Works by Galione, Antony

Results: 51

Chemical Synthesis of the Novel Ca 2 + Messenger NAADP.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2005, v. 24, n. 5-7, p. 513, doi. 10.1081/NCN-200061786

By:

Dowden, James;
Brown, Richard S.;
Moreau, Christelle;
Galione, Antony;
Potter, Barry V. L.

Publication type:

Article

Current methods to analyze lysosome morphology, positioning, motility and function.

Published in:

Traffic, 2022, v. 23, n. 5, p. 238, doi. 10.1111/tra.12839

By:

Barral, Duarte C.;
Staiano, Leopoldo;
Guimas Almeida, Cláudia;
Cutler, Dan F.;
Eden, Emily R.;
Futter, Clare E.;
Galione, Antony;
Marques, André R. A.;
Medina, Diego Luis;
Napolitano, Gennaro;
Settembre, Carmine;
Vieira, Otília V.;
Aerts, Johannes M. F. G.;
Atakpa‐Adaji, Peace;
Bruno, Gemma;
Capuozzo, Antonella;
De Leonibus, Elvira;
Di Malta, Chiara;
Escrevente, Cristina;
Esposito, Alessandra

Publication type:

Article

An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells.

Published in:

Traffic, 2012, v. 13, n. 7, p. 1012, doi. 10.1111/j.1600-0854.2012.01366.x

By:

Larisch, Nina;
Schulze, Christina;
Galione, Antony;
Dietrich, Petra

Publication type:

Article

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Published in:

EMBO Journal, 2015, v. 34, n. 13, p. 1743, doi. 10.15252/embj.201490009

By:

Ruas, Margarida;
Davis, Lianne C;
Chen, Cheng‐Chang;
Morgan, Anthony J;
Chuang, Kai‐Ting;
Walseth, Timothy F;
Grimm, Christian;
Garnham, Clive;
Powell, Trevor;
Platt, Nick;
Platt, Frances M;
Biel, Martin;
Wahl‐Schott, Christian;
Parrington, John;
Galione, Antony

Publication type:

Article

Chemical Synthesis of the Second Messenger Nicotinic Acid Adenine Dinucleotide Phosphate by Total Synthesis of Nicotinamide Adenine Dinucleotide PhosphateThis research was funded by the Biotechnology and Biology Sciences Research Council and an Engineering and Physical Sciences Research Council (EPSRC) studentship. We acknowledge the use of the EPSRC Chemical Database Service at Daresbury.

Published in:

Angewandte Chemie, 2004, v. 116, n. 35, p. 4737, doi. 10.1002/ange.200460054

By:

James Dowden;
Christelle Moreau;
Richard S. Brown;
Georgina Berridge;
Antony Galione;
Barry V. L. Potter

Publication type:

Article

Mechanistic convergence and shared therapeutic targets in Niemann‐Pick disease.

Published in:

Journal of Inherited Metabolic Disease, 2020, v. 43, n. 3, p. 574, doi. 10.1002/jimd.12191

By:

Colaco, Alexandria;
Kaya, Ecem;
Adriaenssens, Elias;
Davis, Lianne C.;
Zampieri, Stefania;
Fernández‐Suárez, María E.;
Tan, Chong Y.;
Deegan, Patrick B.;
Porter, Forbes D.;
Galione, Antony;
Bembi, Bruno;
Dardis, Andrea;
Platt, Frances M.

Publication type:

Article

Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88906-0

By:

Heister, Paula Maria;
Powell, Trevor;
Galione, Antony

Publication type:

Article

NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca2+ nanodomains, calcineurin and dynamin.

Published in:

EMBO Journal, 2020, v. 39, n. 14, p. 1, doi. 10.15252/embj.2019104058

By:

Davis, Lianne C;
Morgan, Anthony J;
Galione, Antony

Publication type:

Article

The functional roles of Ca2+ mobilizing pyridine nucleotides cADPR and NAADP in detrusor and taenia caceum.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1161

By:

Durlu-Kandilci, Nezahat Tugba;
Galione, Antony

Publication type:

Article

NAADP mobilizes calcium from acidic organelles through two-pore channels.

Published in:

Nature, 2009, v. 459, n. 7246, p. 596, doi. 10.1038/nature08030

By:

Calcraft, Peter J.;
Ruas, Margarida;
Pan, Zui;
Cheng, Xiaotong;
Arredouani, Abdelilah;
Hao, Xuemei;
Tang, Jisen;
Rietdorf, Katja;
Teboul, Lydia;
Chuang, Kai-Ting;
Lin, Peihui;
Xiao, Rui;
Wang, Chunbo;
Zhu, Yingmin;
Lin, Yakang;
Wyatt, Christopher N.;
Parrington, John;
Ma, Jianjie;
Evans, A. Mark;
Galione, Antony

Publication type:

Article

Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 37, p. 11077, doi. 10.1002/anie.201604336

By:

Rodrigues, Tiago;
Sieglitz, Florian;
Somovilla, Víctor J.;
Cal, Pedro M. S. D.;
Galione, Antony;
Corzana, Francisco;
Bernardes, Gonçalo J. L.

Publication type:

Article

Flipping the switch: How a sperm activates the egg at fertilization.

Published in:

Developmental Dynamics, 2007, v. 236, n. 8, p. 2027, doi. 10.1002/dvdy.21255

By:

John Parrington;
Lianne C. Davis;
Antony Galione;
Gary Wessel

Publication type:

Article

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans.

Published in:

Genetics, 2014, v. 198, n. 1, p. 17, doi. 10.1534/genetics.114.162982

By:

Shirng-Wern Tsaih;
Holl, Katie;
Shuang Jia;
Kaldunski, Mary;
Tschannen, Michael;
Hong He;
Andrae, Jaime Wendt;
Shun-Hua Li;
Stoddard, Alex;
Wiederhold, Andrew;
Parrington, John;
Ruas da Silva, Margarida;
Galione, Antony;
Meigs, James;
Hoffmann, Raymond G.;
Simpson, Pippa;
Jacob, Howard;
Hessner, Martin;
Solberg Woods, Leah C.

Publication type:

Article

Two-pore channels ( TPCs): Current controversies.

Published in:

BioEssays, 2014, v. 36, n. 2, p. 173, doi. 10.1002/bies.201300118

By:

Morgan, Anthony J.;
Galione, Antony

Publication type:

Article

TPC: the NAADP discovery channel?

Published in:

Biochemical Society Transactions, 2015, v. 43, n. 3, p. 384, doi. 10.1042/BST20140300

By:

Morgan, Anthony J.;
Davis, Lianne C.;
Ruas, Margarida;
Galione, Antony

Publication type:

Article

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Published in:

Nature Medicine, 2008, v. 14, n. 11, p. 1247, doi. 10.1038/nm.1876

By:

Lloyd-Evans, Emyr;
Morgan, Anthony J.;
Xingxuan He;
Smith, David A.;
Elliot-Smith, Elena;
Sillence, Daniel J.;
Churchill, Grant C.;
Schuchman, Edward H.;
Galione, Antony;
Platt, Frances M.

Publication type:

Article

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Published in:

2018

By:

Hamilton, Alexander;
Quan Zhang;
Salehi, Albert;
Willems, Mara;
Knudsen, Jakob G.;
Ringgaard, Anna K.;
Chapman, Caroline E.;
Gonzalez-Alvarez, Alejandro;
Surdo, Nicoletta C.;
Zaccolo, Manuela;
Basco, Davide;
Johnson, Paul R. V.;
Ramracheya, Reshma;
Rutter, Guy A.;
Galione, Antony;
Rorsman, Patrik;
Tarasov, Andrei I.;
Zhang, Quan

Publication type:

journal article

Reply to "TPC1 Knockout Knocks Out TPC1".

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 10, p. 1884, doi. 10.1128/MCB.00083-15

By:

Ruas, Margarida;
Galione, Antony;
Parrington, John

Publication type:

Article

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 21, p. 3981, doi. 10.1128/MCB.00113-14

By:

Ruas, Margarida;
Kai-Ting Chuang;
Davis, Lianne C.;
Al-Douri, Areej;
Tynan, Patricia W.;
Tunn, Ruth;
Teboul, Lydia;
Galione, Antony;
Parrington, John

Publication type:

Article

Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels.

Published in:

Angewandte Chemie, 2016, v. 128, n. 37, p. 11243, doi. 10.1002/ange.201604336

By:

Rodrigues, Tiago;
Sieglitz, Florian;
Somovilla, Víctor J.;
Cal, Pedro M. S. D.;
Galione, Antony;
Corzana, Francisco;
Bernardes, Gonçalo J. L.

Publication type:

Article

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels.

Published in:

Pflügers Archiv: European Journal of Physiology, 2009, v. 458, n. 5, p. 869, doi. 10.1007/s00424-009-0682-y

By:

Galione, Antony;
Evans, A. Mark;
Jianjie Ma;
Parrington, John;
Arredouani, Abdelilah;
Xiaotong Cheng;
Zhu, Michael X.

Publication type:

Article

Cytolytic granules supply Ca2+ for their own exocytosis via NAADP and resident two-pore channels.

Published in:

Communicative & Integrative Biology, 2013, v. 6, n. 3, p. e24175-1, doi. 10.4161/cib.24175

By:

Davis, Lianne C.;
Galione, Antony

Publication type:

Article

Physiological roles of NAADP-mediated Ca signaling.

Published in:

SCIENCE CHINA Life Sciences, 2011, v. 54, n. 8, p. 725, doi. 10.1007/s11427-011-4207-5

By:

Galione, Antony;
Parrington, John;
Funnell, Tim

Publication type:

Article

Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles.

Published in:

Journal of Cell Biology, 2013, v. 200, n. 6, p. 789, doi. 10.1083/jcb.201204078

By:

Morgan, Anthony J.;
Davis, Lianne C.;
Wagner, Siegfried K. T. Y.;
Lewis, Alexander M.;
Parrington, John;
Churchill, Grant C.;
Galione, Antony

Publication type:

Article

Acetylation turns leucine into a drug by membrane transporter switching.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95255-5

By:

Churchill, Grant C.;
Strupp, Michael;
Factor, Cailley;
Bremova-Ertl, Tatiana;
Factor, Mallory;
Patterson, Marc C.;
Platt, Frances M.;
Galione, Antony

Publication type:

Article

Two-pore channels for integrative Ca2+ signaling.

Published in:

Communicative & Integrative Biology, 2010, v. 3, n. 1, p. 12, doi. 10.4161/cib.3.1.9793

By:

Zhu, Michael X.;
Evans, Mark D.;
Ma, Jianjie;
Parrington, John;
Galione, Antony

Publication type:

Article

Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.

Published in:

EMBO Journal, 2002, v. 21, n. 5, p. 909, doi. 10.1093/emboj/21.5.909

By:

Cancela, Jose M.;
van Coppenolle, Fabien;
Galione, Antony;
Tepikin, Alexei V.;
Petersen, Ole H.

Publication type:

Article

NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.

Published in:

EMBO Journal, 2001, v. 20, n. 11, p. 2666, doi. 10.1093/emboj/20.11.2666

By:

Churchill, Grant C.;
Galione, Antony

Publication type:

Article

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.

Published in:

Nature, 1999, v. 398, n. 6722, p. 74, doi. 10.1038/18032

By:

Cancela, Jose Manuel;
Churchill, Grant C.;
Galione, Antony

Publication type:

Article

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling.

Published in:

Science Signaling, 2018, v. 11, n. 558, p. 1, doi. 10.1126/scisignal.aat9093

By:

Foster, William J.;
Taylor, Henry B. C.;
Padamsey, Zahid;
Jeans, Alexander F.;
Galione, Antony;
Emptage, Nigel J.

Publication type:

Article

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+.

Published in:

Science Signaling, 2014, v. 7, n. 326, p. 1, doi. 10.1126/scisignal.2004854

By:

Pitt, Samantha J.;
Lam, Andy K. M.;
Rietdorf, Katja;
Galione, Antony;
Sitsapesan, Rebecca

Publication type:

Article

Microinjection of cyclic ADP-ribose triggers a regenerative wave of Ca2+ release and exocytosis of cortical alveoli in medaka eggs.

Published in:

Zygote, 1999, v. 7, n. 4, p. 285, doi. 10.1017/s0967199499000684

By:

Fluck, Richard;
Abraham, Vivek;
Miller, Andrew;
Galione, Antony

Publication type:

Article

Hax-1 identified as a two-pore channel (TPC)-binding protein.

Published in:

FEBS Letters, 2013, v. 587, n. 23, p. 3782, doi. 10.1016/j.febslet.2013.10.031

By:

Lam, Andy K.M.;
Galione, Antony;
Lai, F. Anthony;
Zissimopoulos, Spyros

Publication type:

Article

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

Published in:

Scientific Reports, 2017, p. 40620, doi. 10.1038/srep40620

By:

Aston, Daniel;
Capel, Rebecca A.;
Ford, Kerrie L.;
Christian, Helen C.;
Mirams, Gary R.;
Rog-Zielinska, Eva A.;
Kohl, Peter;
Galione, Antony;
Burton, Rebecca A. B.;
Terrar, Derek A.

Publication type:

Article

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.

Published in:

Scientific Reports, 2017, p. 40687, doi. 10.1038/srep40687

By:

Wang, Yanwen;
Lin, Wee Khang;
Crawford, William;
Ni, Haibo;
Bolton, Emma L.;
Khan, Huma;
Shanks, Julia;
Bub, Gil;
Wang, Xin;
Paterson, David J.;
Zhang, Henggui;
Galione, Antony;
Ebert, Steven N.;
Terrar, Derek A.;
Lei, Ming

Publication type:

Article

Chemical Synthesis of the Second Messenger Nicotinic Acid Adenine Dinucleotide Phosphate by Total Synthesis of Nicotinamide Adenine Dinucleotide PhosphateThis research was funded by the Biotechnology and Biology Sciences Research Council and an Engineering and Physical Sciences Research Council (EPSRC) studentship. We acknowledge the use of the EPSRC Chemical Database Service at Daresbury.

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 35, p. 4637, doi. 10.1002/anie.200460054

By:

James Dowden;
Christelle Moreau;
Richard S. Brown;
Georgina Berridge;
Antony Galione;
Barry V. L. Potter

Publication type:

Article

Two-pore channels: going with the flows.

Published in:

Biochemical Society Transactions, 2022, v. 50, n. 4, p. 1143, doi. 10.1042/BST20220229

By:

Morgan, Anthony J.;
Martucci, Lora L.;
Davis, Lianne C.;
Galione, Antony

Publication type:

Article

A two-pore channel protein required for regulating mTORC1 activity on starvation.

Published in:

BMC Biology, 2020, v. 18, n. 1, p. 1, doi. 10.1186/s12915-019-0735-4

By:

Chang, Fu-Sheng;
Wang, Yuntao;
Dmitriev, Phillip;
Gross, Julian;
Galione, Antony;
Pears, Catherine

Publication type:

Article

Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).

Published in:

FEBS Journal, 2005, v. 272, n. 18, p. 4598, doi. 10.1111/j.1742-4658.2005.04860.x

By:

Yamasaki, Michiko;
Churchill, Grant C.;
Galione, Antony

Publication type:

Article

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.

Published in:

2011

By:

Kashir, Junaid;
Jones, Celine;
Lee, Hoi Chang;
Rietdorf, Katja;
Nikiforaki, Dimitra;
Durrans, Claire;
Ruas, Margarida;
Tee, Sze Tian;
Heindryckx, Bjorn;
Galione, Antony;
De Sutter, Petra;
Fissore, Rafael A.;
Parrington, John;
Coward, Kevin

Publication type:

journal article

Defective platelet function in Niemann‐Pick disease type C1.

Published in:

Journal of Inherited Metabolic Disease Reports, 2020, v. 56, n. 1, p. 46, doi. 10.1002/jmd2.12148

By:

Chen, Oscar C. W.;
Colaco, Alexandria;
Davis, Lianne C.;
Kiskin, Fedir N.;
Farhat, Nicole Y.;
Speak, Anneliese O.;
Smith, David A.;
Morris, Lauren;
Eden, Emily;
Tynan, Patricia;
Churchill, Grant C.;
Galione, Antony;
Porter, Forbes D.;
Platt, Frances M.

Publication type:

Article

Revealing the secrets of secretion.

Published in:

eLife, 2018, p. 1, doi. 10.7554/eLife.43512

By:

GALIONE, ANTONY;
DAVIS, LIANNE C.

Publication type:

Article

Intracellular sphingosine releases calcium from lysosomes.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.10616

By:

Höglinger, Doris;
Haberkant, Per;
Aguilera-Romero, Auxiliadora;
Riezman, Howard;
Porter, Forbes D.;
Platt, Frances M.;
Galione, Antony;
Schultz, Carsten

Publication type:

Article

Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease.

Published in:

Cells (2073-4409), 2025, v. 14, n. 1, p. 35, doi. 10.3390/cells14010035

By:

Platt, Nick;
Shepherd, Dawn;
Smith, David A.;
Smith, Claire;
Wallom, Kerri-Lee;
Luqmani, Raashid;
Churchill, Grant C.;
Galione, Antony;
Platt, Frances M.

Publication type:

Article

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

Published in:

PLoS ONE, 2020, v. 15, n. 2, p. 1, doi. 10.1371/journal.pone.0229585

By:

Churchill, Grant C.;
Strupp, Michael;
Galione, Antony;
Platt, Frances M.

Publication type:

Article

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

Published in:

FEBS Letters, 2010, v. 584, n. 10, p. 1966, doi. 10.1016/j.febslet.2010.02.028

By:

Zhu, Michael X.;
Ma, Jianjie;
Parrington, John;
Galione, Antony;
Mark Evans, A.

Publication type:

Article

Identification of a chemical probe for NAADP by virtual screening.

Published in:

Nature Chemical Biology, 2009, v. 5, n. 4, p. 220, doi. 10.1038/nchembio.150

By:

Naylor, Edmund;
Arredouani, Abdelilah;
Vasudevan, Sridhar R.;
Lewis, Alexander M.;
Parkesh, Raman;
Mizote, Akiko;
Rosen, Daniel;
Thomas, Justyn M.;
Izumi, Minoru;
Ganesan, A.;
Galione, Antony;
Churchill, Grant C.

Publication type:

Article

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22179-z

By:

Jagannath, Aarti;
Varga, Norbert;
Dallmann, Robert;
Rando, Gianpaolo;
Gosselin, Pauline;
Ebrahimjee, Farid;
Taylor, Lewis;
Mosneagu, Dragos;
Stefaniak, Jakub;
Walsh, Steven;
Palumaa, Teele;
Di Pretoro, Simona;
Sanghani, Harshmeena;
Wakaf, Zeinab;
Churchill, Grant C.;
Galione, Antony;
Peirson, Stuart N.;
Boison, Detlev;
Brown, Steven A.;
Foster, Russell G.

Publication type:

Article

A multiscale analysis in CD38-/- mice unveils major prefrontal cortex dysfunctions.

Published in:

FASEB Journal, 2019, v. 33, n. 5, p. 5823, doi. 10.1096/fj.201800489R

By:

Martucci, Lora L.;
Amar, Muriel;
Chaussenot, Remi;
Benet, Gabriel;
Bauer, Oscar;
de Zélicourt, Antoine;
Nosjean, Anne;
Launay, Jean-Marie;
Callebert, Jacques;
Sebrié, Catherine;
Galione, Antony;
Edeline, Jean-Marc;
de la Porte, Sabine;
Fossier, Philippe;
Granon, Sylvie;
Vaillend, Cyrille;
Cancela, José-Manuel

Publication type:

Article

A novel signalling role for NAADP in arterial smooth muscle.

Published in:

FASEB Journal, 2013, v. 27, p. 877.5, doi. 10.1096/fasebj.27.1_supplement.877.5

By:

Lim, Chloe;
Churchill, Grant;
Galione, Antony;
Garland, Christopher;
Dora, Kim

Publication type:

Article