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Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Published in:
Diabetologia, 2006, v. 49, n. 6, p. 1209, doi. 10.1007/s00125-006-0227-2
By:
- Patel, S.;
- Minton, J. A. L.;
- Weedon, M. N.;
- Frayling, T. M.;
- Ricketts, C.;
- Hitman, G. A.;
- McCarthy, M. I.;
- Hattersley, A. T.;
- Walker, M.;
- Barrett, T. G.
Publication type:
Article
Large-scale studies of the association between variation at the TNF/ LTA locus and susceptibility to type 2 diabetes.
Published in:
Diabetologia, 2005, v. 48, n. 10, p. 2013, doi. 10.1007/s00125-005-1902-4
By:
- Zeggini, E.;
- Groves, C. J.;
- Parkinson, J. R. C.;
- Halford, S. R.;
- Owen, K. R.;
- Frayling, T. M.;
- Walker, M.;
- Hitman, G. A.;
- Levy, J. C.;
- O'Rahilly, S.;
- Hattersley, A. T.;
- McCarthy, M. I.
Publication type:
Article
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Published in:
Diabetologia, 2004, v. 47, n. 12, p. 2168, doi. 10.1007/s00125-004-1575-4
By:
- Liew, C. F.;
- Groves, C. J.;
- Wiltshire, S.;
- Zeggini, E.;
- Frayling, T. M.;
- Owen, K. R.;
- Walker, M.;
- Hitman, G. A.;
- Levy, J. C.;
- O’Rahilly, S.;
- Hattersley, A. T.;
- Johnston, D. G.;
- McCarthy, M. I.
Publication type:
Article
Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
Published in:
Diabetologia, 2004, v. 47, n. 5, p. 957, doi. 10.1007/s00125-004-1397-4
By:
- Owen, K. R.;
- Evans, J. C.;
- McCarthy, M. I.;
- Walker, M.;
- Hitman, G. A.;
- Frayling, T. M.;
- Hattersley, A. T.
Publication type:
Article
Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
Published in:
Diabetologia, 2003, v. 46, n. 7, p. 1021, doi. 10.1007/s00125-003-1135-3
By:
- Weedon, M. N.;
- Gloyn, A. L.;
- Davey Smith, G.;
- Ben-Shlomo, Y.;
- Frayling, T. M.;
- Hattersley, A. T.
Publication type:
Article
Conflicting results on variation in the IGFI gene highlight methodological considerations in the design of genetic association studies.
Published in:
Diabetologia, 2002, v. 45, n. 11, p. 1605, doi. 10.1007/s00125-002-0951-1
By:
- Frayling, T. M.;
- Hattersley, A. T;
- Smith, G. D.;
- Ben-Shlomo, Y.
Publication type:
Article
Association of the calpain-10 gene with microvascular function A.C. Shore et al.: Calpain 10 and microvascular function.
Published in:
Diabetologia, 2002, v. 45, n. 6, p. 899, doi. 10.1007/s00125-002-0847-0
By:
- Shore, A. C.;
- Evans, J. C.;
- Frayling, T. M.;
- Clark, P. M.;
- Lee, B. C.;
- Horikawa, Y.;
- Hattersley, A. T.;
- Tooke, J. E.
Publication type:
Article
Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with Type II diabetes.
Published in:
Diabetologia, 2002, v. 45, n. 4, p. 580, doi. 10.1007/s00125-002-0779-8
By:
- Gloyn, A. L.;
- Desai, M.;
- Clark, A.;
- Levy, J. C.;
- Holman, R. R.;
- Frayling, T. M.;
- Hattersley, A. T.;
- Ashcroft, S. J. H.
Publication type:
Article
Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.
Published in:
Diabetologia, 2000, v. 43, n. 12, p. 1558, doi. 10.1007/s001250051569
By:
- Cassell, P. G.;
- Saker, P. J.;
- Huxtable, S. J.;
- Kousta, E.;
- Jackson, A. E.;
- Hattersley, A. T.;
- Frayling, T. M.;
- Walker, M.;
- Kopelman, P. G.;
- Ramachandran, A.;
- Snehelatha, C.;
- Hitman, G. A.;
- McCarthy, M. I.
Publication type:
Article
Intermediate expansions of a X25/frataxin gene GAA repeat and Type II diabetes: assessment using parent-offspring trios.
Published in:
Diabetologia, 2000, v. 43, n. 3, p. 384
By:
- Lynn, S.;
- Hattersley, A.T.;
- McCarthy, M. I.;
- Frayling, T. M.;
- Turnbull, D. M.;
- Walker, M.
Publication type:
Article
A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.
Published in:
Genes & Immunity, 2007, v. 8, n. 7, p. 552, doi. 10.1038/sj.gene.6364414
By:
- Rafiq, S.;
- Frayling, T. M.;
- Murray, A.;
- Hurst, A.;
- Stevens, K.;
- Weedon, M. N.;
- Henley, W.;
- Ferrucci, L.;
- Bandinelli, S.;
- Corsi, A.-M.;
- Guralnik, J. M.;
- Melzer, D.
Publication type:
Article
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.
Published in:
Genes & Immunity, 2007, v. 8, n. 4, p. 344, doi. 10.1038/sj.gene.6364393
By:
- Rafiq, S.;
- Stevens, K.;
- Hurst, A. J.;
- Murray, A.;
- Henley, W.;
- Weedon, M. N.;
- Bandinelli, S.;
- Corsi, A. M.;
- Guralnik, J. M.;
- Ferruci, L.;
- Melzer, D.;
- Frayling, T. M.
Publication type:
Article
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Published in:
Diabetic Medicine, 2011, v. 28, n. 6, p. 681, doi. 10.1111/j.1464-5491.2011.03269.x
By:
- Edghill, E. L.;
- Khamis, A.;
- Weedon, M. N.;
- Walker, M.;
- Hitman, G. A.;
- McCarthy, M. I.;
- Owen, K. R.;
- Ellard, S.;
- Hattersley, A. T.;
- Frayling, T. M.
Publication type:
Article
An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.
Published in:
Diabetic Medicine, 2011, v. 28, n. 6, p. 673, doi. 10.1111/j.1464-5491.2011.03257.x
By:
- Rees, S. D.;
- Islam, M.;
- Hydrie, M. Z. I.;
- Chaudhary, B.;
- Bellary, S.;
- Hashmi, S.;
- O'Hare, J. P.;
- Kumar, S.;
- Sanghera, D. K.;
- Chaturvedi, N.;
- Barnett, A. H.;
- Shera, A. S.;
- Weedon, M. N.;
- Basit, A.;
- Frayling, T. M.;
- Kelly, M. A.;
- Jafar, T. H.
Publication type:
Article
The transcription factor 7-like 2 ( TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Published in:
Diabetic Medicine, 2007, v. 24, n. 10, p. 1067, doi. 10.1111/j.1464-5491.2007.02253.x
By:
- De Silva, N. M. G.;
- Steele, A.;
- Shields, B.;
- Knight, B.;
- Parnell, K.;
- Weedon, M. N.;
- Hattersley, A. T.;
- Frayling, T. M.
Publication type:
Article
A new era in finding Type 2 diabetes genes—the unusual suspects.
Published in:
Diabetic Medicine, 2007, v. 24, n. 7, p. 696, doi. 10.1111/j.1464-5491.2007.02172.x
By:
- Frayling, T. M.
Publication type:
Article
Asian MODY: are we missing an important diagnosis?
Published in:
Diabetic Medicine, 2006, v. 23, n. 11, p. 1257, doi. 10.1111/j.1464-5491.2006.01958.x
By:
- Porter, J. R.;
- Rangasami, J. J.;
- Ellard, S.;
- Gloyn, A. L.;
- Shields, B. M.;
- Edwards, J.;
- Anderson, J. M.;
- Shaw, N. J.;
- Hattersley, A. T.;
- Frayling, T. M.;
- Plunkett, M.;
- Barrett, T. G.
Publication type:
Article
Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Published in:
Diabetic Medicine, 2005, v. 22, n. 12, p. 1696, doi. 10.1111/j.1464-5491.2005.01717.x
By:
- Zeggini, E.;
- Parkinson, J. R C.;
- Halford, S.;
- Owen, K. R.;
- Walker, M.;
- Hitman, G. A.;
- Levy, J. C.;
- Sampson, M. J.;
- Frayling, T. M.;
- Hattersley, A. T.;
- McCarthy, M. I.
Publication type:
Article
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.
Published in:
International Journal of Obesity, 2011, v. 35, n. 2, p. 300, doi. 10.1038/ijo.2010.137
By:
- Timpson, N. J.;
- Nordestgaard, B. G.;
- Harbord, R. M.;
- Zacho, J.;
- Frayling, T. M.;
- Tybjærg-Hansen, A.;
- Davey Smith, G.
Publication type:
Article
Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans.
Published in:
Annals of Human Genetics, 2006, v. 70, n. 6, p. 726, doi. 10.1111/j.1469-1809.2006.00289.x
By:
- Wiltshire, S.;
- Bell, J. T.;
- Groves, C. J.;
- Dina, C.;
- Hattersley, A. T.;
- Frayling, T. M.;
- Walker, M.;
- Hitman, G. A.;
- Vaxillaire, M.;
- Farrall, M.;
- Froguel, P.;
- McCarthy, M. I.
Publication type:
Article
CME GENETICS. Genome-wide association studies: the good, the bad and the ugly.
Published in:
Clinical Medicine, 2014, v. 14, n. 4, p. 428, doi. 10.7861/clinmedicine.14-4-428
By:
- Frayling, T. M.
Publication type:
Article
Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.
Published in:
Clinical & Experimental Immunology, 2010, v. 161, n. 2, p. 284, doi. 10.1111/j.1365-2249.2010.04185.x
By:
- Rafiq, S.;
- Frayling, T. M.;
- Vyse, T. J.;
- Graham, D. S. Cunninghame;
- Eggleton, P.
Publication type:
Article
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
Published in:
2001
By:
- Frayling, T M;
- Evans, J C;
- Bulman, M P;
- Pearson, E;
- Allen, L;
- Owen, K;
- Bingham, C;
- Hannemann, M;
- Shepherd, M;
- Ellard, S;
- Hattersley, A T
Publication type:
journal article
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
Published in:
2001
By:
- Pearson, Ewan R.;
- Velho, Gilberto;
- Clark, Penny;
- Stride, Amanda;
- Shepherd, Maggie;
- Frayling, Timothy M.;
- Bulman, Michael P.;
- Ellard, Sian;
- Froguel, Phillipe;
- Hattersley, Andrew T.;
- Pearson, E R;
- Velho, G;
- Clark, P;
- Stride, A;
- Shepherd, M;
- Frayling, T M;
- Bulman, M P;
- Ellard, S;
- Froguel, P;
- Hattersley, A T
Publication type:
journal article
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Published in:
2000
By:
- Huxtable, Stewart J.;
- Saker, Philip J.;
- Haddad, Lema;
- Walker, Mark;
- Frayling, Timothy M.;
- Levy, Jonathan C.;
- Hitman, Graham A.;
- O'Rahilly, Stephen;
- Hattersley, Andrew T.;
- McCarthy, Mark I.;
- Huxtable, S J;
- Saker, P J;
- Haddad, L;
- Walker, M;
- Frayling, T M;
- Levy, J C;
- Hitman, G A;
- O'Rahilly, S;
- Hattersley, A T;
- McCarthy, M I
Publication type:
journal article
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Published in:
1999
By:
- Frayling TM;
- Walker M;
- McCarthy MI;
- Evans JC;
- Allen LI;
- Lynn S;
- Ayres S;
- Millauer B;
- Turner C;
- Turner RC;
- Sampson MJ;
- Hitman GA;
- Ellard S;
- Hattersley AT;
- Frayling, T M;
- Walker, M;
- McCarthy, M I;
- Evans, J C;
- Allen, L I;
- Lynn, S
Publication type:
journal article
Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young.
Published in:
1999
By:
- Ellard, Sian;
- Bulman, Michael P.;
- Frayling, Timothy M.;
- Allen, Lisa I.S.;
- Dronsfield, Mark J.;
- Tack, Cees J.;
- Hattersley, Andrew T.;
- Ellard, S;
- Bulman, M P;
- Frayling, T M;
- Allen, L I;
- Dronsfield, M J;
- Tack, C J;
- Hattersley, A T
Publication type:
journal article
Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
Published in:
1997
By:
- Frayling, Timothy M.;
- Bulman, Michael P.;
- Ellard, Sian;
- Appleton, Maggie;
- Dronsfleld, Mark J.;
- Mackie, Alasdair D. R.;
- Baird, Joyce D.;
- Kaisaki, Pamela J.;
- Yamagata, Kazuya;
- Bell, Graeme I.;
- Bain, Stephen C.;
- Hattersley, Andrew T.;
- Frayling, T M;
- Bulamn, M P;
- Ellard, S;
- Appleton, M;
- Dronsfield, M J;
- Mackie, A D;
- Baird, J D;
- Kaisaki, P J
Publication type:
journal article
Estimating sleep parameters using an accelerometer without sleep diary.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31266-z
By:
- van Hees, Vincent Theodoor;
- Sabia, S.;
- Jones, S. E.;
- Wood, A. R.;
- Anderson, K. N.;
- Kivimäki, M.;
- Frayling, T. M.;
- Pack, A. I.;
- Bucan, M.;
- Trenell, M. I.;
- Mazzotti, Diego R.;
- Gehrman, P. R.;
- Singh-Manoux, B. A.;
- Weedon, M. N.
Publication type:
Article

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