Works by Głuch‐Lutwin, Monika

Results: 31

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 2, p. 229, doi. 10.3390/ph17020229

By:

Kazek, Grzegorz;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Menaszek, Elżbieta;
Kubacka, Monika;
Jurowska, Anna;
Cież, Dariusz;
Trzewik, Bartosz;
Szklarzewicz, Janusz;
Papież, Monika A.

Publication type:

Article

Novel Multimodal Salicylamide Derivative with Antidepressant-like, Anxiolytic-like, Antipsychotic-like, and Anti-Amnesic Activity in Mice.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 175, doi. 10.3390/ph16020175

By:

Żmudzka, Elżbieta;
Lustyk, Klaudia;
Głuch-Lutwin, Monika;
Wolak, Małgorzata;
Jaśkowska, Jolanta;
Kołaczkowski, Marcin;
Sapa, Jacek;
Pytka, Karolina

Publication type:

Article

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT 1A and D 2 Receptors.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 8, p. 744, doi. 10.3390/ph14080744

By:

Sałaciak, Kinga;
Malikowska-Racia, Natalia;
Lustyk, Klaudia;
Siwek, Agata;
Głuch-Lutwin, Monika;
Kazek, Grzegorz;
Popiół, Justyna;
Sapa, Jacek;
Marona, Henryk;
Żelaszczyk, Dorota;
Pytka, Karolina

Publication type:

Article

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists.

Published in:

PLoS ONE, 2020, v. 15, n. 8, p. 1, doi. 10.1371/journal.pone.0237196

By:

Partyka, Anna;
Zagórska, Agnieszka;
Kotańska, Magdalena;
Walczak, Maria;
Jastrzębska-Więsek, Magdalena;
Knutelska, Joanna;
Bednarski, Marek;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Janiszewska, Paulina;
Wesołowska, Anna

Publication type:

Article

Synthesis of N‐(phenoxyalkyl)‐, N‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System.

Published in:

ChemistrySelect, 2019, v. 4, n. 32, p. 9381, doi. 10.1002/slct.201902648

By:

Pańczyk, Katarzyna;
Pytka, Karolina;
Jakubczyk, Magdalena;
Rapacz, Anna;
Siwek, Agata;
Głuch‐Lutwin, Monika;
Gryboś, Anna;
Słoczyńska, Karolina;
Koczurkiewicz, Paulina;
Ryszawy, Damian;
Pękala, Elżbieta;
Budziszewska, Bogusława;
Starek‐Świechowicz, Beata;
Suraj‐Prażmowska, Joanna;
Walczak, Maria;
Żesławska, Ewa;
Nitek, Wojciech;
Bucki, Adam;
Kołaczkowski, Marcin;
Żelaszczyk, Dorota

Publication type:

Article

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 10, doi. 10.1080/14756366.2016.1198902

By:

Zagórska, Agnieszka;
Bucki, Adam;
Kołaczkowski, Marcin;
Siwek, Agata;
Głuch-Lutwin, Monika;
Starowicz, Gabriela;
Kazek, Grzegorz;
Partyka, Anna;
Wesołowska, Anna;
Słoczyńska, Karolina;
Pękala, Elżbieta;
Pawłowski, Maciej

Publication type:

Article

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1 H -imidazo[2,1- f ]purine-2,4(3 H ,8 H )-dione as potential antidepressant agents.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 10, doi. 10.1080/14756366.2016.1198902

By:

Zagórska, Agnieszka;
Bucki, Adam;
Kołaczkowski, Marcin;
Siwek, Agata;
Głuch-Lutwin, Monika;
Starowicz, Gabriela;
Kazek, Grzegorz;
Partyka, Anna;
Wesołowska, Anna;
Słoczyńska, Karolina;
Pękala, Elżbieta;
Pawłowski, Maciej

Publication type:

Article

Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1048, doi. 10.3109/14756366.2015.1088844

By:

Chłoń-Rzepa, Grażyna;
Bucki, Adam;
Kołaczkowski, Marcin;
Partyka, Anna;
Jastrzębska-Więsek, Magdalena;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Kalinowska-Tłuścik, Justyna;
Kazek, Grzegorz;
Mordyl, Barbara;
Głuch-Lutwin, Monika;
Wesołowska, Anna

Publication type:

Article

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0165495

By:

Pytka, Karolina;
Głuch-Lutwin, Monika;
Knutelska, Joanna;
Jakubczyk, Magdalena;
Waszkielewicz, Anna;
Kotańska, Magdalena

Publication type:

Article

Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15929, doi. 10.3390/ijms232415929

By:

Żmudzka, Elżbieta;
Lustyk, Klaudia;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Zakrzewska-Sito, Alicja;
Mierzejewski, Paweł;
Jaśkowska, Jolanta;
Kołaczkowski, Marcin;
Sapa, Jacek;
Pytka, Karolina

Publication type:

Article

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5750, doi. 10.3390/ijms21165750

By:

Góra, Małgorzata;
Czopek, Anna;
Rapacz, Anna;
Dziubina, Anna;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Obniska, Jolanta

Publication type:

Article

Vanadium complexes with salicylaldehyde-based Schiff base ligands—structure, properties and biological activity.

Published in:

Journal of Coordination Chemistry, 2020, v. 73, n. 6, p. 986, doi. 10.1080/00958972.2020.1755036

By:

Szklarzewicz, Janusz;
Jurowska, Anna;
Hodorowicz, Maciej;
Gryboś, Ryszard;
Kruczała, Krzysztof;
Głuch-Lutwin, Monika;
Kazek, Grzegorz

Publication type:

Article

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Published in:

Angewandte Chemie, 2025, v. 137, n. 6, p. 1, doi. 10.1002/ange.202420510

By:

Panek, Dawid;
Pasieka, Anna;
Jończyk, Jakub;
Gawlińska, Milena;
Zaręba, Paula;
Siwek, Agata;
Wolak, Małgorzata;
Mordyl, Barbara;
Głuch‐Lutwin, Monika;
Latacz, Gniewomir;
Brazzolotto, Xavier;
Chantegreil, Fabien;
Nachon, Florian;
Zdarova Karasova, Jana;
Pejchal, Jaroslav;
Mzik, Martin;
Sestak, Vit;
Prchal, Lukas;
Odvarkova, Jitka;
Soukup, Ondrej

Publication type:

Article

The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress.

Published in:

Psychopharmacology, 2021, v. 238, n. 8, p. 2249, doi. 10.1007/s00213-021-05849-0

By:

Głuch-Lutwin, Monika;
Sałaciak, Kinga;
Gawalska, Alicja;
Jamrozik, Marek;
Sniecikowska, Joanna;
Newman-Tancredi, Adrian;
Kołaczkowski, Marcin;
Pytka, Karolina

Publication type:

Article

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.

Published in:

Journal of Psychopharmacology, 2020, v. 34, n. 12, p. 1431, doi. 10.1177/0269881120959605

By:

Sałaciak, Kinga;
Głuch-Lutwin, Monika;
Siwek, Agata;
Szafarz, Małgorzata;
Kazek, Grzegorz;
Bednarski, Marek;
Nowiński, Leszek;
Mitchell, Emma;
Jastrzębska-Więsek, Magdalena;
Partyka, Anna;
Wesołowska, Anna;
Kołaczkowski, Marcin;
Szkaradek, Natalia;
Marona, Henryk;
Sapa, Jacek;
Pytka, Karolina

Publication type:

Article

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 7, p. 1079, doi. 10.3390/biom13071079

By:

Załuski, Michał;
Karcz, Tadeusz;
Drabczyńska, Anna;
Vielmuth, Christin;
Olejarz-Maciej, Agnieszka;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Siwek, Agata;
Satała, Grzegorz;
Müller, Christa E.;
Kieć-Kononowicz, Katarzyna

Publication type:

Article

Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in some in vitro and ex vivo assays.

Published in:

Toxicology Mechanisms & Methods, 2014, v. 24, n. 3, p. 204, doi. 10.3109/15376516.2013.879973

By:

Sałat, Kinga;
Głuch-Lutwin, Monika;
Nawieśniak, Barbara;
Gawlik, Katarzyna;
Pawlica-Gosiewska, Dorota;
Witalis, Jadwiga;
Kazek, Grzegorz;
Filipek, Barbara;
Librowski, Tadeusz;
Więckowski, Krzysztof;
Solnica, Bogdan

Publication type:

Article

Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A/5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.

Published in:

Archiv der Pharmazie, 2016, v. 349, n. 12, p. 889, doi. 10.1002/ardp.201600260

By:

Chłoń ‐ Rzepa, Grażyna;
Zagórska, Agnieszka;
Żmudzki, Paweł;
Bucki, Adam;
Kołaczkowski, Marcin;
Partyka, Anna;
Wesołowska, Anna;
Kazek, Grzegorz;
Głuch ‐ Lutwin, Monika;
Siwek, Agata;
Starowicz, Gabriela;
Pawłowski, Maciej

Publication type:

Article

Structure-5-HT/D2 Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.

Published in:

Archiv der Pharmazie, 2016, v. 349, n. 10, p. 774, doi. 10.1002/ardp.201600162

By:

Żmudzki, Paweł;
Satała, Grzegorz;
Chłoń ‐ Rzepa, Grażyna;
Bojarski, Andrzej J.;
Kazek, Grzegorz;
Siwek, Agata;
Gryboś, Anna;
Głuch ‐ Lutwin, Monika;
Wesołowska, Anna;
Pawłowski, Maciej

Publication type:

Article

Aryl-1,3,5-triazine ligands of histamine H receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide.

Published in:

Inflammation Research, 2017, v. 66, n. 1, p. 79, doi. 10.1007/s00011-016-0997-z

By:

Mogilski, Szczepan;
Kubacka, Monika;
Łażewska, Dorota;
Więcek, Małgorzata;
Głuch-Lutwin, Monika;
Tyszka-Czochara, Małgorzata;
Bukowska-Strakova, Karolina;
Filipek, Barbara;
Kieć-Kononowicz, Katarzyna

Publication type:

Article

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0142499

By:

Pytka, Karolina;
Partyka, Anna;
Jastrzębska-Więsek, Magdalena;
Siwek, Agata;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Kazek, Grzegorz;
Rapacz, Anna;
Olczyk, Adrian;
Gałuszka, Adam;
Błachuta, Marian;
Waszkielewicz, Anna;
Marona, Henryk;
Sapa, Jacek;
Filipek, Barbara;
Wesołowska, Anna

Publication type:

Article

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141327

By:

Dudek, Magdalena;
Knutelska, Joanna;
Bednarski, Marek;
Nowiński, Leszek;
Zygmunt, Małgorzata;
Mordyl, Barbara;
Głuch-Lutwin, Monika;
Kazek, Grzegorz;
Sapa, Jacek;
Pytka, Karolina

Publication type:

Article

Single Administration of HBK-15—a Triple 5-HT1A, 5-HT7, and 5-HT3 Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 5, p. 3931, doi. 10.1007/s12035-017-0605-4

By:

Pytka, Karolina;
Głuch-Lutwin, Monika;
Kotańska, Magdalena;
Waszkielewicz, Anna;
Kij, Agnieszka;
Walczak, Maria

Publication type:

Article

HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.01146

By:

Pytka, Karolina;
Głuch-Lutwin, Monika;
Żmudzka, Elżbieta;
Sałaciak, Kinga;
Siwek, Agata;
Niemczyk, Katarzyna;
Walczak, Maria;
Smolik, Magdalena;
Olczyk, Adrian;
Gałuszka, Adam;
Śmieja, Jarosław;
Filipek, Barbara;
Sapa, Jacek;
Kołaczkowski, Marcin;
Pańczyk, Katarzyna;
Waszkielewicz, Anna;
Marona, Henryk

Publication type:

Article

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors.

Published in:

Molecules, 2024, v. 29, n. 11, p. 2616, doi. 10.3390/molecules29112616

By:

Góral, Izabella;
Wichur, Tomasz;
Sługocka, Emilia;
Godyń, Justyna;
Szałaj, Natalia;
Zaręba, Paula;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Panek, Dawid;
Więckowska, Anna

Publication type:

Article

Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors.

Published in:

Molecules, 2024, v. 29, n. 3, p. 571, doi. 10.3390/molecules29030571

By:

Straszak, Dominik;
Woźniak, Sylwia;
Siwek, Agata;
Głuch-Lutwin, Monika;
Kołaczkowski, Marcin;
Pietrzak, Aldona;
Drop, Bartłomiej;
Matosiuk, Dariusz

Publication type:

Article

Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity.

Published in:

Molecules, 2022, v. 27, n. 24, p. 8728, doi. 10.3390/molecules27248728

By:

Shabbir, Hasan;
Wojtaszek, Konrad;
Rutkowski, Bogdan;
Csapó, Edit;
Bednarski, Marek;
Adamiec, Anita;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Druciarek, Julia;
Kotańska, Magdalena;
Ozga, Piotr;
Wojnicki, Marek

Publication type:

Article

Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2- a ]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action.

Published in:

Molecules, 2022, v. 27, n. 9, p. 2930, doi. 10.3390/molecules27092930

By:

Straszak, Dominik;
Siwek, Agata;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Kołaczkowski, Marcin;
Pietrzak, Aldona;
Rahnama-Hezavah, Mansur;
Drop, Bartłomiej;
Matosiuk, Dariusz

Publication type:

Article

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.

Published in:

Molecules, 2020, v. 25, n. 17, p. 3868, doi. 10.3390/molecules25173868

By:

Czopek, Anna;
Partyka, Anna;
Bucki, Adam;
Pawłowski, Maciej;
Kołaczkowski, Marcin;
Siwek, Agata;
Głuch-Lutwin, Monika;
Koczurkiewicz, Paulina;
Pękala, Elżbieta;
Jaromin, Anna;
Tyliszczak, Bożena;
Wesołowska, Anna;
Zagórska, Agnieszka;
Jampilek, Josef

Publication type:

Article

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 6, p. 1, doi. 10.1002/anie.202420510

By:

Panek, Dawid;
Pasieka, Anna;
Jończyk, Jakub;
Gawlińska, Milena;
Zaręba, Paula;
Siwek, Agata;
Wolak, Małgorzata;
Mordyl, Barbara;
Głuch‐Lutwin, Monika;
Latacz, Gniewomir;
Brazzolotto, Xavier;
Chantegreil, Fabien;
Nachon, Florian;
Zdarova Karasova, Jana;
Pejchal, Jaroslav;
Mzik, Martin;
Sestak, Vit;
Prchal, Lukas;
Odvarkova, Jitka;
Soukup, Ondrej

Publication type:

Article

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

Published in:

Chemical Biology & Drug Design, 2019, v. 93, n. 4, p. 511, doi. 10.1111/cbdd.13442

By:

Zagórska, Agnieszka;
Partyka, Anna;
Bucki, Adam;
Kołaczkowski, Marcin;
Jastrzębska‐Więsek, Magdalena;
Czopek, Anna;
Siwek, Agata;
Głuch‐Lutwin, Monika;
Bednarski, Marek;
Bajda, Marek;
Jończyk, Jakub;
Piska, Kamil;
Koczurkiewicz, Paulina;
Wesołowska, Anna;
Pawłowski, Maciej

Publication type:

Article

Works by Głuch‐Lutwin, Monika

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances.

Novel Multimodal Salicylamide Derivative with Antidepressant-like, Anxiolytic-like, Antipsychotic-like, and Anti-Amnesic Activity in Mice.

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT 1A and D 2 Receptors.

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT<sub>1A</sub> receptor partial agonists.

Synthesis of N‐(phenoxyalkyl)‐, N‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System.

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1 H -imidazo[2,1- f ]purine-2,4(3 H ,8 H )-dione as potential antidepressant agents.

Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats.

Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents.

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione.

Vanadium complexes with salicylaldehyde-based Schiff base ligands—structure, properties and biological activity.

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress.

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.

Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in some in vitro and ex vivo assays.

Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Receptor Ligands and PDE Inhibitors with Antidepressant Activity.

Structure-5-HT/D<sub>2</sub> Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.

Aryl-1,3,5-triazine ligands of histamine H receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide.

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Antagonists in Animal Models.

A Comparison of the Anorectic Effect and Safety of the Alpha<sub>2</sub>-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.

Single Administration of HBK-15—a Triple 5-HT<sub>1A</sub>, 5-HT<sub>7</sub>, and 5-HT<sub>3</sub> Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.

HBK-17, a 5-HT<sub>1A</sub> Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors.

Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors.

Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity.

Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2- a ]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action.

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities