Works by Geacintov, Nicholas E.

Results: 76

Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion.

Published in:

PLoS Biology, 2006, v. 4, n. 1, p. 1, doi. 10.1371/journal.pbio.0040011

By:

Rechkoblit, Olga;
Malinina, Lucy;
Cheng, Yuan;
Kuryavyi, Vitaly;
Broyde, Suse;
Geacintov, Nicholas E;
Patel, Dinshaw J

Publication type:

Article

Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion.

Published in:

PLoS Biology, 2006, v. 4, n. 1, p. e11, doi. 10.1371/journal.pbio.0040011

By:

Rechkoblit, Olga;
Malinina, Lucy;
Yuan Cheng;
Kuryavyi, Vitaly;
Broyde, Suse;
Geacintov, Nicholas E.;
Patel, Dinshaw J.

Publication type:

Article

Oxidation of Guanine and 8-oxo-7,8-Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen-18 Labeling Experiments.

Published in:

Angewandte Chemie, 2005, v. 117, n. 32, p. 5185, doi. 10.1002/ange.200500991

By:

Conor Crean;
Nicholas E. Geacintov;
Vladimir Shafirovich

Publication type:

Article

Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism.

Published in:

Antioxidants, 2022, v. 11, n. 11, p. 2110, doi. 10.3390/antiox11112110

By:

Sales, Ana H.;
Kolbanovskiy, Marina;
Geacintov, Nicholas E.;
Chen, Kun-Ming;
Sun, Yuan-Wan;
El-Bayoumy, Karam

Publication type:

Article

5′,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance.

Published in:

Cells (2073-4409), 2019, v. 8, n. 6, p. 513, doi. 10.3390/cells8060513

By:

Chatgilialoglu, Chryssostomos;
Ferreri, Carla;
Geacintov, Nicholas E.;
Krokidis, Marios G.;
Liu, Yuan;
Masi, Annalisa;
Shafirovich, Vladimir;
Terzidis, Michael A.;
Tsegay, Pawlos S.

Publication type:

Article

The processing of a Benzo(a)pyrene adduct into a frameshift or a base substitution mutation requires a different set of genes in Escherichia coli.

Published in:

Molecular Microbiology, 2000, v. 38, n. 2, p. 299, doi. 10.1046/j.1365-2958.2000.02116.x

By:

Lenne-Samuel, Nathalie;
Janel-Bintz, Regine;
Kolbanovskiy, Aleksandr;
Geacintov, Nicholas E.;
Fuchs, Robert P. P.

Publication type:

Article

Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 19, p. 9675, doi. 10.1093/nar/gks788

By:

Mu, Hong;
Kropachev, Konstantin;
Wang, Lihua;
Zhang, Lu;
Kolbanovskiy, Alexander;
Kolbanovskiy, Marina;
E. Geacintov, Nicholas;
Broyde, Suse

Publication type:

Article

Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 18, p. 9193, doi. 10.1093/nar/gks653

By:

Lior-Hoffmann, Lee;
Wang, Lihua;
Wang, Shenglong;
Geacintov, Nicholas E.;
Broyde, Suse;
Zhang, Yingkai

Publication type:

Article

Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 6, p. 2506, doi. 10.1093/nar/gkr1087

By:

Ding, Shuang;
Kropachev, Konstantin;
Cai, Yuqin;
Kolbanovskiy, Marina;
Durandina, Svetlana A.;
Liu, Zhi;
Shafirovich, Vladimir;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 20, p. 8752, doi. 10.1093/nar/gkr537

By:

Reeves, Dara A.;
Mu, Hong;
Kropachev, Konstantin;
Cai, Yuqin;
Ding, Shuang;
Kolbanovskiy, Alexander;
Kolbanovskiy, Marina;
Chen, Ying;
Krzeminski, Jacek;
Amin, Shantu;
Patel, Dinshaw J.;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

The N-clasp of human DNA polymerase κ promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 20, p. 6571, doi. 10.1093/nar/gkn719

By:

Jia, Lei;
Geacintov, Nicholas E.;
Broyde, Suse

Publication type:

Article

Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 3, p. 742, doi. 10.1093/nar/gkm1092

By:

Crean, Conor;
Uvaydov, Yuriy;
Geacintov, Nicholas E.;
Shafirovich, Vladimir

Publication type:

Article

Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 13, p. 4275, doi. 10.1093/nar/gkm416

By:

Xu, Pingna;
Oum, Lida;
Beese, Lorena S.;
Geacintov, Nicholas E.;
Broyde, Suse

Publication type:

Article

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 5, p. 1555

By:

Rodríguez, Fabián A.;
Cai, Yuqin;
Lin, Chin;
Tang, Yijin;
Kolbanovskiy, Alexander;
Amin, Shantu;
Patel, Dinshaw J.;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 5, p. 1666, doi. 10.1093/nar/gkl056

By:

Zhao, Bo;
Wang, Jillian;
Geacintov, Nicholas E.;
Wang, Zhigang

Publication type:

Article

Polη, Polζ and Rev1 together are required for G to T transversion mutations induced by the (+)- and (−)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 2, p. 417, doi. 10.1093/nar/gkj446

By:

Zhao, Bo;
Wang, Jillian;
Geacintov, Nicholas E.;
Wang, Zhigang

Publication type:

Article

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 20, p. 6004, doi. 10.1093/nar/gkg771

By:

Schinecker, Thomas M.;
Perlow, Rebecca A.;
Broyde, Suse;
Geacintov, Nicholas E.;
Scicchitano, David A.

Publication type:

Article

Construction and purification of site‐specifically modified DNA templates for transcription assays.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 7, p. e40, doi. 10.1093/nar/gng040

By:

Perlow, Rebecca A.;
Schinecker, Thomas M.;
Kim, Se Jun;
Geacintov, Nicholas E.;
Scicchitano, David A.

Publication type:

Article

Relating repair susceptibility of carcinogen‐damaged DNA with structural distortion and thermodynamic stability.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 15, p. 3422

By:

Wu, Min;
Yan, Shixiang;
Patel, Dinshaw J.;
Geacintov, Nicholas E.;
Broyde, Suse

Publication type:

Article

Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 7, p. 1630, doi. 10.1093/nar/30.7.1630

By:

Zhang, Yanbin;
Wu, Xiaohua;
Rechkoblit, Olga;
Geacintov, Nicholas E.;
Taylor, John-Stephen;
WangTo whom correspondence should be addressed. Tel: +1 859 323 5784; Fax: +1 859 323 1059; Email: zwang@uky.edu, Zhigang

Publication type:

Article

Probing murine methyltransfease Dnmt3a interactions with benzo[ a]pyrene-modified DNA by fluorescence methods.

Published in:

FEBS Journal, 2012, v. 279, n. 20, p. 3965, doi. 10.1111/j.1742-4658.2012.08756.x

By:

Minero, Antonio S.;
Lukashevich, Olga V.;
Cherepanova, Natalia A.;
Kolbanovskiy, Alexander;
Geacintov, Nicholas E.;
Gromova, Elizaveta S.

Publication type:

Article

The stereochemistry of benzo[ a]pyrene-2′-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases.

Published in:

FEBS Journal, 2007, v. 274, n. 8, p. 2121, doi. 10.1111/j.1742-4658.2007.05754.x

By:

Subach, Oksana M.;
Maltseva, Diana V.;
Shastry, Anant;
Kolbanovskiy, Alexander;
Klimašauskas, Saulius;
Geacintov, Nicholas E.;
Gromova, Elizaveta S.

Publication type:

Article

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells.

Published in:

PLoS Genetics, 2011, v. 7, n. 9, p. 1, doi. 10.1371/journal.pgen.1002262

By:

Hendel, Ayal;
Krijger, Peter H. L.;
Diamant, Noam;
Goren, Zohar;
Langerak, Petra;
Kim, Jungmin;
Reißner, Thomas;
Lee, Kyoo-young;
Geacintov, Nicholas E.;
Carell, Thomas;
Myung, Kyungjae;
Tateishi, Satoshi;
D'Andrea, Alan;
Jacobs, Heinz;
Livneh, Zvi

Publication type:

Article

Variable Inhibition of DNA Unwinding Rates Catalyzed by the SARS-CoV-2 Helicase Nsp13 by Structurally Distinct Single DNA Lesions.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 14, p. 7930, doi. 10.3390/ijms25147930

By:

Sales, Ana H.;
Fu, Iwen;
Durandin, Alexander;
Ciervo, Sam;
Lupoli, Tania J.;
Shafirovich, Vladimir;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

Inhibition of E. coli RecQ Helicase Activity by Structurally Distinct DNA Lesions: Structure—Function Relationships.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15654, doi. 10.3390/ijms232415654

By:

Sales, Ana H.;
Zheng, Vincent;
Kenawy, Maya A.;
Kakembo, Mark;
Zhang, Lu;
Shafirovich, Vladimir;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6957, doi. 10.3390/ijms22136957

By:

Swain, Umakanta;
Friedlander, Gilgi;
Sehrawat, Urmila;
Sarusi-Portuguez, Avital;
Rotkopf, Ron;
Ebert, Charlotte;
Paz-Elizur, Tamar;
Dikstein, Rivka;
Carell, Thomas;
Geacintov, Nicholas E.;
Livneh, Zvi

Publication type:

Article

Excision of Oxidatively Generated Guanine Lesions by Competitive DNA Repair Pathways.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 5, p. 2698, doi. 10.3390/ijms22052698

By:

Shafirovich, Vladimir;
Geacintov, Nicholas E.;
Rak, Janusz Adam;
Kumar, Anil;
Zdrowowicz, Magdalena

Publication type:

Article

Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.

Published in:

Biopolymers, 2002, v. 65, n. 3, p. 202, doi. 10.1002/bip.10239

By:

Geacintov, Nicholas E.;
Broyde, Suse;
Buterin, Tonko;
Naegeli, Hanspeter;
Wu, Min;
Yan, Shixiang;
Patel, Dinshaw J.

Publication type:

Article

Linear dichroism characteristics of ethidium-and proflavine-supercoiled DNA complexes.

Published in:

Biopolymers, 1990, v. 29, n. 14, p. 1735, doi. 10.1002/bip.360291406

By:

Swenberg, Charles E.;
Carberry, Susan E.;
Geacintov, Nicholas E.

Publication type:

Article

Generation of 8‐oxo‐7,8‐dihydroguanine in G‐Quadruplexes Models of Human Telomere Sequences by One‐electron Oxidation.

Published in:

Photochemistry & Photobiology, 2019, v. 95, n. 1, p. 244, doi. 10.1111/php.12926

By:

Merta, Tomasz J.;
Geacintov, Nicholas E.;
Shafirovich, Vladimir

Publication type:

Article

Error-prone lesion bypass by human DNA polymerase η.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 23, p. 4717, doi. 10.1093/nar/28.23.4717

By:

Zhang, Yanbin;
Yuan, Fenghua;
Wu, Xiaohua;
Rechkoblit, Olga;
Taylor, John-Stephen;
Geacintov, Nicholas E.;
Wang, Zhigang

Publication type:

Article

Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 21, p. 4138, doi. 10.1093/nar/28.21.4138

By:

Zhang, Yanbin;
Yuan, Fenghua;
Wu, Xiaohua;
Wang, Mu;
Rechkoblit, Olga;
Taylor, John-Stephen;
Geacintov, Nicholas E.;
Wang, Zhigang

Publication type:

Article

Base Sequence Context Effects on Nucleotide Excision Repair.

Published in:

Journal of Nucleic Acids, 2010, p. 1, doi. 10.4061/2010/174252

By:

Cai, Yuqin;
Patel, Dinshaw J.;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

Solvent Exposure Associated with Single Abasic Sites Alters the Base Sequence Dependence of Oxidation of Guanine in DNA in GG Sequence Contexts.

Published in:

ChemBioChem, 2011, v. 12, n. 11, p. 1731, doi. 10.1002/cbic.201100140

By:

Lee, Young-Ae;
Liu, Zhi;
Dedon, Peter C.;
Geacintov, Nicholas E.;
Shafirovich, Vladimir

Publication type:

Article

Oxidation of Guanine by Carbonate Radicals Derived from Photolysis of Carbonatotetramminecobalt(III) Complexes and the pH Dependence of Intrastrand DNA Cross-Links Mediated by Guanine Radical Reactions.

Published in:

ChemBioChem, 2008, v. 9, n. 12, p. 1985, doi. 10.1002/cbic.200800105

By:

Crean, Conor;
Lee, Young Ae;
Yun, Byeong Hwa;
Geacintov, Nicholas E.;
Shafirovich, Vladimir

Publication type:

Article

Absolute configurations of DNA lesions determined by comparisons of experimental ECD and ORD spectra with DFT calculations.

Published in:

Chirality, 2009, v. 21, n. 1E, p. E231, doi. 10.1002/chir.20804

By:

Ding, Shuang;
Kolbanovskiy, Alexander;
Durandin, Alexander;
Crean, Conor;
Shafirovich, Vladimir;
Broyde, Suse;
Geacintov, Nicholas E.

Publication type:

Article

Site-specific adducts derived from the binding of anti-5-methylchrysene diol epoxide enantiomers to DNA: Synthesis and characteristics.

Published in:

Carcinogenesis, 1996, v. 17, n. 9, p. 2035, doi. 10.1093/carcin/17.9.2035

By:

Xu, Rong;
Dwarakanath, Sulatha;
Cosman, Monique;
Amin, Shantu;
Geacintov, Nicholas E.

Publication type:

Article

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.

Published in:

Nature Communications, 2014, v. 5, n. 11, p. 5437, doi. 10.1038/ncomms6437

By:

Ziv, Omer;
Zeisel, Amit;
Mirlas-Neisberg, Nataly;
Swain, Umakanta;
Nevo, Reinat;
Ben-Chetrit, Nir;
Martelli, Maria Paola;
Rossi, Roberta;
Schiesser, Stefan;
Canman, Christine E.;
Carell, Thomas;
Geacintov, Nicholas E.;
Falini, Brunangelo;
Domany, Eytan;
Livneh, Zvi

Publication type:

Article

Oxidation of Guanine and 8-oxo-7,8-Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen-18 Labeling ExperimentsThis work was supported by the National Institutes of Health Grant 5-R01-ES11589, and by a grant from the Kresge Foundation.

Published in:

Angewandte Chemie International Edition, 2005, v. 44, n. 32, p. 5057, doi. 10.1002/anie.200500991

By:

Conor Crean;
Nicholas E. Geacintov;
Vladimir Shafirovich

Publication type:

Article

EFFECT OF SPATIAL NON-UNIFORMITY OF ILLUMINATION IN NON-LINEAR INTENSITY-DEPENDENT PHOTO PHYSICAL EXPERIMENTS. APPLICATION TO SOME FLUORESCENCE YIELD MEASUREMENTS IN PHOTOSYNTHETIC SYSTEMS.

Published in:

Photochemistry & Photobiology, 1983, v. 37, n. 4, p. 475, doi. 10.1111/j.1751-1097.1983.tb04502.x

By:

Paillotin, Guy;
Geacintov, Nicholas E.;
Breton, Jacques

Publication type:

Article

RELATIVE CONTRIBUTIONS OF TRYPTOPHAN and TYROSINE TO THE PHOSPHORESCENCE EMISSION OF HUMAN SERUM ALBUMIN AT LOW TEMPERATURES.

Published in:

Photochemistry & Photobiology, 1982, v. 35, n. 3, p. 299, doi. 10.1111/j.1751-1097.1982.tb02565.x

By:

Waldmeyer, Jurg;
Korkidis, Katherine;
Geacintov, Nicholas E.

Publication type:

Article

FLUORESCENCE STUDY OF THE PHYSICO-CHEMICAL PROPERTIES OF A BENZO(A)PYRENE 7,8-DIHYDRODIOL 9,10-OXIDE DERIVATIVE BOUND COVALENTLY TO DNA.

Published in:

Photochemistry & Photobiology, 1979, v. 29, n. 2, p. 223, doi. 10.1111/j.1751-1097.1979.tb07043.x

By:

Prusik, Thaddeus;
Geacintov, Nicholas E.;
Tobiasz, Christopher;
Ivanovic, Vesna;
Weinstein, I. Bernard

Publication type:

Article

A LINEAR DICHROISM STUDY OF THE ORIENTATION OF AROMATIC PROTEIN RESIDUES IN MAGNETICALLY ORIENTED BOVINE ROD OUTER SEGMENTS.

Published in:

Photochemistry & Photobiology, 1978, v. 27, n. 1, p. 51, doi. 10.1111/j.1751-1097.1978.tb07564.x

By:

Becker, Joseph F.;
Trentacosti, Florence;
Geacintov, Nicholas E.

Publication type:

Article

A SINGLE PULSE PICOSECOND LASER STUDY OF EXCITON DYNAMICS IN CHLOROPLASTS.

Published in:

Photochemistry & Photobiology, 1977, v. 26, n. 6, p. 629, doi. 10.1111/j.1751-1097.1977.tb07542.x

By:

Geacintov, Nicholas E.;
Breton, Jacques;
Swenberg, Charles E.;
Paillotin, Guy

Publication type:

Article

Differing structures and dynamics of two photolesions portray verification differences by the human XPD helicase.

Published in:

Nucleic Acids Research, 2023, v. 52, n. 22, p. 12261, doi. 10.1093/nar/gkad974

By:

Fu, Iwen;
Geacintov, Nicholas E;
Broyde, Suse

Publication type:

Article

Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 12, p. 6837, doi. 10.1093/nar/gkac496

By:

Fu, Iwen;
Mu, Hong;
Geacintov, Nicholas E;
Broyde, Suse

Publication type:

Article

Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 8, p. 5020, doi. 10.1093/nar/gku162

By:

Kropachev, Konstantin;
Ding, Shuang;
Terzidis, Michael A.;
Masi, Annalisa;
Liu, Zhi;
Cai, Yuqin;
Kolbanovskiy, Marina;
Chatgilialoglu, Chryssostomos;
Broyde, Suse;
Geacintov, Nicholas E.;
Shafirovich, Vladimir

Publication type:

Article

Mechanism of error-free replication across benzo [a]pyrene stereoisomers by Rev1 DNA polymerase.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01013-5

By:

Rechkoblit, Olga;
Landes, Hannah;
Aggarwal, Aneel K.;
Kolbanovskiy, Alexander;
Geacintov, Nicholas E.

Publication type:

Article

One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA.

Published in:

International Journal of Radiation Biology, 2014, v. 90, n. 6, p. 423, doi. 10.3109/09553002.2013.877176

By:

Cadet, Jean;
Wagner, J. Richard;
Shafirovich, Vladimir;
Geacintov, Nicholas E.

Publication type:

Article

The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions.

Published in:

EMBO Journal, 2007, v. 26, n. 12, p. 2923, doi. 10.1038/sj.emboj.7601730

By:

Mocquet, Vincent;
Kropachev, Konstantin;
Kolbanovskiy, Marina;
Kolbanovskiy, Alexander;
Tapias, Angels;
Cai, Yuqin;
Broyde, Suse;
Geacintov, Nicholas E;
Egly, Jean-Marc

Publication type:

Article