Works matching AU Ganey, Patricia

Results: 50

Current Challenges and Controversies in Drug-Induced Liver Injury.

Published in:

Drug Safety, 2012, v. 35, n. 12, p. 1099, doi. 10.2165/11632970-000000000-00000

By:

Corsini, Alberto;
Ganey, Patricia;
Ju, Cynthia;
Kaplowitz, Neil;
Pessayre, Dominique;
Roth, Robert;
Watkins, Paul B.;
Albassam, Mudher;
Liu, Baolian;
Stancic, Saray;
Suter, Laura;
Bortolini, Michele

Publication type:

Article

Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242 (R) and Aroclor 1254 (R)

Published in:

Environmental Toxicology & Chemistry, 2000, v. 19, n. 5, p. 1311

By:

Boyd, Stephen A.;
Mousa, Mahmoud A.;
Wagner, Margaret A.;
Ganey, Patricia E.;
Fischer, Lawrence J.;
Quensen, John F.

Publication type:

Article

Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example.

Published in:

International Journal of Molecular Sciences, 2010, v. 11, n. 11, p. 4697, doi. 10.3390/ijms11114697

By:

Liguori, Michael J.;
Ditewig, Amy C.;
Maddox, Jane F.;
Luyendyk, James P.;
Lehman-McKeeman, Lois D.;
Nelson, David M.;
Bhaskaran, Vasanthi M.;
Waring, Jeffrey F.;
Ganey, Patricia E.;
Roth, Robert A.;
Blomme, Eric A. G.

Publication type:

Article

Bacterial- and Viral-Induced Inflammation Increases Sensitivity to Acetaminophen Hepatotoxicity.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2010, v. 73, n. 1, p. 58, doi. 10.1080/15287390903249057

By:

Maddox, Jane F.;
Amuzie, Chidozie J.;
Maoxiang Li;
Newport, Sandra W.;
Sparkenbaugh, Erica;
Cuff, Christopher F.;
Pestka, James J.;
Cantor, Glenn H.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Neutrophils Contribute to Endotoxin Enhancement of Allyl Alcohol Hepatotoxicity.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2004, v. 67, n. 12, p. 911, doi. 10.1080/15287390490443704

By:

Kinser, Shawn;
Sneed, Rosie A.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

THE TEMPORAL RELATIONSHIP BETWEEN BACTERIAL LIPOPOLYSACCHARIDE AND MONOCROTALINE EXPOSURES INFLUENCES TOXICITY: SHIFT IN RESPONSE FROM HEPATOTOXICITY TO NITRIC OXIDE-DEPENDENT LETHALITY.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2002, v. 65, n. 14, p. 961, doi. 10.1080/00984100290071261

By:

Yee, Steven B.;
Copple, Bryan L.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

6-Keto Prostaglandin F<sub>1α</sub> and Thromboxane B<sub>2</sub> in Isolated, Buffer-Perfused Lungs from Monocrotaline Pyrrole-treated Rats.

Published in:

Experimental Lung Research, 1987, v. 12, n. 3, p. 195, doi. 10.3109/01902148709064300

By:

Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

EFFECT OF BYPRODUCTS FROM THE OZONATION OF PYRENE: BIPHENYL-2,2',6,6'-TETRACARBALDEHYDE AND BIPHENYL-2,2',6,6'-TETRACARBOXYLIC ACID ON GAP JUNCTION INTERCELLULAR COMMUNICATION AND NEUTROPHIL FUNCTION.

Published in:

Environmental Toxicology & Chemistry, 2005, v. 24, n. 3, p. 26, doi. 10.1897/04-679.1

By:

Luster-Teasley, Stephanie L.;
Ganey, Patricia E.;
DiOrio, Mary;
Ward III, Joseph S.;
Maleczka Jr., Robert E.;
Trosko, James E.;
Masten, Susan J.

Publication type:

Article

Dioxin alters inflammatory responses to lipopolysaccharide.

Published in:

Toxicological & Environmental Chemistry, 2011, v. 93, n. 6, p. 1180, doi. 10.1080/02772248.2011.577554

By:

Olivero-Verbel, Jesus;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Commending Exceptional Society of Toxicology Leadership During Extraordinary Times.

Published in:

Toxicological Sciences, 2020, v. 175, n. 1, p. 1, doi. 10.1093/toxsci/kfaa047

By:

Cook, Jon C;
Naas, Leigh Ann Burns;
Ganey, Patricia E

Publication type:

Article

Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines.

Published in:

Toxicological Sciences, 2016, v. 149, n. 2, p. 372, doi. 10.1093/toxsci/kfv249

By:

Maiuri, Ashley R.;
Breier, Anna B.;
Turkus, Jonathan D.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinase.

Published in:

Toxicological Sciences, 2015, v. 146, n. 2, p. 265, doi. 10.1093/toxsci/kfv091

By:

Maiuri, Ashley R.;
Breier, Anna B.;
Gora, Lukas F.J.;
Parkins, Robert V.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Molecular Mechanisms of Hepatocellular Apoptosis Induced by Trovafloxacin-Tumor Necrosis Factor-alpha Interaction.

Published in:

Toxicological Sciences, 2014, v. 137, n. 1, p. 91, doi. 10.1093/toxsci/kft226

By:

Beggs, Kevin M.;
Fullerton, Aaron M.;
Miyakawa, Kazuhisa;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Pretreatment With TCDD Exacerbates Liver Injury From Concanavalin A: Critical Role for NK Cells.

Published in:

Toxicological Sciences, 2013, v. 136, n. 1, p. 72, doi. 10.1093/toxsci/kft174

By:

Fullerton, Aaron M.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Roles of the Hemostatic System and Neutrophils in Liver Injury From Co-exposure to Amiodarone and Lipopolysaccharide.

Published in:

Toxicological Sciences, 2013, v. 136, n. 1, p. 51, doi. 10.1093/toxsci/kft170

By:

Lu, Jingtao;
Roth, Robert A.;
Malle, Ernst;
Ganey, Patricia E.

Publication type:

Article

Tumor Necrosis Factor-alpha Potentiates the Cytotoxicity of Amiodarone in Hepa1c1c7 Cells: Roles of Caspase Activation and Oxidative Stress.

Published in:

Toxicological Sciences, 2013, v. 131, n. 1, p. 164, doi. 10.1093/toxsci/kfs289

By:

Lu, Jingtao;
Miyakawa, Kazuhisa;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha.

Published in:

Toxicological Sciences, 2012, v. 125, n. 1, p. 126, doi. 10.1093/toxsci/kfr266

By:

Lu, Jingtao;
Jones, A. Daniel;
Harkema, Jack R.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Natural Killer Cells Mediate Severe Liver Injury in a Murine Model of Halothane Hepatitis.

Published in:

Toxicological Sciences, 2011, v. 120, n. 2, p. 507, doi. 10.1093/toxsci/kfr005

By:

Dugan, Christine M.;
Fullerton, Aaron M.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity.

Published in:

Toxicological Sciences, 2010, v. 118, n. 1, p. 7, doi. 10.1093/toxsci/kfq168

By:

Shaw, Patrick J.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Acute Exposure to Ozone Exacerbates Acetaminophen-Induced Liver Injury in Mice.

Published in:

Toxicological Sciences, 2010, v. 115, n. 1, p. 267, doi. 10.1093/toxsci/kfq034

By:

Ibrahim Aibo, Daher;
Birmingham, Neil P.;
Lewandowski, Ryan;
Maddox, Jane F.;
Roth, Robert A.;
Ganey, Patricia E.;
Wagner, James G.;
Harkema, Jack R.

Publication type:

Article

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity.

Published in:

Toxicological Sciences, 2009, v. 111, n. 2, p. 288, doi. 10.1093/toxsci/kfp163

By:

Shaw, Patrick J.;
Beggs, Kevin M.;
Sparkenbaugh, Erica M.;
Dugan, Christine M.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Hepatotoxic Interaction of Sulindac with Lipopolysaccharide: Role of the Hemostatic System.

Published in:

Toxicological Sciences, 2009, v. 108, n. 1, p. 184, doi. 10.1093/toxsci/kfn259

By:

Wei Zou;
Sachin S. Devi;
Erica Sparkenbaugh;
Husam S. Younis;
Robert A. Roth;
Patricia E. Ganey

Publication type:

Article

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma-Dependent Liver Injury.

Published in:

Toxicological Sciences, 2009, v. 107, n. 1, p. 270, doi. 10.1093/toxsci/kfn205

By:

Patrick J. Shaw;
Amy C. Ditewig;
Jeffrey F. Waring;
Michael J. Liguori;
Eric A. Blomme;
Patricia E. Ganey;
Robert A. Roth

Publication type:

Article

Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha.

Published in:

Toxicological Sciences, 2007, v. 100, n. 1, p. 259, doi. 10.1093/toxsci/kfm218

By:

Patrick J. Shaw;
Marie J. Hopfensperger;
Patricia E. Ganey;
Robert A. Roth

Publication type:

Article

The Role of Tumor Necrosis Factor Alpha in Lipopolysaccharide/Ranitidine-Induced Inflammatory Liver Injury.

Published in:

Toxicological Sciences, 2007, v. 100, n. 1, p. 267, doi. 10.1093/toxsci/kfm209

By:

Francis F. Tukov;
James P. Luyendyk;
Patricia E. Ganey;
Robert A. Roth

Publication type:

Article

Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis.

Published in:

Toxicological Sciences, 2007, v. 96, n. 1, p. 2

By:

Ruth A. Roberts;
Patricia E. Ganey;
Cynthia Ju;
Lisa M. Kamendulis;
Ivan Rusyn;
James E. Klaunig

Publication type:

Article

Unique Gene Expression and Hepatocellular Injury in the Lipopolysaccharide-Ranitidine Drug Idiosyncrasy Rat Model: Comparison with Famotidine.

Published in:

Toxicological Sciences, 2006, v. 90, n. 2, p. 569, doi. 10.1093/toxsci/kfj103

By:

Luyendyk, James P.;
Lehman-McKeeman, Lois D.;
Nelson, David M.;
Bhaskaran, Vasanthi M.;
Reilly, Timothy P.;
Car, Bruce D.;
Cantor, Glenn H.;
Maddox, Jane F.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Effects of 2,2′,4,4′-Tetrachlorobiphenyl on Granulocytic HL-60 Cell Function and Expression of Cyclooxygenase-2.

Published in:

Toxicological Sciences, 2005, v. 84, n. 2, p. 328, doi. 10.1093/toxsci/kfi093

By:

Bezdecny, Steven A.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Gene Expression Analysis Points to Hemostasis in Livers of Rats Cotreated with Lipopolysaccharide and Ranitidine.

Published in:

Toxicological Sciences, 2004, v. 80, n. 1, p. 203, doi. 10.1093/toxsci/kfh146

By:

Luyendyk, James P.;
Mattes, William B.;
Burgoon, Lyle D.;
Zacharewski, Timothy R.;
Maddox, Jane F.;
Cosma, Gregory N.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

15-Deoxy Prostaglandin J2 Enhances Allyl Alcohol–Induced Toxicity in Rat Hepatocytes.

Published in:

Toxicological Sciences, 2004, v. 77, n. 2, p. 290, doi. 10.1093/toxsci/kfh028

By:

Maddox, Jane F.;
Domzalski, Alison C.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Modes of Cell Death in Rat Liver after Monocrotaline Exposure.

Published in:

Toxicological Sciences, 2004, v. 77, n. 1, p. 172, doi. 10.1093/toxsci/kfh011

By:

Copple, Bryan L.;
Rondelli, Catherine M.;
Maddox, Jane F.;
Hoglen, Niel C.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Basement Membrane and Matrix Metalloproteinases in Monocrotaline-Induced Liver Injury.

Published in:

Toxicological Sciences, 2003, v. 76, n. 1, p. 237, doi. 10.1093/toxsci/kfg222

By:

Umesh M. Hanumegowda;
Bryan L. Copple;
Masabumi Shibuya;
Ernst Malle;
Patricia E. Ganey;
Robert A. Roth

Publication type:

Article

Endothelial Cell Injury and Coagulation System Activation during Synergistic Hepatotoxicity from Monocrotaline and Bacterial Lipopolysaccharide Coexposure.

Published in:

Toxicological Sciences, 2003, v. 74, n. 1, p. 203, doi. 10.1093/toxsci/kfg106

By:

Yee, Steven B.;
Hanumegowda, Umesh M.;
Copple, Bryan L.;
Shibuya, Masabumi;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Augmentation of Aflatoxin B1 Hepatotoxicity by Endotoxin: Involvement of Endothelium and the Coagulation System.

Published in:

Toxicological Sciences, 2003, v. 72, n. 1, p. 171, doi. 10.1093/toxsci/kfg007

By:

Luyendyk, James P.;
Copple, Bryan L.;
Barton, Charles C.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Role of Neutrophils in the Synergistic Liver Injury from Monocrotaline and Bacterial Lipopolysaccharide Exposure.

Published in:

Toxicological Sciences, 2003, v. 72, n. 1, p. 43, doi. 10.1093/toxsci/kfg019

By:

Yee, Steven B.;
Hanumegowda, Umesh M.;
Hotchkiss, Jon A.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

The Role of Kupffer Cells and TNF-α in Monocrotaline and Bacterial Lipopolysaccharide-Induced Liver Injury.

Published in:

Toxicological Sciences, 2003, v. 71, n. 1, p. 124, doi. 10.1093/toxsci/71.1.124

By:

Yee, Steven B.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Enhancement of Allyl Alcohol Hepatotoxicity by Endotoxin Requires Extrahepatic Factors.

Published in:

Toxicological Sciences, 2002, v. 69, n. 2, p. 470, doi. 10.1093/toxsci/69.2.470

By:

Kinser, Shawn;
Copple, Bryan L.;
Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Bacterial Lipopolysaccharide Exposure Alters Aflatoxin B1 Hepatotoxicity: Benchmark Dose Analysis for Markers of Liver Injury.

Published in:

Toxicological Sciences, 2002, v. 68, n. 1, p. 220, doi. 10.1093/toxsci/68.1.220

By:

Luyendyk, James P.;
Shores, Kate C.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Endothelial Cell Injury and Fibrin Deposition in Rat Liver after Monocrotaline Exposure.

Published in:

Toxicological Sciences, 2002, v. 65, n. 2, p. 309, doi. 10.1093/toxsci/65.2.309

By:

Copple, Bryan L.;
Banes, Amy;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Lipopolysaccharide Augments Aflatoxin B1-Induced Liver Injury through Neutrophil-Dependent and -Independent Mechanisms.

Published in:

Toxicological Sciences, 2000, v. 58, n. 1, p. 208, doi. 10.1093/toxsci/58.1.208

By:

Barton, C. Charles;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Pentoxifylline Attenuates Bacterial Lipopolysaccharide-Induced Enhancement of Allyl Alcohol Hepatotoxicity.

Published in:

Toxicological Sciences, 2000, v. 56, n. 1, p. 203, doi. 10.1093/toxsci/56.1.203

By:

Sneed, Rosie A.;
Buchweitz, John P.;
Jean, Paul A.;
Ganey, Patricia E.

Publication type:

Article

Bacterial Lipopolysaccharide Exposure Augments Aflatoxin B1-Induced Liver Injury.

Published in:

Toxicological Sciences, 2000, v. 55, n. 2, p. 444, doi. 10.1093/toxsci/55.2.444

By:

Barton, C. Charles;
Hill, Dwayne A.;
Yee, Steven B.;
Barton, Eva X.;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds.

Published in:

Toxicological Sciences, 2000, v. 53, n. 1, p. 40, doi. 10.1093/toxsci/53.1.40

By:

Tithof, Patricia K.;
Olivero, Jesus;
Ruehle, Kirsten;
Ganey, Patricia E.

Publication type:

Article

Neutrophil Activation by Polychlorinated Biphenyls: Structure—Activity Relationship.

Published in:

Toxicological Sciences, 1998, v. 46, n. 2, p. 308, doi. 10.1093/toxsci/46.2.308

By:

Brown, Alan P.;
Olivero-Verbel, Jesus;
Holdan, Wendy L.;
Ganey, Patricia E.

Publication type:

Article

Animal models of idiosyncratic drug-induced liver injury-Current status.

Published in:

Critical Reviews in Toxicology, 2011, v. 41, n. 9, p. 723, doi. 10.3109/10408444.2011.575765

By:

Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Pharmacokinetic and toxicodynamic concepts in idiosyncratic, drug-induced liver injury.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2022, v. 18, n. 7/8, p. 469, doi. 10.1080/17425255.2022.2113379

By:

Roth, Robert A.;
Kana, Omar;
Filipovic, David;
Ganey, Patricia E.

Publication type:

Article

What have we learned from animal models of idiosyncratic, drug-induced liver injury?

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2020, v. 16, n. 6, p. 475, doi. 10.1080/17425255.2020.1760246

By:

Roth, Robert A.;
Ganey, Patricia E.

Publication type:

Article

Coexposure to trovafloxacin and lipopolysaccharide causes tumor necrosis factor alpha -dependent liver injury: a murine model of idiosyncratic liver injury.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1137, doi. 10.1096/fasebj.21.6.a1137-d

By:

Shaw, Patrick Joseph;
Fullerton, Aaron;
Ganey, Patricia E.;
Roth, Robert A.

Publication type:

Article

An Approach to Evaluation of the Effect of Bioremediation on Biological Activity of Environmental Contaminants: Dechlorination of Polychlorinated Biphenyls.

Published in:

Environmental Health Perspectives, 2005, v. 113, n. 2, p. 180, doi. 10.1289/ehp.6935

By:

Ganey, Patricia E.;
Boyd, Steven A.

Publication type:

Article

Symposium Overview: Toxicity of Non-Coplanar PCBs12.

Published in:

Toxicological Sciences, 1998, v. 41, n. 1, p. 49, doi. 10.1093/toxsci/41.1.49

By:

Fischer, Lawrence J.;
Seegal, Richard F.;
Ganey, Patricia E.;
Pessah, Isaac N.;
Kodavanti, Prasada Rao S.

Publication type:

Article