Works by Fraser, Douglas D.

Results: 58

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00610-z

By:

Patel, Maitray A.;
Knauer, Michael J.;
Nicholson, Michael;
Daley, Mark;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00548-8

By:

Patel, Maitray A.;
Knauer, Michael J.;
Nicholson, Michael;
Daley, Mark;
Van Nynatten, Logan R.;
Martin, Claudio;
Patterson, Eric K.;
Cepinskas, Gediminas;
Seney, Shannon L.;
Dobretzberger, Verena;
Miholits, Markus;
Webb, Brian;
Fraser, Douglas D.

Publication type:

Article

Pivoting injury prevention efforts during a pandemic: results of an international survey.

Published in:

Injury Epidemiology, 2023, v. 10, n. 1, p. 1, doi. 10.1186/s40621-023-00472-3

By:

Charyk Stewart, Tanya;
Unni, Purnima;
Hanson, Holly Renee;
Gilliland, Jason;
Clark, Andrew;
Fraser, Douglas D.

Publication type:

Article

Neutralizing antibodies to SARS-CoV-2 variants of concern: a pediatric surveillance study.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-95956-1

By:

Fraser, Douglas D.;
Singh, Devika;
Cela, Enis;
Patel, Maitray A.;
Assaf, Maysaa;
Quintero, Maritza;
Knauer, Michael;
Miller, Michael R.;
Bellini, Melina;
Li, Angela;
Hahn, Paul;
Hrek, Marta;
Cruz-Aguado, Jorge

Publication type:

Article

Cardiac Arrest Following Ketamine Administration for Rapid Sequence Intubation.

Published in:

Journal of Intensive Care Medicine, 2013, v. 28, n. 6, p. 375, doi. 10.1177/0885066612448732

By:

Dewhirst, Elisabeth;
Frazier, W. Joshua;
Leder, Marc;
Fraser, Douglas D.;
Tobias, Joseph D.

Publication type:

Article

Pretreatment of Human Cerebrovascular Endothelial Cells with CO-releasing Molecule-3 Interferes with JNK/ AP-1 Signaling and Suppresses LPS-induced Proadhesive Phenotype.

Published in:

Microcirculation, 2015, v. 22, n. 1, p. 28, doi. 10.1111/micc.12161

By:

Serizawa, Fukashi;
Patterson, Eric;
Potter, Richard F.;
Fraser, Douglas D.;
Cepinskas, Gediminas

Publication type:

Article

Diabetic Ketoacidosis Elicits Systemic Inflammation Associated with Cerebrovascular Endothelial Cell Dysfunction.

Published in:

Microcirculation, 2013, v. 20, n. 6, p. 534, doi. 10.1111/micc.12053

By:

Close, Taylor E.;
Cepinskas, Gediminas;
Omatsu, Tatsushi;
Rose, Keeley L.;
Summers, Kelly;
Patterson, Eric K.;
Fraser, Douglas D.

Publication type:

Article

A Distinct Metabolite Signature in Military Personnel Exposed to Repetitive Low-Level Blasts.

Published in:

Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.831792

By:

Miller, Michael R.;
DiBattista, Alicia;
Patel, Maitray A.;
Daley, Mark;
Tenn, Catherine;
Nakashima, Ann;
Rhind, Shawn G.;
Vartanian, Oshin;
Shiu, Maria Y.;
Caddy, Norleen;
Garrett, Michelle;
Saunders, Doug;
Smith, Ingrid;
Jetly, Rakesh;
Fraser, Douglas D.

Publication type:

Article

Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics.

Published in:

Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.787480

By:

Miller, Michael R.;
Robinson, Michael;
Fischer, Lisa;
DiBattista, Alicia;
Patel, Maitray A.;
Daley, Mark;
Bartha, Robert;
Dekaban, Gregory A.;
Menon, Ravi S.;
Shoemaker, J. Kevin;
Diamandis, Eleftherios P.;
Prassas, Ioannis;
Fraser, Douglas D.

Publication type:

Article

Research Priorities in the Field of Posttraumatic Pain and Disability: Results of a Transdisciplinary Consensus-Generating Workshop.

Published in:

2016

By:

Walton, David M.;
Elliott, James M.;
Lee, Joshua;
Loh, Eldon;
MacDermid, Joy C.;
Schabrun, Siobhan;
Siqueira, Walter L.;
Corneil, Brian D.;
Aal, Bill;
Birmingham, Trevor;
Brown, Amy;
Cooper, Lynn K.;
Dickey, James P.;
Dixon, S. Jeffrey;
Fraser, Douglas D.;
Gati, Joseph S.;
Gloor, Gregory B.;
Good, Gordon;
Holdsworth, David;
McLean, Samuel A.

Publication type:

journal article

Plasma Protein Profiling by Proximity Extension Assay Technology Reveals Novel Biomarkers of Traumatic Brain Injury—A Pilot Study.

Published in:

Journal of Applied Laboratory Medicine, 2021, v. 6, n. 5, p. 1165, doi. 10.1093/jalm/jfab004

By:

Chen, Michelle;
Ren, Annie H;
Prassas, Ioannis;
Soosaipillai, Antoninus;
Lim, Bryant;
Fraser, Douglas D;
Diamandis, Eleftherios P

Publication type:

Article

Patients with severe COVID-19 do not have elevated autoantibodies against common diagnostic autoantigens.

Published in:

Clinical Chemistry & Laboratory Medicine, 2022, v. 60, n. 7, p. 1116, doi. 10.1515/cclm-2022-0239

By:

Ulndreaj, Antigona;
Wang, Mingyue;
Misaghian, Salvia;
Paone, Louis;
Sigal, George B.;
Stengelin, Martin;
Campbell, Christopher;
Van Nynatten, Logan R.;
Soosaipillai, Antoninus;
Ghorbani, Atefeh;
Mathew, Anu;
Fraser, Douglas D.;
Diamandis, Eleftherios P.;
Prassas, Ioannis

Publication type:

Article

Novel severe traumatic brain injury blood outcome biomarkers identified with proximity extension assay.

Published in:

Clinical Chemistry & Laboratory Medicine, 2021, v. 59, n. 10, p. 1662, doi. 10.1515/cclm-2021-0103

By:

Fraser, Douglas D.;
Chen, Michelle;
Ren, Annie;
Miller, Michael R.;
Martin, Claudio;
Daley, Mark;
Diamandis, Eleftherios P.;
Prassas, Ioannis

Publication type:

Article

Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro.

Published in:

Critical Care, 2015, v. 19, n. 1, p. 1, doi. 10.1186/s13054-015-0883-z

By:

Blom, Chris;
Deller, Brittany L.;
Fraser, Douglas D.;
Patterson, Eric K.;
Martin, Claudio M.;
Young, Bryan;
Liaw, Patricia C.;
Yazdan-Ashoori, Payam;
Ortiz, Angelica;
Webb, Brian;
Kilmer, Greg;
Carter, David E.;
Cepinskas, Gediminas

Publication type:

Article

A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage.

Published in:

Pathophysiology, 2021, v. 28, n. 3, p. 320, doi. 10.3390/pathophysiology28030021

By:

Patterson, Eric K.;
Vanin Moreno, Nicolas;
Fraser, Douglas D.;
Cepinskas, Gediminas;
Iida, Takaya;
Berard, Roberta A.

Publication type:

Article

Critically Ill COVID-19 Patients Exhibit Anti-SARS-CoV-2 Serological Responses.

Published in:

Pathophysiology, 2021, v. 28, n. 2, p. 212, doi. 10.3390/pathophysiology28020014

By:

Fraser, Douglas D.;
Cepinskas, Gediminas;
Slessarev, Marat;
Martin, Claudio M.;
Daley, Mark;
Patel, Maitray A.;
Miller, Michael R.;
Patterson, Eric K.;
O'Gorman, David B.;
Gill, Sean E.;
Higgins, Ian;
John, Julius P. P.;
Melo, Christopher;
Nini, Lylia;
Wang, Xiaoqin;
Zeidler, Johannes;
Cruz-Aguado, Jorge A.

Publication type:

Article

Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores.

Published in:

Journal of Inflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12950-024-00379-w

By:

Leonard, Sean;
Guertin, Hailey;
Odoardi, Natalya;
Miller, Michael R.;
Patel, Maitray A.;
Daley, Mark;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Astrocytic GABA receptors.

Published in:

Glia (0894-1491), 1994, v. 11, n. 2, p. 83, doi. 10.1002/glia.440110203

By:

Fraser, Douglas D.;
Mudrick-Donnon, Lori A.;
Macvicar, Brian A.

Publication type:

Article

Initial evaluation of extracorporeal immunomodulatory therapy for the treatment of critically ill COVID-19 infected patients.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21944-4

By:

Lemoine, Sandrine;
Penny, Jarrin;
Fraser, Douglas D.;
Salerno, Fabio R.;
Dorie, Justin;
Tamasi, Tanya;
Arntfield, Robert;
House, Andrew;
Slessarev, Marat;
McIntyre, Christopher W.

Publication type:

Article

Severe Hypernatremic Dehydration and Metabolic Acidosis due to Neonatal Intestinal Microvillus Inclusion Disease.

Published in:

Neonatology (16617800), 2012, v. 101, n. 2, p. 154, doi. 10.1159/000330570

By:

Shahid, Shaneela;
Fraser, Douglas D.;
Driman, David K.;
Bax, Kevin C.

Publication type:

Article

Neutrophil serine proteases in vitro: How much and why?

Published in:

Journal of Leukocyte Biology, 2022, v. 112, n. 4, p. 585, doi. 10.1002/JLB.3LT0722-360R

By:

Patterson, Eric K.;
Fraser, Douglas D.;
Cepinskas, Gediminas

Publication type:

Article

Complications of mechanical ventilation in the pediatric population.

Published in:

Pediatric Pulmonology, 2011, v. 46, n. 5, p. 452, doi. 10.1002/ppul.21389

By:

Principi, Tania;
Fraser, Douglas D.;
Morrison, Gavin C.;
Farsi, Sami Al;
Carrelas, Jose F.;
Maurice, Elizabeth A.;
Kornecki, Alik

Publication type:

Article

Cohort-Specific Serological Recognition of SARS-CoV-2 Variant RBD Antigens.

Published in:

Annals of Clinical & Laboratory Science, 2022, v. 52, n. 4, p. 651

By:

Fraser, Douglas D.;
Miller, Michael R.;
Martin, Claudio M.;
Slessarev, Marat;
Hahn, Paul;
Higgins, Ian;
Melo, Christopher;
Pest, Michael A.;
Rothery, Nate;
Xiaoqin Wang;
Zeidler, Johannes;
Cruz-Aguado, Jorge A.

Publication type:

Article

A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.

Published in:

Clinical Proteomics, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12014-024-09488-3

By:

Patel, Maitray A.;
Daley, Mark;
Van Nynatten, Logan R.;
Slessarev, Marat;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Correction: Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients.

Published in:

2024

By:

Kaneko, Tomonori;
Ezra, Sally;
Abdo, Rober;
Voss, Courtney;
Zhong, Shanshan;
Liu, Xuguang;
Hovey, Owen;
Slessarev, Marat;
Van Nynatten, Logan Robert;
Ye, Mingliang;
Fraser, Douglas D.;
Li, Shawn Shun‑Cheng

Publication type:

Correction Notice

Correction: Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients.

Published in:

2024

By:

Kaneko, Tomonori;
Ezra, Sally;
Abdo, Rober;
Voss, Courtney;
Zhong, Shanshan;
Liu, Xuguang;
Hovey, Owen;
Slessarev, Marat;
Van Nynatten, Logan Robert;
Ye, Mingliang;
Fraser, Douglas D.;
Li, Shawn Shun‑Cheng

Publication type:

Correction Notice

Novel plasma protein biomarkers from critically ill sepsis patients.

Published in:

Clinical Proteomics, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12014-022-09389-3

By:

Van Nynatten, Logan R.;
Slessarev, Marat;
Martin, Claudio M.;
Leligdowicz, Aleks;
Miller, Michael R.;
Patel, Maitray A.;
Daley, Mark;
Patterson, Eric K.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in postmortem brain obtained from children with generalized epilepsy.

Published in:

2001

By:

Wang, Wei;
Dow, Kimberly E.;
Fraser, Douglas D.;
Wang, W;
Dow, K E;
Fraser, D D

Publication type:

journal article

Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function.

Published in:

Journal of Translational Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12967-023-04149-9

By:

Iosef, Cristiana;
Knauer, Michael J.;
Nicholson, Michael;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Draghici, Sorin;
Han, Victor K. M.;
Fraser, Douglas D.

Publication type:

Article

The utility of syndecan-1 circulating levels as a biomarker in patients with previous or active COVID-19: a systematic review and meta-analysis.

Published in:

BMC Infectious Diseases, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12879-023-08473-9

By:

Ghondaghsaz, Elina;
Khalaji, Amirmohammad;
Norouzi, Mitra;
Fraser, Douglas D.;
Alilou, Sanam;
Behnoush, Amir Hossein

Publication type:

Article

Differential expression of plasma proteins and pathway enrichments in pediatric diabetic ketoacidosis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-024-01056-7

By:

Spagnolo, Paolo;
Cela, Enis;
Patel, Maitray A.;
Tweddell, David;
Daley, Mark;
Clarson, Cheril;
Stranges, Saverio;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-01046-9

By:

Spagnolo, Paolo;
Tweddell, David;
Cela, Enis;
Daley, Mark;
Clarson, Cheril;
Rupar, C. Anthony;
Stranges, Saverio;
Bravo, Michael;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-00806-x

By:

Patel, Maitray A.;
Fraser, Douglas D.;
Daley, Mark;
Cepinskas, Gediminas;
Veraldi, Noemi;
Grazioli, Serge

Publication type:

Article

Assessing the Risk of SARS-CoV-2 Transmission via Surgical Electrocautery Plume.

Published in:

2021

By:

Sowerby, Leigh J.;
Nichols, Anthony C.;
Gibson, Richard;
Sommer, Doron D.;
Moore, Corey;
Fraser, Douglas D.;
Arts, Eric

Publication type:

journal article

Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1452788

By:

Bédard-Matteau, Jérôme;
Soule, Antoine;
Liu, Katelyn Yixiu;
Fourcade, Lyvia;
Fraser, Douglas D.;
Emad, Amin;
Rousseau, Simon

Publication type:

Article

Application of Human Plasma/Serum to Cell Culture In Vitro: A Translational Research Approach to Better Define Disease Mechanisms.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 3, p. 1, doi. 10.1111/cts.70161

By:

Cela, Enis;
Patterson, Eric K.;
Gill, Sean E.;
Cepinskas, Gediminas;
Fraser, Douglas D.

Publication type:

Article

Traumatic brain injury: classification, models, and markers.

Published in:

Biochemistry & Cell Biology, 2018, v. 96, n. 4, p. 391, doi. 10.1139/bcb-2016-0160

By:

Najem, Dema;
Rennie, Kerry;
Ribecco-Lutkiewicz, Maria;
Ly, Dao;
Haukenfrers, Julie;
Liu, Qing;
Nzau, Munyao;
Fraser, Douglas D.;
Bani-Yaghoub, Mahmud

Publication type:

Article

Plasma Biomarkers of Traumatic Brain Injury in Adolescents With Sport-Related Concussion.

Published in:

JAMA Network Open, 2024, v. 7, n. 9, p. e2431959, doi. 10.1001/jamanetworkopen.2024.31959

By:

Tabor, Jason B.;
Penner, Linden C.;
Galarneau, Jean-Michel;
Josafatow, Nik;
Cooper, Jennifer;
Ghodsi, Mohammad;
Huang, Johnny;
Fraser, Douglas D.;
Smirl, Jonathan;
Esser, Michael J.;
Yeates, Keith Owen;
Wellington, Cheryl L.;
Debert, Chantel T.;
Emery, Carolyn A.

Publication type:

Article

A novel multiplex biomarker panel for profiling human acute and chronic kidney disease.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-47418-9

By:

Van Nynatten, Logan R.;
Miller, Michael R.;
Patel, Maitray A.;
Daley, Mark;
Filler, Guido;
Badrnya, Sigrun;
Miholits, Markus;
Webb, Brian;
McIntyre, Christopher W.;
Fraser, Douglas D.

Publication type:

Article

Endocrine dysregulation in COVID-19: molecular mechanisms and insights.

Published in:

Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2024.1459724

By:

Iosef, Cristiana;
Matusa, Andrei M.;
Han, Victor K. M.;
Fraser, Douglas D.

Publication type:

Article

Agitated behavior scale in pediatric traumatic brain injury.

Published in:

Brain Injury, 2019, v. 33, n. 7, p. 916, doi. 10.1080/02699052.2019.1565893

By:

Nowicki, Magda;
Pearlman, Lisa;
Campbell, Craig;
Hicks, Rhiannon;
Fraser, Douglas D.;
Hutchison, Jamie

Publication type:

Article

Brain Metabolite Levels in Sedentary Women and Non-contact Athletes Differ From Contact Athletes.

Published in:

Frontiers in Human Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnhum.2020.593498

By:

Schranz, Amy L.;
Dekaban, Gregory A.;
Fischer, Lisa;
Blackney, Kevin;
Barreira, Christy;
Doherty, Timothy J.;
Fraser, Douglas D.;
Brown, Arthur;
Holmes, Jeff;
Menon, Ravi S.;
Bartha, Robert

Publication type:

Article

Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity.

Published in:

Experimental Biology & Medicine, 2025, p. 1, doi. 10.3389/ebm.2025.10308

By:

Fraser, Douglas D.;
Roy, Swapan;
Kuruc, Matt;
Quintero, Maritza;
Van Nynatten, Logan R.;
Cepinskas, Gediminas;
Zheng, Haiyan;
Soherwardy, Amenah;
Roy, Devjit

Publication type:

Article

Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis.

Published in:

Experimental Biology & Medicine, 2021, v. 246, n. 21, p. 2338, doi. 10.1177/15353702211029284

By:

Patterson, Eric K;
Gillio-Meina, Carolina;
Martin, Claudio M;
Fraser, Douglas D;
Van Nynatten, Logan R;
Slessarev, Marat;
Cepinskas, Gediminas

Publication type:

Article

Cerebrovascular Endothelial Cell Activation in Paediatric Diabetic Ketoacidosis.

Published in:

FASEB Journal, 2013, v. 27, p. 870.8, doi. 10.1096/fasebj.27.1_supplement.870.8

By:

Omatsu, Tatsushi;
Cepinskas, Gediminas;
Fraser, Douglas D

Publication type:

Article

Severe sepsis cytomix elicits inflammation in cerebrovascular endothelial cells and polymorphonuclear (PMN) leukocytes in vitro.

Published in:

FASEB Journal, 2013, v. 27, p. 868.7, doi. 10.1096/fasebj.27.1_supplement.868.7

By:

Blom, Christopher;
Deller, Brittany;
Fraser, Douglas D;
Martin, Claudio;
Young, Bryan;
Cepinskas, Gediminas

Publication type:

Article

Modulating Myeloperoxidase‐Induced Endothelial Permeability by a Carbon Monoxide‐Releasing Molecule, CORM‐3.

Published in:

FASEB Journal, 2013, v. 27, p. 646.12, doi. 10.1096/fasebj.27.1_supplement.646.12

By:

Patterson, Eric K;
Serizawa, Fukashi;
Capretta, Alfredo;
Fraser, Douglas D;
Potter, Richard F;
Cepinskas, Gediminas

Publication type:

Article

Sodium hydrogen exchanger (NHE) antagonist methyl isobutyl amiloride inhibits cerebral edema associated with diabetic ketoacidosis (DKA-CE).

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A964, doi. 10.1096/fasebj.21.6.a964

By:

Rose, Keeley;
Drysdale, Thomas A.;
Fraser, Douglas D.

Publication type:

Article

Widened mediastinum in a child with severe trauma.

Published in:

Canadian Medical Association Journal (CMAJ), 2007, v. 177, n. 10, p. 1181, doi. 10.1503/cmaj.070936

By:

Buffo-Sequeira, Ilan;
Fraser, Douglas D.

Publication type:

Article

Osmotic Myelinolysis with Malignant Cerebellar Edema Occurring after DDAVP-Induced Hyponatremia in a Child.

Published in:

Pediatric Neurosurgery, 2011, v. 46, n. 4, p. 318, doi. 10.1159/000320146

By:

Ranger, Adrianna;
Szymczak, Artur;
Levin, Simon;
Salvadori, Marina;
Fraser, Douglas D.

Publication type:

Article