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ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 9, p. 3170, doi. 10.1172/JCI63608
By:
- Young-Ho Ahn;
- Gibbons, Don L.;
- Chakravarti, Deepavali;
- Creighton, Chad J.;
- Rizvi, Zain H.;
- Adams, Henry P.;
- Pertsemlidis, Alexander;
- Gregory, Philip A.;
- Wright, Josephine A.;
- Goodall, Gregory J.;
- Flores, Elsa R.;
- Kurie, Jonathan M.
Publication type:
Article
Author Correction: ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.
Published in:
2022
By:
- Napoli, Marco;
- Wu, Sarah J.;
- Gore, Bethanie L.;
- Abbas, Hussein A.;
- Lee, Kyubum;
- Checker, Rahul;
- Dhar, Shilpa;
- Rajapakshe, Kimal;
- Tan, Aik Choon;
- Lee, Min Gyu;
- Coarfa, Cristian;
- Flores, Elsa R.
Publication type:
Correction Notice
ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28202-1
By:
- Napoli, Marco;
- Wu, Sarah J.;
- Gore, Bethanie L.;
- Abbas, Hussein;
- Lee, Kyubum;
- Checker, Rahul;
- Dhar, Shilpa;
- Rajapakshe, Kimal;
- Tan, Aik Choon;
- Lee, Min Gyu;
- Coarfa, Cristian;
- Flores, Elsa R.
Publication type:
Article
TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures.
Published in:
Bioinformatics, 2021, v. 37, n. 20, p. 3681, doi. 10.1093/bioinformatics/btab244
By:
- Xie, Mengyu;
- Lee, Kyubum;
- Lockhart, John H;
- Cukras, Scott D;
- Carvajal, Rodrigo;
- Beg, Amer A;
- Flores, Elsa R;
- Teng, Mingxiang;
- Chung, Christine H;
- Tan, Aik Choon
Publication type:
Article
The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.
Published in:
PLoS Genetics, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.pgen.1008642
By:
- Setty, Bhuvana A.;
- Jinesh, Goodwin G.;
- Arnold, Michael;
- Pettersson, Fredrik;
- Cheng, Chia-Ho;
- Cen, Ling;
- Yoder, Sean J.;
- Teer, Jamie K.;
- Flores, Elsa R.;
- Reed, Damon R.;
- Brohl, Andrew S.
Publication type:
Article
Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming.
Published in:
Cancers, 2022, v. 14, n. 17, p. 4310, doi. 10.3390/cancers14174310
By:
- Yang, Yuanzheng;
- Peng, Zhanglong;
- Flores, Elsa R.;
- Kleinerman, Eugenie S.
Publication type:
Article
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.
Published in:
EMBO Journal, 2009, v. 28, n. 13, p. 1904, doi. 10.1038/emboj.2009.151
By:
- Xiaohua Su;
- Min Soon Cho;
- Young-Jin Gi;
- Ayanga, Bernard A.;
- Sherr, Charles J.;
- Flores, Elsa R.
Publication type:
Article
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.
Published in:
Nature, 2010, v. 467, n. 7318, p. 986, doi. 10.1038/nature09459
By:
- Su, Xiaohua;
- Chakravarti, Deepavali;
- Cho, Min Soon;
- Liu, Lingzhi;
- Gi, Young Jin;
- Lin, Yu-Li;
- Leung, Marco L.;
- El-Naggar, Adel;
- Creighton, Chad J.;
- Suraokar, Milind B.;
- Wistuba, Ignacio;
- Flores, Elsa R.
Publication type:
Article
Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.
Published in:
Neuro-Oncology, 2015, v. 17, n. 11, p. 1463, doi. 10.1093/neuonc/nov041
By:
- Singh, Melissa M.;
- Johnson, Blake;
- Venkatarayan, Avinashnarayan;
- Flores, Elsa R.;
- Jianping Zhang;
- Xiaoping Su;
- Barton, Michelle;
- Lang, Frederick;
- Chandra, Joya
Publication type:
Article
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
Published in:
2017
By:
- Ke Liang;
- Qingsong Hu;
- Ping Li;
- Jun Yao;
- Chunlai Li;
- Wenhao Yang;
- Park, Peter K.;
- Weiya Xia;
- Dihua Yu;
- Chunru Lin;
- Mien-Chie Hung;
- Liuqing Yang;
- Shouyu Wang;
- Marks, Jeffrey R.;
- Lopez-Berestein, Gabriel;
- Flores, Elsa R.;
- Suyun Huang;
- Jianwei Zhou;
- Jian Song;
- Gallick, Gary E.
Publication type:
journal article
The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy.
Published in:
2017
By:
- Napoli, Marco;
- Flores, Elsa R
Publication type:
journal article
P63 and p73 are required for p53-dependent apoptosis in response to DNA damage.
Published in:
Nature, 2002, v. 416, n. 6880, p. 560, doi. 10.1038/416560a
By:
- Flores, Elsa R.;
- Tsai, Kenneth Y.;
- Crowley, Denise;
- Sengupta, Shomit;
- Yang, Annie;
- McKeon, Frank;
- Jacks, Tyler
Publication type:
Article
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Published in:
Nature, 2000, v. 407, n. 6804, p. 645, doi. 10.1038/35036614
By:
- Irwin, Meredith;
- Marin, Maria Carmen;
- Phillips, Andrew C.;
- Seelan, Ratnam S.;
- Smith, David I.;
- Liu, Wanguo;
- Flores, Elsa R.;
- Tsai, Kenneth Y.;
- Jacks, Tyler;
- Vousden, Karen H.;
- Kaelin Jr., William G.
Publication type:
Article
Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-91924-7
By:
- Jinesh, Goodwin G.;
- Napoli, Marco;
- Smallin, Marian T.;
- Davis, Andrew;
- Ackerman, Hayley D.;
- Raulji, Payal;
- Montey, Nicole;
- Flores, Elsa R.;
- Brohl, Andrew S.
Publication type:
Article
Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-74051-7
By:
- Nguyen, Tran N.;
- Rajapakshe, Kimal;
- Nicholas, Courtney;
- Tordesillas, Leticia;
- Ehli, Erik A.;
- Davis, Christel M.;
- Coarfa, Cristian;
- Flores, Elsa R.;
- Dickinson, Sally E.;
- Curiel-Lewandrowski, Clara;
- Tsai, Kenneth Y.
Publication type:
Article
Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-69179-5
By:
- Jinesh, Goodwin G.;
- Napoli, Marco;
- Ackerman, Hayley D.;
- Raulji, Payal M.;
- Montey, Nicole;
- Flores, Elsa R.;
- Brohl, Andrew S.
Publication type:
Article
p63, a key regulator of Ago2, links to the microRNA-144 cluster.
Published in:
Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04854-1
By:
- Wang, Benfan;
- Wu, H. Helena;
- Abuetabh, Yasser;
- Leng, Sarah;
- Davidge, Sandra T.;
- Flores, Elsa R.;
- Eisenstat, David D.;
- Leng, Roger
Publication type:
Article
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.
Published in:
Nature, 2015, v. 517, n. 7536, p. 626, doi. 10.1038/nature13910
By:
- Venkatanarayan, Avinashnarayan;
- Raulji, Payal;
- Norton, William;
- Chakravarti, Deepavali;
- Coarfa, Cristian;
- Su, Xiaohua;
- Sandur, Santosh K.;
- Ramirez, Marc S.;
- Lee, Jaehuk;
- Kingsley, Charles V.;
- Sananikone, Eliot F.;
- Rajapakshe, Kimal;
- Naff, Katherine;
- Parker-Thornburg, Jan;
- Bankson, James A.;
- Tsai, Kenneth Y.;
- Gunaratne, Preethi H.;
- Flores, Elsa R.
Publication type:
Article
Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI).
Published in:
NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00419-3
By:
- Lockhart, John H.;
- Ackerman, Hayley D.;
- Lee, Kyubum;
- Abdalah, Mahmoud;
- Davis, Andrew John;
- Hackel, Nicole;
- Boyle, Theresa A.;
- Saller, James;
- Keske, Aysenur;
- Hänggi, Kay;
- Ruffell, Brian;
- Stringfield, Olya;
- Cress, W. Douglas;
- Tan, Aik Choon;
- Flores, Elsa R.
Publication type:
Article
Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation.
Published in:
Nucleic Acids Research, 2021, v. 49, n. 5, p. 2740, doi. 10.1093/nar/gkab081
By:
- Wu, H Helena;
- Wang, Benfan;
- Armstrong, Stephen R;
- Abuetabh, Yasser;
- Leng, Sarah;
- Roa, Wilson H Y;
- Atfi, Azeddine;
- Marchese, Adriano;
- Wilson, Beverly;
- Sergi, Consolato;
- Flores, Elsa R;
- Eisenstat, David D;
- Leng, Roger P
Publication type:
Article
TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03796-7
By:
- Chunmei Wang;
- Yanlin He;
- Pingwen Xu;
- Yongjie Yang;
- Kenji Saito;
- Yan Xia;
- Xiaofeng Yan;
- Hinton Jr., Antentor;
- Chunling Yan;
- Hongfang Ding;
- Likai Yu;
- Gang Shu;
- Gupta, Rajat;
- Qi Wu;
- Qingchun Tong;
- Lagor, William R.;
- Flores, Elsa R.;
- Yong Xu
Publication type:
Article
Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.
Published in:
2019
By:
- Gunaratne, Preethi H.;
- Pan, Yinghong;
- Rao, Abhi K.;
- Lin, Chunru;
- Hernandez‐Herrera, Anadulce;
- Liang, Ke;
- Rait, Antonina S.;
- Venkatanarayan, Avinashnarayan;
- Benham, Ashley L.;
- Rubab, Farwah;
- Kim, Sang Soo;
- Rajapakshe, Kimal;
- Chan, Clara K.;
- Mangala, Lingegowda S.;
- Lopez‐Berestein, Gabriel;
- Sood, Anil K.;
- Rowat, Amy C.;
- Coarfa, Cristian;
- Pirollo, Kathleen F.;
- Flores, Elsa R.
Publication type:
journal article
p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair.
Published in:
PLoS Genetics, 2009, v. 5, n. 10, p. 1, doi. 10.1371/journal.pgen.1000680
By:
- Yu-Li Lin;
- Sengupta, Shomit;
- Gurdziel, Katherine;
- Bell, George W.;
- Jacks, Tyler;
- Flores, Elsa R.
Publication type:
Article
Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.
Published in:
PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0206008
By:
- Jinesh, Goodwin G.;
- Flores, Elsa R.;
- Brohl, Andrew S.
Publication type:
Article
Elective neck dissection versus observation in patients with head and neck cutaneous squamous cell carcinoma.
Published in:
Cancer (0008543X), 2021, v. 127, n. 23, p. 4413, doi. 10.1002/cncr.33773
By:
- Amit, Moran;
- Liu, Chuan;
- Mansour, Jobran;
- Gleber‐Netto, Frederico O.;
- Tam, Samantha;
- Baruch, Erez N.;
- Aashiq, Mohamed;
- El‐Naggar, Adel K.;
- Moreno, Amy C.;
- Rosenthal, David I.;
- Glisson, Bonnie S.;
- Ferrarotto, Renata;
- Wong, Michael K.;
- Tsai, Kenneth;
- Flores, Elsa R.;
- Migden, Michael R.;
- Silverman, Deborah A.;
- Li, Goujun;
- Khanna, Anshu;
- Goepfert, Ryan P.
Publication type:
Article
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.
Published in:
Nature Reviews Cancer, 2013, v. 13, n. 2, p. 136, doi. 10.1038/nrc3446
By:
- Su, Xiaohua;
- Chakravarti, Deepavali;
- Flores, Elsa R.
Publication type:
Article
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.
Published in:
2012
By:
- Su X;
- Chakravarti D;
- Flores ER;
- Su, Xiaohua;
- Chakravarti, Deepavali;
- Flores, Elsa R
Publication type:
research
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.
Published in:
Aging Cell, 2016, v. 15, n. 4, p. 646, doi. 10.1111/acel.12476
By:
- Wang, Yang;
- Wang, Xinwei;
- Flores, Elsa R.;
- Yu, Jian;
- Chang, Sandy
Publication type:
Article
Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma.
Published in:
JNCI: Journal of the National Cancer Institute, 2022, v. 114, n. 12, p. 1619, doi. 10.1093/jnci/djac163
By:
- Rodriguez, Cristina P;
- Kang, Hyunseok;
- Geiger, Jessica L;
- Burtness, Barbara;
- Chung, Christine H;
- Pickering, Curtis R;
- Fakhry, Carole;
- Le, Quynh Thu;
- Yom, Sue S;
- Galloway, Thomas J;
- Golemis, Erica;
- Li, Alice;
- Shoop, Jeffrey;
- Wong, Stuart;
- Mehra, Ranee;
- Skinner, Heath;
- Saba, Nabil F;
- Flores, Elsa R;
- Myers, Jeffrey N;
- Ford, James M
Publication type:
Article
Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-18973-w
By:
- Napoli, Marco;
- Li, Xiaobo;
- Ackerman, Hayley D.;
- Deshpande, Avani A.;
- Barannikov, Ivan;
- Pisegna, Marlese A.;
- Bedrosian, Isabelle;
- Mitsch, Jürgen;
- Quinlan, Philip;
- Thompson, Alastair;
- Rajapakshe, Kimal;
- Coarfa, Cristian;
- Gunaratne, Preethi H.;
- Marchion, Douglas C.;
- Magliocco, Anthony M.;
- Tsai, Kenneth Y.;
- Flores, Elsa R.
Publication type:
Article
Stem Cell Proliferation in the Skin: α-Catenin Takes Over the Hippo Pathway.
Published in:
Science Signaling, 2011, v. 4, n. 183, p. 1, doi. 10.1126/scisignal.2002311
By:
- Flores, Elsa R.;
- Halder, Georg
Publication type:
Article
P63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 31, p. 12569, doi. 10.1523/JNEUROSCI.1251-13.2013
By:
- Cancino, Gonzalo I.;
- Yiu, Adelaide P.;
- Fait, Michael P.;
- Dugani, Chandrasagar B.;
- Flores, Elsa R.;
- Frankland, Paul W.;
- Josselyn, Sheena A.;
- Miller, Freda D.;
- Kaplan, David R.
Publication type:
Article

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