Works by Friberg, Lena E.

Results: 91

Simulation-based evaluation of the impact of dose fractionation study design on antibiotic PKPD analyses.

Published in:

JAC-Antimicrobial Resistance, 2025, v. 7, n. 2, p. 1, doi. 10.1093/jacamr/dlaf057

By:

Saporta, Raphaël;
Madan, Muskan;
Friberg, Lena E

Publication type:

Article

A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime.

Published in:

JAC-Antimicrobial Resistance, 2025, v. 7, n. 2, p. 1, doi. 10.1093/jacamr/dlaf036

By:

O'Jeanson, Amaury;
Nielsen, Elisabet I;
Friberg, Lena E

Publication type:

Article

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 5, p. 839, doi. 10.1007/s00280-009-1089-3

By:

Hansson, Emma K.;
Wallin, Johan E.;
Lindman, Henrik;
Sandström, Marie;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats.

Published in:

2000

By:

Jonsson, Elin;
Friberg, Lena E.;
Karlsson, Mats O.;
Bashir Hassan, Saadia;
Freijs, Agneta;
Hansen, Klaus;
Larsson, Rolf;
Jonsson, E;
Friberg, L E;
Karlsson, M O;
Hassan, S B;
Freijs, A;
Hansen, K;
Larsson, R

Publication type:

journal article

Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel.

Published in:

Cancers, 2021, v. 13, n. 15, p. 3915, doi. 10.3390/cancers13153915

By:

van Doorn, Leni;
van Rosmalen, Mandy M.;
van der Deure, Wendy M.;
Oomen-de Hoop, Esther;
Porrazzo, Robert;
Wijngaard, Sophie M.;
Boere, Ingrid A.;
Veenstra, Paola;
Ibrahim, Eman;
de Bruijn, Peter;
Friberg, Lena E.;
Koolen, Stijn L. W.;
Mathijssen, Ron H. J.;
Jager, Agnes

Publication type:

Article

A simultaneous analysis of the time-course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic myelosuppression model.

Published in:

Investigational New Drugs, 2012, v. 30, n. 2, p. 833, doi. 10.1007/s10637-010-9603-3

By:

Quartino, Angelica Linnea;
Friberg, Lena E.;
Karlsson, Mats O.

Publication type:

Article

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 1, p. 301, doi. 10.1093/jac/dkae409

By:

Hernández-Lozano, Irene;
Aranzana-Climent, Vincent;
Cao, Sha;
Matias, Carina;
Hansen, Jon Ulf;
Liepinsh, Edgars;
Hughes, Diarmaid;
Hobbie, Sven N;
Lundberg, Carina Vingsbo;
Friberg, Lena E

Publication type:

Article

Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 1, p. 79, doi. 10.1093/jac/dkae375

By:

O'Jeanson, Amaury;
Nielsen, Elisabet I;
Friberg, Lena E

Publication type:

Article

Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 12, p. 3150, doi. 10.1093/jac/dkae334

By:

Saporta, Raphaël;
Nielsen, Elisabet I;
Menetrey, Annick;
Cameron, David R;
Nicolas-Metral, Valérie;
Friberg, Lena E

Publication type:

Article

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.988728

By:

Arrazuria, Rakel;
Kerscher, Bernhard;
Huber, Karen E.;
Hoover, Jennifer L.;
Lundberg, Carina Vingsbo;
Hansen, Jon Ulf;
Sordello, Sylvie;
Renard, Stephane;
Aranzana-Climent, Vincent;
Hughes, Diarmaid;
Gribbon, Philip;
Friberg, Lena E.;
Bekeredjian-Ding, Isabelle

Publication type:

Article

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.988725

By:

Arrazuria, Rakel;
Kerscher, Bernhard;
Huber, Karen E.;
Hoover, Jennifer L.;
Lundberg, Carina Vingsbo;
Hansen, Jon Ulf;
Sordello, Sylvie;
Renard, Stephane;
Aranzana-Climent, Vincent;
Hughes, Diarmaid;
Gribbon, Philip;
Friberg, Lena E.;
Bekeredjian-Ding, Isabelle

Publication type:

Article

Population Pharmacokinetics and Exposure‐Response Relationships of Astegolimab in Patients With Severe Asthma.

Published in:

Journal of Clinical Pharmacology, 2022, v. 62, n. 7, p. 905, doi. 10.1002/jcph.2021

By:

Kotani, Naoki;
Dolton, Michael;
Svensson, Robin J.;
Ribbing, Jakob;
Friberg, Lena E.;
Vadhavkar, Shweta;
Cheung, Dorothy;
Staton, Tracy;
Sperinde, Gizette;
Jin, Jin;
Putnam, Wendy S.;
Quartino, Angelica

Publication type:

Article

Human methyl parathion poisoning.

Published in:

Clinical Toxicology (15563650), 2007, v. 45, n. 8, p. 956, doi. 10.1080/15563650701232745

By:

Isbister, Geoffrey K.;
Mills, Katie;
Friberg, Lena E.;
Hodge, Mary;
O'Connor, Enda;
Patel, Renu;
Abeyewardene, Manel;
Eddleston, Michael

Publication type:

Article

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever.

Published in:

Cancer Reports, 2022, v. 5, n. 10, p. 1, doi. 10.1002/cnr2.1585

By:

Maarbjerg, Sabine F.;
Thorsted, Anders;
Friberg, Lena E.;
Nielsen, Elisabet I.;
Wang, Mikala;
Schrøder, Henrik;
Albertsen, Birgitte K.

Publication type:

Article

Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes.

Published in:

2004

By:

Mathijssen, Ron H. J.;
de Jong, Floris A.;
van Schaik, Ron H. N.;
Lepper, Erin R.;
Friberg, Lena E.;
Rietveld, Trinet;
de Bruijn, Peter;
Graveland, Wilfried J.;
Figg, William D.;
Verweij, Jaap;
Sparreboom, Alex

Publication type:

journal article

Assessment of early combination effects of colistin and meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii in dynamic time-kill experiments.

Published in:

Infectious Diseases, 2017, v. 49, n. 7, p. 521, doi. 10.1080/23744235.2017.1296183

By:

Tängdén, Thomas;
Karvanen, Matti;
Friberg, Lena E.;
Odenholt, Inga;
Cars, Otto

Publication type:

Article

Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer.

Published in:

Cancers, 2019, v. 11, n. 2, p. 173, doi. 10.3390/cancers11020173

By:

Toxopeus, Eelke L.A.;
de Man, Femke M.;
Krak, Nanda;
Biermann, Katharina;
Nieuweboer, Annemieke J.M.;
Friberg, Lena E.;
Oomen-de Hoop, Esther;
van Lanschot, Jan J.B.;
Shapiro, Joel;
Wijnhoven, Bas P.L.;
Mathijssen, Ron H.J.

Publication type:

Article

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6.

Published in:

PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0211981

By:

Thorsted, Anders;
Bouchene, Salim;
Tano, Eva;
Castegren, Markus;
Lipcsey, Miklós;
Sjölin, Jan;
Karlsson, Mats O.;
Friberg, Lena E.;
Nielsen, Elisabet I.

Publication type:

Article

Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 7, p. 1, doi. 10.1111/cts.13870

By:

Aranzana‐Climent, Vincent;
van Os, Wisse;
Nutman, Amir;
Lellouche, Jonathan;
Dishon‐Benattar, Yael;
Rakovitsky, Nadya;
Daikos, George L.;
Skiada, Anna;
Pavleas, Ioannis;
Durante‐Mangoni, Emanuele;
Theuretzbacher, Ursula;
Paul, Mical;
Carmeli, Yehuda;
Friberg, Lena E.

Publication type:

Article

Optimization of blood pressure measurement practices for pharmacodynamic analyses of tyrosine-kinase inhibitors.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 1, p. 73, doi. 10.1111/cts.13423

By:

Centanni, Maddalena;
Thijs, Abel;
Desar, Ingrid;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 2, p. 297, doi. 10.1007/s00280-024-04678-0

By:

Centanni, Maddalena;
Zaher, Omar;
Elhad, David;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring.

Published in:

2017

By:

Netterberg, Ida;
Nielsen, Elisabet;
Friberg, Lena;
Karlsson, Mats;
Nielsen, Elisabet I;
Friberg, Lena E;
Karlsson, Mats O

Publication type:

journal article

Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.759146

By:

van Eerden, Ruben A. G.;
van Doorn, Leni;
de Man, Femke M.;
Heersche, Niels;
Doukas, Michail;
van den Bosch, Thierry P. P.;
Oomen-de Hoop, Esther;
de Bruijn, Peter;
Bins, Sander;
Ibrahim, Eman;
Nikkessen, Suzan;
Friberg, Lena E.;
Koolen, Stijn L. W.;
Spaander, Manon C. W.;
Mathijssen, Ron H. J.

Publication type:

Article

Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828.

Published in:

Drug Development Research, 2004, v. 61, n. 4, p. 218, doi. 10.1002/ddr.10353

By:

Elin Lindhagen;
Pernille?Julia Vig Hjarnaa;
Lena E. Friberg;
Scilla Latini;
Rolf Larsson

Publication type:

Article

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time–kill experiments: agreement with in silico predictions.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 2, p. 391, doi. 10.1093/jac/dkad394

By:

Olsson, Anna;
Malmberg, Christer;
Zhao, Chenyan;
Friberg, Lena E;
Nielsen, Elisabet I;
Lagerbäck, Pernilla;
Tängdén, Thomas

Publication type:

Article

Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose.

Published in:

2022

By:

Zhao, Chenyan;
Chirkova, Anna;
Villar, Rodrigo Palma;
Lindberg, Johan;
Hobbie, Sven N;
Friberg, Lena E;
Rosenborg, Staffan;
Palma Villar, Rodrigo

Publication type:

journal article

Large-scale WGS of carbapenem-resistant Acinetobacter baumannii isolates reveals patterns of dissemination of ST clades associated with antibiotic resistance.

Published in:

2022

By:

Frenk, Sammy;
Temkin, Elizabeth;
Lurie-Weinberger, Mor N.;
Keren-Paz, Alona;
Rov, Reut;
Rakovitsky, Nadya;
Wullfhart, Liat;
Nutman, Amir;
Daikos, George L.;
Skiada, Anna;
Durante-Mangoni, Emanuele;
Benattar, Yael Dishon;
Bitterman, Roni;
Yahav, Dafna;
Daitch, Vered;
Bernardo, Mariano;
Iossa, Domenico;
Zusman, Oren;
Friberg, Lena E.;
Mouton, Johan W.

Publication type:

journal article

Erratum to: Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen.

Published in:

2020

By:

Thorsted, Anders;
Kristoffersson, Anders N;
Maarbjerg, Sabine F;
Schrøder, Henrik;
Wang, Mikala;
Brock, Birgitte;
Nielsen, Elisabet I;
Friberg, Lena E

Publication type:

journal article

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen.

Published in:

2019

By:

Thorsted, Anders;
Kristoffersson, Anders N;
Maarbjerg, Sabine F;
Schrøder, Henrik;
Wang, Mikala;
Brock, Birgitte;
Nielsen, Elisabet I;
Friberg, Lena E

Publication type:

journal article

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.

Published in:

2017

By:

Friberg, Lena E.;
Nielsen, Elisabet I.;
Khan, David D.;
Cao, Sha;
Lustig, Ulrika;
Hughes, Diarmaid;
Andersson, Dan I.

Publication type:

journal article

A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin.

Published in:

2016

By:

Khan, David D.;
Friberg, Lena E.;
Nielsen, Elisabet I.

Publication type:

journal article

Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model.

Published in:

2016

By:

Mohamed, Ami F.;
Kristoffersson, Anders N.;
Karvanen, Matti;
Nielsen, Elisabet I.;
Cars, Otto;
Friberg, Lena E.

Publication type:

journal article

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants.

Published in:

2015

By:

Khan, David D.;
Lagerbäck, Pernilla;
Sha Cao;
Lustig, Ulrika;
Nielsen, Elisabet I.;
Cars, Otto;
Hughes, Diarmaid;
Andersson, Dan I.;
Friberg, Lena E.;
Cao, Sha

Publication type:

journal article

A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing.

Published in:

2014

By:

Mohamed, Ami F;
Cars, Otto;
Friberg, Lena E

Publication type:

Journal Article

A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 5, p. 1350, doi. 10.1093/jac/dkt520

By:

Mohamed, Ami F.;
Cars, Otto;
Friberg, Lena E.

Publication type:

Article

Translational Physiologically Based Pharmacokinetic Modeling to Predict Human Pulmonary Kinetics After Lung Delivery.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 796, doi. 10.1002/psp4.13316

By:

Wen, Haini;
Sadiq, Muhammad Waqas;
Friberg, Lena E.;
Svensson, Elin M.

Publication type:

Article

Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 4, p. 612, doi. 10.1002/psp4.13105

By:

Yin, Anyue;
Veerman, G. D. Marijn;
van Hasselt, Johan G. C.;
Steendam, Christi M. J.;
Dubbink, Hendrikus Jan;
Guchelaar, Henk‐Jan;
Friberg, Lena E.;
Dingemans, Anne‐Marie C.;
Mathijssen, Ron H. J.;
Moes, Dirk Jan A. R.

Publication type:

Article

Multistate modeling for survival analysis in critically ill patients treated with meropenem.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 2, p. 222, doi. 10.1002/psp4.13072

By:

Peng, Yaru;
Minichmayr, Iris K.;
Liu, Han;
Xie, Feifan;
Friberg, Lena E.

Publication type:

Article

Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 12, p. 1972, doi. 10.1002/psp4.13046

By:

Thorsted, Anders;
Pham, Anh Duc;
Friberg, Lena E.;
Nielsen, Elisabet I.

Publication type:

Article

A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 11, p. 1804, doi. 10.1002/psp4.13065

By:

Sánchez, Javier;
Claus, Christina;
Albrecht, Rosmarie;
Gaillard, Brenda C.;
Marinho, Joana;
McIntyre, Christine;
Tanos, Tamara;
Boehnke, Axel;
Friberg, Lena E.;
Jönsson, Siv;
Frances, Nicolas

Publication type:

Article

A multistate modeling and simulation framework to learn dose–response of oncology drugs: Application to bintrafusp alfa in non‐small cell lung cancer.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 11, p. 1738, doi. 10.1002/psp4.12976

By:

Liu, Han;
Milenković‐Grišić, Ana‐Marija;
Krishnan, Sreenath M.;
Jönsson, Siv;
Friberg, Lena E.;
Girard, Pascal;
Venkatakrishnan, Karthik;
Vugmeyster, Yulia;
Khandelwal, Akash;
Karlsson, Mats O.

Publication type:

Article

Assessment of ibrutinib scheduling on leukocyte, lymph node size and blood pressure dynamics in chronic lymphocytic leukemia through pharmacokinetic‐pharmacodynamic models.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1305, doi. 10.1002/psp4.13010

By:

Ibrahim, Eman I. K.;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Rituximab pharmacokinetic and pharmacokinetic–pharmacodynamic evaluation based on a study in diffuse large B‐cell lymphoma: Influence of tumor size on pharmacokinetic and assessment of pharmacokinetic similarity.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 2, p. 154, doi. 10.1002/psp4.12885

By:

Svensson, Robin J.;
Ooi, Qing Xi;
Friberg, Lena E.;
Maharaj, Narendra;
Reddy, Pramod Kumar;
López‐Lázaro, Luis;
Hansson, Emma

Publication type:

Article

Bayesian forecasting of tumor size metrics and overall survival.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1604, doi. 10.1002/psp4.12869

By:

Krishnan, Sreenath M.;
Friberg, Lena E.

Publication type:

Article

Multistate model for pharmacometric analyses of overall survival in HER2‐negative breast cancer patients treated with docetaxel.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1255, doi. 10.1002/psp4.12693

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Bruno, René;
Beyer, Ulrich;
Jin, Jin Y.;
Karlsson, Mats O.

Publication type:

Article

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 7, p. 649, doi. 10.1002/psp4.12680

By:

Rowland Yeo, Karen;
Hennig, Stefanie;
Krishnaswami, Sriram;
Strydom, Natasha;
Ayyar, Vivaswath S.;
French, Jonathan;
Sinha, Vikram;
Sobie, Eric;
Zhao, Ping;
Friberg, Lena E.;
Mentré, France

Publication type:

Article

Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2‐negative breast cancer patients treated with docetaxel.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 511, doi. 10.1002/psp4.12629

By:

Krishnan, Sreenath M.;
Laarif, Sofiene S.;
Bender, Brendan C.;
Quartino, Angelica L.;
Friberg, Lena E.

Publication type:

Article

Dr. Hartmut Derendorf, PhD, a world‐renowned expert in pharmacokinetics and pharmacometrics (1953–2020).

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 6, p. 527, doi. 10.1002/psp4.12609

By:

Sinha, Vikram;
Friberg, Lena E.;
Zhao, Ping

Publication type:

Article

Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 115, doi. 10.1002/psp4.12489

By:

Netterberg, Ida;
Bruno, René;
Chen, Ya‐Chi;
Winter, Helen;
Li, Chi‐Chung;
Jin, Jin Y.;
Friberg, Lena E.

Publication type:

Article

Publisher Correction: Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance.

Published in:

2022

By:

Yin, Anyue;
van Hasselt, Johan G. C.;
Guchelaar, Henk-Jan;
Friberg, Lena E.;
Moes, Dirk Jan A. R.

Publication type:

Correction Notice