Works by Frezza, Christian

Results: 56
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    Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia.

    Published in:
    Cancers, 2022, v. 14, n. 4, p. 963, doi. 10.3390/cancers14040963
    By:
    • Petruzzelli, Michele;
    • Ferrer, Miriam;
    • Schuijs, Martijn J.;
    • Kleeman, Sam O.;
    • Mourikis, Nicholas;
    • Hall, Zoe;
    • Perera, David;
    • Raghunathan, Shwethaa;
    • Vacca, Michele;
    • Gaude, Edoardo;
    • Lukey, Michael J.;
    • Jodrell, Duncan I.;
    • Frezza, Christian;
    • Wagner, Erwin F.;
    • Venkitaraman, Ashok R.;
    • Halim, Timotheus Y. F.;
    • Janowitz, Tobias
    Publication type:
    Article
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    Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.

    Published in:
    Cancers, 2021, v. 13, n. 7, p. 1727, doi. 10.3390/cancers13071727
    By:
    • Sant'Anna-Silva, Ana Carolina B.;
    • Perez-Valencia, Juan A.;
    • Sciacovelli, Marco;
    • Lalou, Claude;
    • Sarlak, Saharnaz;
    • Tronci, Laura;
    • Nikitopoulou, Efterpi;
    • Meszaros, Andras T.;
    • Frezza, Christian;
    • Rossignol, Rodrigue;
    • Gnaiger, Erich;
    • Klocker, Helmut;
    • Kofler, Barbara;
    • Arsenian-Henriksson, Marie
    Publication type:
    Article
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    Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

    Published in:
    2020
    By:
    • Lord, Simon R.;
    • Collins, Jennifer M.;
    • Cheng, Wei-Chen;
    • Haider, Syed;
    • Wigfield, Simon;
    • Gaude, Edoardo;
    • Fielding, Barbara A.;
    • Pinnick, Katherine E.;
    • Harjes, Ulrike;
    • Segaran, Ashvina;
    • Jha, Pooja;
    • Hoefler, Gerald;
    • Pollak, Michael N.;
    • Thompson, Alastair M.;
    • Roy, Pankaj G.;
    • English, Ruth.;
    • Adams, Rosie F.;
    • Frezza, Christian;
    • Buffa, Francesca M.;
    • Karpe, Fredrik
    Publication type:
    journal article
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    Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

    Published in:
    EMBO Journal, 2014, v. 33, n. 12, p. 1365, doi. 10.15252/embj.201386874
    By:
    • Zecchini, Vincent;
    • Madhu, Basetti;
    • Russell, Roslin;
    • Pértega‐Gomes, Nelma;
    • Warren, Anne;
    • Gaude, Edoardo;
    • Borlido, Joana;
    • Stark, Rory;
    • Ireland‐Zecchini, Heather;
    • Rao, Roheet;
    • Scott, Helen;
    • Boren, Joan;
    • Massie, Charlie;
    • Asim, Mohammad;
    • Brindle, Kevin;
    • Griffiths, John;
    • Frezza, Christian;
    • Neal, David E;
    • Mills, Ian G
    Publication type:
    Article
    8

    Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses.

    Published in:
    Molecular Systems Biology, 2021, v. 17, n. 1, p. 1, doi. 10.15252/msb.20209730
    By:
    • Dugourd, Aurelien;
    • Kuppe, Christoph;
    • Sciacovelli, Marco;
    • Gjerga, Enio;
    • Gabor, Attila;
    • Emdal, Kristina B.;
    • Vieira, Vitor;
    • Bekker‐Jensen, Dorte B.;
    • Kranz, Jennifer;
    • Bindels, Eric.M.J.;
    • Costa, Ana S.H.;
    • Sousa, Abel;
    • Beltrao, Pedro;
    • Rocha, Miguel;
    • Olsen, Jesper V.;
    • Frezza, Christian;
    • Kramann, Rafael;
    • Saez‐Rodriguez, Julio
    Publication type:
    Article
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    Mechanism of succinate efflux upon reperfusion of the ischaemic heart.

    Published in:
    Cardiovascular Research, 2021, v. 117, n. 4, p. 1188, doi. 10.1093/cvr/cvaa148
    By:
    • Prag, Hiran A;
    • Gruszczyk, Anja V;
    • Huang, Margaret M;
    • Beach, Timothy E;
    • Young, Timothy;
    • Tronci, Laura;
    • Nikitopoulou, Efterpi;
    • Mulvey, John F;
    • Ascione, Raimondo;
    • Hadjihambi, Anna;
    • Shattock, Michael J;
    • Pellerin, Luc;
    • Saeb-Parsy, Kourosh;
    • Frezza, Christian;
    • James, Andrew M;
    • Krieg, Thomas;
    • Murphy, Michael P;
    • Aksentijević, Dunja
    Publication type:
    Article
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    Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.

    Published in:
    EMBO Journal, 2023, v. 42, n. 18, p. 1, doi. 10.15252/embj.2022113190
    By:
    • Serrano‐Benitez, Almudena;
    • Wells, Sophie E;
    • Drummond‐Clarke, Lylah;
    • Russo, Lilian C;
    • Thomas, John Christopher;
    • Leal, Giovanna A;
    • Farrow, Mark;
    • Edgerton, James Michael;
    • Balasubramanian, Shankar;
    • Yang, Ming;
    • Frezza, Christian;
    • Gautam, Amit;
    • Brazina, Jan;
    • Burdova, Kamila;
    • Hoch, Nicolas C;
    • Jackson, Stephen P;
    • Caldecott, Keith W
    Publication type:
    Article
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    Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

    Published in:
    Nature, 2012, v. 491, n. 7424, p. 458, doi. 10.1038/nature11540
    By:
    • Chaneton, Barbara;
    • Hillmann, Petra;
    • Zheng, Liang;
    • Martin, Agnès C. L.;
    • Maddocks, Oliver D. K.;
    • Chokkathukalam, Achuthanunni;
    • Coyle, Joseph E.;
    • Jankevics, Andris;
    • Holding, Finn P.;
    • Vousden, Karen H.;
    • Frezza, Christian;
    • O'Reilly, Marc;
    • Gottlieb, Eyal
    Publication type:
    Article
    27

    Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

    Published in:
    Nature, 2011, v. 477, n. 7363, p. 225, doi. 10.1038/nature10363
    By:
    • Frezza, Christian;
    • Zheng, Liang;
    • Folger, Ori;
    • Rajagopalan, Kartik N.;
    • MacKenzie, Elaine D.;
    • Jerby, Livnat;
    • Micaroni, Massimo;
    • Chaneton, Barbara;
    • Adam, Julie;
    • Hedley, Ann;
    • Kalna, Gabriela;
    • Tomlinson, Ian P. M.;
    • Pollard, Patrick J.;
    • Watson, Dave G.;
    • Deberardinis, Ralph J.;
    • Shlomi, Tomer;
    • Ruppin, Eytan;
    • Gottlieb, Eyal
    Publication type:
    Article
    28

    The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.

    Published in:
    EMBO Reports, 2020, v. 21, n. 9, p. 1, doi. 10.15252/embr.201948260
    By:
    • Xu, Ruoyan;
    • Jones, William;
    • Wilcz‐Villega, Ewa;
    • Costa, Ana SH;
    • Rajeeve, Vinothini;
    • Bentham, Robert B;
    • Bryson, Kevin;
    • Nagano, Ai;
    • Yaman, Busra;
    • Olendo Barasa, Sheila;
    • Wang, Yewei;
    • Chelala, Claude;
    • Cutillas, Pedro;
    • Szabadkai, Gyorgy;
    • Frezza, Christian;
    • Bianchi, Katiuscia
    Publication type:
    Article
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    Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

    Published in:
    PLoS Genetics, 2017, v. 13, n. 3, p. 1, doi. 10.1371/journal.pgen.1006620
    By:
    • Connor, Thomas M.;
    • Hoer, Simon;
    • Mallett, Andrew;
    • Gale, Daniel P.;
    • Gomez-Duran, Aurora;
    • Posse, Viktor;
    • Antrobus, Robin;
    • Moreno, Pablo;
    • Sciacovelli, Marco;
    • Frezza, Christian;
    • Duff, Jennifer;
    • Sheerin, Neil S.;
    • Sayer, John A.;
    • Ashcroft, Margaret;
    • Wiesener, Michael S.;
    • Hudson, Gavin;
    • Gustafsson, Claes M.;
    • Chinnery, Patrick F.;
    • Maxwell, Patrick H.
    Publication type:
    Article
    31

    Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

    Published in:
    Nature, 2014, v. 515, n. 7527, p. 431, doi. 10.1038/nature13909
    By:
    • Chouchani, Edward T.;
    • Eaton, Simon;
    • Davidson, Sean M.;
    • Saeb-Parsy, Kourosh;
    • Pell, Victoria R.;
    • Hu, Chou-Hui;
    • Krieg, Thomas;
    • Gaude, Edoardo;
    • Costa, Ana S. H.;
    • Frezza, Christian;
    • Aksentijević, Dunja;
    • Shattock, Michael J.;
    • Sundier, Stephanie Y.;
    • Duchen, Michael R.;
    • Robb, Ellen L.;
    • Logan, Angela;
    • Smith, Anthony C.;
    • Eyassu, Filmon;
    • Dare, Anna J.;
    • James, Andrew M.
    Publication type:
    Article
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    Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.

    Published in:
    eLife, 2022, p. 1, doi. 10.7554/eLife.74690
    By:
    • Lundahl, Mimmi L. E.;
    • Mitermite, Morgane;
    • Ryan, Dylan Gerard;
    • Case, Sarah;
    • Williams, Niamh C.;
    • Ming Yang;
    • Lynch, Roisin I.;
    • Lagan, Eimear;
    • Lebre, Filipa M.;
    • Gorman, Aoife L.;
    • Stojkovic, Bojan;
    • Bracken, Adrian P.;
    • Frezza, Christian;
    • Sheedy, Frederick J.;
    • Scanlan, Eoin M.;
    • O'Neill, Luke A. J.;
    • Gordon, Stephen V.;
    • Lavelle, Ed C.
    Publication type:
    Article
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    Fumarate induces redox-dependent senescence by modifying glutathione metabolism.

    Published in:
    Nature Communications, 2015, v. 6, n. 1, p. 6001, doi. 10.1038/ncomms7001
    By:
    • Zheng, Liang;
    • Cardaci, Simone;
    • Jerby, Livnat;
    • MacKenzie, Elaine D.;
    • Sciacovelli, Marco;
    • Johnson, T. Isaac;
    • Gaude, Edoardo;
    • King, Ayala;
    • Leach, Joshua D. G.;
    • Edrada-Ebel, RuAngelie;
    • Hedley, Ann;
    • Morrice, Nicholas A.;
    • Kalna, Gabriela;
    • Blyth, Karen;
    • Ruppin, Eytan;
    • Frezza, Christian;
    • Gottlieb, Eyal
    Publication type:
    Article
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    A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function.

    Published in:
    Human Molecular Genetics, 2008, v. 17, n. 21, p. 3291, doi. 10.1093/hmg/ddn225
    By:
    • Spinazzi, Marco;
    • Cazzola, Silvia;
    • Bortolozzi, Mario;
    • Baracca, Alessandra;
    • Loro, Emanuele;
    • Casarin, Alberto;
    • Solaini, Giancarlo;
    • Sgarbi, Gianluca;
    • Casalena, Gabriella;
    • Cenacchi, Giovanna;
    • Malena, Adriana;
    • Frezza, Christian;
    • Carrara, Franco;
    • Angelini, Corrado;
    • Scorrano, Luca;
    • Salviati, Leonardo;
    • Vergani, Lodovica
    Publication type:
    Article
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    Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.

    Published in:
    EMBO Molecular Medicine, 2024, v. 16, n. 6, p. 1379, doi. 10.1038/s44321-024-00071-9
    By:
    • Clerici, Sara;
    • Podrini, Christine;
    • Stefanoni, Davide;
    • Distefano, Gianfranco;
    • Cassina, Laura;
    • Steidl, Maria Elena;
    • Tronci, Laura;
    • Canu, Tamara;
    • Chiaravalli, Marco;
    • Spies, Daniel;
    • Bell 3rd, Thomas A;
    • Costa, Ana SH;
    • Esposito, Antonio;
    • D'Alessandro, Angelo;
    • Frezza, Christian;
    • Bachi, Angela;
    • Boletta, Alessandra
    Publication type:
    Article
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