Works by Fon, Edward A.

Results: 58
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    Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.

    Published in:
    Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07680-1
    By:
    • Tullo, Stephanie;
    • Park, Janice;
    • Gallino, Daniel;
    • Park, Megan;
    • Mar, Kristie;
    • Novikov, Vladislav;
    • Sandoval Contreras, Rodrigo;
    • Patel, Raihaan;
    • del Cid-Pellitero, Esther;
    • Fon, Edward A.;
    • Luo, Wen;
    • Shlaifer, Irina;
    • Durcan, Thomas M.;
    • Prado, Marco A. M.;
    • Prado, Vania F.;
    • Devenyi, Gabriel A.;
    • Chakravarty, M. Mallar
    Publication type:
    Article
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    Activation of parkin by a molecular glue.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51889-3
    By:
    • Sauvé, Véronique;
    • Stefan, Eric;
    • Croteau, Nathalie;
    • Goiran, Thomas;
    • Fakih, Rayan;
    • Bansal, Nupur;
    • Hadzipasic, Adelajda;
    • Fang, Jing;
    • Murugan, Paramasivam;
    • Chen, Shimin;
    • Fon, Edward A.;
    • Hirst, Warren D.;
    • Silvian, Laura F.;
    • Trempe, Jean-François;
    • Gehring, Kalle
    Publication type:
    Article
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    Analysis of Heterozygous PRKN Variants and Copy‐Number Variations in Parkinson's Disease.

    Published in:
    Movement Disorders, 2021, v. 36, n. 1, p. 178, doi. 10.1002/mds.28299
    By:
    • Yu, Eric;
    • Rudakou, Uladzislau;
    • Krohn, Lynne;
    • Mufti, Kheireddin;
    • Ruskey, Jennifer A.;
    • Asayesh, Farnaz;
    • Estiar, Mehrdad A.;
    • Spiegelman, Dan;
    • Surface, Matthew;
    • Fahn, Stanley;
    • Waters, Cheryl H.;
    • Greenbaum, Lior;
    • Espay, Alberto J.;
    • Dauvilliers, Yves;
    • Dupré, Nicolas;
    • Rouleau, Guy A.;
    • Hassin‐Baer, Sharon;
    • Fon, Edward A.;
    • Alcalay, Roy N.;
    • Gan‐Or, Ziv
    Publication type:
    Article
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    Structure-based design and characterization of Parkin-activating mutations.

    Published in:
    Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201419
    By:
    • Stevens, Michael U.;
    • Croteau, Nathalie;
    • Eldeeb, Mohamed A.;
    • Antico, Odetta;
    • Zhi Wei Zeng;
    • Toth, Rachel;
    • Durcan, Thomas M.;
    • Springer, Wolfdieter;
    • Fon, Edward A.;
    • Muqit, Miratul M. K.;
    • Trempe, Jean-François
    Publication type:
    Article
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    T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease.

    Published in:
    NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-01001-3
    By:
    • Johansson, Emil;
    • Freuchet, Antoine;
    • Williams, Gregory P.;
    • Michealis, Tanner;
    • Frazier, April;
    • Litvan, Irene;
    • Goldman, Jennifer G.;
    • Alcalay, Roy N.;
    • Standaert, David G.;
    • Amara, Amy W.;
    • Stover, Natividad;
    • Fon, Edward A.;
    • Postuma, Ronald B.;
    • Sidney, John;
    • Sulzer, David;
    • Lindestam Arlehamn, Cecilia S.;
    • Sette, Alessandro
    Publication type:
    Article
    22

    LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.

    Published in:
    NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-00934-z
    By:
    • Parlar, Sitki Cem;
    • Senkevich, Konstantin;
    • Yu, Eric;
    • Ruskey, Jennifer A.;
    • Ahmad, Jamil;
    • Asayesh, Farnaz;
    • Spiegelman, Dan;
    • Waters, Cheryl;
    • Monchi, Oury;
    • Dauvilliers, Yves;
    • Dupré, Nicolas;
    • Greenbaum, Lior;
    • Hassin-Baer, Sharon;
    • Miliukhina, Irina;
    • Timofeeva, Alla;
    • Emelyanov, Anton;
    • Pchelina, Sofya;
    • Alcalay, Roy N.;
    • Fon, Edward A.;
    • Trempe, Jean-François
    Publication type:
    Article
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    Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.

    Published in:
    Journal of Neurochemistry, 2024, v. 168, n. 8, p. 1546, doi. 10.1111/jnc.15967
    By:
    • Tullo, Stephanie;
    • Miranda, Aline S.;
    • del Cid‐Pellitero, Esther;
    • Lim, Mei Peng;
    • Gallino, Daniel;
    • Attaran, Anoosha;
    • Patel, Raihaan;
    • Novikov, Vladislav;
    • Park, Megan;
    • Beraldo, Flavio H.;
    • Luo, Wen;
    • Shlaifer, Irina;
    • Durcan, Thomas M.;
    • Bussey, Timothy J.;
    • Saksida, Lisa M.;
    • Fon, Edward A.;
    • Prado, Vania F.;
    • Prado, Marco A. M.;
    • Chakravarty, M. Mallar
    Publication type:
    Article
    25

    Rab7A regulates tau secretion.

    Published in:
    Journal of Neurochemistry, 2017, v. 141, n. 4, p. 592, doi. 10.1111/jnc.13994
    By:
    • Rodriguez, Lilia;
    • Mohamed, Nguyen‐Vi;
    • Desjardins, Alexandre;
    • Lippé, Roger;
    • Fon, Edward A;
    • Leclerc, Nicole
    Publication type:
    Article
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    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.

    Published in:
    Acta Neuropathologica, 2022, v. 144, n. 5, p. 881, doi. 10.1007/s00401-022-02491-8
    By:
    • Lackie, Rachel E.;
    • de Miranda, Aline S.;
    • Lim, Mei Peng;
    • Novikov, Vladislav;
    • Madrer, Nimrod;
    • Karunatilleke, Nadun C.;
    • Rutledge, Benjamin S.;
    • Tullo, Stephanie;
    • Brickenden, Anne;
    • Maitland, Matthew E. R.;
    • Greenberg, David;
    • Gallino, Daniel;
    • Luo, Wen;
    • Attaran, Anoosha;
    • Shlaifer, Irina;
    • Del Cid Pellitero, Esther;
    • Schild-Poulter, Caroline;
    • Durcan, Thomas M.;
    • Fon, Edward A.;
    • Duennwald, Martin
    Publication type:
    Article
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    An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders.

    Published in:
    Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00723-x
    By:
    • Dorion, Marie-France;
    • Casas, Diana;
    • Shlaifer, Irina;
    • Yaqubi, Moein;
    • Fleming, Peter;
    • Karpilovsky, Nathan;
    • Chen, Carol X.-Q.;
    • Nicouleau, Michael;
    • Piscopo, Valerio E. C.;
    • MacDougall, Emma J.;
    • Alluli, Aeshah;
    • Goldsmith, Taylor M.;
    • Schneider, Alexandria;
    • Dorion, Samuel;
    • Aprahamian, Nathalia;
    • MacDonald, Adam;
    • Thomas, Rhalena A.;
    • Dudley, Roy W. R.;
    • Hall, Jeffrey A.;
    • Fon, Edward A.
    Publication type:
    Article
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    MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.

    Published in:
    Brain: A Journal of Neurology, 2024, v. 147, n. 2, p. 427, doi. 10.1093/brain/awad298
    By:
    • Dorion, Marie-France;
    • Yaqubi, Moein;
    • Senkevich, Konstantin;
    • Kieran, Nicholas W;
    • MacDonald, Adam;
    • Chen, Carol X Q;
    • Luo, Wen;
    • Wallis, Amber;
    • Shlaifer, Irina;
    • Hall, Jeffery A;
    • Dudley, Roy W R;
    • Glass, Ian A;
    • Laboratory, Birth Defects Research;
    • Stratton, Jo Anne;
    • Fon, Edward A;
    • Bartels, Tim;
    • Antel, Jack P;
    • Gan-or, Ziv;
    • Durcan, Thomas M;
    • Healy, Luke M
    Publication type:
    Article
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    EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain.

    Published in:
    Journal of Neurochemistry, 2010, v. 113, n. 1, p. 153, doi. 10.1111/j.1471-4159.2010.06582.x
    By:
    • Bouvier, David;
    • Tremblay, Marie-Ève;
    • Riad, Mustapha;
    • Corera, Amadou T.;
    • Gingras, Diane;
    • Horn, Katherine E.;
    • Fotouhi, Maryam;
    • Girard, Martine;
    • Murai, Keith K.;
    • Kennedy, Timothy E.;
    • McPherson, Peter S.;
    • Pasquale, Elena B.;
    • Fon, Edward A.;
    • Doucet, Guy
    Publication type:
    Article
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    Ubiquitin is phosphorylated by PINK1 to activate parkin.

    Published in:
    Nature, 2014, v. 510, n. 7503, p. 162, doi. 10.1038/nature13392
    By:
    • Koyano, Fumika;
    • Okatsu, Kei;
    • Kosako, Hidetaka;
    • Tamura, Yasushi;
    • Go, Etsu;
    • Kimura, Mayumi;
    • Kimura, Yoko;
    • Tsuchiya, Hikaru;
    • Yoshihara, Hidehito;
    • Hirokawa, Takatsugu;
    • Endo, Toshiya;
    • Fon, Edward A.;
    • Trempe, Jean-François;
    • Saeki, Yasushi;
    • Tanaka, Keiji;
    • Matsuda, Noriyuki
    Publication type:
    Article
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    Canadian guideline for Parkinson disease.

    Published in:
    2019
    By:
    • Grimes, David;
    • Fitzpatrick, Megan;
    • Gordon, Joyce;
    • Miyasaki, Janis;
    • Fon, Edward A.;
    • Schlossmacher, Michael;
    • Suchowersky, Oksana;
    • Rajput, Alexander;
    • Lafontaine, Anne Louise;
    • Mestre, Tiago;
    • Appel-Cresswell, Silke;
    • Kalia, Suneil K.;
    • Schoffer, Kerrie;
    • Zurowski, Mateusz;
    • Postuma, Ronald B.;
    • Udow, Sean;
    • Fox, Susan;
    • Barbeau, Pauline;
    • Hutton, Brian
    Publication type:
    journal article