Works by Fleming, Angeleen

Results: 28
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    A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation.

    Published in:
    Frontiers in Molecular Biosciences, 2024, p. 1, doi. 10.3389/fmolb.2024.1420691
    By:
    • Bonavita, Raffaella;
    • Di Martino, Rosaria;
    • Cortone, Giuseppe;
    • Prodomo, Antonello;
    • Di Gennaro, Mariagrazia;
    • Scerra, Gianluca;
    • Panico, Valentino;
    • Nuzzo, Silvia;
    • Salvatore, Marco;
    • Williams, Sarah V.;
    • Vitale, Fulvia;
    • Caporaso, Maria Gabriella;
    • D’Agostino, Massimo;
    • Pisani, Francesca M.;
    • Fleming, Angeleen;
    • Renna, Maurizio
    Publication type:
    Article
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    Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

    Published in:
    EMBO Molecular Medicine, 2015, v. 7, n. 2, p. 127, doi. 10.15252/emmm.201404137
    By:
    • Schiebler, Mark;
    • Brown, Karen;
    • Hegyi, Krisztina;
    • Newton, Sandra M;
    • Renna, Maurizio;
    • Hepburn, Lucy;
    • Klapholz, Catherine;
    • Coulter, Sarah;
    • Obregón‐Henao, Andres;
    • Henao Tamayo, Marcela;
    • Basaraba, Randall;
    • Kampmann, Beate;
    • Henry, Katherine M;
    • Burgon, Joseph;
    • Renshaw, Stephen A;
    • Fleming, Angeleen;
    • Kay, Robert R;
    • Anderson, Karen E;
    • Hawkins, Phillip T;
    • Ordway, Diane J
    Publication type:
    Article
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    Non-Associative Learning in Larval Zebrafish.

    Published in:
    Neuropsychopharmacology, 2008, v. 33, n. 6, p. 1206, doi. 10.1038/sj.npp.1301489
    By:
    • Best, Jonathan D.;
    • Berghmans, Stéphane;
    • Hunt, Julia J. F. G.;
    • Clarke, Samantha C.;
    • Fleming, Angeleen;
    • Goldsmith, Paul;
    • Roach, Alan G.
    Publication type:
    Article
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    Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

    Published in:
    2019
    By:
    • Siddiqi, Farah H.;
    • Menzies, Fiona M.;
    • Lopez, Ana;
    • Stamatakou, Eleanna;
    • Karabiyik, Cansu;
    • Ureshino, Rodrigo;
    • Ricketts, Thomas;
    • Jimenez-Sanchez, Maria;
    • Esteban, Miguel Angel;
    • Lai, Liangxue;
    • Tortorella, Micky D.;
    • Luo, Zhiwei;
    • Liu, Hao;
    • Metzakopian, Emmanouil;
    • Fernandes, Hugo J. R.;
    • Bassett, Andrew;
    • Karran, Eric;
    • Miller, Bruce L.;
    • Fleming, Angeleen;
    • Rubinsztein, David C.
    Publication type:
    Correction Notice
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    Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09494-2
    By:
    • Siddiqi, Farah H.;
    • Menzies, Fiona M.;
    • Lopez, Ana;
    • Stamatakou, Eleanna;
    • Karabiyik, Cansu;
    • Ureshino, Rodrigo;
    • Ricketts, Thomas;
    • Jimenez-Sanchez, Maria;
    • Esteban, Miguel Angel;
    • Lai, Liangxue;
    • Tortorella, Micky D.;
    • Luo, Zhiwei;
    • Liu, Hao;
    • Metzakopian, Emmanouil;
    • Fernandes, Hugo J. R.;
    • Bassett, Andrew;
    • Karran, Eric;
    • Miller, Bruce L.;
    • Fleming, Angeleen;
    • Rubinsztein, David C.
    Publication type:
    Article
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    A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.

    Published in:
    2017
    By:
    • Lopez, Ana;
    • Lee, Suzee E.;
    • Wojta, Kevin;
    • Ramos, Eliana Marisa;
    • Klein, Eric;
    • Chen, Jason;
    • Boxer, Adam L.;
    • Gorno-Tempini, Maria Luisa;
    • Geschwind, Daniel H.;
    • Schlotawa, Lars;
    • Ogryzko, Nikolay V.;
    • Bigio, Eileen H.;
    • Rogalski, Emily;
    • Weintraub, Sandra;
    • Mesulam, Marsel M.;
    • Consortium, Tauopathy Genetics;
    • Fleming, Angeleen;
    • Coppola, Giovanni;
    • Miller, Bruce L.;
    • Rubinsztein, David C.
    Publication type:
    journal article
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    Corrigendum: PICALM modulates autophagy activity and tau accumulation.

    Published in:
    Nature Communications, 2015, v. 6, n. 1, p. 6110, doi. 10.1038/ncomms7110
    By:
    • Moreau, Kevin;
    • Fleming, Angeleen;
    • Imarisio, Sara;
    • Lopez Ramirez, Ana;
    • Mercer, Jacob L.;
    • Jimenez-Sanchez, Maria;
    • Bento, Carla F.;
    • Puri, Claudia;
    • Zavodszky, Eszter;
    • Siddiqi, Farah;
    • Lavau, Catherine P.;
    • Betton, Maureen;
    • O'Kane, Cahir J.;
    • Wechsler, Daniel S.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    PICALM modulates autophagy activity and tau accumulation.

    Published in:
    Nature Communications, 2014, v. 5, n. 9, p. 4998, doi. 10.1038/ncomms5998
    By:
    • Moreau, Kevin;
    • Fleming, Angeleen;
    • Imarisio, Sara;
    • Lopez Ramirez, Ana;
    • Mercer, Jacob L.;
    • Jimenez-Sanchez, Maria;
    • Bento, Carla F.;
    • Puri, Claudia;
    • Zavodszky, Eszter;
    • Siddiqi, Farah;
    • Lavau, Catherine P.;
    • Betton, Maureen;
    • O'Kane, Cahir J.;
    • Wechsler, Daniel S.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

    Published in:
    Human Molecular Genetics, 2015, v. 24, n. 23, p. 6840, doi. 10.1093/hmg/ddv369
    By:
    • Keatinge, Marcus;
    • Hai Bui;
    • Menke, Aswin;
    • Yu-Chia Chen;
    • Sokol, Anna M.;
    • Qing Bai;
    • Ellett, Felix;
    • Da Costa, Marc;
    • Burke, Derek;
    • Gegg, Matthew;
    • Trollope, Lisa;
    • Payne, Thomas;
    • McTighe, Aimee;
    • Mortiboys, Heather;
    • de Jager, Sarah;
    • Nuthall, Hugh;
    • Ming-Shang Kuo;
    • Fleming, Angeleen;
    • Schapira, Anthony H. V.;
    • Renshaw, Stephen A.
    Publication type:
    Article
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    IGF-1 receptor antagonism inhibits autophagy.

    Published in:
    Human Molecular Genetics, 2013, v. 22, n. 22, p. 4528, doi. 10.1093/hmg/ddt300
    By:
    • Renna, Maurizio;
    • Bento, Carla F.;
    • Fleming, Angeleen;
    • Menzies, Fiona M.;
    • Siddiqi, Farah H.;
    • Ravikumar, Brinda;
    • Puri, Claudia;
    • Garcia-Arencibia, Moises;
    • Sadiq, Oana;
    • Corrochano, Silvia;
    • Carter, Sarah;
    • Brown, Steve D.M.;
    • Acevedo-Arozena, Abraham;
    • Rubinsztein, David C.
    Publication type:
    Article
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    siRNA screen identifies QPCT as a druggable target for Huntington's disease.

    Published in:
    Nature Chemical Biology, 2015, v. 11, n. 5, p. 347, doi. 10.1038/nchembio.1790
    By:
    • Jimenez-Sanchez, Maria;
    • Lam, Wun;
    • Hannus, Michael;
    • Sönnichsen, Birte;
    • Imarisio, Sara;
    • Fleming, Angeleen;
    • Tarditi, Alessia;
    • Menzies, Fiona;
    • Ed Dami, Teresa;
    • Xu, Catherine;
    • Gonzalez-Couto, Eduardo;
    • Lazzeroni, Giulia;
    • Heitz, Freddy;
    • Diamanti, Daniela;
    • Massai, Luisa;
    • Satagopam, Venkata P;
    • Marconi, Guido;
    • Caramelli, Chiara;
    • Nencini, Arianna;
    • Andreini, Matteo
    Publication type:
    Article
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    Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

    Published in:
    Nature Chemical Biology, 2008, v. 4, n. 5, p. 295, doi. 10.1038/nchembio.79
    By:
    • Williams, Andrea;
    • Sarkar, Sovan;
    • Cuddon, Paul;
    • Ttofi, Evangelia K.;
    • Saiki, Shinji;
    • Siddiqi, Farah H.;
    • Jahreiss, Luca;
    • Fleming, Angeleen;
    • Pask, Dean;
    • Goldsmith, Paul;
    • O'Kane, Cahir J.;
    • Floto, Rodrigo Andres;
    • Rubinsztein, David C.
    Publication type:
    Article
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