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The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Published in:
2007
By:
- De Silva NM;
- Steele A;
- Shields B;
- Knight B;
- Parnell K;
- Weedon MN;
- Hattersley AT;
- Frayling TM
Publication type:
Journal Article
Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Published in:
2005
By:
- Zeggini E;
- Parkinson JRC;
- Halford S;
- Owen KR;
- Walker M;
- Hitman GA;
- Levy JC;
- Sampson MJ;
- Frayling TM;
- Hattersley AT;
- McCarthy MI
Publication type:
Journal Article
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
Published in:
2008
By:
- Barroso I;
- Luan J;
- Wheeler E;
- Whittaker P;
- Wasson J;
- Zeggini E;
- Weedon MN;
- Hunt S;
- Venkatesh R;
- Frayling TM;
- Delgado M;
- Neuman RJ;
- Zhao J;
- Sherva R;
- Glaser B;
- Walker M;
- Hitman G;
- McCarthy MI;
- Hattersley AT;
- Permutt MA
Publication type:
journal article
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Published in:
2007
By:
- Pascoe L;
- Tura A;
- Patel SK;
- Ibrahim IM;
- Ferrannini E;
- Zeggini E;
- Weedon MN;
- Mari A;
- Hattersley AT;
- McCarthy MI;
- Frayling TM;
- Walker M;
- RISC Consortium;
- Pascoe, Laura;
- Tura, Andrea;
- Patel, Sheila K;
- Ibrahim, Ibrahim M;
- Ferrannini, Ele;
- Zeggini, Eleftheria;
- Weedon, Michael N
Publication type:
journal article
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
Published in:
2007
By:
- Owen KR;
- Groves CJ;
- Hanson RL;
- Knowler WC;
- Shuldiner AR;
- Elbein SC;
- Mitchell BD;
- Froguel P;
- Ng MC;
- Chan JC;
- Jia W;
- Deloukas P;
- Hitman GA;
- Walker M;
- Frayling TM;
- Hattersley AT;
- Zeggini E;
- McCarthy MI;
- Owen, Katharine R;
- Groves, Christopher J
Publication type:
journal article
Assessment of the Role of Common Genetic Variation in the Transient Neonatal Diabetes Mellitus (TNDM) Region in Type 2 Diabetes: A Comparative Genomic and Tagging Single Nucleotide Polymorphism Approach.
Published in:
2006
By:
- Gloyn AL;
- Mackay DJ;
- Weedon MN;
- McCarthy MI;
- Walker M;
- Hitman G;
- Knight BA;
- Owen KR;
- Hattersley AT;
- Frayling TM
Publication type:
Journal Article
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Published in:
2005
By:
- Weedon MN;
- Owen KR;
- Shields B;
- Hitman G;
- Walker M;
- McCarthy MI;
- Hattersley AT;
- Frayling TM;
- Weedon, Michael N;
- Owen, Katharine R;
- Shields, Beverley;
- Hitman, Graham;
- Walker, Mark;
- McCarthy, Mark I;
- Hattersley, Andrew T;
- Frayling, Timothy M
Publication type:
journal article
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Published in:
2005
By:
- Weedon MN;
- Frayling TM;
- Shields B;
- Knight B;
- Turner T;
- Metcalf BS;
- Voss L;
- Wilkin TJ;
- McCarthy A;
- Ben-Shlomo Y;
- Smith GD;
- Ring S;
- Jones R;
- Golding J;
- Byberg L;
- Mann V;
- Axelsson T;
- Syvänen A;
- Leon D;
- Hattersley AT
Publication type:
journal article
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Published in:
2003
By:
- Frayling TM;
- Lindgren CM;
- Chevre JC;
- Menzel S;
- Wishart M;
- Benmezroua Y;
- Brown A;
- Evans JC;
- Rao PS;
- Dina C;
- Lecoeur C;
- Kanninen T;
- Almgren P;
- Bulman MP;
- Wang Y;
- Mills J;
- Wright-Pascoe R;
- Mahtani MM;
- Prisco F;
- Costa A
Publication type:
journal article
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Published in:
1999
By:
- Frayling TM;
- Walker M;
- McCarthy MI;
- Evans JC;
- Allen LI;
- Lynn S;
- Ayres S;
- Millauer B;
- Turner C;
- Turner RC;
- Sampson MJ;
- Hitman GA;
- Ellard S;
- Hattersley AT;
- Frayling, T M;
- Walker, M;
- McCarthy, M I;
- Evans, J C;
- Allen, L I;
- Lynn, S
Publication type:
journal article
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.
Published in:
2008
By:
- Lawlor DA;
- Timpson NJ;
- Harbord RM;
- Leary S;
- Ness A;
- McCarthy MI;
- Frayling TM;
- Hattersley AT;
- Smith GD;
- Lawlor, Debbie A;
- Timpson, Nicholas J;
- Harbord, Roger M;
- Leary, Sam;
- Ness, Andy;
- McCarthy, Mark I;
- Frayling, Timothy M;
- Hattersley, Andrew T;
- Smith, George Davey
Publication type:
journal article

Found: 11