Works by Galun, Eithan

Results: 70

Efficient transgene expression from naked DNA delivered into an arterio-venous fistula model for kidney dialysis.

Published in:

Journal of Gene Medicine, 2011, v. 13, n. 11, p. 611, doi. 10.1002/jgm.1615

By:

Globerman, Anat S.;
Chaouat, Malka;
Shlomai, Zippora;
Galun, Eithan;
Zeira, Evelyn;
Zamir, Gideon

Publication type:

Article

RNA interference for antiviral therapy.

Published in:

Journal of Gene Medicine, 2006, v. 8, n. 8, p. 933, doi. 10.1002/jgm.929

By:

Ketzinel-Gilad, Mali;
Shaul, Yosef;
Galun, Eithan

Publication type:

Article

MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells.

Published in:

PLoS Pathogens, 2014, v. 10, n. 2, p. 1, doi. 10.1371/journal.ppat.1003963

By:

Nachmani, Daphna;
Zimmermann, Albert;
Oiknine Djian, Esther;
Weisblum, Yiska;
Livneh, Yoav;
Khanh Le, Vu Thuy;
Galun, Eithan;
Horejsi, Vaclav;
Isakov, Ofer;
Shomron, Noam;
Wolf, Dana G.;
Hengel, Hartmut;
Mandelboim, Ofer

Publication type:

Article

Brucellosis in Patients with Heart Disease: When Should Endocarditis Be Diagnosed?

Published in:

Cardiology, 1990, v. 77, n. 4, p. 313, doi. 10.1159/000174614

By:

Flugelman, Moshe Y.;
Galun, Eithan;
Ben-Chetrit, Eldad;
Caraco, Joseph;
Rubinow, Alan

Publication type:

Article

Identification of the novel HLA‐B allele, HLA‐B*15:539, in a South‐Sudanese individual.

Published in:

HLA: Immune Response Genetics, 2019, v. 94, n. 4, p. 380, doi. 10.1111/tan.13624

By:

Benedek, Gil;
Abed El‐Latif, Mahmoud;
Miller, Keren;
Galun, Eithan;
Levite, Mia

Publication type:

Article

DNA damage alters EGFR signaling and reprograms cellular response via Mre-11.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09779-5

By:

Volman, Yael;
Hefetz, Ruth;
Galun, Eithan;
Rachmilewitz, Jacob

Publication type:

Article

Incomplete thermal ablation of tumors promotes increased tumorigenesis.

Published in:

International Journal of Hyperthermia, 2021, v. 38, n. 1, p. 263, doi. 10.1080/02656736.2021.1887942

By:

Markezana, Aurelia;
Goldberg, S. Nahum;
Kumar, Gaurav;
Zorde-Khvalevsky, Elina;
Gourevtich, Svetlana;
Rozenblum, Nir;
Galun, Eithan;
Ahmed, Muneeb

Publication type:

Article

Moderate hyperthermic heating encountered during thermal ablation increases tumor cell activity.

Published in:

International Journal of Hyperthermia, 2020, v. 37, n. 1, p. 119, doi. 10.1080/02656736.2020.1714084

By:

Markezana, Aurelia;
Ahmed, Muneeb;
Kumar, Gaurav;
Zorde-Khvalevsky, Elina;
Rozenblum, Nir;
Galun, Eithan;
Goldberg, S. Nahum

Publication type:

Article

Radiofrequency ablation (RFA)-induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins.

Published in:

International Journal of Hyperthermia, 2018, v. 34, n. 7, p. 934, doi. 10.1080/02656736.2018.1462535

By:

Ahmed, Muneeb;
Kumar, Gaurav;
Goldberg, S. Nahum;
Gourevitch, Svetlana;
Levchenko, Tatyana;
Torchilin, Vladimir;
Galun, Eithan

Publication type:

Article

Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy.

Published in:

PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0128910

By:

Ahmed, Muneeb;
Kumar, Gaurav;
Navarro, Gemma;
Wang, Yuanguo;
Gourevitch, Svetlana;
Moussa, Marwan H.;
Rozenblum, Nir;
Levchenko, Tatyana;
Galun, Eithan;
Torchilin, Vladimir P.;
Goldberg, S. Nahum

Publication type:

Article

Natural Killer Cell-Dependent Anti-Fibrotic Pathway in Liver Injury via Toll-Like Receptor-9.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082571

By:

Abu-Tair, Lina;
Axelrod, Jonathan H.;
Doron, Sarit;
Ovadya, Yossi;
Krizhanovsky, Valery;
Galun, Eithan;
Amer, Johnny;
Safadi, Rifaat

Publication type:

Article

Gene Transfer to Chicks Using Lentiviral Vectors Administered via the Embryonic Chorioallantoic Membrane.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036531

By:

Hen, Gideon;
Yosefi, Sara;
Shinder, Dmitry;
Or, Adi;
Mygdal, Sivan;
Condiotti, Reba;
Galun, Eithan;
Bor, Amir;
Sela-Donenfeld, Dalit;
Friedman-Einat, Miriam

Publication type:

Article

Comprehensive Gene and microRNA Expression Profiling Reveals a Role for microRNAs in Human Liver Development.

Published in:

PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007511

By:

Tzur, Galit;
Israel, Ariel;
Levy, Asaf;
Benjamin, Hila;
Meiri, Eti;
Shufaro, Yoel;
Meir, Karen;
Khvalevsky, Elina;
Spector, Yael;
Rojansky, Nathan;
Bentwich, Zvi;
Reubinoff, Benjamin E.;
Galun, Eithan

Publication type:

Article

Increased MicroRNA Activity in Human Cancers.

Published in:

PLoS ONE, 2009, v. 4, n. 6, p. 1, doi. 10.1371/journal.pone.0006045

By:

Israel, Ariel;
Sharan, Roded;
Ruppin, Eytan;
Galun, Eithan

Publication type:

Article

Interaction between CXCR4 and CCL20 Pathways Regulates Tumor Growth.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005125

By:

Beider, Katia;
Abraham, Michal;
Begin, Michal;
Wald, Hanna;
Weiss, Ido D.;
Wald, Ori;
Pikarsky, Eli;
Abramovitch, Rinat;
Zeira, Evelyne;
Galun, Eithan;
Nagler, Arnon;
Peled, Amnon

Publication type:

Article

HCV Tumor Promoting Effect Is Dependent on Host Genetic Background.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005025

By:

Klopstock, Naama;
Katzenellenbogen, Mark;
Pappo, Orit;
Sklair-Levy, Miriam;
Olam, Devorah;
Mizrahi, Lina;
Potikha, Tamara;
Galun, Eithan;
Goldenberg, Daniel

Publication type:

Article

A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme -- A Preclinical and Phase I Investigation.

Published in:

PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004792

By:

Aviezer, David;
Brill-Almon, Einat;
Shaaltiel, Yoseph;
Hashmueli, Sharon;
Bartfeld, Daniel;
Mizrachi, Sarah;
Liberman, Yael;
Freeman, Arnold;
Zimran, Ari;
Galun, Eithan

Publication type:

Article

MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells.

Published in:

PLoS ONE, 2008, v. 3, n. 11, p. 1, doi. 10.1371/journal.pone.0003726

By:

Tzur, Galit;
Levy, Asaf;
Meiri, Eti;
Barad, Omer;
Spector, Yael;
Bentwich, Zvi;
Mizrahi, Lina;
Katzenellenbogen, Mark;
Ben-Shushan, Etti;
Reubinoff, Benjamin E.;
Galun, Eithan

Publication type:

Article

Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model.

Published in:

FASEB Journal, 2019, v. 33, n. 7, p. 7995, doi. 10.1096/fj.201900017R

By:

Potikha, Tamara;
Pappo, Orit;
Mizrahi, Lina;
Olam, Devorah;
Maller, Sebastián M.;
Rabinovich, Gabriel A.;
Galun, Eithan;
Goldenberg, Daniel S.

Publication type:

Article

Femtosecond laser: a new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization.

Published in:

FASEB Journal, 2007, v. 21, n. 13, p. 3522, doi. 10.1096/fj.06-7528com

By:

Zeira, Evelyne;
Manevitch, Alexandra;
Manevitch, Zakharia;
Kedar, Eli;
Gropp, Michal;
Daudi, Nili;
Barsuk, Rimma;
Harati, Menahem;
Yotvat, Habit;
Troilo, Philip J.;
Griffiths II, Thomas G.;
Pacchione, Stephen J.;
Rocien, Dana F.;
Niu, Zhutian;
Nussbaum, Ofer;
Zamir, Gideon;
Papo, Orit;
Hemo, Izhack;
Lewis, Aaron;
Galun, Eithan

Publication type:

Article

Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis.

Published in:

FASEB Journal, 2004, v. 18, n. 11, p. 1240, doi. 10.1096/fj.03-0935fje

By:

Darash-Yahana, Merav;
Pikarsky, Eli;
Abramovitch, Rinat;
Zeira, Evelyne;
Pal, Boaz;
Karplus, Rebekah;
Beider, Katia;
Avniel, Shani;
Kasem, Shafika;
Galun, Eithan;
Peled, Amnon

Publication type:

Article

Hepatic radiofrequency ablation: markedly reduced systemic effects by modulating periablational inflammation via cyclooxygenase-2 inhibition.

Published in:

2017

By:

Kumar, Gaurav;
Goldberg, S.;
Wang, Yuanguo;
Velez, Erik;
Gourevitch, Svetlana;
Galun, Eithan;
Ahmed, Muneeb;
Goldberg, S Nahum

Publication type:

journal article

The use of the hydrodynamic HBV animal model to study HBV biology and anti-viral therapy

Published in:

Hepatology Research, 2006, v. 34, n. 4, p. 228, doi. 10.1016/j.hepres.2006.01.008

By:

Ketzinel-Gilad, Mali;
Zauberman, Arie;
Nussbaum, Ofer;
Shoshany, Yariv;
Ben-Moshe, Ofer;
Pappo, Orit;
Felig, Yaakov;
Ilan, Ehud;
Wald, Hanna;
Dagan, Shlomo;
Galun, Eithan

Publication type:

Article

Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42819-2

By:

Markezana, Aurelia;
Paldor, Mor;
Liao, Haixing;
Ahmed, Muneeb;
Zorde-Khvalevsky, Elina;
Rozenblum, Nir;
Stechele, Matthias;
Salvermoser, Lukas;
Laville, Flinn;
Goldmann, Salome;
Rosenberg, Nofar;
Andrasina, Tomas;
Ricke, Jens;
Galun, Eithan;
Goldberg, Shraga Nahum

Publication type:

Article

Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42819-2

By:

Markezana, Aurelia;
Paldor, Mor;
Liao, Haixing;
Ahmed, Muneeb;
Zorde-Khvalevsky, Elina;
Rozenblum, Nir;
Stechele, Matthias;
Salvermoser, Lukas;
Laville, Flinn;
Goldmann, Salome;
Rosenberg, Nofar;
Andrasina, Tomas;
Ricke, Jens;
Galun, Eithan;
Goldberg, Shraga Nahum

Publication type:

Article

Development of novel Promiscuous anti-chemokine Peptibodies for Treating autoimmunity and inflammation.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01432

By:

Abraham, Michal;
Wald, Hanna;
Vaizel-Ohayon, Dalit;
Grabovsky, Valentin;
Oren, Zohar;
Karni, Arnon;
Weiss, Lola;
Galun, Eithan;
Peled, Amnon;
Eizenberg, Orly

Publication type:

Article

Protection or susceptibility to devastating childhood epilepsy: Nodding Syndrome associates with immunogenetic fingerprints in the HLA binding groove.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008436

By:

Benedek, Gil;
Abed El Latif, Mahmoud;
Miller, Keren;
Rivkin, Mila;
Ramadhan Lasu, Ally Ahmed;
Riek, Lul P.;
Lako, Richard;
Edvardson, Shimon;
Alon, Sagit-Arbel;
Galun, Eithan;
Levite, Mia

Publication type:

Article

Pyoderma Gangrenosum Complicating Ulcerative Colitis: Successful Treatment with Methylprednisolone Pulse Therapy and Dapsone.

Published in:

American Journal of Gastroenterology (Springer Nature), 1986, v. 81, n. 10, p. 988

By:

Galun, Eithan;
Flugelman, Moshe Y.;
Rachmilewitz, Daniel

Publication type:

Article

TLR3 signaling in a hepatoma cell line is skewed towards apoptosis.

Published in:

Journal of Cellular Biochemistry, 2007, v. 100, n. 5, p. 1301, doi. 10.1002/jcb.21119

By:

Khvalevsky, Elina;
Rivkin, Ludmila;
Rachmilewitz, Jacob;
Galun, Eithan;
Giladi, Hilla

Publication type:

Article

Testing transgenic regulatory elements through live mouse imaging

Published in:

FEBS Letters, 2007, v. 581, n. 21, p. 3986, doi. 10.1016/j.febslet.2007.07.029

By:

Klopstock, Naama;
Levy, Carol;
Olam, Devorah;
Galun, Eithan;
Goldenberg, Daniel

Publication type:

Article

Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gut.

Published in:

Liver International, 2009, v. 29, n. 8, p. 1273, doi. 10.1111/j.1478-3231.2009.02048.x

By:

Rudich, Noam;
Zamir, Gideon;
Pappo, Orit;
Shlomai, Zipora;
Faroja, Muhamad;
Weiss, Ido D.;
Wald, Hanna;
Galun, Eithan;
Peled, Amnon;
Wald, Ori

Publication type:

Article

The lncRNA H19-Derived MicroRNA-675 Promotes Liver Necroptosis by Targeting FADD.

Published in:

Cancers, 2021, v. 13, n. 3, p. 411, doi. 10.3390/cancers13030411

By:

Harari-Steinfeld, Rona;
Gefen, Maytal;
Simerzin, Alina;
Zorde-Khvalevsky, Elina;
Rivkin, Mila;
Ella, Ezra;
Friehmann, Tomer;
Gerlic, Mordechay;
Zucman-Rossi, Jessica;
Caruso, Stefano;
Leveille, Mélissa;
Estall, Jennifer L.;
Goldenberg, Daniel S.;
Giladi, Hilla;
Galun, Eithan;
Bromberg, Zohar;
de Franciscis, Vittorio

Publication type:

Article

Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis.

Published in:

Clinical & Translational Oncology, 2012, v. 14, n. 3, p. 232, doi. 10.1007/s12094-012-0789-z

By:

Sonnenblick, Amir;
Shriki, Anat;
Galun, Eithan;
Axelrod, Jonathan;
Daum, Hagit;
Rottenberg, Yakir;
Hamburger, Tamar;
Mali, Bela;
Peretz, Tamar

Publication type:

Article

Molecular Imaging of the Skeleton: Quantitative Real-Time Bioluminescence Monitoring Gene Expression in Bone Repair and Development.

Published in:

Journal of Bone & Mineral Research, 2003, v. 18, n. 3, p. 570, doi. 10.1359/jbmr.2003.18.3.570

By:

Bar, Iris;
Zilberman, Yoram;
Zeira, Eveline;
Galun, Eithan;
Honigman, Alik;
Turgeman, Gadi;
Clemens, Thomas;
Gazit, Zulma;
Gazit, Dan

Publication type:

Article

Transduction of Fetal Mice With a Feline Lentiviral Vector Induces Liver Tumors Which Exhibit an E2F Activation Signature.

Published in:

Molecular Therapy, 2014, v. 22, n. 1, p. 59, doi. 10.1038/mt.2013.193

By:

Condiotti, Reba;
Goldenberg, Daniel;
Giladi, Hilla;
Schnitzer-Perlman, Temima;
Waddington, Simon N;
Buckley, Suzanne MK;
Heim, Denise;
Cheung, Wing;
Themis, Matthew;
Coutelle, Charles;
Simerzin, Alina;
Osejindu, Emma;
Wege, Henning;
Themis, Michael;
Galun, Eithan

Publication type:

Article

Neonatal Gene Therapy of Glycogen Storage Disease Type Ia Using a Feline Immunodeficiency Virus–based Vector.

Published in:

Molecular Therapy, 2010, v. 18, n. 9, p. 1592, doi. 10.1038/mt.2010.119

By:

Grinshpun, Albert;
Condiotti, Reba;
N Waddington, Simon;
Peer, Michael;
Zeig, Eli;
Peretz, Sima;
Simerzin, Alina;
Chou, Janice;
Chi-Jiunn Pann;
Giladi, Hilla;
Galun, Eithan

Publication type:

Article

Replication-deficient Adenovirus Induces Host Topoisomerase I Activity: Implications for Adenovirus-mediated Gene Expression.

Published in:

Molecular Therapy, 2007, v. 15, n. 4, p. 772, doi. 10.1038/sj.mt.6300110

By:

Zamir, Gideon;
Zeira, Evelyne;
Gelman, Andrew E;
Shaked, Abraham;
Olthoff, Kim M;
Eid, Ahmed;
Galun, Eithan

Publication type:

Article

Lentiviral Vectors Harboring a Dual-Gene System Allow High and Homogeneous Transgene Expression in Selected Polyclonal Human Embryonic Stem Cells.

Published in:

Molecular Therapy, 2006, v. 14, n. 2, p. 255, doi. 10.1016/j.ymthe.2006.02.010

By:

Ben-Dor, Israel;
Itsykson, Pavel;
Goldenberg, Daniel;
Galun, Eithan;
Reubinoff, Benjamin E.

Publication type:

Article

Phase I/II Trial of Intravenous NDV-HUJ Oncolytic Virus in Recurrent Glioblastoma Multiforme.

Published in:

Molecular Therapy, 2006, v. 13, n. 1, p. 221, doi. 10.1016/j.ymthe.2005.08.016

By:

Freeman, Arnold I.;
Zakay-Rones, Zichria;
Gomori, John M.;
Linetsky, Eduard;
Rasooly, Linda;
Greenbaum, Evgeniya;
Rozenman-Yair, Shira;
Panet, Amos;
Libson, Eugene;
Irving, Charles S.;
Galun, Eithan;
Siegal, Tali

Publication type:

Article

Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction

Published in:

Molecular Therapy, 2005, v. 12, n. 1, p. 137, doi. 10.1016/j.ymthe.2005.02.022

By:

Shai, Ela;
Palmon, Aaron;
Panet, Amos;
Marmary, Yitzhak;
Sherman, Yoav;
Curran, Michael A.;
Galun, Eithan;
Condiotti, Reba

Publication type:

Article

837. Prolonged Gene Expression in Murine Salivary Glands Following FIV-Based Lentiviral Vector Transduction

Published in:

2005

By:

Shai, Ela;
Condiotti, Reba;
Curran, Michael A.;
Nolan, Garry P.;
Galun, Eithan

Publication type:

Abstract

806. Phase I/II Trial of Intravenous NDV-HUJ (OV001) Oncolytic Virus in Recurrent Glioblastoma Multiforme

Published in:

2005

By:

Freeman, Arnold I.;
Zakay-Rones, Zichria;
Gomori, John M.;
Linetsky, Eduard;
Rasooly, Linda;
Panet, Amos;
Libson, Eugene;
Irving, Charles S.;
Siegal, Tali;
Galun, Eithan

Publication type:

Abstract

744. Enhanced Expression of Adenovirus Transgenes in the Mouse Liver and Human Tumors Following Topoisomerase I Inhibition

Published in:

2005

By:

Zamir, Gideon;
Zeira, Evelyne;
Galun, Eithan

Publication type:

Abstract

735. Femtosecond Laser- A New Intradermal DNA Delivery Method for Gene Expression and Vaccination

Published in:

2005

By:

Zeira, Evelyne;
Manevitch, Alexandra;
Manevitch, Zakharia;
Harati, Menahem;
Yotvat, Hagit;
Gropp, Michal;
Papo, Orit;
Daudi, Nili;
Kedar, Eli;
Lewis, Aaron;
Galun, Eithan

Publication type:

Abstract

342. Human Erythropoietin Gene Therapy for Patients with Chronic Renal Failure

Published in:

2005

By:

Lippin, Yitzhak;
Dranitzki-Elhale, Michal;
Brill-Almon, Einat;
Mei–Zahav, Chava;
Mizrachi, Sarah;
Liberman, Yael;
Iaina, Adrian;
Kaplan, Eli;
Podjarny, Eduardo;
Casadevall, Nicole;
Shani, Noam;
Galun, Eithan

Publication type:

Abstract

The Twelfth Annual Meeting of the European Society of Gene Therapy

Published in:

2005

By:

Grez, Manuel;
Galun, Eithan;
Moullier, Philippe

Publication type:

Proceeding

Gene Therapy Platform for Bone Regeneration Using an Exogenously Regulated, AAV-2-Based Gene Expression System

Published in:

Molecular Therapy, 2004, v. 9, n. 4, p. 587, doi. 10.1016/j.ymthe.2003.12.009

By:

Gafni, Yossi;
Pelled, Gadi;
Zilberman, Yoram;
Turgeman, Gadi;
Apparailly, Florence;
Yotvat, Hagit;
Galun, Eithan;
Gazit, Zulma;
Jorgensen, Christian;
Gazit, Dan

Publication type:

Article

Small interfering RNA Inhibits Hepatitis B virus replication in mice

Published in:

Molecular Therapy, 2003, v. 8, n. 5, p. 769, doi. 10.1016/S1525-0016(03)00244-2

By:

Giladi, Hilla;
Ketzinel-Gilad, Mali;
Rivkin, Ludmila;
Felig, Yaakov;
Nussbaum, Ofer;
Galun, Eithan

Publication type:

Article

Femtosecond infrared laser—an efficient and safe in vivo gene delivery system for prolonged expression

Published in:

Molecular Therapy, 2003, v. 8, n. 2, p. 342, doi. 10.1016/S1525-0016(03)00184-9

By:

Zeira, Evelyne;
Manevitch, Alexandra;
Khatchatouriants, Artium;
Pappo, Orit;
Hyam, Esti;
Darash-Yahana, Merav;
Tavor, Einat;
Honigman, Alik;
Lewis, Aaron;
Galun, Eithan

Publication type:

Article

Stable genetic modification of human embryonic stem cells by lentiviral vectors

Published in:

Molecular Therapy, 2003, v. 7, n. 2, p. 281, doi. 10.1016/S1525-0016(02)00047-3

By:

Gropp, Michal;
Itsykson, Pavel;
Singer, Orna;
Ben-Hur, Tamir;
Reinhartz, Etti;
Galun, Eithan;
Reubinoff, Benjamin E.

Publication type:

Article