Works by Gambacorta, Nicola

Results: 33

Synthesis and biological evaluation of 3,5‐diaryl‐pyrazole derivatives as potential antiprostate cancer agents.

Published in:

Archiv der Pharmazie, 2021, v. 354, n. 12, p. 1, doi. 10.1002/ardp.202100225

By:

Anil, Derya;
Caykoylu, Emine U.;
Sanli, Fatma;
Gambacorta, Nicola;
Karatas, Omer F.;
Nicolotti, Orazio;
Algul, Oztekin;
Burmaoglu, Serdar

Publication type:

Article

Making sense of chemical space network shows signs of criticality.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-48107-3

By:

Amoroso, Nicola;
Gambacorta, Nicola;
Mastrolorito, Fabrizio;
Togo, Maria Vittoria;
Trisciuzzi, Daniela;
Monaco, Alfonso;
Pantaleo, Ester;
Altomare, Cosimo Damiano;
Ciriaco, Fulvio;
Nicolotti, Orazio

Publication type:

Article

CRAT missense variants cause abnormal carnitine acetyltransferase function in an early‐onset case of Leigh syndrome.

Published in:

Human Mutation, 2020, v. 41, n. 1, p. 110, doi. 10.1002/humu.23901

By:

Laera, Luna;
Punzi, Giuseppe;
Porcelli, Vito;
Gambacorta, Nicola;
Trisolini, Lucia;
Pierri, Ciro L.;
De Grassi, Anna

Publication type:

Article

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.

Published in:

Molecules, 2022, v. 27, n. 13, p. 4269, doi. 10.3390/molecules27134269

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
Samarelli, Francesco;
Lopopolo, Gianfranco;
de Candia, Modesto;
Catto, Marco;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors.

Published in:

Molecules, 2022, v. 27, n. 12, p. 3801, doi. 10.3390/molecules27123801

By:

Alagöz, Mehmet Abdullah;
Oh, Jong Min;
Zenni, Yaren Nur;
Özdemir, Zeynep;
Abdelgawad, Mohamed A.;
Naguib, Ibrahim A.;
Ghoneim, Mohammed M.;
Gambacorta, Nicola;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 19, p. 6004, doi. 10.3390/molecules26196004

By:

Venkidath, Anusree;
Oh, Jong Min;
Dev, Sanal;
Amin, Elham;
Rasheed, Shebina P.;
Vengamthodi, Ajeesh;
Gambacorta, Nicola;
Khames, Ahmed;
Abdelgawad, Mohamed A.;
George, Ginson;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5208, doi. 10.3390/molecules26175208

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
de Candia, Modesto;
Catto, Marco;
Rullo, Mariagrazia;
Pisani, Leonardo;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease †.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5773, doi. 10.3390/molecules25235773

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
Catto, Marco;
de Candia, Modesto;
Pisani, Leonardo;
Espargaró, Alba;
Sabaté, Raimon;
Cellamare, Saverio;
Nicolotti, Orazio;
Altomare, Cosimo D.;
McPhee, Derek J.

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 22, p. 5371, doi. 10.3390/molecules25225371

By:

Çeçen, Muhammed;
Oh, Jong Min;
Özdemir, Zeynep;
Büyüktuncel, Saliha Ebru;
Uysal, Mehtap;
Abdelgawad, Mohamed A.;
Musa, Arafa;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon;
Filippis, Barbara De;
Eckert, Gunter Peter

Publication type:

Article

Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4210, doi. 10.3390/molecules25184210

By:

Carofiglio, Francesca;
Trisciuzzi, Daniela;
Gambacorta, Nicola;
Leonetti, Francesco;
Stefanachi, Angela;
Nicolotti, Orazio;
Schenone, Silvia

Publication type:

Article

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 10, p. 2356, doi. 10.3390/molecules25102356

By:

Oh, Jong Min;
Rangarajan, T. M.;
Chaudhary, Reeta;
Singh, Rishi Pal;
Singh, Manjula;
Singh, Raj Pal;
Tondo, Anna Rita;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor.

Published in:

Molecules, 2020, v. 25, n. 8, p. 1817, doi. 10.3390/molecules25081817

By:

Cicalini, Ilaria;
De Filippis, Barbara;
Gambacorta, Nicola;
Di Michele, Antonio;
Valentinuzzi, Silvia;
Ammazzalorso, Alessandra;
Della Valle, Alice;
Amoroso, Rosa;
Nicolotti, Orazio;
Del Boccio, Piero;
Giampietro, Letizia

Publication type:

Article

Rational Discovery of Antiviral Whey Protein-Derived Small Peptides Targeting the SARS-CoV-2 Main Protease.

Published in:

Biomedicines, 2022, v. 10, n. 5, p. 1067, doi. 10.3390/biomedicines10051067

By:

Gambacorta, Nicola;
Caputo, Leonardo;
Quintieri, Laura;
Monaci, Linda;
Ciriaco, Fulvio;
Nicolotti, Orazio

Publication type:

Article

Synthesis of N ′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 13, p. 5830, doi. 10.3390/app11135830

By:

Sellitepe, Hasan Erdinç;
Oh, Jong Min;
Doğan, İnci Selin;
Yildirim, Sercan;
Aksel, Ahmet Buğra;
Jeong, Geum Seok;
Khames, Ahmed;
Abdelgawad, Mohamed A.;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

From Deep Learning to the Discovery of Promising VEGFR‐2 Inhibitors.

Published in:

ChemMedChem, 2024, v. 19, n. 16, p. 1, doi. 10.1002/cmdc.202400108

By:

Yucel, Mehmet Ali;
Adal, Ercan;
Aktekin, Mine Buga;
Hepokur, Ceylan;
Gambacorta, Nicola;
Nicolotti, Orazio;
Algul, Oztekin

Publication type:

Article

Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors.

Published in:

ChemMedChem, 2020, v. 15, n. 23, p. 2257, doi. 10.1002/cmdc.202000491

By:

Jeong, Geum Seok;
Kaipakasseri, Swafvan;
Lee, Sang Ryong;
Marraiki, Najat;
Batiha, Gaber El‐Saber;
Dev, Sanal;
Palakkathondi, Ashique;
Kavully, Fathima Sahla;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

A New Potent and Selective Monoamine Oxidase‐B Inhibitor with Extended Conjugation in a Chalcone Framework: 1‐[4‐(Morpholin‐4‐yl)phenyl]‐5‐phenylpenta‐2,4‐dien‐1‐one.

Published in:

ChemMedChem, 2020, v. 15, n. 17, p. 1629, doi. 10.1002/cmdc.202000305

By:

Maliyakkal, Naseer;
Eom, Bo Hyun;
Heo, Jeong Hyun;
Abdullah Almoyad, Mohammad Ali;
Thomas Parambi, Della Grace;
Gambacorta, Nicola;
Nicolotti, Orazio;
Beeran, Asmy Appadath;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

MD simulation of the interaction between sialoglycans and the second sialic acid binding site of influenza A virus N1 neuraminidase.

Published in:

Biochemical Journal, 2021, v. 478, n. 2, p. 423, doi. 10.1042/BCJ20200670

By:

Elli, Stefano;
Gambacorta, Nicola;
Rudd, Timothy R.;
Matrosovich, Mikhail;
Guerrini, Marco

Publication type:

Article

PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 5245, doi. 10.3390/ijms23095245

By:

Ciriaco, Fulvio;
Gambacorta, Nicola;
Trisciuzzi, Daniela;
Nicolotti, Orazio

Publication type:

Article

fragSMILES as a chemical string notation for advanced fragment and chirality representation.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01423-3

By:

Mastrolorito, Fabrizio;
Ciriaco, Fulvio;
Togo, Maria Vittoria;
Gambacorta, Nicola;
Trisciuzzi, Daniela;
Altomare, Cosimo Damiano;
Amoroso, Nicola;
Grisoni, Francesca;
Nicolotti, Orazio

Publication type:

Article

New Insights Regarding Hemin Inhibition of the Purified Rat Brain 2-Oxoglutarate Carrier and Relationships with Mitochondrial Dysfunction.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 24, p. 7519, doi. 10.3390/jcm11247519

By:

Miniero, Daniela Valeria;
Gambacorta, Nicola;
Spagnoletta, Anna;
Tragni, Vincenzo;
Loizzo, Stefano;
Nicolotti, Orazio;
Pierri, Ciro Leonardo;
De Palma, Annalisa

Publication type:

Article

FAD/NADH Dependent Oxidoreductases: From Different Amino Acid Sequences to Similar Protein Shapes for Playing an Ancient Function.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 12, p. 2117, doi. 10.3390/jcm8122117

By:

Trisolini, Lucia;
Gambacorta, Nicola;
Gorgoglione, Ruggiero;
Montaruli, Michele;
Laera, Luna;
Colella, Francesco;
Volpicella, Mariateresa;
De Grassi, Anna;
Pierri, Ciro Leonardo

Publication type:

Article

Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.

Published in:

Pharmaceutics, 2021, v. 13, n. 6, p. 850, doi. 10.3390/pharmaceutics13060850

By:

Koyiparambath, Vishal Payyalot;
Oh, Jong Min;
Khames, Ahmed;
Abdelgawad, Mohamed A.;
Nair, Aathira Sujathan;
Nath, Lekshmi R.;
Gambacorta, Nicola;
Ciriaco, Fulvio;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091152

By:

Rehuman, Nisha Abdul;
Oh, Jong Min;
Abdelgawad, Mohamed A.;
Beshr, Eman A. M.;
Abourehab, Mohammed A. S.;
Gambacorta, Nicola;
Nicolotti, Orazio;
Jat, Rakesh Kumar;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 10, p. 984, doi. 10.3390/ph14100984

By:

Fantacuzzi, Marialuigia;
Gallorini, Marialucia;
Gambacorta, Nicola;
Ammazzalorso, Alessandra;
Aturki, Zeineb;
Balaha, Marwa;
Carradori, Simone;
Giampietro, Letizia;
Maccallini, Cristina;
Cataldi, Amelia;
Nicolotti, Orazio;
Amoroso, Rosa;
De Filippis, Barbara

Publication type:

Article

Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 3, p. 450, doi. 10.3390/v16030450

By:

Samarelli, Francesco;
Graziano, Giovanni;
Gambacorta, Nicola;
Graps, Elisabetta Anna;
Leonetti, Francesco;
Nicolotti, Orazio;
Altomare, Cosimo Damiano

Publication type:

Article

Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.

Published in:

Environmental Science & Pollution Research, 2021, v. 28, n. 29, p. 38855, doi. 10.1007/s11356-021-13320-y

By:

Mathew, Bijo;
Oh, Jong Min;
Baty, Roua S.;
Batiha, Gaber El-Saber;
Parambi, Della Grace Thomas;
Gambacorta, Nicola;
Nicolotti, Orazio;
Kim, Hoon

Publication type:

Article

Integrating Atom‐Based 3D‐QSAR, Molecular Docking, and Molecular Dynamics: A Multistep Approach for the Discovery of Potent Adenosine A<sub>2</sub>A Receptor Antagonists.

Published in:

ChemistrySelect, 2025, v. 10, n. 12, p. 1, doi. 10.1002/slct.202403808

By:

Sudevan, Sachithra Thazhathuveedu;
Chandran, Namitha;
Radhakrishnan, Vishnu Vasanthi;
Bindra, Sandeep;
Presanna, Aneesh Thankappan;
Maliyakkal, Naseer;
Abdelgawad, Mohamed A.;
El‐Ghorab, Ahmed H.;
Selim, Samy;
Trisciuzzi, Daniela;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo

Publication type:

Article

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 188, doi. 10.1080/14756366.2020.1842390

By:

Sasidharan, Rani;
Eom, Bo Hyun;
Heo, Jeong Hyun;
Park, Jong Eun;
Abdelgawad, Mohamed A.;
Musa, Arafa;
Gambacorta, Nicola;
Nicolotti, Orazio;
Manju, Sreedharannair Leelabaiamma;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

Modulatory Effect of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) on the 2-Oxoglutarate Mitochondrial Carrier.

Published in:

Molecules, 2024, v. 29, n. 21, p. 5154, doi. 10.3390/molecules29215154

By:

Spagnoletta, Anna;
Miniero, Daniela Valeria;
Gambacorta, Nicola;
Oppedisano, Francesca;
De Grassi, Anna;
Nicolotti, Orazio;
Pierri, Ciro Leonardo;
De Palma, Annalisa

Publication type:

Article

Chalcones with N‐Methylpiperazine Moiety: Synthesis, Monoamine Oxidase Inhibition, Neuroprotective Effect and Computer Simulation Study.

Published in:

ChemistrySelect, 2024, v. 9, n. 14, p. 1, doi. 10.1002/slct.202400465

By:

Jayan, Jayalakshmi;
Trisciuzzi, Daniela;
Benny, Feba;
Kumar, Sunil;
Gambacorta, Nicola;
Catto, Marco;
Abdelgawad, Mohamed A.;
Ghoneim, Mohammed M.;
Al‐Serwi, Rasha Hamed;
Gahtori, Prashant;
Zachariah, Subin Mary;
Nicolotti, Orazio;
Mathew, Bijo

Publication type:

Article

The Interaction of Hemin, a Porphyrin Derivative, with the Purified Rat Brain 2-Oxoglutarate Carrier.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 8, p. 1175, doi. 10.3390/biom11081175

By:

Miniero, Daniela Valeria;
Spagnoletta, Anna;
Gambacorta, Nicola;
Scalera, Vito;
Pierri, Ciro Leonardo;
Nicolotti, Orazio;
De Palma, Annalisa

Publication type:

Article

MzDOCK: A free ready‐to‐use GUI‐based pipeline for molecular docking simulations.

Published in:

Journal of Computational Chemistry, 2024, v. 45, n. 23, p. 1980, doi. 10.1002/jcc.27390

By:

Kabier, Muzammil;
Gambacorta, Nicola;
Trisciuzzi, Daniela;
Kumar, Sunil;
Nicolotti, Orazio;
Mathew, Bijo

Publication type:

Article