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Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers.
- Published in:
- European Journal of Clinical Pharmacology, 2024, v. 80, n. 9, p. 1271, doi. 10.1007/s00228-024-03697-3
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- Publication type:
- Article
Understanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail.
- Published in:
- European Journal of Clinical Pharmacology, 2024, v. 80, n. 7, p. 1069, doi. 10.1007/s00228-024-03673-x
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- Publication type:
- Article
A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes.
- Published in:
- Drugs in R&D, 2024, v. 24, n. 2, p. 187, doi. 10.1007/s40268-024-00466-6
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- Publication type:
- Article
Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units.
- Published in:
- CTS: Clinical & Translational Science, 2023, v. 16, n. 12, p. 2421, doi. 10.1111/cts.13655
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- Publication type:
- Article
Improved correction formulas to estimate iohexol clearance from simple models.
- Published in:
- European Journal of Clinical Pharmacology, 2023, v. 79, n. 9, p. 1215, doi. 10.1007/s00228-023-03535-y
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- Publication type:
- Article
Population pharmacokinetics of meropenem in patients undergoing automated peritoneal dialysis.
- Published in:
- Peritoneal Dialysis International, 2023, v. 43, n. 5, p. 402, doi. 10.1177/08968608231167237
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7‐Dihydroxybergamottin to Describe CYP3A4 Mediated Grapefruit‐Drug Interactions.
- Published in:
- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 2, p. 470, doi. 10.1002/cpt.2968
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- Publication type:
- Article
Population Pharmacokinetics as a Tool to Reevaluate the Complex Disposition of Ethanol in the Fed and Fasted States.
- Published in:
- Journal of Clinical Pharmacology, 2023, v. 63, n. 6, p. 681, doi. 10.1002/jcph.2205
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- Publication type:
- Article
A population pharmacokinetic model of remdesivir and its major metabolites based on published mean values from healthy subjects.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 1, p. 73, doi. 10.1007/s00210-022-02292-6
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- Publication type:
- Article
A population pharmacokinetic model for creatinine with and without ingestion of a cooked meat meal.
- Published in:
- 2022
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- Publication type:
- Letter to the Editor
Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors.
- Published in:
- 2022
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- Publication type:
- journal article
Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 4, p. 494, doi. 10.1002/psp4.12776
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- Publication type:
- Article
Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol.
- Published in:
- Cancers, 2021, v. 13, n. 24, p. 6281, doi. 10.3390/cancers13246281
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- Publication type:
- Article
Clinical Pharmacokinetics and Pharmacodynamics of Cefiderocol.
- Published in:
- Clinical Pharmacokinetics, 2021, v. 60, n. 12, p. 1495, doi. 10.1007/s40262-021-01063-5
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- Publication type:
- Article
Advancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01892-1
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- Publication type:
- Article
A Model‐Based Approach to Assess Unstable Creatinine Clearance in Critically Ill Patients.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1240, doi. 10.1002/cpt.2341
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- Publication type:
- Article
Rationale of a lower dexamethasone dose in prenatal congenital adrenal hyperplasia therapy based on pharmacokinetic modelling.
- Published in:
- European Journal of Endocrinology, 2021, v. 185, n. 3, p. 365, doi. 10.1530/EJE-21-0395
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- Publication type:
- Article
A Population Pharmacokinetic Model of (R)‐ and (S‐) Oxybutynin and Its Active Metabolites After Oral and Intravesical Administration to Healthy Volunteers.
- Published in:
- Journal of Clinical Pharmacology, 2021, v. 61, n. 7, p. 961, doi. 10.1002/jcph.1809
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- Publication type:
- Article
Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients.
- Published in:
- 2021
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- Publication type:
- journal article
Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis.
- Published in:
- 2021
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- Publication type:
- journal article
The parent drugs chloroquine and hydroxychloroquine do not inhibit human CYP3A activity in vitro.
- Published in:
- 2020
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- Publication type:
- Letter
A Novel Study Design Using Continuous Intravenous and Intraduodenal Infusions of Midazolam and Voriconazole for Mechanistic Quantitative Assessment of Hepatic and Intestinal CYP3A Inhibition.
- Published in:
- Journal of Clinical Pharmacology, 2020, v. 60, n. 9, p. 1237, doi. 10.1002/jcph.1619
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- Publication type:
- Article
Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-69326-y
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- Publication type:
- Article
A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.
- Published in:
- 2020
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- Publication type:
- journal article
Frequency and Types of Pathological Upper Gastrointestinal Endoscopy Findings in Clinically Healthy Individuals.
- Published in:
- Drugs in R&D, 2020, v. 20, n. 2, p. 115, doi. 10.1007/s40268-020-00303-6
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- Publication type:
- Article
Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic-pharmacodynamic model in gastrointestinal cancer patients.
- Published in:
- 2020
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- Publication type:
- journal article
A Clinical Drug‐Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.
- Published in:
- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 6, p. 1398, doi. 10.1002/cpt.1564
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- Publication type:
- Article
A population pharmacokinetic model of intravenous telavancin in healthy individuals to assess tissue exposure.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2019, v. 392, n. 9, p. 1097, doi. 10.1007/s00210-019-01647-w
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- Publication type:
- Article
A Single Dose of Baicalin Has No Clinically Significant Effect on the Pharmacokinetics of Cyclosporine A in Healthy Chinese Volunteers.
- Published in:
- Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00518
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- Publication type:
- Article
Response to "Impact of Acute Alcohol Exposure on P‐Glycoprotein Function at the Blood–Brain Barrier Assessed Using <sup>11</sup>C‐Metoclopramide PET Imaging".
- Published in:
- 2019
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- Publication type:
- Letter to the Editor
Ciprofloxacin in critically ill subjects: considering hepatic function, age and sex to choose the optimal dose.
- Published in:
- 2019
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- Publication type:
- journal article
Using a three-compartment model improves the estimation of iohexol clearance to assess glomerular filtration rate.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-35989-x
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- Publication type:
- Article
Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?
- Published in:
- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 6, p. 1249, doi. 10.1002/cpt.1083
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- Publication type:
- Article
Quantification of Hydrochlorothiazide and Ramipril/Ramiprilate in Blood Serum and Cerebrospinal Fluid: A Pharmacokinetic Assessment of Central Nervous System Adverse Effects.
- Published in:
- Pharmacology, 2018, v. 102, n. 3/4, p. 133, doi. 10.1159/000489999
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- Publication type:
- Article
Pharmacokinetic Phenotyping to Predict Drug-Drug Interactions: Time to Divorce the Hybrid Concept of Simultaneous Mechanistic-Based and Exposure-Based Assessment.
- Published in:
- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 1, p. 42, doi. 10.1002/cpt.772
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- Publication type:
- Article
Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.
- Published in:
- Pharmacology, 2017, v. 101, n. 1/2, p. 29, doi. 10.1159/000480091
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- Publication type:
- Article
Optimization of linezolid therapy in the critically ill: the effect of adjusted infusion regimens.
- Published in:
- 2017
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- Publication type:
- journal article
Assessment of inhibitory effects on major human cytochrome P450 enzymes by spasmolytics used in the treatment of overactive bladder syndrome.
- Published in:
- Therapeutic Advances in Urology, 2017, v. 9, n. 7, p. 163, doi. 10.1177/1756287217708951
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- Publication type:
- Article
Comparison of Pantoprazole Concentrations in Simultaneous Cerebrospinal Fluid and Serum Samples.
- Published in:
- Pharmacology, 2016, v. 98, n. 1/2, p. 70, doi. 10.1159/000445720
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- Publication type:
- Article
A Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients.
- Published in:
- AAPS Journal, 2015, v. 17, n. 6, p. 1483, doi. 10.1208/s12248-015-9815-8
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- Publication type:
- Article
Adverse events during placebo vs. no drug administration-results of a randomised interventional trial in 160 volunteers.
- Published in:
- 2015
- By:
- Publication type:
- Letter
Channeling the flood of meta-analyses.
- Published in:
- 2015
- By:
- Publication type:
- Editorial
Population Pharmacokinetic Analysis of Circadian Rhythms in Hepatic CYP3A Activity Using Midazolam.
- Published in:
- Journal of Clinical Pharmacology, 2014, v. 54, n. 10, p. 1162, doi. 10.1002/jcph.318
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- Publication type:
- Article
Sorafenib in the Treatment of Early Breast Cancer: Results of the Neoadjuvant Phase II Study - SOFIA*.
- Published in:
- Breast Care, 2014, v. 9, n. 3, p. 169, doi. 10.1159/000363430
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- Publication type:
- Article
A Novel Toxicokinetic Modeling of Cypermethrin and Permethrin and Their Metabolites in Humans for Dose Reconstruction from Biomarker Data.
- Published in:
- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0088517
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- Publication type:
- Article
Impact of Impaired Renal Function on the Pharmacokinetics of the Antiepileptic Drug Lacosamide.
- Published in:
- Clinical Pharmacokinetics, 2013, v. 52, n. 10, p. 897, doi. 10.1007/s40262-013-0080-7
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- Publication type:
- Article
A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole.
- Published in:
- Clinical Pharmacokinetics, 2013, v. 52, n. 9, p. 763, doi. 10.1007/s40262-013-0070-9
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- Publication type:
- Article
Quantifying the Effect of Covariates on Concentrations and Effects of Steady-State Phenprocoumon Using a Population Pharmacokinetic/Pharmacodynamic Model.
- Published in:
- Clinical Pharmacokinetics, 2013, v. 52, n. 5, p. 359, doi. 10.1007/s40262-013-0043-z
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- Publication type:
- Article
Modeling NSCLC Progression: Recent Advances and Opportunities Available.
- Published in:
- AAPS Journal, 2013, v. 15, n. 2, p. 542, doi. 10.1208/s12248-013-9461-y
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- Publication type:
- Article
Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 3, p. 749, doi. 10.1007/s00280-013-2069-1
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- Publication type:
- Article