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The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer.
Published in:
Breast Cancer Research & Treatment, 2023, v. 197, n. 2, p. 319, doi. 10.1007/s10549-022-06797-9
By:
- Bardia, Aditya;
- Mayer, Ingrid;
- Winer, Eric;
- Linden, Hannah M.;
- Ma, Cynthia X.;
- Parker, Barbara A.;
- Bellet, Meritxell;
- Arteaga, Carlos L.;
- Cheeti, Sravanthi;
- Gates, Mary;
- Chang, Ching-Wei;
- Fredrickson, Jill;
- Spoerke, Jill M.;
- Moore, Heather M.;
- Giltnane, Jennifer;
- Friedman, Lori S.;
- Chow Maneval, Edna;
- Chan, Iris;
- Jhaveri, Komal
Publication type:
Article
Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036402
By:
- Wallin, Jeffrey J.;
- Guan, Jane;
- Edgar, Kyle A.;
- Wei Zhou;
- Francis, Ross;
- Torres, Anthony C.;
- Haverty, Peter M.;
- Eastham-Anderson, Jeffrey;
- Arena, Sabrina;
- Bardelli, Alberto;
- Griffin, Sue;
- Goodall, John E.;
- Grimshaw, Kyla M.;
- Hoeflich, Klaus P.;
- Torrance, Christopher;
- Belvin, Marcia;
- Friedman, Lori S.
Publication type:
Article
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.
Published in:
Proteomics, 2016, v. 16, n. 14, p. 1992, doi. 10.1002/pmic.201600118
By:
- Gnad, Florian;
- Wallin, Jeffrey;
- Edgar, Kyle;
- Doll, Sophia;
- Arnott, David;
- Robillard, Liliane;
- Kirkpatrick, Donald S.;
- Stokes, Matthew P.;
- Vijapurkar, Ulka;
- Hatzivassiliou, Georgia;
- Friedman, Lori S.;
- Belvin, Marcia
Publication type:
Article
Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.
Published in:
Proteomics, 2016, v. 16, n. 14, p. 1998, doi. 10.1002/pmic.201600119
By:
- Gnad, Florian;
- Doll, Sophia;
- Song, Kyung;
- Stokes, Matthew P.;
- Moffat, John;
- Liu, Bonnie;
- Arnott, David;
- Wallin, Jeffrey;
- Friedman, Lori S.;
- Hatzivassiliou, Georgia;
- Belvin, Marcia
Publication type:
Article
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Published in:
Nature, 2010, v. 464, n. 7287, p. 431, doi. 10.1038/nature08833
By:
- Hatzivassiliou, Georgia;
- Song, Kyung;
- Yen, Ivana;
- Brandhuber, Barbara J.;
- Anderson, Daniel J.;
- Alvarado, Ryan;
- Ludlam, Mary J. C.;
- Stokoe, David;
- Gloor, Susan L.;
- Vigers, Guy;
- Morales, Tony;
- Aliagas, Ignacio;
- Liu, Bonnie;
- Sideris, Steve;
- Hoeflich, Klaus P.;
- Jaiswal, Bijay S.;
- Seshagiri, Somasekar;
- Koeppen, Hartmut;
- Belvin, Marcia;
- Friedman, Lori S.
Publication type:
Article
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Published in:
Journal of Cell Biology, 2008, v. 183, n. 1, p. 101, doi. 10.1083/jcb.200801099
By:
- Degtyarev, Michael;
- De Mazière, Ann;
- Orr, Christine;
- Lin, Jie;
- Lee, Brian B.;
- Tien, Janet Y.;
- Prior, Wei W.;
- van Dijk, Suzanne;
- Hong Wu;
- Gray, Daniel C.;
- Davis, David P.;
- Stern, Howard M.;
- Murray, Lesley J.;
- Hoeflich, Klaus P.;
- Klumperman, Judith;
- Friedman, Lori S.;
- Kui Lin
Publication type:
Article
Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer.
Published in:
Science Translational Medicine, 2010, v. 2, n. 48, p. 1, doi. 10.1126/scitranslmed.3000630
By:
- Wallin, Jeffrey J.;
- Guan, Jane;
- Prior, Wei Wei;
- Edgar, Kyle A.;
- Kassees, Robert;
- Sampath, Deepak;
- Belvin, Marcia;
- Friedman, Lori S.
Publication type:
Article
Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.
Published in:
Genes, Chromosomes & Cancer, 1999, v. 25, n. 2, p. 91, doi. 10.1002/(SICI)1098-2264(199906)25:2<91::AID-GCC3>3.0.CO;2-5
By:
- Ramus, Susan J.;
- Bobrow, Lynda G.;
- Pharoah, Paul D.P.;
- Finnigan, Damon S.;
- Fishman, Ami;
- Altaras, Marco;
- Harrington, Patricia A.;
- Gayther, Simon A.;
- Ponder, Bruce A.J.;
- Friedman, Lori S.
Publication type:
Article
Erratum: Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Published in:
Nature, 2013, v. 502, n. 7470, p. 258, doi. 10.1038/nature12659
By:
- Hatzivassiliou, Georgia;
- Haling, Jacob R.;
- Chen, Huifen;
- Song, Kyung;
- Price, Steve;
- Heald, Robert;
- Hewitt, Joanne F. M.;
- Zak, Mark;
- Peck, Ariana;
- Orr, Christine;
- Merchant, Mark;
- Hoeflich, Klaus P.;
- Chan, Jocelyn;
- Luoh, Shiuh-Ming;
- Anderson, Daniel J.;
- Ludlam, Mary J. C.;
- Wiesmann, Christian;
- Ultsch, Mark;
- Friedman, Lori S.;
- Malek, Shiva
Publication type:
Article
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Published in:
Nature, 2013, v. 501, n. 7466, p. 232, doi. 10.1038/nature12441
By:
- Hatzivassiliou, Georgia;
- Haling, Jacob R.;
- Chen, Huifen;
- Song, Kyung;
- Price, Steve;
- Heald, Robert;
- Hewitt, Joanne F. M.;
- Zak, Mark;
- Peck, Ariana;
- Orr, Christine;
- Merchant, Mark;
- Hoeflich, Klaus P.;
- Chan, Jocelyn;
- Luoh, Shiuh-Ming;
- Anderson, Daniel J.;
- Ludlam, Mary J. C.;
- Wiesmann, Christian;
- Ultsch, Mark;
- Friedman, Lori S.;
- Malek, Shiva
Publication type:
Article
P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma.
Published in:
JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 9, p. 606, doi. 10.1093/jnci/djt054
By:
- Ong, Christy C.;
- Jubb, Adrian M.;
- Jakubiak, Diana;
- Zhou, Wei;
- Rudolph, Joachim;
- Haverty, Peter M.;
- Kowanetz, Marcin;
- Yan, Yibing;
- Tremayne, Jarrod;
- Lisle, Richard;
- Harris, Adrian L.;
- Friedman, Lori S.;
- Belvin, Marcia;
- Middleton, Mark R.;
- Blackwood, Elizabeth M.;
- Koeppen, Hartmut;
- Hoeflich, Klaus P.
Publication type:
Article
Low Proportion of BRCA1 and BRCA2 Mutations in Finnish Breast Cancer Families: Evidence for Additional Susceptibility Genes.
Published in:
Human Molecular Genetics, 1997, v. 6, n. 13, p. 2309, doi. 10.1093/hmg/6.13.2309
By:
- Vehmanen, Paula;
- Friedman, Lori S.;
- Eerola, Hannaleena;
- McClure, Melody;
- Ward, Brian;
- Sarantaus, Laura;
- Kainu, Tommi;
- Syrjäkoski, Kirsi;
- Pyrhönen, Seppo;
- Kallioniemi, Olli-P.;
- Muhonen, Timo;
- Luce, Michael;
- Frank, Thomas S.;
- Nevanlinna, Heli
Publication type:
Article
Two independent polymorphisms at the 17β-hydroxysteroid dehydrogenase (EDH17B) gene (17q21).
Published in:
Human Molecular Genetics, 1993, v. 2, n. 6, p. 821
By:
- Friedman, Lori S.;
- Lynch, Eric D.;
- King, Mary-Claire
Publication type:
Article
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt.
Published in:
Science Signaling, 2012, v. 5, n. 223, p. 1, doi. 10.1126/scisignal.2002618
By:
- Kui Lin;
- Jie Lin;
- Wen-I Wu;
- Ballard, Joshua;
- Lee, Brian B.;
- Gloor, Susan L.;
- Vigers, Guy P. A.;
- Morales, Tony H.;
- Friedman, Lori S.;
- Skelton, Nicholas;
- Brandhuber, Barbara J.
Publication type:
Article

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