Works matching AU Freathy, Rachel M.

Results: 55
    1

    Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs.

    Published in:
    2020
    By:
    • Chen, Jing;
    • Bacelis, Jonas;
    • Sole-Navais, Pol;
    • Srivastava, Amit;
    • Juodakis, Julius;
    • Rouse, Amy;
    • Hallman, Mikko;
    • Teramo, Kari;
    • Melbye, Mads;
    • Feenstra, Bjarke;
    • Freathy, Rachel M.;
    • Smith, George Davey;
    • Lawlor, Deborah A.;
    • Murray, Jeffrey C.;
    • Williams, Scott M.;
    • Jacobsson, Bo;
    • Muglia, Louis J.;
    • Zhang, Ge
    Publication type:
    journal article
    2
    3

    Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes.

    Published in:
    BMC Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12916-023-03167-0
    By:
    • Borges, Maria Carolina;
    • Clayton, Gemma L.;
    • Freathy, Rachel M.;
    • Felix, Janine F.;
    • Fernández-Sanlés, Alba;
    • Soares, Ana Gonçalves;
    • Kilpi, Fanny;
    • Yang, Qian;
    • McEachan, Rosemary R. C.;
    • Richmond, Rebecca C.;
    • Liu, Xueping;
    • Skotte, Line;
    • Irizar, Amaia;
    • Hattersley, Andrew T.;
    • Bodinier, Barbara;
    • Scholtens, Denise M.;
    • Nohr, Ellen A.;
    • Bond, Tom A.;
    • Hayes, M. Geoffrey;
    • West, Jane
    Publication type:
    Article
    4

    Common variants at 12q15 and 12q24 are associated with infant head circumference.

    Published in:
    Nature Genetics, 2012, v. 44, n. 5, p. 532, doi. 10.1038/ng.2238
    By:
    • Taal, H Rob;
    • St Pourcain, Beate;
    • Thiering, Elisabeth;
    • Das, Shikta;
    • Mook-Kanamori, Dennis O;
    • Warrington, Nicole M;
    • Kaakinen, Marika;
    • Kreiner-Møller, Eskil;
    • Bradfield, Jonathan P;
    • Freathy, Rachel M;
    • Geller, Frank;
    • Guxens, Mònica;
    • Cousminer, Diana L;
    • Kerkhof, Marjan;
    • Timpson, Nicholas J;
    • Ikram, M Arfan;
    • Beilin, Lawrence J;
    • Bønnelykke, Klaus;
    • Buxton, Jessica L;
    • Charoen, Pimphen
    Publication type:
    Article
    5

    Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

    Published in:
    Nature Genetics, 2010, v. 42, n. 5, p. 430, doi. 10.1038/ng.567
    By:
    • Freathy, Rachel M.;
    • Mook-Kanamori, Dennis O.;
    • Sovio, Ulla;
    • Prokopenko, Inga;
    • Timpson, Nicholas J.;
    • Berry, Diane J.;
    • Warrington, Nicole M.;
    • Widen, Elisabeth;
    • Hottenga, Jouke Jan;
    • Kaakinen, Marika;
    • Lange, Leslie A.;
    • Bradfield, Jonathan P.;
    • Kerkhof, Marjan;
    • Marsh, Julie A.;
    • Mägi, Reedik;
    • Chih-Mei Chen;
    • Lyon, Helen N.;
    • Kirin, Mirna;
    • Adair, Linda S.;
    • Aulchenko, Yurii S.
    Publication type:
    Article
    6

    Common variants near MC4R are associated with fat mass, weight and risk of obesity.

    Published in:
    Nature Genetics, 2008, v. 40, n. 6, p. 768, doi. 10.1038/ng.140
    By:
    • Loos, Ruth J. F.;
    • Lindgren, Cecilia M.;
    • Li, Shengxu;
    • Wheeler, Eleanor;
    • Zhao, Jing Hua;
    • Prokopenko, Inga;
    • Inouye, Michael;
    • Freathy, Rachel M.;
    • Attwood, Antony P.;
    • Beckmann, Jacques S.;
    • Berndt, Sonja I.;
    • Jacobs, Kevin B.;
    • Chanock, Stephen J.;
    • Hayes, Richard B.;
    • Bergmann, Sven;
    • Bennett, Amanda J.;
    • Bingham, Sheila A.;
    • Bochud, Murielle;
    • Brown, Morris;
    • Cauchi, Stéphane
    Publication type:
    Article
    7

    Genome-wide association analysis identifies 20 loci that influence adult height.

    Published in:
    Nature Genetics, 2008, v. 40, n. 5, p. 575, doi. 10.1038/ng.121
    By:
    • Weedon, Michael N.;
    • Lango, Hana;
    • Lindgren, Cecilia M.;
    • Wallace, Chris;
    • Evans, David M.;
    • Mangino, Massimo;
    • Freathy, Rachel M.;
    • Perry, John R. B.;
    • Stevens, Suzanne;
    • Hall, Alistair S.;
    • Samani, Nilesh J.;
    • Shields, Beverly;
    • Prokopenko, Inga;
    • Farrall, Martin;
    • Dominiczak, Anna;
    • Johnson, Toby;
    • Bergmann, Sven;
    • Beckmann, Jacques S.;
    • Vollenweider, Peter;
    • Waterworth, Dawn M.
    Publication type:
    Article
    8

    A common variant of HMGA2 is associated with adult and childhood height in the general population.

    Published in:
    Nature Genetics, 2007, v. 39, n. 10, p. 1245, doi. 10.1038/ng2121
    By:
    • Weedon, Michael N.;
    • Lettre, Guillaume;
    • Freathy, Rachel M.;
    • Lindgren, Cecilia M.;
    • Voight, Benjamin F.;
    • Perry, John R. B.;
    • Elliott, Katherine S.;
    • Hackett, Rachel;
    • Guiducci, Candace;
    • Shields, Beverley;
    • Zeggini, Eleftheria;
    • Lango, Hana;
    • Lyssenko, Valeriya;
    • Timpson, Nicholas J.;
    • Burtt, Noel P.;
    • Rayner, Nigel W.;
    • Saxena, Richa;
    • Ardlie, Kristin;
    • Tobias, Jonathan H.;
    • Ness, Andrew R.
    Publication type:
    Article
    9

    Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease.

    Published in:
    PLoS Genetics, 2014, v. 10, n. 2, p. 1, doi. 10.1371/journal.pgen.1004123
    By:
    • Medici, Marco;
    • Porcu, Eleonora;
    • Pistis, Giorgio;
    • Teumer, Alexander;
    • Brown, Suzanne J.;
    • Jensen, Richard A.;
    • Rawal, Rajesh;
    • Roef, Greet L.;
    • Plantinga, Theo S.;
    • Vermeulen, Sita H.;
    • Lahti, Jari;
    • Simmonds, Matthew J.;
    • Husemoen, Lise Lotte N.;
    • Freathy, Rachel M.;
    • Shields, Beverley M.;
    • Pietzner, Diana;
    • Nagy, Rebecca;
    • Broer, Linda;
    • Chaker, Layal;
    • Korevaar, Tim I. M.
    Publication type:
    Article
    10

    A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function.

    Published in:
    PLoS Genetics, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.pgen.1003266
    By:
    • Porcu, Eleonora;
    • Medici, Marco;
    • Pistis, Giorgio;
    • Volpato, Claudia B.;
    • Wilson, Scott G.;
    • Cappola, Anne R.;
    • Bos, Steffan D.;
    • Deelen, Joris;
    • den Heijer, Martin;
    • Freathy, Rachel M.;
    • Lahti, Jari;
    • Chunyu Liu;
    • Lopez, Lorna M.;
    • Nolte, Ilja M.;
    • O'Connell, Jeffrey R.;
    • Tanaka, Toshiko;
    • Trompet, Stella;
    • Arnold, Alice;
    • Bandinelli, Stefania;
    • Beekman, Marian
    Publication type:
    Article
    11
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    Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.

    Published in:
    Human Molecular Genetics, 2022, v. 31, n. 11, p. 1762, doi. 10.1093/hmg/ddab356
    By:
    • Thompson, William D;
    • Beaumont, Robin N;
    • Kuang, Alan;
    • Warrington, Nicole M;
    • Ji, Yingjie;
    • Tyrrell, Jessica;
    • Wood, Andrew R;
    • Scholtens, Denise M;
    • Knight, Bridget A;
    • Evans, David M;
    • Jr, William L Lowe;
    • Santorelli, Gillian;
    • Azad, Raq;
    • Mason, Dan;
    • Hattersley, Andrew T;
    • Frayling, Timothy M;
    • Yaghootkar, Hanieh;
    • Borges, Maria Carolina;
    • Lawlor, Deborah A;
    • Freathy, Rachel M
    Publication type:
    Article
    14
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    Genetics of early growth traits.

    Published in:
    Human Molecular Genetics, 2020, v. 29, n. R1, p. R66, doi. 10.1093/hmg/ddaa149
    By:
    • Cousminer, Diana L;
    • Freathy, Rachel M
    Publication type:
    Article
    17

    Genetics of early growth traits.

    Published in:
    Human Molecular Genetics, 2020, v. 29, n. 16, p. R66, doi. 10.1093/hmg/ddaa149
    By:
    • Cousminer, Diana L;
    • Freathy, Rachel M
    Publication type:
    Article
    18

    Common variants at 12q15 and 12q24 are associated with infant head circumference.

    Published in:
    Nature Genetics, 2013, v. 45, n. 6, p. 713, doi. 10.1038/ng0613-713a
    By:
    • Taal, H Rob;
    • St Pourcain, Beate;
    • Thiering, Elisabeth;
    • Das, Shikta;
    • Mook-Kanamori, Dennis O;
    • Warrington, Nicole M;
    • Kaakinen, Marika;
    • Kreiner-Møller, Eskil;
    • Bradfield, Jonathan P;
    • Freathy, Rachel M;
    • Geller, Frank;
    • Guxens, Mònica;
    • Cousminer, Diana L;
    • Kerkhof, Marjan;
    • Timpson, Nicholas J;
    • Ikram, M Arfan;
    • Beilin, Lawrence J;
    • Bønnelykke, Klaus;
    • Buxton, Jessica L;
    • Charoen, Pimphen
    Publication type:
    Article
    19
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    Using genetics to understand the causal influence of higher BMI on depression.

    Published in:
    2019
    By:
    • Tyrrell, Jessica;
    • Mulugeta, Anwar;
    • Wood, Andrew R;
    • Zhou, Ang;
    • Beaumont, Robin N;
    • Tuke, Marcus A;
    • Jones, Samuel E;
    • Ruth, Katherine S;
    • Yaghootkar, Hanieh;
    • Sharp, Seth;
    • Thompson, William D;
    • Ji, Yingjie;
    • Harrison, Jamie;
    • Freathy, Rachel M;
    • Murray, Anna;
    • Weedon, Michael N;
    • Lewis, Cathryn;
    • Frayling, Timothy M;
    • Hyppönen, Elina
    Publication type:
    journal article
    23
    24

    Gene-obesogenic environment interactions in the UK Biobank study.

    Published in:
    2017
    By:
    • Tyrrell, Jessica;
    • Wood, Andrew R.;
    • Ames, Ryan M.;
    • Yaghootkar, Hanieh;
    • Beaumont, Robin N.;
    • Jones, Samuel E.;
    • Tuke, Marcus A.;
    • Ruth, Katherine S.;
    • Freathy, Rachel M.;
    • Smith, George Davey;
    • Joost, Stéphane;
    • Guessous, Idris;
    • Murray, Anna;
    • Strachan, David P.;
    • Kutalik, Zolt_n;
    • Weedon, Michael N.;
    • Frayling, Timothy M.;
    • Davey Smith, George;
    • Kutalik, Zoltán
    Publication type:
    journal article
    25
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    Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile.

    Published in:
    Diabetologia, 2021, v. 64, n. 12, p. 2790, doi. 10.1007/s00125-021-05570-9
    By:
    • Thompson, William D.;
    • Beaumont, Robin N.;
    • Kuang, Alan;
    • Warrington, Nicole M.;
    • Ji, Yingjie;
    • Tyrrell, Jessica;
    • Wood, Andrew R.;
    • Scholtens, Denise M.;
    • Knight, Bridget A.;
    • Evans, David M.;
    • Lowe Jr, William L.;
    • Santorelli, Gillian;
    • Azad, Rafaq;
    • Mason, Dan;
    • Hattersley, Andrew T.;
    • Frayling, Timothy M.;
    • Yaghootkar, Hanieh;
    • Borges, Maria Carolina;
    • Lawlor, Deborah A.;
    • Freathy, Rachel M.
    Publication type:
    Article
    30
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    Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.

    Published in:
    2016
    By:
    • Yaghootkar, Hanieh;
    • Lotta, Luca A.;
    • Tyrrell, Jessica;
    • Smit, Roelof A. J.;
    • Jones, Sam E.;
    • Donnelly, Louise;
    • Beaumont, Robin;
    • Campbell, Archie;
    • Tuke, Marcus A.;
    • Hayward, Caroline;
    • Ruth, Katherine S.;
    • Padmanabhan, Sandosh;
    • Wouter Jukema, J.;
    • Palmer, Colin C.;
    • Hattersley, Andrew;
    • Freathy, Rachel M.;
    • Langenberg, Claudia;
    • Wareham, Nicholas J.;
    • Wood, Andrew R.;
    • Murray, Anna
    Publication type:
    journal article
    34

    Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion.

    Published in:
    Diabetes, 2015, v. 64, n. 6, p. 2279, doi. 10.2337/db14-1456
    By:
    • Yaghootkar, Hanieh;
    • Stancáková, Alena;
    • Freathy, Rachel M.;
    • Vangipurapu, Jagadish;
    • Weedon, Michael N.;
    • Weijia Xie;
    • Wood, Andrew R.;
    • Ferrannini, Ele;
    • Mari, Andrea;
    • Ring, Susan M.;
    • Lawlor, Debbie A.;
    • Smith, George Davey;
    • Jørgensen, Torben;
    • Hansen, Torben;
    • Pedersen, Oluf;
    • Steinthorsdottir, Valgerdur;
    • Guðbjartsson, Daniel F.;
    • Thorleifsson, Gudmar;
    • Thorsteinsdottir, Unnur;
    • Stefansson, Kari
    Publication type:
    Article
    35

    Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance.

    Published in:
    Diabetes, 2011, v. 60, n. 3, p. 1008, doi. 10.2337/db10-1317
    By:
    • De Silva, N. Maneka G.;
    • Freathy, Rachel M.;
    • Palmer, Tom M.;
    • Donnelly, Louise A.;
    • Jian'an Luan;
    • Gaunt, Tom;
    • Langenberg, Claudia;
    • Weedon, Michael N.;
    • Shields, Beverley;
    • Knight, Beatrice A.;
    • Ward, Kirsten J.;
    • Sandhu, Manjinder S.;
    • Harbord, Roger M.;
    • McCarthy, Mark I.;
    • Smith, George Davey;
    • Ebrahim, Shah;
    • Hattersley, Andrew T.;
    • Wareham, Nicholas;
    • Lawlor, Debbie A.;
    • Morris, Andrew D.
    Publication type:
    Article
    36

    Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups

    Published in:
    Diabetes, 2010, v. 59, n. 10, p. 2682, doi. 10.2337/db10-0177
    By:
    • Freathy, Rachel M.;
    • Hayes, M. Geoffrey;
    • Urbanek, Margrit;
    • Lowe, Lynn P.;
    • Lee, Hoon;
    • Ackerman, Christine;
    • Frayling, Timothy M.;
    • Cox, Nancy J.;
    • Dunger, David B.;
    • Dyer, Alan R.;
    • Hattersley, Andrew T.;
    • Metzger, Boyd E.;
    • Lowe Jr., William L.
    Publication type:
    Article
    37

    Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth.

    Published in:
    Diabetes, 2009, v. 58, n. 6, p. 1428, doi. 10.2337/db08-1739
    By:
    • Freathy, Rachel M.;
    • Bennett, Amanda J.;
    • Ring, Susan M.;
    • Shields, Beverley;
    • Groves, Christopher J.;
    • Timpson, Nicholas J.;
    • Weedon, Michael N.;
    • Zeggini, Eleftheria;
    • Lindgren, Cecilia M.;
    • Lango, Hana;
    • Perry, John R. B.;
    • Pouta, Anneli;
    • Ruokonen, Aimo;
    • Hyppönen, Elina;
    • Power, Chris;
    • Elliott, Paul;
    • Strachan, David P.;
    • Järvelin, Marjo-Riitta;
    • Smith, George Davey;
    • McCarthy, Mark I.
    Publication type:
    Article
    38

    Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI.

    Published in:
    Diabetes, 2008, v. 57, n. 5, p. 1419, doi. 10.2337/db07-1466
    By:
    • Freathy, Rachel M.;
    • Timpson, Nicholas J.;
    • Lawlor, Debbie A.;
    • Pouta, Anneli;
    • Ben-Shlomo, Yoav;
    • Ruokonen, Aimo;
    • Ebrahim, Shah;
    • Shields, Beverley;
    • Zeggini, Eleftheria;
    • Weedon, Michael N.;
    • Lindgren, Cecilia M.;
    • Lango, Hana;
    • Melzer, David;
    • Ferrucci, Luigi;
    • Paolisso, Giuseppe;
    • Neville, Matthew J.;
    • Karpe, Fredrik;
    • Palmer, Colin N. A.;
    • Morris, Andrew D.;
    • Elliott, Paul
    Publication type:
    Article
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    Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension.

    Published in:
    2019
    By:
    • Yingjie Ji;
    • Yiorkas, Andrianos M.;
    • Frau, Francesca;
    • Mook-Kanamori, Dennis;
    • Staiger, Harald;
    • Thomas, E.Louise;
    • Atabaki-Pasdar, Naeimeh;
    • Campbell, Archie;
    • Tyrrell, Jessica;
    • Jones, Samuel E.;
    • Beaumont, Robin N.;
    • Wood, Andrew R.;
    • Tuke, Marcus A.;
    • Ruth, Katherine S.;
    • Mahajan, Anubha;
    • Murray, Anna;
    • Freathy, Rachel M.;
    • Weedon, Michael N.;
    • Hattersley, Andrew T.;
    • Hayward, Caroline
    Publication type:
    journal article
    50