, Luca;
Adamska-Bartłomiejczyk, Anna;
Piekielna-Ciesielska, Justyna;
Ruzza, Chiara;
Sturaro, Chiara;
Calò, Girolamo;
Pieretti, Stefano;
Kluczyk, Alicja;
McDonald, John;
Lambert, David G.;
Janecka, Anna

Publication type:

Article

Leukocyte Integrin Antagonists as a Novel Option to Treat Dry Age-Related Macular Degeneration.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.617836

By:

Baiula, Monica;
Caligiana, Alberto;
Bedini, Andrea;
Zhao, Junwei;
Santino, Federica;
Cirillo, Martina;
Gentilucci, Luca;
Giacomini, Daria;
Spampinato, Santi

Publication type:

Article

Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist.

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00188

By:

Bedini, Andrea;
Di Cesare Mannelli, Lorenzo;
Micheli, Laura;
Baiula, Monica;
Vaca, Gabriela;
De Marco, Rossella;
Gentilucci, Luca;
Ghelardini, Carla;
Spampinato, Santi

Publication type:

Article

DS-70, a novel and potent α4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs.

Published in:

2018

By:

Dattoli, Samantha Deianira;
Baiula, Monica;
De Marco, Rossella;
Bedini, Andrea;
Anselmi, Michele;
Gentilucci, Luca;
Spampinato, Santi

Publication type:

journal article

Controlling Cyclopeptide Backbone Conformation with β/α-Hybrid Peptide-Heterocycle Scaffolds.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 19, p. 3243, doi. 10.1002/ejoc.201600448

By:

Gentilucci, Luca;
Gallo, Francesca;
Meloni, Fernanda;
Mastandrea, Marco;
Del Secco, Benedetta;
De Marco, Rossella

Publication type:

Article

Convenient Synthesis of the Antibiotic Linezolid via an Oxazolidine-2,4-dione Intermediate Derived from the Chiral Building Block Isoserine.

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 34, p. 7614, doi. 10.1002/ejoc.201402888

By:

Greco, Arianna;
De Marco, Rossella;
Tani, Sara;
Giacomini, Daria;
Galletti, Paola;
Tolomelli, Alessandra;
Juaristi, Eusebio;
Gentilucci, Luca

Publication type:

Article

Synthesis of Constrained Peptidomimetics Containing 2-Oxo-1,3-oxazolidine-4-carboxylic Acids.

Published in:

European Journal of Organic Chemistry, 2011, v. 2011, n. 25, p. 4925, doi. 10.1002/ejoc.201100346

By:

Gentilucci, Luca;
Tolomelli, Alessandra;
De Marco, Rossella;
Tomasini, Claudia;
Feddersen, Sören

Publication type:

Article

Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 10, p. 1, doi. 10.1002/pro.5161

By:

Stefan, Alessandra;
Gentilucci, Luca;
Ruffolo, Francesca;
Rossi, Valentina;
Sordi, Sofia;
He, Tingting;
di Stefano, Giuseppina;
Santino, Federica;
Brigotti, Maurizio;
Scotti, Claudia;
Iamele, Luisa;
de Jonge, Hugo;
Piaz, Fabrizio Dal;
Santarcangelo, Danilo Rocco;
Hochkoeppler, Alejandro

Publication type:

Article

Easy preparation of dehydroalanine building blocks equipped with oxazolidin-2-one chiral auxiliaries, and applications to the stereoselective synthesis of substituted tryptophans.

Published in:

Amino Acids, 2014, v. 46, n. 12, p. 2823, doi. 10.1007/s00726-014-1839-3

By:

Marco, Rossella;
Cavina, Lorenzo;
Greco, Arianna;
Gentilucci, Luca

Publication type:

Article

A straightforward route to enantiopure 2-substituted-3,4-dehydro-β-proline via ring closing metathesis.

Published in:

Amino Acids, 2011, v. 41, n. 3, p. 575, doi. 10.1007/s00726-011-0921-3

By:

Tolomelli, Alessandra;
Gentilucci, Luca;
Mosconi, Elisa;
Viola, Angelo;
Paradisi, Enrico

Publication type:

Article

Development of Isoxazoline-Containing Peptidomimetics as Dual αvβ3 and α5β1 Integrin Ligands.

Published in:

ChemMedChem, 2011, v. 6, n. 12, p. 2264, doi. 10.1002/cmdc.201100372

By:

Tolomelli, Alessandra;
Gentilucci, Luca;
Mosconi, Elisa;
Viola, Angelo;
Dattoli, Samantha Deianira;
Baiula, Monica;
Spampinato, Santi;
Belvisi, Laura;
Civera, Monica

Publication type:

Article

The Inverse Type II β-Turn on D-Trp-Phe, a Pharmacophoric Motif for MOR Agonists.

Published in:

ChemMedChem, 2011, v. 6, n. 9, p. 1640, doi. 10.1002/cmdc.201100169

By:

Gentilucci, Luca;
Tolomelli, Alessandra;
De Marco, Rossella;
Spampinato, Santi;
Bedini, Andrea;
Artali, Roberto

Publication type:

Article

Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic β-Turn Templates and Validation as 3D Scaffolds.

Published in:

ChemMedChem, 2009, v. 4, n. 4, p. 517, doi. 10.1002/cmdc.200800407

By:

Gentilucci, Luca;
Cardillo, Giuliana;
Tolomelli, Alessandra;
De Marco, Rossella;
Garelli, Andrea;
Spampinato, Santi;
Spartà, Antonino;
Juaristi, Eusebio

Publication type:

Article

Synthesis and Analysis of the Conformational Preferences of 5-Aminomethyloxazolidine-2,4-dione Scaffolds: First Examples of β2- and β2, 2-Homo-Freidinger Lactam Analogues.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 41, p. 13390, doi. 10.1002/chem.201402519

By:

Greco, Arianna;
Tani, Sara;
De Marco, Rossella;
Gentilucci, Luca

Publication type:

Article

Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic.

Published in:

Biopolymers, 2016, v. 106, n. 3, p. 309, doi. 10.1002/bip.22846

By:

Piekielna, Justyna;
De Marco, Rossella;
Gentilucci, Luca;
Cerlesi, Maria Camilla;
Calo', Girolamo;
Tömböly, Csaba;
Artali, Roberto;
Janecka, Anna

Publication type:

Article

5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists.

Published in:

Biopolymers, 2015, v. 104, n. 5, p. 636, doi. 10.1002/bip.22704

By:

De Marco, Rossella;
Mazzotti, Giacomo;
Dattoli, Samantha D.;
Baiula, Monica;
Spampinato, Santi;
Greco, Arianna;
Gentilucci, Luca

Publication type:

Article

Asymmetric Synthesis of Alkyl Aziridine-2-Carboxylates from Chiral 3′-Benzyloxy-aminoimides.

Published in:

Angewandte Chemie International Edition, 1996, v. 35, n. 16, p. 1848, doi. 10.1002/anie.199618481

By:

Cardillo, Giuliana;
Casolari, Sonia;
Gentilucci, Luca;
Tomasini, Claudia

Publication type:

Article

Highly Regio- and Diastereoselective Palladium-Catalyzed Allylic Substitution. Synthesis of 3-(2-Aminobutylidene)- 4-arylazetidin-2-ones.

Published in:

Advanced Synthesis & Catalysis, 2005, v. 347, n. 6, p. 833, doi. 10.1002/adsc.200404385

By:

Giuliana Cardillo;
Serena Fabbroni;
Luca Gentilucci;
Rossana Perciaccante;
Alessandra Tolomelli

Publication type:

Article

Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects.

Published in:

Medicinal Research Reviews, 2016, v. 36, n. 3, p. 389, doi. 10.1002/med.21383

By:

Marco, Rossella;
Tolomelli, Alessandra;
Juaristi, Eusebio;
Gentilucci, Luca

Publication type:

Article

Integrin-Targeting Dye-Doped PEG-Shell/Silica-Core Nanoparticles Mimicking the Proapoptotic Smac/DIABLO Protein.

Published in:

Nanomaterials (2079-4991), 2020, v. 10, n. 6, p. 1211, doi. 10.3390/nano10061211

By:

De Marco, Rossella;
Rampazzo, Enrico;
Zhao, Junwei;
Prodi, Luca;
Paolillo, Mayra;
Picchetti, Pierre;
Gallo, Francesca;
Calonghi, Natalia;
Gentilucci, Luca

Publication type:

Article

Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects.

Published in:

Molecules, 2023, v. 28, n. 1, p. 346, doi. 10.3390/molecules28010346

By:

Santino, Federica;
Gentilucci, Luca

Publication type:

Article

Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives.

Published in:

Molecules, 2023, v. 28, n. 1, p. 265, doi. 10.3390/molecules28010265

By:

Zhao, Junwei;
Carbone, Jacopo;
Farruggia, Giovanna;
Janecka, Anna;
Gentilucci, Luca;
Calonghi, Natalia

Publication type:

Article

PacDOCK: A Web Server for Positional Distance-Based and Interaction-Based Analysis of Docking Results.

Published in:

Molecules, 2022, v. 27, n. 20, p. 6884, doi. 10.3390/molecules27206884

By:

Carbone, Jacopo;
Ghidini, Alessia;
Romano, Antonio;
Gentilucci, Luca;
Musiani, Francesco

Publication type:

Article

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation.

Published in:

Molecules, 2021, v. 26, n. 1, p. 13, doi. 10.3390/molecules26010013

By:

Piekielna-Ciesielska, Justyna;
Artali, Roberto;
Azzam, Ammar A. H.;
Lambert, David G.;
Kluczyk, Alicja;
Gentilucci, Luca;
Janecka, Anna;
Gelmi, Maria Luisa;
Pellegrino, Sara

Publication type:

Article

A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation.

Published in:

Synthetic Communications, 2003, v. 33, n. 9, p. 1587, doi. 10.1081/SCC-120018782

By:

Cardillo, Giuliana;
Fabbroni, Serena;
Gentilucci, Luca;
Gianotti, Massimo;
Tolomelli, Alessandra

Publication type:

Article

Works by Gentilucci, Luca

Engineering and Exploiting Immobilized Peptide Organocatalysts for Modern Synthesis.

Selective detection of α4β1 integrin (VLA‐4)‐expressing cells using peptide‐functionalized nanostructured materials mimicking endothelial surfaces adjacent to inflammatory sites.

Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates.

Preparation of Non-Toxic Fluorescent Peptide-Coated Silica/PEG Nanoparticles from Peptide-Block Copolymer Conjugates.

Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications.

Design of α/β-Hybrid Peptide Ligands of α4β1 Integrin Equipped with a Linkable Side Chain for Chemoselective Biofunctionalization of Microstructured Materials.

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N -Methylated Mini-Hepcidins.

Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials.

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α 4 β 1 Integrin.

Synthesis, Biological Activity and Molecular Docking of Chimeric Peptides Targeting Opioid and NOP Receptors.

Leukocyte Integrin Antagonists as a Novel Option to Treat Dry Age-Related Macular Degeneration.

Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist.

DS-70, a novel and potent α<sub>4</sub> integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs.

Controlling Cyclopeptide Backbone Conformation with β/α-Hybrid Peptide-Heterocycle Scaffolds.

Convenient Synthesis of the Antibiotic Linezolid via an Oxazolidine-2,4-dione Intermediate Derived from the Chiral Building Block Isoserine.

Synthesis of Constrained Peptidomimetics Containing 2-Oxo-1,3-oxazolidine-4-carboxylic Acids.

Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells.

Easy preparation of dehydroalanine building blocks equipped with oxazolidin-2-one chiral auxiliaries, and applications to the stereoselective synthesis of substituted tryptophans.

A straightforward route to enantiopure 2-substituted-3,4-dehydro-β-proline via ring closing metathesis.

Development of Isoxazoline-Containing Peptidomimetics as Dual α<sub>v</sub>β<sub>3</sub> and α<sub>5</sub>β<sub>1</sub> Integrin Ligands.

The Inverse Type II β-Turn on D-Trp-Phe, a Pharmacophoric Motif for MOR Agonists.

Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic β-Turn Templates and Validation as 3D Scaffolds.

Synthesis and Analysis of the Conformational Preferences of 5-Aminomethyloxazolidine-2,4-dione Scaffolds: First Examples of β<sup>2</sup>- and β<sup>2, 2</sup>-Homo-Freidinger Lactam Analogues.

Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic.

5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists.

Asymmetric Synthesis of Alkyl Aziridine-2-Carboxylates from Chiral 3′-Benzyloxy-aminoimides.

Highly Regio- and Diastereoselective Palladium-Catalyzed Allylic Substitution. Synthesis of 3-(2-Aminobutylidene)- 4-arylazetidin-2-ones.

Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects.

Integrin-Targeting Dye-Doped PEG-Shell/Silica-Core Nanoparticles Mimicking the Proapoptotic Smac/DIABLO Protein.

Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects.

Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives.

PacDOCK: A Web Server for Positional Distance-Based and Interaction-Based Analysis of Docking Results.

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation.

A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation.