Works by Gambin, Yann

Results: 42

Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels.

Published in:

2025

By:

Kobe, Bostjan;
Nanson, Jeffrey D.;
Hoad, Mikayla;
Blumenthal, Antje;
Gambin, Yann;
Sierecki, Emma;
Stacey, Katryn J.;
Ve, Thomas;
Halfmann, Randal

Publication type:

Literature Review

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02624-x

By:

Leitão, André D. G.;
Rudolffi-Soto, Paulina;
Chappard, Alexandre;
Bhumkar, Akshay;
Lau, Derrick;
Hunter, Dominic J. B.;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

Evolutionary Landscape of SOX Genes to Inform Genotype-to-Phenotype Relationships.

Published in:

Genes, 2023, v. 14, n. 1, p. 222, doi. 10.3390/genes14010222

By:

Underwood, Adam;
Rasicci, Daniel T;
Hinds, David;
Mitchell, Jackson T;
Zieba, Jacob K;
Mills, Joshua;
Arnold, Nicholas E;
Cook, Taylor W;
Moustaqil, Mehdi;
Gambin, Yann;
Sierecki, Emma;
Fontaine, Frank;
Vanderweele, Sophie;
Das, Akansha S;
Cvammen, William;
Sirpilla, Olivia;
Soehnlen, Xavier;
Bricker, Kristen;
Alokaili, Maram;
Green, Morgan

Publication type:

Article

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.61407

By:

McMahon, Kerrie-Ann;
Stroud, David A.;
Gambin, Yann;
Tillu, Vikas;
Bastiani, Michele;
Sierecki, Emma;
Polinkovsky, Mark E.;
Hall, Thomas E.;
Gomez, Guillermo A.;
Yeping Wu;
Parat, Marie-Odile;
Martel, Nick;
Lo, Harriet P.;
Khanna, Kum Kum;
Alexandrov, Kirill;
Daly, Roger;
Yap, Alpha;
Ryan, Michael T.;
Parton, Robert G.

Publication type:

Article

A robust method for particulate detection of a genetic tag for 3D electron microscopy.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.64630

By:

Rae, James;
Ferguson, Charles;
Ariotti, Nicholas;
Webb, Richard I.;
Han-Hao Cheng;
Mead, James L.;
Riches, James D.;
Hunter, Dominic JB;
Martel, Nick;
Baltos, Joanne;
Christopoulos, Arthur;
Bryce, Nicole S.;
Cagigas, Maria Lastra;
Fonseka, Sachini;
Sayre, Marcel E.;
Hardeman, Edna C.;
Gunning, Peter W.;
Gambin, Yann;
Hall, Thomas E.;
Parton, Robert G.

Publication type:

Article

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25796-w

By:

Meyer, Bjoern;
Chiaravalli, Jeanne;
Gellenoncourt, Stacy;
Brownridge, Philip;
Bryne, Dominic P.;
Daly, Leonard A.;
Grauslys, Arturas;
Walter, Marius;
Agou, Fabrice;
Chakrabarti, Lisa A.;
Craik, Charles S.;
Eyers, Claire E.;
Eyers, Patrick A.;
Gambin, Yann;
Jones, Andrew R.;
Sierecki, Emma;
Verdin, Eric;
Vignuzzi, Marco;
Emmott, Edward

Publication type:

Article

Tracking Membrane Protein Association in Model Membranes.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005035

By:

Reffay, Myriam;
Gambin, Yann;
Benabdelhak, Houssain;
Phan, Gilles;
Taulier, Nicolas;
Ducruix, Arnaud;
Hodges, Robert S.;
Urbach, Wladimir

Publication type:

Article

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.

Published in:

EMBO Journal, 2024, v. 43, n. 4, p. 533, doi. 10.1038/s44318-024-00030-7

By:

Akefe, Isaac O;
Saber, Saber H;
Matthews, Benjamin;
Venkatesh, Bharat G;
Gormal, Rachel S;
Blackmore, Daniel G;
Alexander, Suzy;
Sieriecki, Emma;
Gambin, Yann;
Bertran-Gonzalez, Jesus;
Vitale, Nicolas;
Humeau, Yann;
Gaudin, Arnaud;
Ellis, Sevannah A;
Michaels, Alysee A;
Xue, Mingshan;
Cravatt, Benjamin;
Joensuu, Merja;
Wallis, Tristan P;
Meunier, Frédéric A

Publication type:

Article

The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner.

Published in:

EMBO Journal, 2023, v. 42, n. 5, p. 1, doi. 10.15252/embj.2021109032

By:

Chiang, Ivy K N;
Graus, Matthew S;
Kirschnick, Nils;
Davidson, Tara;
Luu, Winnie;
Harwood, Richard;
Jiang, Keyi;
Li, Bitong;
Wong, Yew Yan;
Moustaqil, Mehdi;
Lesieur, Emmanuelle;
Skoczylas, Renae;
Kouskoff, Valerie;
Kazenwadel, Jan;
Arriola‐Martinez, Luis;
Sierecki, Emma;
Gambin, Yann;
Alitalo, Kari;
Kiefer, Friedmann;
Harvey, Natasha L

Publication type:

Article

Probing the architecture of the Mediator complex (939.3).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.939.3

By:

Sierecki, Emma;
Polinkovsky, Mark;
Giles, Nichole;
Moustaqil, Mehdi;
Alexandrov, Kirill;
Gambin, Yann

Publication type:

Article

Uncovering transcription factor binding pockets in the tail subdomain of the human mediator complex (943.2).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.943.2

By:

Polinkovsky, Mark;
Sierecki, Emma;
Giles, Nichole;
Alexandrov, Kirill;
Gambin, Yann

Publication type:

Article

Single molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae (602.1).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.602.1

By:

Gambin, Yann;
Sierecki, Emma;
Polinkovsky, Mark;
Alexandrov, Kirill;
Parton, Robert

Publication type:

Article

A novel approach to investigate the assembly of the NOD‐like receptor inflammasomes (152.7).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.152.7

By:

Giles, Nichole;
Sierecki, Emma;
Polinkovsky, Mark;
Schroder, Kate;
Alexandrov, Kirill;
Gambin, Yann

Publication type:

Article

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death.

Published in:

PLoS Pathogens, 2020, v. 16, n. 7, p. 1, doi. 10.1371/journal.ppat.1008473

By:

Steain, Megan;
Baker, Max O. D. G.;
Pham, Chi L. L.;
Shanmugam, Nirukshan;
Gambin, Yann;
Sierecki, Emma;
McSharry, Brian P.;
Avdic, Selmir;
Slobedman, Barry;
Sunde, Margaret;
Abendroth, Allison

Publication type:

Article

Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach.

Published in:

mAbs (1942-0862), 2018, v. 10, n. 4, p. 596, doi. 10.1080/19420862.2018.1451288

By:

Fontaine, Frank R.;
Goodall, Stephen;
Prokop, Jeremy W.;
Howard, Christopher B.;
Moustaqil, Mehdi;
Kumble, Sumukh;
Rasicci, Daniel T.;
Osborne, Geoffrey W.;
Gambin, Yann;
Sierecki, Emma;
Jones, Martina L.;
Zuegg, Johannes;
Mahler, Stephen;
Francois, Mathias

Publication type:

Article

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells.

Published in:

Autophagy, 2021, v. 17, n. 9, p. 2200, doi. 10.1080/15548627.2020.1820787

By:

Ariotti, Nicholas;
Wu, Yeping;
Okano, Satomi;
Gambin, Yann;
Follett, Jordan;
Rae, James;
Ferguson, Charles;
Teasdale, Rohan D.;
Alexandrov, Kirill;
Meunier, Frederic A.;
Hill, Michelle M.;
Parton, Robert G.

Publication type:

Article

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence.

Published in:

Scientific Reports, 2016, p. 37630, doi. 10.1038/srep37630

By:

Sierecki, Emma;
Giles, Nichole;
Bowden, Quill;
Polinkovsky, Mark E.;
Steinbeck, Janina;
Arrioti, Nicholas;
Rahman, Diya;
Bhumkar, Akshay;
Nicovich, Philip R.;
Ross, Ian;
Parton, Robert G.;
Böcking, Till;
Gambin, Yann

Publication type:

Article

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies.

Published in:

EMBO Reports, 2019, v. 20, n. 2, p. N.PAG, doi. 10.15252/embr.201846518

By:

Pham, Chi LL;
Shanmugam, Nirukshan;
Strange, Merryn;
O'Carroll, Ailis;
Brown, James WP;
Sierecki, Emma;
Gambin, Yann;
Steain, Megan;
Sunde, Margaret

Publication type:

Article

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22590-6

By:

Clabbers, Max T. B.;
Holmes, Susannah;
Muusse, Timothy W.;
Vajjhala, Parimala R.;
Thygesen, Sara J.;
Malde, Alpeshkumar K.;
Hunter, Dominic J. B.;
Croll, Tristan I.;
Flueckiger, Leonie;
Nanson, Jeffrey D.;
Rahaman, Md. Habibur;
Aquila, Andrew;
Hunter, Mark S.;
Liang, Mengning;
Yoon, Chun Hong;
Zhao, Jingjing;
Zatsepin, Nadia A.;
Abbey, Brian;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88.

Published in:

BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0611-7

By:

O'Carroll, Ailís;
Chauvin, Brieuc;
Brown, James W. P.;
Meagher, Ava;
Coyle, Joanne;
Schill, Jurgen;
Bhumkhar, Akshay;
Hunter, Dominic J. B.;
Ve, Thomas;
Kobe, Bostjan;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

Ultrastructural localisation of protein interactions using conditionally stable nanobodies.

Published in:

PLoS Biology, 2018, v. 16, n. 4, p. 1, doi. 10.1371/journal.pbio.2005473

By:

Ariotti, Nicholas;
Rae, James;
Giles, Nichole;
Martel, Nick;
Sierecki, Emma;
Gambin, Yann;
Hall, Thomas E.;
Parton, Robert G.

Publication type:

Article

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins.

Published in:

Molecules, 2022, v. 27, n. 11, p. 3382, doi. 10.3390/molecules27113382

By:

Baker, Max O. D. G.;
Shanmugam, Nirukshan;
Pham, Chi L. L.;
Ball, Sarah R.;
Sierecki, Emma;
Gambin, Yann;
Steain, Megan;
Sunde, Margaret

Publication type:

Article

Cell-free formation and interactome analysis of caveolae.

Published in:

Journal of Cell Biology, 2018, v. 217, n. 6, p. 2141, doi. 10.1083/jcb.201707004

By:

WooRam Jung;
Sierecki, Emma;
Bastiani, Michele;
O’Carroll, Ailis;
Alexandrov, Kirill;
Rae, James;
Johnston, Wayne;
Hunter, Dominic J. B.;
Ferguson, Charles;
Gambin, Yann;
Ariotti, Nicholas;
Parton, Robert G.

Publication type:

Article

Munc18-1 is a molecular chaperone for a-synuclein, controlling its self-replicating aggregation.

Published in:

Journal of Cell Biology, 2016, v. 214, n. 6, p. 705, doi. 10.1083/jcb.201512016

By:

Ye Jin Chai;
Sierecki, Emma;
Tomatis, Vanesa M.;
Gormal, Rachel S.;
Giles, Nichole;
Morrow, Isabel C.;
Di Xia;
Götz, Jürgen;
Parton, Robert G.;
Collins, Brett M.;
Gambin, Yann;
Meunier, Frédéric A.

Publication type:

Article

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.

Published in:

Nature Methods, 2011, v. 8, n. 3, p. 239, doi. 10.1038/nmeth.1568

By:

Gambin, Yann;
VanDelinder, Virginia;
Ferreon, Allan Chris M;
Lemke, Edward A;
Groisman, Alex;
Deniz, Ashok A

Publication type:

Article

Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients.

Published in:

Angewandte Chemie, 2021, v. 133, n. 21, p. 11981, doi. 10.1002/ange.202014898

By:

Bhumkar, Akshay;
Magnan, Chloe;
Lau, Derrick;
Jun, Eugene Soh Wei;
Dzamko, Nicolas;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 19, p. 10931, doi. 10.1093/nar/gkab820

By:

McCann, Alex J;
Lou, Jieqiong;
Moustaqil, Mehdi;
Graus, Matthew S;
Blum, Ailisa;
Fontaine, Frank;
Liu, Hui;
Luu, Winnie;
Rudolffi-Soto, Paulina;
Koopman, Peter;
Sierecki, Emma;
Gambin, Yann;
Meunier, Frédéric A;
Liu, Zhe;
Hinde, Elizabeth;
Francois, Mathias

Publication type:

Article

Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 21, p. 11381, doi. 10.1093/nar/gky897

By:

Moustaqil, Mehdi;
Fontaine, Frank;
Overman, Jeroen;
McCann, Alex;
Bailey, Timothy L;
Rudolffi Soto, Paulina;
Bhumkar, Akshay;
Giles, Nichole;
Hunter, Dominic J B;
Gambin, Yann

Publication type:

Article

Ultrafast cooling reveals microsecond-scale biomolecular dynamics.

Published in:

Nature Communications, 2014, v. 5, n. 12, p. 5737, doi. 10.1038/ncomms6737

By:

Polinkovsky, Mark E.;
Gambin, Yann;
Banerjee, Priya R.;
Erickstad, Michael J.;
Groisman, Alex;
Deniz, Ashok A.

Publication type:

Article

Single-molecule detection on a portable 3D-printed microscope.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13617-0

By:

Brown, James W. P.;
Bauer, Arnaud;
Polinkovsky, Mark E;
Bhumkar, Akshay;
Hunter, Dominic J. B.;
Gaus, Katharina;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12279-2

By:

Pang, Siew Siew;
Bayly-Jones, Charles;
Radjainia, Mazdak;
Spicer, Bradley A.;
Law, Ruby H. P.;
Hodel, Adrian W.;
Parsons, Edward S.;
Ekkel, Susan M.;
Conroy, Paul J.;
Ramm, Georg;
Venugopal, Hariprasad;
Bird, Phillip I.;
Hoogenboom, Bart W.;
Voskoboinik, Ilia;
Gambin, Yann;
Sierecki, Emma;
Dunstone, Michelle A.;
Whisstock, James C.

Publication type:

Article

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11111-1

By:

McMahon, Kerrie-Ann;
Wu, Yeping;
Gambin, Yann;
Sierecki, Emma;
Tillu, Vikas A.;
Hall, Thomas;
Martel, Nick;
Okano, Satomi;
Moradi, Shayli Varasteh;
Ruelcke, Jayde E.;
Ferguson, Charles;
Yap, Alpha S.;
Alexandrov, Kirill;
Hill, Michelle M.;
Parton, Robert G.

Publication type:

Article

Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 21, p. 11874, doi. 10.1002/anie.202014898

By:

Bhumkar, Akshay;
Magnan, Chloe;
Lau, Derrick;
Jun, Eugene Soh Wei;
Dzamko, Nicolas;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 15, p. 12134, doi. 10.3390/ijms241512134

By:

Graves, Noah J.;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 7, p. 2301, doi. 10.3390/ijms21072301

By:

Moustaqil, Mehdi;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

Thinking Outside the Bug: Molecular Targets and Strategies to Overcome Antibiotic Resistance.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 6, p. 1255, doi. 10.3390/ijms20061255

By:

Monserrat-Martinez, Ana;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 2, p. 334, doi. 10.3390/ijms19020334

By:

Leitao, Andre;
Bhumkar, Akshay;
Hunter, Dominic J. B.;
Gambin, Yann;
Sierecki, Emma

Publication type:

Article

A Split-Luciferase Reporter Recognizing GFP and mCherry Tags to Facilitate Studies of Protein-Protein Interactions.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 12, p. 2681, doi. 10.3390/ijms18122681

By:

Moustaqil, Mehdi;
Bhumkar, Akshay;
Gonzalez, Laura;
Raoul, Lisa;
Hunter, Dominic J. B.;
Carrive, Pascal;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide.

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 5, p. 655, doi. 10.3390/ijms17050655

By:

Gambin, Yann;
Polinkovsky, Mark;
Francois, Bill;
Giles, Nichole;
Bhumkar, Akshay;
Sierecki, Emma

Publication type:

Article

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.

Published in:

Emerging Microbes & Infections, 2021, v. 10, n. 1, p. 178, doi. 10.1080/22221751.2020.1870414

By:

Moustaqil, Mehdi;
Ollivier, Emma;
Chiu, Hsin-Ping;
Van Tol, Sarah;
Rudolffi-Soto, Paulina;
Stevens, Christian;
Bhumkar, Akshay;
Hunter, Dominic J. B.;
Freiberg, Alexander N.;
Jacques, David;
Lee, Benhur;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

Unexpected instabilities explain batch‐to‐batch variability in cell‐free protein expression systems.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 1904, doi. 10.1002/bit.26604

By:

Hunter, Dominic J. B.;
Bhumkar, Akshay;
Giles, Nichole;
Sierecki, Emma;
Gambin, Yann

Publication type:

Article

Performance Benchmarking of Four Cell-Free Protein Expression Systems.

Published in:

Biotechnology & Bioengineering, 2016, v. 113, n. 2, p. 292, doi. 10.1002/bit.25814

By:

Gagoski, Dejan;
Polinkovsky, Mark E.;
Mureev, Sergey;
Kunert, Anne;
Johnston, Wayne;
Gambin, Yann;
Alexandrov, Kirill

Publication type:

Article