Works by Frieg, Benedikt

Results: 17

Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects.

Published in:

Biological Chemistry, 2021, v. 402, n. 9, p. 1063, doi. 10.1515/hsz-2021-0166

By:

Frieg, Benedikt;
Görg, Boris;
Gohlke, Holger;
Häussinger, Dieter

Publication type:

Article

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-17913-6

By:

Gopalswamy, Mohanraj;
Kroeger, Tobias;
Bickel, David;
Frieg, Benedikt;
Akter, Shahina;
Schott-Verdugo, Stephan;
Viegas, Aldino;
Pauly, Thomas;
Mayer, Manuela;
Przibilla, Julia;
Reiners, Jens;
Nagel-Steger, Luitgard;
Smits, Sander H. J.;
Groth, Georg;
Etzkorn, Manuel;
Gohlke, Holger

Publication type:

Article

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03948-y

By:

Frieg, Benedikt;
Geraets, James A.;
Strohäker, Timo;
Dienemann, Christian;
Mavroeidi, Panagiota;
Jung, Byung Chul;
Kim, Woojin S.;
Lee, Seung-Jae;
Xilouri, Maria;
Zweckstetter, Markus;
Schröder, Gunnar F.

Publication type:

Article

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03360-6

By:

Kondapuram, Mahesh;
Frieg, Benedikt;
Yüksel, Sezin;
Schwabe, Tina;
Sattler, Christian;
Lelle, Marco;
Schweinitz, Andrea;
Schmauder, Ralf;
Benndorf, Klaus;
Gohlke, Holger;
Kusch, Jana

Publication type:

Article

The 3D structure of lipidic fibrils of α-synuclein.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34552-7

By:

Frieg, Benedikt;
Antonschmidt, Leif;
Dienemann, Christian;
Geraets, James A.;
Najbauer, Eszter E.;
Matthes, Dirk;
de Groot, Bert L.;
Andreas, Loren B.;
Becker, Stefan;
Griesinger, Christian;
Schröder, Gunnar F.

Publication type:

Article

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32797-w

By:

Antonschmidt, Leif;
Matthes, Dirk;
Dervişoğlu, Rıza;
Frieg, Benedikt;
Dienemann, Christian;
Leonov, Andrei;
Nimerovsky, Evgeny;
Sant, Vrinda;
Ryazanov, Sergey;
Giese, Armin;
Schröder, Gunnar F.;
Becker, Stefan;
de Groot, Bert L.;
Griesinger, Christian;
Andreas, Loren B.

Publication type:

Article

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177024

By:

Kroeger, Tobias;
Frieg, Benedikt;
Zhang, Tao;
Hansen, Finn K.;
Marmann, Andreas;
Proksch, Peter;
Nagel-Steger, Luitgard;
Groth, Georg;
Smits, Sander H. J.;
Gohlke, Holger

Publication type:

Article

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40).

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-43822-x

By:

Frieg, Benedikt;
Han, Mookyoung;
Giller, Karin;
Dienemann, Christian;
Riedel, Dietmar;
Becker, Stefan;
Andreas, Loren B.;
Griesinger, Christian;
Schröder, Gunnar F.

Publication type:

Article

α-Aminoxy Peptoids: A Unique Peptoid Backbone with a Preference for cis-Amide Bonds.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 15, p. 3699, doi. 10.1002/chem.201605100

By:

Krieger, Viktoria;
Ciglia, Emanuele;
Thoma, Roland;
Vasylyeva, Vera;
Frieg, Benedikt;
de Sousa Amadeu, Nader;
Kurz, Thomas;
Janiak, Christoph;
Gohlke, Holger;
Hansen, Finn K.

Publication type:

Article

α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 49, p. 17600, doi. 10.1002/chem.201602521

By:

Diedrich, Daniela;
Moita, Ana J. Rodrigues;
Rüther, Anja;
Frieg, Benedikt;
Reiss, Guido J.;
Hoeppner, Astrid;
Kurz, Thomas;
Gohlke, Holger;
Lüdeke, Steffen;
Kassack, Matthias U.;
Hansen, Finn K.

Publication type:

Article

Frontispiece: α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 49, p. n/a, doi. 10.1002/chem.201684962

By:

Diedrich, Daniela;
Moita, Ana J. Rodrigues;
Rüther, Anja;
Frieg, Benedikt;
Reiss, Guido J.;
Hoeppner, Astrid;
Kurz, Thomas;
Gohlke, Holger;
Lüdeke, Steffen;
Kassack, Matthias U.;
Hansen, Finn K.

Publication type:

Article

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses.

Published in:

Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01765-1

By:

Cukkemane, Abhishek;
Becker, Nina;
Zielinski, Mara;
Frieg, Benedikt;
Lakomek, Nils-Alexander;
Heise, Henrike;
Schröder, Gunnar F.;
Willbold, Dieter;
Weiergräber, Oliver H.

Publication type:

Article

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

Published in:

PLoS Computational Biology, 2016, v. 12, n. 2, p. 1, doi. 10.1371/journal.pcbi.1004693

By:

Frieg, Benedikt;
Görg, Boris;
Homeyer, Nadine;
Keitel, Verena;
Häussinger, Dieter;
Gohlke, Holger

Publication type:

Article

Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease.

Published in:

Brain: A Journal of Neurology, 2024, v. 147, n. 5, p. 1644, doi. 10.1093/brain/awae061

By:

Pesch, Verena;
Flores-Fernandez, José Miguel;
Reithofer, Sara;
Ma, Liang;
Özdüzenciler, Pelin;
Busch, Yannick;
Sriraman, Aishwarya;
Wang, YongLiang;
Amidian, Sara;
Kroepel, Chiara V M;
Müller, Laura;
Lien, Yi;
Rudtke, Olivia;
Frieg, Benedikt;
Schröder, Gunnar F;
Wille, Holger;
Tamgüney, Gültekin

Publication type:

Article

Extracting binding energies and binding modes from biomolecular simulations of fragment binding to endothiapepsin.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 5, p. 1, doi. 10.1002/ardp.202300612

By:

Schmitz, Birte;
Frieg, Benedikt;
Homeyer, Nadine;
Jessen, Gisela;
Gohlke, Holger

Publication type:

Article

Partially inserted nascent chain unzips the lateral gate of the Sec translocon.

Published in:

EMBO Reports, 2019, v. 20, n. 10, p. N.PAG, doi. 10.15252/embr.201948191

By:

Kater, Lukas;
Frieg, Benedikt;
Berninghausen, Otto;
Gohlke, Holger;
Beckmann, Roland;
Kedrov, Alexej

Publication type:

Article

Structural basis of lantibiotic recognition by the nisin resistance protein from Streptococcus agalactiae.

Published in:

Scientific Reports, 2016, p. 18679, doi. 10.1038/srep18679

By:

Khosa, Sakshi;
Frieg, Benedikt;
Mulnaes, Daniel;
Kleinschrodt, Diana;
Hoeppner, Astrid;
Gohlke, Holger;
Smits, Sander H. J.

Publication type:

Article