Works matching AU Freeman, Willard M.

Results: 70

P-glycoprotein expression skews mitochondrial dye measurements in T cells.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1560104

By:

Sok, Sophia P. M.;
Cheng, Jianan;
Strucinska, Klaudia;
Popescu, Narcis I.;
Wu, Lihua;
Ke, Qiuqing;
Kiosses, William B.;
Stanford, David;
Freeman, Willard M.;
Matsuzaki, Satoshi;
Lewis Jr., Tommy L.;
Zhao, Meng

Publication type:

Article

Revisiting the genomic hypomethylation hypothesis of aging.

Published in:

Annals of the New York Academy of Sciences, 2018, v. 1418, n. 1, p. 69, doi. 10.1111/nyas.13533

By:

Unnikrishnan, Archana;
Hadad, Niran;
Masser, Dustin R.;
Jackson, Jordan;
Freeman, Willard M.;
Richardson, Arlan

Publication type:

Article

Early-life DNA methylation profiles are indicative of age-related transcriptome changes.

Published in:

Epigenetics & Chromatin, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13072-019-0306-5

By:

Hadad, Niran;
Masser, Dustin R.;
Blanco-Berdugo, Laura;
Stanford, David R.;
Freeman, Willard M.

Publication type:

Article

Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing.

Published in:

Epigenetics & Chromatin, 2013, v. 6, n. 1, p. 2, doi. 10.1186/1756-8935-6-33

By:

Masser, Dustin R.;
Berg, Arthur S.;
Freeman, Willard M.

Publication type:

Article

Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.

Published in:

Age (0161-9152), 2016, v. 38, n. 3, p. 1, doi. 10.1007/s11357-016-9914-1

By:

Masser, Dustin R.;
Stanford, David R.;
Hadad, Niran;
Giles, Cory B.;
Wren, Jonathan D.;
Sonntag, William E.;
Richardson, Arlan;
Freeman, Willard M.

Publication type:

Article

A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity.

Published in:

FASEB Journal, 2025, v. 39, n. 5, p. 1, doi. 10.1096/fj.202500177R

By:

Murach, Kevin A.;
Englund, Davis A.;
Chambers, Toby L.;
Dungan, Cory M.;
Porter, Hunter L.;
Wren, Jonathan D.;
Freeman, Willard M.;
Dupont‐Versteegden, Esther E.;
Wen, Yuan

Publication type:

Article

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2021, v. 64, n. 4, p. 426, doi. 10.1165/rcmb.2020-0302OC

By:

Bodas, Manish;
Moore, Andrew R.;
Subramaniyan, Bharathiraja;
Georgescu, Constantin;
Wren, Jonathan D.;
Freeman, Willard M.;
Brown, Brent R.;
Metcalf, Jordan P.;
Walters, Matthew S.

Publication type:

Article

Depletion of abundant proteins from non-human primate serum for biomarker studies.

Published in:

Proteomics, 2006, v. 6, n. 10, p. 3109, doi. 10.1002/pmic.200500717

By:

Willard M. Freeman;
Melinda E. Lull;
Michael T. Guilford;
Kent E. Vrana

Publication type:

Article

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-01418-x

By:

Chucair-Elliott, Ana J.;
Ocañas, Sarah R.;
Stanford, David R.;
Ansere, Victor A.;
Buettner, Kyla B.;
Porter, Hunter;
Eliason, Nicole L.;
Reid, Justin J.;
Sharpe, Amanda L.;
Stout, Michael B.;
Beckstead, Michael J.;
Miller, Benjamin F.;
Richardson, Arlan;
Freeman, Willard M.

Publication type:

Article

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.

Published in:

Cells (2073-4409), 2021, v. 10, n. 11, p. 3215, doi. 10.3390/cells10113215

By:

Bodas, Manish;
Subramaniyan, Bharathiraja;
Moore, Andrew R.;
Metcalf, Jordan P.;
Ocañas, Sarah R.;
Freeman, Willard M.;
Georgescu, Constantin;
Wren, Jonathan D.;
Walters, Matthew S.

Publication type:

Article

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02870-2

By:

Ocañas, Sarah R.;
Pham, Kevin D.;
Cox, Jillian E. J.;
Keck, Alex W.;
Ko, Sunghwan;
Ampadu, Felix A.;
Porter, Hunter L.;
Ansere, Victor A.;
Kulpa, Adam;
Kellogg, Collyn M.;
Machalinski, Adeline H.;
Thomas, Manu A.;
Wright, Zsabre;
Chucair-Elliott, Ana J.;
Freeman, Willard M.

Publication type:

Article

Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer.

Published in:

International Journal of Oncology, 2020, v. 57, n. 6, p. 1319, doi. 10.3892/ijo.2020.5133

By:

Oh, Sangphil;
Song, Hoogeun;
Freeman, Willard M.;
Shin, Sook;
Janknecht, Ralf

Publication type:

Article

Weight Loss Results in Increased Expression of Anti-Inflammatory Protein CRISPLD2 in Mouse Adipose Tissue.

Published in:

2019

By:

Jackson, Robert M.;
Griesel, Beth A.;
Short, Kevin R.;
Sparling, David;
Freeman, Willard M.;
Olson, Ann Louise

Publication type:

journal article

Long‐term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 6, p. 1908, doi. 10.1002/jcsm.12790

By:

Rodrigues, Anna Carolina Zaia;
Messi, María Laura;
Wang, Zhong‐Min;
Bonilla, Henry Jacob;
Freeman, Willard M.;
Delbono, Osvaldo

Publication type:

Article

Heart and neural crest derivative 2‐induced preservation of sympathetic neurons attenuates sarcopenia with aging.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2021, v. 12, n. 1, p. 91, doi. 10.1002/jcsm.12644

By:

Rodrigues, Anna Carolina Zaia;
Wang, Zhong‐Min;
Messi, María Laura;
Bonilla, Henry Jacob;
Liu, Liang;
Freeman, Willard M.;
Delbono, Osvaldo

Publication type:

Article

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2019, v. 10, n. 2, p. 411, doi. 10.1002/jcsm.12375

By:

Ahn, Bumsoo;
Ranjit, Rojina;
Premkumar, Pavithra;
Pharaoh, Gavin;
Piekarz, Katarzyna M.;
Matsuzaki, Satoshi;
Claflin, Dennis R.;
Riddle, Kaitlyn;
Judge, Jennifer;
Bhaskaran, Shylesh;
Satara Natarajan, Kavithalakshmi;
Barboza, Erika;
Wronowski, Benjamin;
Kinter, Michael;
Humphries, Kenneth M.;
Griffin, Timothy M.;
Freeman, Willard M.;
Richardson, Arlan;
Brooks, Susan V.;
Van Remmen, Holly

Publication type:

Article

Transcriptomic Analysis Reveals That Excessive Thyroid Hormone Signaling Impairs Phototransduction and Mitochondrial Bioenergetics and Induces Cellular Stress in Mouse Cone Photoreceptors.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 13, p. 7435, doi. 10.3390/ijms25137435

By:

Ma, Hongwei;
Stanford, David;
Freeman, Willard M.;
Ding, Xi-Qin

Publication type:

Article

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.59616

By:

Mann, Shivani N.;
Hadad, Niran;
Holte, Molly Nelson;
Rothman, Alicia R.;
Sathiaseelan, Roshini;
Mondal, Samim Ali;
Agbaga, Martin-Paul;
Unnikrishnan, Archana;
Subramaniam, Malayannan;
Hawse, John;
Huffman, Derek M.;
Freeman, Willard M.;
Stout, Michael B.

Publication type:

Article

Transcriptome analysis of frontal cortex in alcohol‐preferring and nonpreferring rats.

Published in:

Journal of Neuroscience Research, 2005, v. 80, n. 4, p. 529, doi. 10.1002/jnr.20496

By:

Travis J. Worst;
John C. Tan;
Daniel J. Robertson;
Willard M. Freeman;
Petri Hyytia;
Kalervo Kiianmaa;
Kent E. Vrana

Publication type:

Article

Clinical application for the preservation of phosphoproteins through in-situ tissue stabilization.

Published in:

Proteome Science, 2010, v. 8, p. 61, doi. 10.1186/1477-5956-8-61

By:

Rountree, C Bart;
Van Kirk, Colleen A.;
Hanning You;
Wei Ding;
Hien Dang;
VanGuilder, Heather D.;
Freeman, Willard M.

Publication type:

Article

Differences in the BAL proteome after Klebsiellapneumoniae infection in wild type and SP-A-/- mice.

Published in:

Proteome Science, 2010, v. 8, p. 34, doi. 10.1186/1477-5956-8-34

By:

Ali, Mehboob;
Umstead, Todd M.;
Haque, Rizwanul;
Mikerov, Anatoly N.;
Freeman, Willard M.;
Floros, Joanna;
Phelps, David S.

Publication type:

Article

The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome.

Published in:

Proteome Science, 2009, v. 7, p. 1, doi. 10.1186/1477-5956-7-12

By:

Haque, Rizwanul;
Umstead, Todd M.;
Freeman, Willard M.;
Floros, Joanna;
Phelps, David S.

Publication type:

Article

The Kinetics of Cardiopulmonary Bypass: A Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass.

Published in:

Artificial Organs, 2012, v. 36, n. 1, p. E1, doi. 10.1111/j.1525-1594.2011.01412.x

By:

Umstead, Todd M.;
Lu, Chia-jung K.;
Freeman, Willard M.;
Myers, John L.;
Clark, J. Brian;
Thomas, Neal J.;
Icitovic, Nikolina;
Chinchilli, Vernon M.;
Ündar, Akif;
Phelps, David S.

Publication type:

Article

Protein biomarkers of alcohol abuse.

Published in:

Expert Review of Proteomics, 2012, v. 9, n. 4, p. 425, doi. 10.1586/EPR.12.38

By:

Torrente, Mariana P.;
Freeman, Willard M.;
Vrana, Kent E.

Publication type:

Article

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons.

Published in:

Journal of Neurochemistry, 2018, v. 144, n. 6, p. 723, doi. 10.1111/jnc.14304

By:

Mangold, Colleen A.;
Yao, Pamela J.;
Du, Mei;
Freeman, Willard M.;
Benkovic, Stephen J.;
Szpara, Moriah L.

Publication type:

Article

Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy.

Published in:

Journal of Neurochemistry, 2017, v. 143, n. 5, p. 595, doi. 10.1111/jnc.14216

By:

Masser, Dustin R.;
Otalora, Laura;
Clark, Nicholas W.;
Kinter, Michael T.;
Elliott, Michael H.;
Freeman, Willard M.

Publication type:

Article

Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases.

Published in:

GeroScience, 2023, v. 45, n. 6, p. 3241, doi. 10.1007/s11357-023-00955-7

By:

Selvarani, Ramasamy;
Van Michelle Nguyen, Hoang;
Thadathil, Nidheesh;
Wolf, Roman F.;
Freeman, Willard M.;
Wiley, Christopher D.;
Deepa, Sathyaseelan S.;
Richardson, Arlan

Publication type:

Article

Correction to: Microglial MHC‑I induction with aging and Alzheimer's is conserved in mouse models and humans.

Published in:

2023

By:

Kellogg, Collyn M.;
Pham, Kevin;
Machalinski, Adeline H.;
Porter, Hunter L.;
Blankenship, Harris E.;
Tooley, Kyla B.;
Stout, Michael B.;
Rice, Heather C.;
Sharpe, Amanda L.;
Beckstead, Michael J.;
Chucair‑Elliott, Ana J.;
Ocañas, Sarah R.;
Freeman, Willard M.

Publication type:

Correction Notice

Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans.

Published in:

GeroScience, 2023, v. 45, n. 5, p. 3019, doi. 10.1007/s11357-023-00859-6

By:

Kellogg, Collyn M.;
Pham, Kevin;
Machalinski, Adeline H.;
Porter, Hunter L.;
Blankenship, Harris E.;
Tooley, Kyla B.;
Stout, Michael B.;
Rice, Heather C.;
Sharpe, Amanda L.;
Beckstead, Michael J.;
Chucair-Elliott, Ana J.;
Ocañas, Sarah R.;
Freeman, Willard M.

Publication type:

Article

Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques.

Published in:

GeroScience, 2023, v. 45, n. 4, p. 2337, doi. 10.1007/s11357-023-00767-9

By:

Stout, Michael B.;
Vaughan, Kelli L.;
Isola, Jose V. V.;
Mann, Shivani N.;
Wellman, Bayli;
Hoffman, Jessica M.;
Porter, Hunter L.;
Freeman, Willard M.;
Mattison, Julie A.

Publication type:

Article

Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function.

Published in:

GeroScience, 2021, v. 43, n. 5, p. 2183, doi. 10.1007/s11357-021-00454-7

By:

Van Remmen, Holly;
Freeman, Willard M.;
Miller, Benjamin F.;
Kinter, Michael;
Wren, Jonathan D.;
Chiao, Ann;
Towner, Rheal A.;
Snider, Timothy A.;
Sonntag, William E.;
Richardson, Arlan

Publication type:

Article

Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia.

Published in:

GeroScience, 2020, v. 42, n. 4, p. 1101, doi. 10.1007/s11357-020-00189-x

By:

Sataranatarajan, Kavithalakshmi;
Pharaoh, Gavin;
Brown, Jacob L.;
Ranjit, Rojina;
Piekarz, Katarzyna M.;
Street, Kaitlyn;
Wren, Jonathan D.;
Georgescu, Constantin;
Kinter, Caroline;
Kinter, Michael;
Freeman, Willard M.;
Richardson, Arlan;
Van Remmen, Holly

Publication type:

Article

Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies.

Published in:

GeroScience, 2019, v. 41, n. 5, p. 691, doi. 10.1007/s11357-019-00090-2

By:

Chucair-Elliott, Ana J.;
Ocanas, Sarah R.;
Stanford, David R.;
Hadad, Niran;
Wronowski, Benjamin;
Otalora, Laura;
Stout, Michael B.;
Freeman, Willard M.

Publication type:

Article

Analysis of DNA modifications in aging research.

Published in:

GeroScience, 2018, v. 40, n. 1, p. 11, doi. 10.1007/s11357-018-0005-3

By:

Masser, Dustin R.;
Hadad, Niran;
Porter, Hunter;
Stout, Michael B.;
Unnikrishnan, Archana;
Stanford, David R.;
Freeman, Willard M.

Publication type:

Article

Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia.

Published in:

Aging Cell, 2022, v. 21, n. 3, p. 1, doi. 10.1111/acel.13569

By:

Ahn, Bumsoo;
Ranjit, Rojina;
Kneis, Parker;
Xu, Hongyang;
Piekarz, Katarzyna M.;
Freeman, Willard M.;
Kinter, Michael;
Richardson, Arlan;
Ran, Qitao;
Brooks, Susan V.;
Van Remmen, Holly

Publication type:

Article

Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging.

Published in:

Aging Cell, 2021, v. 20, n. 11, p. 1, doi. 10.1111/acel.13492

By:

Porter, Hunter L.;
Brown, Chase A.;
Roopnarinesingh, Xiavan;
Giles, Cory B.;
Georgescu, Constantin;
Freeman, Willard M.;
Wren, Jonathan D.

Publication type:

Article

17α‐estradiol acts through hypothalamic pro‐opiomelanocortin expressing neurons to reduce feeding behavior.

Published in:

Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12703

By:

Steyn, Frederik J.;
Ngo, Shyuan T.;
Chen, Vicky Ping;
Bailey‐Downs, Lora C.;
Xie, Teresa Y.;
Ghadami, Martin;
Brimijoin, Stephen;
Freeman, Willard M.;
Rubinstein, Marcelo;
Low, Malcolm J.;
Stout, Michael B.

Publication type:

Article

Sexually divergent DNA methylation patterns with hippocampal aging.

Published in:

Aging Cell, 2017, v. 16, n. 6, p. 1342, doi. 10.1111/acel.12681

By:

Masser, Dustin R.;
Hadad, Niran;
Porter, Hunter L.;
Mangold, Colleen A.;
Unnikrishnan, Archana;
Ford, Matthew M.;
Giles, Cory B.;
Georgescu, Constantin;
Dozmorov, Mikhail G.;
Wren, Jonathan D.;
Richardson, Arlan;
Stanford, David R.;
Freeman, Willard M.

Publication type:

Article

A NOVEL COCAINE ANALOG, 2β-PROPANOYL-3β-(4-TOLYL)-TROPANE (PTT) REDUCES TYROSINE HYDROXYLASE EXPRESSION IN THE MESOLIMBIC DOPAMINE PATHWAY.

Published in:

1999

By:

Freeman, Willard M.;
Daunais, Jim B.;
Gioia, Lynda;
Porrino, Linda J.;
Davies, Huw M. L.;
Vrana, Kent E.

Publication type:

Abstract

MULTIPLEX ANALYSIS OF COCAINE-RESPONSIVE GENE EXPRESSION IN NON-HUMAN PRIMATES.

Published in:

1999

By:

Freeman, Willard M.;
Gioia, Lynda;
Nader, Susan;
Daunais, James;
Porrino, Linda;
Friedman, David;
Nader, Michael;
Vrana, Kent E.

Publication type:

Abstract

Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.

Published in:

BMC Neuroscience, 2010, v. 11, p. 29, doi. 10.1186/1471-2202-11-29

By:

Freeman, Willard M.;
Lull, Melinda E.;
Patel, Kruti M.;
Brucklacher, Robert M.;
Morgan, Drake;
Roberts, David C. S.;
Vrana, Kent E.

Publication type:

Article

Correlating Human and Animal Studies of Cocaine Abuse and Gene Expression.

Published in:

Annals of the New York Academy of Sciences, 2008, v. 1141, p. 58, doi. 10.1196/annals.1441.013

By:

Lull, Melinda E.;
Freeman, Willard M.;
Vrana, Kent E.;
Mash, Deborah C.

Publication type:

Article

A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer.

Published in:

Oncology Letters, 2018, v. 16, n. 5, p. 6652, doi. 10.3892/ol.2018.9487

By:

Li, Xiaomeng;
Oh, Sangphil;
Song, Hoogeun;
Shin, Sook;
Zhang, Bin;
Freeman, Willard M.;
Janknecht, Ralf

Publication type:

Article

A Comparative Proteomic Analysis of Bronchoalveolar Lavage Fluid in Rats with Aging using 2-DIGE and MALDI-ToF/ToF.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1401

By:

Umsteadj, Todd M.;
Freeman, Willard M.;
Phelps, David S.

Publication type:

Article

Quantitative Proteomic Profiles of BALF in Wild Type and SP-A KO Mice after Exposure to Ozone.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A9, doi. 10.1096/fasebj.21.5.a9-d

By:

Haque, Rizwanul;
Umstead, Todd M.;
Freeman, Willard M.;
Phelps, David S.;
Floros, Joanna

Publication type:

Article

Rapid Impairment of Retinal Protein Synthesis: A Potential Mechanism for Cellular Dysfunction in Diabetic Retinopathy.

Published in:

Diabetes, 2007, v. 56, p. A216

By:

Fort, Patrice E.;
Singh, Ravi S.;
Losiewicz, Mandy K.;
Reiter, Chad E.;
Freeman, Willard M.;
Gilbert, Kirk A.;
Jefferson, Leonard S.;
Kimball, Scot R.;
Gardner, Thomas W.

Publication type:

Article

Diabetic Retinopathy.

Published in:

Diabetes, 2006, v. 55, n. 9, p. 2401, doi. 10.2337/db05-1635

By:

Antonetti, David A.;
Barber, Alistair J.;
Bronson, Sarah K.;
Freeman, Willard M.;
Gardner, Thomas W.;
Jefferson, Leonard S.;
Kester, Mark;
Kimball, Scot R.;
Krady, J. Kyle;
LaNoue, Kathryn F.;
Norbury, Christopher C.;
Quinn, Patrick G.;
Sandirasegarane, Lakshman;
Simpson, Ian A.

Publication type:

Article

Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.

Published in:

Journal of Neurochemistry, 2012, v. 121, n. 1, p. 77, doi. 10.1111/j.1471-4159.2012.07671.x

By:

VanGuilder, Heather D.;
Bixler, Georgina V.;
Sonntag, William E.;
Freeman, Willard M.

Publication type:

Article

Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.

Published in:

Journal of Neurochemistry, 2010, v. 113, n. 6, p. 1577, doi. 10.1111/j.1471-4159.2010.06719.x

By:

VanGuilder, Heather D.;
Yan, Han;
Farley, Julie A.;
Sonntag, William E.;
Freeman, Willard M.

Publication type:

Article

Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats.

Published in:

Journal of Neurochemistry, 2004, v. 89, n. 4, p. 1021, doi. 10.1111/j.1471-4159.2004.02392.x

By:

Tang, Wenxue;
Wesley, Michael;
Freeman, Willard M.;
Liang, Bill;
Hemby, Scott B.

Publication type:

Article